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Osphena (Ospemifene)
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Osphena (ospemifene) is an oral prescription medicine that brings relief from moderate to severe dyspareunia (painful intercourse) and vaginal dryness among postmenopausal women.
The medicine uses an active substance called ospemifene, a Selective Estrogen Receptor Modulator (SERM). It mimics the function of the estrogen to treat discomfort associated with Vulvar and Vaginal Atrophy (VVA).
Osphena addresses dryness and pain during intercourse. This restores moisture and elasticity to the vaginal walls.
The medicine uses a targeted approach to treat the conditions. The active substance’s reenactment of estrogen functions increases superficial cells in the vaginal lining and reduces parabasal cells, which could be linked to VVA. The mechanism improves the overall health and function of vaginal tissues.
The composition of the medicine is as follows.
| Active Substance | Quantity | Inactive Substances |
| Ospemifene | 60 mg | Titanium dioxide, Pregelatinized starch, Hypromellose, Povidone, Lactose monohydrate, Polyethylene glycol, Magnesium stearate, Mannitol, Triacetin, Sodium starch glycolate, Colloidal silicon dioxide, and Microcrystalline cellulose |
Labelled Warning for Osphena
Osphena comes with a boxed warning stating that using it increases the risk of hormone-related cancers and several cardiovascular incidents.
The medicine is not recommended for use among pregnant or breastfeeding women as it increases the risks of complications during labor and delivery.
You should consult with your healthcare provider to make sure if Osphena is appropriate for use. The regular monitoring and open communication are crucial for safe treatment with this medicine.
The medicine should not be taken by women with a history of:
- Heart attack
- Blood clot
- Hormone-related cancers
- Undiagnosed vaginal bleeding
- Underwent a major surgery
- Deep Vein Thrombosis (DVT)
- Pulmonary Embolism (PE)
Benefits of Osphena
Osphena is found to be effective in improving the quality of life for postmenopausal women with clinical trials showing that the substance effectively increases vaginal moisture, addressing one of the most common complaints among postmenopausal women.
Apart from treating conditions, Osphena improves sexual function and intimacy. The reduction in discomfort triggered by VVA allows women to engage more fully in their personal relationships and daily activities.
The medicine has shown promising results with over 2,200 postmenopausal women reported to have noticed improvements in vaginal dryness and painful intercourse when using it. Moreover, the long-term data show that most women experienced relief from symptoms without experiencing side effects.
Precautions of Osphena
Your healthcare provider will perform medical examinations to assess your reproductive health and detect potential issues early while using the medicines.
You should seek immediate medical treatment if you experience serious side effects especially abnormal vaginal bleeding when using the medicine as this could be signs of an underlying life-threatening condition.
It is important that you keep your healthcare provider informed about all medications you are currently taking to avoid complications that occur due to drug interactions.
You should inform your healthcare provider if you have a history of the following conditions before taking this medicine.
- Hormone-related cancer
- Liver disease
- Cardiovascular problems
- Blood clots
- Diabetes
- Obesity
- High blood pressure
- High cholesterol
- Lupus
- Unexplained and untreated vaginal bleeding
Side Effects of Osphena
Osphena is considered an effective treatment option but users can experience side effects of mild to serious nature when using the medicines. Therefore, being informed about them helps you manage these symptoms safely.
Common Side Effects
Common side effects subside on their own as the body adjusts to the contents in Osphena.
- Hot flashes
- Vaginal discharge
- Heavy vaginal bleeding
- Headache
- Night sweats
- Increased sweating
- Muscle spasms
Serious Side Effects
In case you experience serious side effects, discontinue the medicine and get yourself checked at the nearest hospital.
- Stroke
- Balance problems
- Severe headache
- Slurred speech
- Chest pain
- Irregular breathing
- Blood clot in the lung or body
- Sudden cough
- Coughing up blood
- Wheezing
- Any unusual vaginal bleeding
How to Use Osphena
It is important to adhere to the dosing regimen prescribed by your healthcare provider to achieve the best results with Osphena.
The recommended Osphena dose is one tablet daily with food at the same time. Taking the pill after meals helps in absorption as it gets properly metabolized in the body.
If you have skipped a dose, take it as soon as you remember unless the time for your next scheduled dose is near. In that case, the missed dose should be skilled and the following doses should be taken as per the regular dosing schedule.
Don’t take double doses to make up for the missed one as this increases the risk of serious side effects.
Osphena tablets should be stored at room temperature and kept in their original packaging to protect them from moisture and heat. The medicines should be out of children’s reach.
Drug Interactions of Osphena
Despite Osphena being considered an effective medicine for treating painful intercourse and vaginal dryness, its efficacy can be compromised if combined with various medications.
Osphena interacts with Vitamins B12 (cyanocobalamin) and D3 (cholecalciferol).
Patients should inform their healthcare provider about all medications, vitamins, and supplements they are taking This includes both prescription and over-the-counter drugs. This helps healthcare providers assess the risk of interactions and adjust treatment plans accordingly.
For example, they may prohibit you from taking Osphena and Rifampin together since the latter induces CYP3A4 which decreases the systemic exposure of Osphena by around 58%.
The medicine interacts with the following drugs/substances.
- Trazodone
- Folic acid
- Biotin
- Lipitor (atorvastatin)
- Amitriptyline
- Tizanidine
- Gabapentin
- Metformin
- Hydroxyzine
- Meloxicam
- Pantoprazole
- Tramadol
- Singulair (montelukast)
- Nexium (esomeprazole)
- Aspirin Low Strength (aspirin)
- Lisinopril
- Restasis (cyclosporine ophthalmic)
- Prednisone
- Rifadin (rifampin)
- Warfarin
- Losartan
- Zyrtec (cetirizine)
- Bupropion
- Cymbalta (duloxetine)
- Estradiol
- Diflucan (fluconazole)
- Magnesium oxide
- Losec (omeprazole)
- Synthroid (levothyroxine)
Osphena Alternatives
Your healthcare provider may recommend non-hormonal therapies like lubricants or moisturizers which provide temporary relief from vaginal dryness during intercourse.
These below-mentioned treatment options have their benefits and considerations. However, it’s important for women to discuss them with their healthcare provider before deciding the most suitable choice depending on their condition and treatment goals.
The medicines which are touted as Osphena alternatives are:
FAQ for Osphena
How much does Osphena cost in the USA without insurance?
A 30-tablet supply of Osphena (ospemifene) may set you back approximately $266.33 without insurance in the United States. The medicines may be sold at different rates in various pharmacies.
Why is Osphena so expensive?
Osphena is expensive because it’s a brand-name medication. Osphena’s high cost can also be attributed to investment in research and development and limited market competition. The absence of a generic alternative further exacerbates this issue.
Is there a generic version of Osphena available to help reduce costs?
Yes, there are FDA-approved generic versions of Osphena available at cheaper prices.
Why do Americans buy Osphena from Canada?
Many Americans opt to purchase Osphena from Canadian pharmacies due to lower prices compared to U.S. pharmacies. Prescription medications may be sold at cheaper prices in Canada, making it an appealing option for cost-conscious consumers.
Is it legal to purchase Osphena from a Canadian pharmacy?
Yes, you can purchase Osphena from a pharmacy in Canada if you have a valid prescription.
How long should you take Osphena?
Healthcare providers typically recommend Osphena for use till symptoms persist and benefits outweigh risks. However, your healthcare provide will determine the treatment duration with this medicine depending on your needs and response to treatment
Does Osphena cause hair loss?
Hair loss is not commonly reported as a side effect of Osphena; however, individual reactions can vary. If hair loss occurs, it should be discussed with a healthcare provider.
How long does it take for Osphena to work?
It may take several weeks for you to notice improvements in symptoms such as vaginal dryness or discomfort during intercourse.
What should I do if I miss a dose of Osphena?
If you forget a dose of Osphena, take it right away, unless it’s almost time for your next dose. In that case, skip it and continue your regular dosing regimen.
What happens if you stop taking Osphena?
Symptoms related to vaginal atrophy or discomfort during intercourse may return upon discontinuation of Osphena. You are advised to discuss any changes in medication with your healthcare provider before discontinuing use.
Does Osphena cause weight gain?
Weight gain is one of the potential side effects of Osphena but not everyone may experience them.
How do you stop taking Osphena?
Your healthcare provider may recommend a “tapering off” technique where you gradually reduce the dose over time. This approach reduced the risk of returning symptoms associated with vaginal dryness or painful intercourse.
Our Guarantee For Buying Osphena From A Canadian Pharmacy Partner
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IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.
