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Premarin is available as oral tablets and as a vaginal cream. Both contain conjugated estrogens, but they’re used for different goals and can have different risk–benefit considerations. Estrogen therapy has important safety warnings, so treatment should be individualized and reviewed regularly with a prescriber.
We only dispense medications with a valid prescription from a licensed prescriber.
All prescriptions are reviewed and verified before dispensing. Orders may be delayed or declined if prescription details are missing, do not match the patient information on file, appear altered, or are expired. We may also refuse service if we believe an order is intended for resale or redistribution.
What You Receive
From $40.00 – $42.60
Shipping & Delivery
Delivery times may vary based on location and prescription verification.
This page is for general information only and is not medical advice. For medical questions, please speak with your prescriber. See Sources & Methodology for how this information is reviewed and referenced.
A prescription estrogen therapy available in two forms:
Premarin tablets taken by mouth
Premarin vaginal cream applied inside the vagina with an applicator
Premarin tablets may be used for:
Moderate to severe hot flashes due to menopause
Vulvar and vaginal atrophy symptoms due to menopause
Hypoestrogenism due to hypogonadism, castration, or primary ovarian failure
Premarin vaginal cream is used for:
Atrophic vaginitis and kraurosis vulvae
Moderate to severe dyspareunia related to vulvar and vaginal atrophy due to menopause
Premarin provides estrogen to help relieve symptoms caused by low estrogen after menopause or in other low-estrogen conditions. Vaginal cream is intended to treat symptoms in vaginal tissues; tablets treat systemic symptoms like hot flashes.
Estrogen therapy has serious risks in certain patients. For women with a uterus, estrogen-alone therapy increases the risk of endometrial cancer, and any unusual vaginal bleeding requires prompt evaluation.
Estrogens should not be used to prevent cardiovascular disease or dementia, and clot or stroke risk must be assessed before treatment.
Do not use Premarin if:
Key warnings to know
Some effects are mild, but estrogen therapy can be linked to serious events in higher-risk patients. Get urgent care for symptoms of a blood clot or stroke. Contact your prescriber for persistent pelvic pain, severe headaches, chest pain, or any postmenopausal bleeding.
Possible side effects may include:
Get urgent help right away for
Your prescriber should review your full medication list before starting Premarin. The most important issues are duplicate hormone therapy, medicines that may affect estrogen exposure, and situations where clot risk needs special review.
Interactions to review with your prescriber may include:
| Category | Details |
|---|---|
| Brand Name | Premarin |
| Drug Class | Estrogen therapy |
| Indication | Tablets: menopause hot flashes, vulvar/vaginal atrophy symptoms, hypoestrogenism due to specific causes; Cream: atrophic vaginitis, kraurosis vulvae, menopause-related dyspareunia |
| Dosage Forms | Oral tablets; Vaginal cream with applicator |
| Strengths | Tablets: 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg; Vaginal cream: 0.625 mg conjugated estrogens per gram |
| Boxed Warning | Endometrial cancer risk with unopposed estrogen (uterus present), cardiovascular disorders, breast cancer (estrogen + progestin), probable dementia warning in older patients; see full labeling |
| Who should not use | Contraindications include undiagnosed genital bleeding, estrogen-dependent cancers, active/past thromboembolism and other listed conditions |
| With food | Tablets may be taken without regard to meals |
| Storage | Vaginal cream: store at 20° to 25°C, excursions permitted 15° to 30°C |
| Alternatives | Estradiol tablets or patches; for primarily vaginal symptoms, local options such as estradiol vaginal tablets/inserts or estradiol vaginal cream may be considered when appropriate |
1
Select Your Prescribed Premarin Dosage & Strength
Choose the strength and quantity that matches your prescription, then add it to your cart. Orders are limited to a 90-day supply per fill.
2
Complete Checkout
Ensure your shipping and contact information is correct so your order can be processed without delays.
3
Submit Your Premarin Prescription
Upload your prescription at checkout. If you need a transfer, provide your prescriber or current pharmacy details and we will request it on your behalf.
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Premarin at a discounted rate, call 1-888-551-2467.
Tablets are systemic estrogen therapy commonly used for hot flashes and certain other indications. Vaginal cream is used for vaginal and vulvar symptoms related to menopause.
Not always. Your prescriber may consider local vaginal therapy when the primary issue is vulvar/vaginal atrophy symptoms.
Any postmenopausal vaginal bleeding should be reported and evaluated promptly.
No. Estrogen therapy should not be used for prevention of cardiovascular disease or dementia.
Yes. The labeling notes tablets may be taken without regard to meals.
Yes. Premarin tablets and Premarin vaginal cream are prescription medicines.
You can upload it through our Upload Prescription page, email it to info@myrxoutlet.com, or fax it to 1-888-230-1245. If you need a prescription transfer, just let us know at checkout and include your pharmacy or prescriber contact details.
Your payment is processed only after your prescription and order have been reviewed and approved by our licensed pharmacy team. Once everything is confirmed, we’ll process payment and prepare your order for shipping.
Your order may be placed on hold or declined if prescription details are missing, don’t match, are expired, or can’t be confirmed.
Unfortunately no. We can only ship to residencies.
FDA Prescribing Information, Premarin tablets (conjugated estrogens)
https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/004782s179lbl.pdf
FDA Prescribing Information, Premarin vaginal cream (conjugated estrogens)
https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020216s083lbl.pdf
DailyMed, Premarin vaginal cream label
https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=96609623-528e-4aba-cabe-7254aed816d
Health Canada Product Monograph, Premarin Vaginal Cream
https://pdf.hres.ca/dpd_pm/00045945.PDF
