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Brisdelle (Paroxetine)
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Brisdelle (paroxetine) is a non-hormonal medication designed to address moderate to severe menopausal symptoms, especially hot flashes. The medicine alleviates symptoms by increasing serotonin levels in the brain, reducing the frequency and severity of hot flashes experienced by menopausal women.
Your healthcare provider may prescribe Brisdelle for treating symptoms other than those mentioned above. You may have a thorough discussion regarding the medicine’s uses with your doctor or pharmacists before use.
It contains an active substance called paroxetine mesylate, which is categorized into a drug class called Selective Serotonin Reuptake Inhibitor (SSRI). Its compositions are as follows:
| Active Substance | Quantity | Inactive Substance |
| Paroxetine Mesylate | 9.69 mg of paroxetine mesylate (equivalent to 7.5 mg of paroxetine base) | Gelatin, Sodium starch glycolate, Dibasic calcium phosphate, Magnesium stearate, FD&C Yellow #6 and FD&C Red #40. |
Labelled Warning for Brisdelle
Brisdelle is contraindicatory among patients who are allergic to its active ingredient paroxetine mesylate or any other component in the medication.
Brisdelle should not be used by pregnant women and breastfeeding mothers as its active ingredient paroxetine is associated with increased risk of certain conditions that could cause fetal harm and trigger life-threatening conditions in the baby.
Brisdelle comes with a labeled warning stating that there is a high risk of the following ailment when using the medicine.
- Suicidal thoughts
- Abnormal Bleeding
- Angle-Closure Glaucoma
- Hyponatremia
- Seizures
- Akathisia
- Cognitive and Motor Impairment
- Sexual Dysfunction
Benefits of Brisdelle
Brisdelle stands out in the medical field for being the first and only FDA-approved non-hormonal treatment for managing menopausal hot flashes. This is particularly beneficial for women who prefer to avoid hormone replacement therapy (HRT) due to potential risks associated with estrogen use.
Clinical trials showed Brisdelle being an effective medicine in treating the frequency and severity of hot flashes. Studies showed that those using Brisdelle experienced significant reduction in both the number and intensity of Vasomotor Symptoms (VMS) compared to those on placebo in weeks 4 and 12 of the treatment.
Brisdelle showed promising results as far as tolerance was concerned. Around 20% of respondents experienced at least one common side effect with many adverse effects decreasing in frequency over time as treatment continued.
It offers convenience as a single oral dose of 7.5 mg once daily, making it easy for patients to incorporate into their daily routine. This low dosage is notably lower than typical paroxetine doses used for depression. This improves its safety profile for treating VMS.
The alleviation of hot flashes improves the quality of life among menopausal women. The reduced symptoms lead to better sleep quality and enhanced daily functioning.
Precautions of Brisdelle
You are advised to take caution before using Brisdelle to address the increasing frequency and severity of vasomotor symptoms such as hot flashes.
Inform your doctor if you are on an MAO inhibitor (linezolid, tranylcypromine, rasagiline, phenelzine, isocarboxazid, and selegiline) or any other medication you are using as it could trigger a life-threatening drug interaction.
You should monitor your overall well-being when using Brisdelle and any side effects, especially drowsiness, dizziness, and difficulties in decision-making or reaction times should they occur.
You can manage the risks associated with mitigating risks and get menopausal symptoms treated more effectively with this proactive approach.
Inform your healthcare provider if you have a history of these conditions before starting your treatment with Brisdelle
- High blood pressure
- Stroke
- Cardiovascular diseases
- Kidney disease
- Liver diseases
- Abnormal bleeding or bleeding disorder(s)
- Seizure(s) or epilepsy
- Bipolar disorder
- Depression
- Suicidal thoughts
- Sexual problems;
- Glaucoma
Side Effects of Brisdelle
Brisdelle is a well-tolerated medicine but it may cause side effects, ranging in severity. Users are encouraged to seek medical attention if they experience any severe or concerning symptoms. Reporting these issues promptly may lead to timely intervention and adjustments in treatment.
Common Side Effects
- Headache
- Fatigue
- Nausea
- Vomiting
- Dizziness
- Dry mouth
- Insomnia
- Sexual dysfunction
Serious Side Effects
- Allergic reactions (hives, swelling in your face or throat, respiratory problems)
- Severe skin reaction (sore throat, fever, skin pain, red or purple skin rash with blistering and peeling, burning eyes).
- Hallucinations
- Agitation
- Irregular cardiovascular function
- Muscle stiffness
- Serotonin syndrome
- Gastrointestinal distress
- Worsening depression
- Suicidal thoughts or actions
- Serotonin Syndrome
- Abnormal bleeding
- Bone fractures
- Seizures
- Hyponatremia
How to Use Brisdelle
You can make the most out of your treatment plan with Brisdelle if you adhere to the dosing regimen prescribed by your healthcare provider or follow the instructions on the leaflet that comes with the packaging.
The typical dose is one tablet daily with or without food at the same time each day. You are advised to take the pill at bedtime.
If you have forgotten the prescribed dose, take it as soon as you remember unless it’s almost time for your next dose. In that case, the missed dose should be skipped and you should go about your regular dosing schedule.
Brisdelle shall be stored in its original packaging at room temperature. It should be kept away from moisture, heat, and direct light to maintain efficacy.
Drug Interactions of Brisdelle
Brisdelle’s active substance paroxetine is effective in reducing the severity of hot flashes but it may interact with certain drugs, resulting in life-threatening complications.
The medicines/drugs which Brisdelle can interact with are:
- Tramadol
- Phentermine
- Celebrex (celecoxib)
- Dicyclomine
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Hydrochlorothiazide
- Ibuprofen
- Trazodone
- Magnesium oxide
- Metformin
- Flonase (fluticasone nasal)
- Gabapentin
- Zoloft (sertraline)
- Synthroid (levothyroxine)
- Pantoprazole
- Topiramate
- Zyrtec (cetirizine)
- Prilosec (omeprazole)
- Zolpidem
- Tizanidine
- Lyrica (pregabalin)
- Norvasc (amlodipine besylate)
- Lisinopril
- Cymbalta (duloxetine)
- Aspirin
- Biotin
- Lipitor (atorvastatin)
Brisdelle Alternatives
Your healthcare provider may advise you to make lifestyle adjustments such as managing weight and stress, engaging in regular exercise and physical activities, or limiting alcohol and caffeine consumption to complement VMS treatment with Brisdelle.
This is not the complete list of alternatives. You should consult with your healthcare provider regarding medicines that may share the same treatment mechanism as Brisdelle.
The below-mentioned drugs should not be taken without your healthcare approvers as they may have the risk of life-threatening side effects.
The medicines which are documented to be viable alternatives are:
- Citalopram
- Megestrol
- Estrace
- Fluoxetine
- Premarin
- Desvenlafaxine
- Venlafaxine
- Clonidine
FAQ for Brisdelle
Why is Brisdelle so expensive?
The high price of Brisdelle is influenced by several factors. It’s a brand-name drug, which typically costs more than generic alternatives. The research and development costs involved in creating it also contribute to its price. Patent protections also limit competition, allowing the manufacturer to set a higher price.
Can I get Brisdelle at a discounted price through MyRx Outlet?
Yes, Brisdelle can be purchased at a discounted price from MyRx Outlet.
Why do Americans buy Brisdelle from Canada?
Many Americans opt to buy branded medicines like Brisdelle from Canadian pharmacies because the medicine may be available at cheaper rates as compared to U.S. pharmacies.
Canadian pharmacies often sell the same medications at a fraction of the cost found in the U.S., making it an attractive option for those without insurance.
Is it legal to purchase Brisdelle from a Canadian pharmacy?
Purchasing medications from Canadian pharmacies is legal but a prescription must be attached.
Does Brisdelle cause weight gain?
Weight gain is a side effect of Brisdelle but not everyone may experience them.
How long does it take for Brisdelle to start working?
Brisdelle may take several weeks to alleviate symptoms such as hot flashes or mood changes. Patients are advised to continue taking the medication as prescribed even if immediate relief is not felt.
What should I do if I miss a dose of Brisdelle?
If you did not take the prescribed dose of Brisdelle, take it as soon as you remember unless you are close to the next one. Stick to your regular schedule from there on. Extra doses should not be taken to cover for the missed ones due to the increased risk of serious side effects
Can you use Brisdelle for depression?
Brisdelle primarily treats menopause-associated hot flashes but doctors also recommend it to treat depression and anxiety disorders as it contains an active substance called paroxetine, a Selective serotonin reuptake inhibitor.
Is Brisdelle the same as Paxil?
Yes, Brisdelle and Paxil are the same because they both contain paroxetine, which is also the active ingredient in Paxil. However, both medicines are marketed for different use with the former for menopausal symptoms and the latter for depression and anxiety disorders.
What should I do if I accidentally take more than the prescribed dose?
Brisdelle overdose requires seeking medical attention immediately or contacting your local poison control center. You may experience severe drowsiness, nausea, vomiting, or rapid heart rate if the medicine is taken in excess to the prescribed amount.
What time of day should I take Brisdelle?
Brisdelle can be taken at any time of day but you are advised to take it at the same time each day to maintain consistent levels in your bloodstream.
What is the difference between Brisdelle and Paroxetine?
Brisdelle is a brand name for paroxetine specifically formulated for treating menopausal symptoms like hot flashes. Paroxetine is available in various formulations and used primarily for mental health conditions such as depression and anxiety disorders.
Our Guarantee For Buying Brisdelle From A Canadian Pharmacy Partner
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Brisdelle at a discounted rate, call 1-888-551-2467.
IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.
