Fiasp is a type of insulin aspart, which is a rapid-acting insulin analog. It was developed to address the need for quicker insulin action after meals, thus controlling post-meal blood sugar spikes more effectively. The name “Fiasp” stands for “Fast-Acting Insulin Aspart.”

Fiasp is engineered to have an ultra-fast onset of action, meaning it starts working more rapidly (compared to insulins, such as NovoLog) after injection compared to traditional insulin aspart. The formulation contains two excipients that contribute to its faster absorption rate. Vitamin B3 (niacinamide) helps increase the speed of absorption, while a naturally occurring amino acid (L-Arginine) aids in stabilizing the insulin molecules.

Onset of Appearance | Fiasp® (insulin aspart injection) 100 U/mL

When injected subcutaneously, Fiasp enters the bloodstream quickly, allowing it to mimic the body’s natural insulin response more closely. This rapid action helps control blood glucose levels during and after meals, reducing the risk of hyperglycemia.

Fiasp is primarily used in the management of diabetes mellitus, particularly type 1 diabetes and type 2 diabetes. It is indicated for both adults and children above a certain age, as prescribed by a healthcare professional. Fiasp is usually administered in combination with a long-acting insulin or basal insulin to provide comprehensive glycemic control.

Fiasp FlexTouch Pens

Fiasp FlexTouch Pens are a type of insulin pen designed to deliver fast-acting insulin to help manage blood sugar spikes effectively.

Unlike traditional insulin pens, Fiasp FlexTouch Pens are engineered to deliver insulin more rapidly. This means that Fiasp starts working faster, helping to address post-meal blood sugar spikes more efficiently.

The benefits of using Fiasp FlexTouch Pens are numerous. Firstly, their faster action ensures quicker blood sugar control after meals, promoting better overall glucose management. Additionally, Fiasp FlexTouch Pens are easy to use and offer a user-friendly experience, making them suitable for all age groups.

Using Fiasp FlexTouch Pens can be seamlessly integrated into daily diabetes management routines. Its simple administration and fast action make it a reliable companion for individuals with busy lifestyles. Fiasp FlexTouch pens come pre-filled with insulin and are compact, portable, and easy to use.

How To Use

If you require further advice, please contact your healthcare professional. You can also contact our customer service team, who will arrange a free pharmacy consultation.

Preparing for Injection

Before using the Fiasp FlexTouch pen, wash your hands thoroughly with soap and water. Ensure that the insulin inside the pen is clear and colorless; do not use it if it appears cloudy or discolored. Remember to check the expiration date on the pen and never use an expired pen.

Choosing the Injection Site

Selecting the right injection site is crucial for optimal insulin absorption. Common injection sites include the abdomen, thighs, upper arms, and buttocks. Rotate the injection sites to prevent lipohypertrophy (thickened fatty areas) and ensure consistent absorption.

Administering the Injection

Remove the cap from the Fiasp FlexTouch pen and prime it by dialing two units and pressing the injection button. This step ensures that the pen is ready for accurate dosing. After priming, dial the desired dose of insulin as prescribed by your healthcare provider. Insert the needle into the chosen injection site at a 90-degree angle and push the injection button to administer the insulin. Hold the pen in place for a few seconds to ensure that the full dose is delivered.

Fiasp PenFill Cartridges

Fiasp Penfill cartridges are a rapid-acting insulin formulation that contains a modified version of insulin aspart. The modification allows for faster absorption into the bloodstream, resulting in a quicker onset of action compared to traditional insulin. The PenFill cartridges are used to load the FlexTouch Pens. By using the same pen, users are able to save money.

One of the primary benefits of Fiasp Penfill cartridges is the improved post-meal blood sugar control they offer. This rapid-acting insulin can efficiently reduce the rise in blood sugar levels after eating, leading to better overall glucose management. The ability to administer the injection just before or after meals makes it a convenient option for those with busy schedules.

Furthermore, Fiasp Penfill cartridges are designed to be user-friendly. They come in a pre-filled pen, eliminating the need for vials and syringes. This design makes it easier for individuals to measure their doses accurately and inject the insulin without any hassle.

How To Load

Follow these steps to load the Fiasp PenFill cartridge into the insulin pen:

  1. Remove the PenFill cap: Take off the cap from the Fiasp PenFill cartridge, being careful not to touch the needle to prevent contamination.
  2. Insert the cartridge: Hold the insulin pen with the needle pointing up and insert the PenFill cartridge into the pen’s cartridge holder until it clicks into place.
  3. Remove the inner needle cap: Unscrew the inner needle cap from the cartridge. This step is essential to prepare the cartridge for use.

Fiasp Vials

Fiasp vials are available in various strengths, commonly measured in insulin “units.” The concentration of insulin in Fiasp vials typically ranges from 100 units per milliliter (U/mL) to 300 units per milliliter (U/mL). The choice of concentration depends on the individual’s prescribed insulin dosage and their healthcare provider’s recommendations.

Apart from insulin units, Fiasp vials also have a specific insulin content measured in milligrams (mg). The exact milligram quantity in each vial varies based on the concentration of insulin.

Warnings and Precautions

While it is an effective medication, there are certain warnings and precautions that users should be aware of to ensure its safe and optimal use.

  • Consultation with Healthcare Provider: Before starting Fiasp, it is crucial to consult with a qualified healthcare provider. Your doctor will evaluate your medical history, current health condition, and any potential drug interactions to determine if Fiasp is suitable for you.
  • Hypoglycemia Risk: One of the most critical considerations when using Fiasp is the risk of hypoglycemia, commonly known as low blood sugar. Users must monitor their blood glucose levels regularly and be prepared to treat low blood sugar episodes promptly. They should carry a source of fast-acting glucose, such as glucose tablets or gel, to counteract hypoglycemia symptoms.
  • Hypersensitivity Reactions: Some individuals may be hypersensitive to Fiasp or its components. If users experience allergic reactions, such as skin rash, itching, or swelling, they should discontinue use and consult their healthcare provider immediately.
  • Pump or Infusion Set Malfunction: For those using insulin pumps to administer Fiasp, it is essential to ensure proper functioning of the pump and infusion set. Malfunctions could lead to under or over-delivery of insulin, affecting blood sugar levels.
  • Hyperglycemia: While Fiasp is effective in reducing high blood sugar levels, users must be cautious about hyperglycemia, a condition characterized by excessively high blood glucose levels. Patients should regularly monitor their blood sugar levels and follow their healthcare provider’s recommendations for insulin dosage adjustments.
  • Ketoacidosis: Ketoacidosis is a severe condition that can occur if insulin levels are too low in the body. Users should be aware of the symptoms, such as excessive thirst, frequent urination, and nausea, and seek immediate medical attention if these signs arise.
  • Renal Impairment: Fiasp may be excreted through the kidneys, and individuals with renal impairment should use this insulin with caution. Dose adjustments may be necessary in such cases, as advised by a healthcare professional.
  • Hepatic Impairment: Liver function can impact insulin metabolism, and individuals with hepatic impairment should use Fiasp with caution. Dose adjustments may be required under medical supervision.
  • Pediatric Use: Fiasp is generally safe for use in children aged two years and older. However, precise dosing and administration should be determined by a healthcare professional.
  • Geriatric Use: Elderly individuals may have specific health concerns that impact insulin use. Proper monitoring and personalized dosing are vital for this population.
  • Adverse Reactions: While Fiasp is well-tolerated by most users, some may experience side effects such as injection site reactions, skin thickening, or lipodystrophy. Users should report any persistent or bothersome reactions to their healthcare provider.
  • Driving and Operating Machinery: Fiasp can cause dizziness and blurred vision in some individuals. If you experience these side effects, avoid driving or operating heavy machinery until you feel alert and clear-headed.

Side Effects

While most individuals experience only mild and manageable side effects, it’s essential to be aware of the potential common, rare, and severe reactions. By understanding and closely monitoring these side effects, patients and healthcare providers can ensure safe and successful diabetes management with Fiasp.

Common Side Effects

  1. Hypoglycemia: One of the most common side effects of Fiasp is low blood sugar levels or hypoglycemia. This can occur if the dosage is too high or if the individual skips a meal after taking the medication.
  2. Injection Site Reactions: Some individuals may experience redness, swelling, or itching at the injection site. These reactions are usually mild and subside on their own within a short time.
  3. Itching and Rash: Itching and skin rashes are possible side effects. If you experience persistent or severe itching, consult your healthcare provider.
  4. Headache: Headaches are reported as a common side effect of Fiasp. Mild headaches can be alleviated with over-the-counter pain relievers.
  5. Nausea: Fiasp may cause feelings of nausea in some patients. Nausea is usually transient and subsides as the body adjusts to the medication.
  6. Weight Gain: Some individuals may experience weight gain while using Fiasp. Personal experience: Weight gain can be managed through a balanced diet and regular exercise.

Rare Side Effects

  1. Allergic Reactions: Although rare, some people may develop allergic reactions to Fiasp. Seek medical attention immediately if you experience difficulty breathing, swelling of the face or throat, or severe itching.
  2. Vision Changes: Some individuals may experience temporary changes in vision while using Fiasp. Consult an eye specialist if vision changes persist or worsen.
  3. Abdominal Pain: Abdominal pain, along with bloating and discomfort, is a rare side effect of Fiasp.
  4. Fatigue: Some individuals may experience fatigue or general weakness as a result of using Fiasp.
  5. Dizziness: Fiasp can cause dizziness in certain cases, particularly if the blood sugar drops significantly.
  6. Injection Site Lipodystrophy: Lipodystrophy is a rare condition where fat tissue at the injection site changes. The American Diabetes Association highlights the possibility of this occurrence in their literature
  7. Peripheral Edema: Rarely, Fiasp may cause swelling in the hands and feet. Elevating the affected limbs can help reduce swelling.
  8. Insulin Antibodies Formation: In some cases, the body may produce antibodies against Fiasp, affecting its efficacy. If insulin resistance is observed, alternative treatments should be considered.

Severe Side Effects

  1. Diabetic Ketoacidosis (DKA): Although rare, DKA can occur if Fiasp is not used properly or if there is a significant insulin deficiency. DKA is a serious condition that requires immediate medical attention.
  2. Pancreatitis: Although extremely rare, Fiasp may trigger inflammation of the pancreas. The U.S. National Library of Medicine warns of this potential severe side effect.
  3. Hypersensitivity Reactions: In rare cases, individuals may experience allergic reactions to Fiasp. According to the medication’s official website, hypersensitivity reactions are possible but uncommon.
  4. Severe Hypoglycemia: While hypoglycemia is a common side effect, severe cases can be dangerous and require prompt treatment.
  5. Anaphylaxis: Anaphylactic reactions to Fiasp are extremely rare but can be life-threatening. Seek emergency medical help if you experience symptoms like difficulty breathing and swelling of the face or throat.
  6. Hypokalemia (Low Potassium Levels): Fiasp can lead to a decrease in potassium levels, which may have severe implications. Monitoring potassium levels regularly is crucial for individuals on Fiasp.
  7. Liver and Kidney Impairment: Fiasp should be used with caution in patients with liver or kidney problems. The drug’s prescribing information provides guidance on dosage adjustments for such individual

Managing and Minimizing Side Effects

To minimize the risk of side effects, it is essential to use Fiasp as prescribed by your healthcare provider. Always monitor your blood sugar levels regularly and be aware of the symptoms of both hypoglycemia and hyperglycemia. If you experience any unusual or severe side effects, consult your doctor immediately.

Interactions

As with any medication, it’s essential to be aware of potential interactions that may occur when taking Fiasp alongside other drugs, herbal remedies, or certain foods. Understanding these interactions is crucial for managing diabetes effectively and avoiding adverse effects.

Drug Interactions

Beta-Blockers

When Fiasp is combined with beta-blockers, such as propranolol or metoprolol, it may lead to a significant decrease in blood sugar levels. Beta-blockers can mask the symptoms of low blood sugar (hypoglycemia), making it challenging to detect and manage this condition effectively. Patients taking Fiasp with beta-blockers should closely monitor their blood sugar levels and be aware of the signs of hypoglycemia.

Thiazolidinediones

Thiazolidinediones, like pioglitazone and rosiglitazone, can enhance the effects of insulin, including Fiasp, which may increase the risk of hypoglycemia. Regular blood sugar monitoring is essential for individuals using Fiasp in combination with thiazolidinediones to prevent dangerously low blood sugar levels.

ACE Inhibitors

ACE inhibitors, such as lisinopril and enalapril, are commonly prescribed for high blood pressure and heart conditions. When taken with Fiasp, these medications can also increase the risk of hypoglycemia. It is crucial for patients to communicate with their healthcare providers to adjust their insulin doses properly when using ACE inhibitors.

Herbal Interactions

Ginseng

Ginseng, a popular herbal remedy used for various health conditions, can affect blood sugar levels. When combined with Fiasp, ginseng may either lower or raise blood sugar, leading to unpredictable fluctuations. Individuals using ginseng as a supplement should be cautious and monitor their blood sugar levels regularly to prevent complications.

Cinnamon

Cinnamon is another herbal remedy with potential blood sugar-lowering effects. When taken in large amounts or in combination with Fiasp, it may lead to hypoglycemia. Patients using cinnamon supplements should consult their healthcare providers to adjust their insulin doses accordingly and avoid any adverse reactions.

Fenugreek

Fenugreek is a herb known for its hypoglycemic properties. When used alongside Fiasp, it can amplify the insulin-lowering effects, causing a drastic drop in blood sugar levels. Proper monitoring and dose adjustments are necessary for patients taking fenugreek supplements with Fiasp.

Food Interactions

Alcohol

Consuming alcohol while taking Fiasp can lead to a delayed drop in blood sugar levels, increasing the risk of hypoglycemia. It is advisable for individuals with diabetes to drink alcohol in moderation and never on an empty stomach. Monitoring blood sugar levels during and after alcohol consumption is crucial to prevent complications.

High-Fat Meals

High-fat meals can slow down the absorption of Fiasp, leading to delayed effects on blood sugar levels. Individuals on Fiasp should be mindful of their diet and avoid consuming excessively fatty meals to maintain stable blood sugar control.

Grapefruit

Grapefruit and its juice contain compounds that can interfere with the metabolism of Fiasp, potentially leading to increased insulin levels and a higher risk of hypoglycemia. Patients using Fiasp should avoid grapefruit products or consult their healthcare providers for appropriate guidance.

Dosing

Fiasp is a rapid-acting insulin designed to control blood sugar levels effectively. Unlike traditional insulin types, Fiasp begins working within minutes of administration, making it ideal for managing post-meal blood sugar spikes. This benefit ensures better glucose control, reducing the risk of long-term complications associated with diabetes.

Accurate dosing with Fiasp is crucial for achieving optimal diabetes management. Too little insulin can result in high blood sugar levels, while too much can lead to hypoglycemia. Collaborate closely with your healthcare provider to determine the appropriate dosage for your specific needs based on factors such as your weight, diet, activity level, and overall health.

When dosing with Fiasp before meals, consider the carbohydrate content of your food and your current blood sugar level. Your healthcare provider will help you determine the insulin-to-carbohydrate ratio that suits your body’s needs. For example, if your ratio is 1 unit of insulin per 10 grams of carbohydrates, and you’re about to eat a meal containing 50 grams of carbs, your dose would be 5 units of Fiasp.

In cases of high blood sugar, Fiasp can be used to correct the glucose levels. Your healthcare provider will inform you of your correction factor, which represents the drop in blood sugar for each unit of insulin administered. For example, if your correction factor is 30 mg/dL per 1 unit of insulin, and your blood sugar is 200 mg/dL, you would take 2 units of Fiasp to bring it closer to your target range.

Overdose

Overdosing on Fiasp can lead to hypoglycemia, a condition characterized by low blood sugar levels. Hypoglycemia can cause dizziness, confusion, shakiness, and, if severe, can even result in unconsciousness. It’s essential to follow your prescribed dosage and not take extra insulin without medical guidance.

Identifying the early symptoms of an overdose is crucial for prompt intervention. Symptoms may include excessive sweating, rapid heartbeat, intense hunger, and irritability. If you suspect an overdose, check your blood sugar immediately and seek medical help if necessary.

Missed Dose

Missing a dose of Fiasp can lead to high blood sugar levels, but it’s essential not to panic. If you forget to take your insulin, do not double your next dose to compensate. Instead, monitor your blood sugar frequently, and inform your healthcare provider about the missed dose. They will guide you on how to proceed based on your specific situation.

o minimize the risk of missed doses, establish a routine that incorporates insulin administration into your daily schedule. Use reminders on your phone or set alarms to prompt you when it’s time to take your medication. Additionally, keep your insulin and testing supplies readily accessible to ensure you don’t forget to dose.

Pregnancy 

If you are using Fiasp and planning to conceive, it is advisable to consult your healthcare provider beforehand. Your doctor can assess your current insulin regimen and make any necessary adjustments to optimize your blood sugar control before conception. Proper pre-pregnancy planning is crucial for a healthy pregnancy and the well-being of the baby.

The health and development of the fetus are directly influenced by the mother’s blood sugar levels. High blood sugar levels can pose risks to the baby, including macrosomia (large birth weight), birth defects, and an increased chance of developing type 2 diabetes later in life. To mitigate these risks, it is vital to have well-controlled blood sugar levels throughout pregnancy.

Your healthcare provider will consider various factors such as your medical history, overall health, and diabetes management goals before deciding whether to continue Fiasp during pregnancy. In some cases, they may suggest transitioning to a different insulin therapy that aligns better with pregnancy requirements.

Storage

Proper storage is critical for Fiasp insulin to maintain its effectiveness and ensure its potency. Insulin is a delicate hormone, and exposure to extreme temperatures or light can lead to degradation and reduced efficacy.

  • Proper Room Temperature Storage: Fiasp insulin should be stored at room temperature (between 59°F and 86°F or 15°C and 30°C) before its first use. When kept at room temperature, it becomes less viscous, making injections more comfortable. Ensure that the insulin vial is not exposed to direct sunlight or extreme heat, as this may degrade its potency.
  • Refrigeration: Before opening, it’s crucial to store Fiasp insulin in the refrigerator. The recommended temperature for refrigeration is between 36°F and 46°F (2°C and 8°C). Make sure not to freeze the insulin, as it may render it ineffective. Also, never store it near the freezer compartment, as temperature fluctuations can impact its quality.
  • Storage of Opened Fiasp Insulin: Once you’ve started using a vial of Fiasp, you may keep it at room temperature for up to 28 days. Discard any open vials after this period, as the insulin’s effectiveness might decrease over time. Always check the manufacturer’s instructions for specific storage details.
  • Traveling with Fiasp Insulin: For those who travel frequently, preserving the efficacy of Fiasp during trips is essential. When traveling by car, avoid placing the insulin in the glove compartment or on the dashboard, as the heat can quickly rise to levels that degrade the insulin. Instead, use a cooler or insulated bag with ice packs to keep it at the appropriate temperature.
  • Protecting Insulin from Extreme Temperatures: Avoid exposing Fiasp insulin to extreme temperatures, such as leaving it in a hot car during summer or in a freezing bag during winter. Insulin is sensitive to temperature fluctuations, and exposure to extreme conditions can make it less effective.
  • Keeping Insulin Away from Light: Exposure to direct sunlight or fluorescent light can also affect insulin’s potency. To prevent degradation, always store Fiasp in its original packaging or a protective case that shields it from light exposure.
  • Checking Expiration Dates: Always check the expiration date on the insulin vial or pen before use. Using expired insulin can lead to unpredictable blood sugar levels and may not provide the desired effect in managing diabetes.
  • Avoiding Vial Contamination: To prevent contamination, it’s crucial to use sterile techniques when handling insulin vials or pens. Wash your hands thoroughly before administering insulin and avoid touching the needle to maintain sterility.

Disposal

The foremost step in disposing of Fiasp safely is to follow your medical professional’s instructions. Doctors, nurses, or diabetes educators can provide personalized guidelines tailored to your specific needs. Always adhere to their recommendations as they are well-versed in the proper disposal methods.

  • Dispose of Expired or Unused Fiasp: Check the expiration date of your Fiasp and dispose of any expired or unused vials properly. Expired insulin may lose its efficacy and could potentially lead to ineffective glucose control. Contact your local pharmacy or healthcare provider for safe disposal options.
  • Using Sharps Containers: Fiasp, like many other injectable medications, requires the use of syringes or insulin pens. After each use, place the needles in a sharps container. These puncture-proof containers are specifically designed for the safe disposal of medical sharps, preventing accidental injuries.
  • Never Flush Fiasp Down the Toilet: It is crucial never to flush Fiasp or any other medication down the toilet or drain. Flushing medications can contaminate water sources and harm aquatic life. It’s our responsibility to protect the environment and dispose of medications properly.
  • Community Disposal Programs: Many communities offer special disposal programs for medical waste, including unused medications and sharps. Reach out to local hospitals, pharmacies, or health departments to inquire about these programs and drop-off locations.
  • Mail-Back Services: Some regions provide mail-back services for safe disposal of medical waste. These services usually include prepaid mailers for your used sharps and medications, making it convenient and environmentally friendly.
  • Disposing Fiasp Pens and Vials: When your Fiasp pen is empty, dispose of it according to local guidelines for plastic waste. If the vials are made of glass, check if your local recycling program accepts them. Alternatively, your healthcare provider or pharmacist may offer recycling programs.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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