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Finasteride (also sold under the brand name Propecia) is a hair loss-fighting medication for men dealing with male pattern baldness (male androgenetic alopecia). It is also approved to treat benign prostate hyperplasia.
The main ingredient in this medication is finasteride, a 5-alpha-reductase-inhibitor, that blocks the process of turning testosterone to dihydrotestosterone hence preventing hair loss. Finasteride is considered an effective hair-loss treatment for many men because it acts on the hormones that promote hair loss.
Finasteride is a 5-alpha-reductase inhibitor that works by blocking the process of converting testosterone to dihydrotestosterone (DHT). Elevated DHT levels in the scalp cause male pattern baldness. Finasteride inhibits this enzyme, which lowers blood DHT levels hence attacking the cause of hair loss in androgenetic alopecia.
Over time, the reduction in DHT helps the hair follicles to grow thicker and healthier and prevents shrinking. While Finasteride slows hair loss and promotes regrowth, it usually works best when taken early on in the history of hair loss.
Finasteride Medication Table
| Forms | Apidra comes in a vial, pre-filled SoloStar pens, and cartridges used in reusable pens. Can also be administered via insulin pump or IV injection. |
| Precautions & Warnings | Risk of hypoglycemia (especially if combined with other blood sugar-lowering medications). Never share needles. May cause low potassium levels, especially with diuretics. Watch for signs of water retention and heart failure, particularly when combined with glitazones. If using an insulin pump, ensure proper pump function to avoid high blood sugar or ketone buildup. |
| Usage | Rapid-acting insulin for blood sugar control in type 1 and type 2 diabetes. Helps manage post-meal glucose spikes. |
| Mechanism of Action | Rapid onset insulin (insulin aspart) that helps reduce post-meal blood glucose by increasing glucose uptake into cells and inhibiting liver glucose production. |
| Administration Method | Subcutaneous injection using pre-filled SoloStar pen, cartridge in reusable pen, or insulin pump. Can be injected directly or administered via IV in emergencies. |
| Strengths & Dosages | Available in 100 units/mL in SoloStar pens, 3 mL cartridge, and 10 mL vial. Dosage is individualized based on diabetes type, age, and severity. |
| Missed Dose | Inject missed dose as soon as possible. If it’s time for the next dose, skip the missed dose and resume normal schedule. |
| Overdose | Overdose may cause severe hypoglycemia (low blood sugar). Symptoms include shakiness, confusion, or fainting. Seek immediate medical attention. |
| Side Effects | Common: Injection site reactions (redness, pain, itching), low blood sugar (hypoglycemia), weight gain. Serious: Allergic reactions (swelling, difficulty breathing), low potassium, heart failure (with glitazones), seizures. |
| Drug Interactions | Avoid combining with certain antibiotics (e.g., ciprofloxacin, levofloxacin) and medications like thiazide and pioglitazone. Interactions may affect glucose levels. |
| Storage | Store vials and pens in the refrigerator (2°C–8°C). Do not freeze. After first use, pens may be stored at room temperature for up to 28 days. Keep away from heat and light. |
| Alternatives | Humalog (insulin lispro), NovoLog (insulin aspart), other rapid-acting insulins. |
Labeled Warning for Finasteride
Finasteride is contraindicated in pregnant or potentially pregnant women. Exposure to finasteride can give the male fetus potential birth defects. Crushing or breaking tablets should be avoided by pregnant women to reduce skin absorption.
Finasteride occasionally results in modifications to the breast tissue, such as a knot, lump, or areola release.
This medicine may cause sexual adverse effects, including erectile dysfunction, decreased sperm volume, and decreased libido. Even when the medication is stopped, some side effects may persist.
Finasteride may have an impact on prostate-explicit antigen tests. Prostate-specific antigen (PSA) readings may change with finasteride, so discuss this with your doctor before taking a test while under medication.
Finasteride Precautions
The medication undergoes liver metabolism, and impaired hepatic function could influence the processing of this drug, affecting its clearance from the body.
- Allergic Reactions: Finasteride causes serious allergic reactions, including a rash, itching, hives, swelling of the face, lip, tongue, or other parts of the body, and shortness of breath. If you have an allergic reaction to finasteride or any of its ingredients, inform your doctor before taking the medication.
- Prostate Cancer Screening: Finasteride has been linked to cancerous development in the prostate. If while taking this medication, your PSA level increases, it may be a sign of prostate cancerous growth.
- Male Infertility: Males using finasteride have the potential risk of persistent sexual dysfunction and reduced ejaculation. These symptoms may continue even after treatment has been withdrawn, but could also go away on their own after the termination of the drug. Men who plan on having a baby should talk with their doctor about this potential risk.
- Liver Disease: Finasteride should be used with caution in patients suffering from hepatitis.
- Breast Changes: Breast tenderness and enlargement or lumps under the nipples can also occur in men taking finasteride.
Finasteride Side Effects
Finasteride has benefits but it also has several possible side effects. Some notable side effects experienced by patients taking this medication include:
Common Side Effects
- Swelling of the lips and face
- Rashes
- Hives
- Ejaculation issues
- Difficulty breathing or swallowing
- Increase in breast size and tenderness
- Erectile dysfunction
- Itching
- Breast enlargement and tenderness
- Decreased sperm count
- Rapid weight gain
- Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
Severe Side Effects
- Lumps, pain, or swallowing in your chest area
- Depression
- Less interest in having sex
- Blood in your semen
- Problems getting an erection
- Pain in your testicles
- Problems with ejaculating, such as little or no semen
- Nipple discharge
Drug Interactions with Finasteride
Combining Finasteride with other drugs can alter how it works and react with your body. Understanding these interactions is crucial for ensuring safe and effective use of finasteride.
| Drug | Interaction |
| Rifampin | Rifampin can induce liver enzymes that metabolize Finasteride. This may decrease its effectiveness and cause side effects, potentially worsening the treated condition. |
| Verapamil | Verapamil can increase the blood levels of Finasteride, leading to enhanced side effects like dizziness, fatigue, and sexual dysfunction. |
| Dutasteride | Combining Dutasteride and Finasteride can increase the risk of addictive side effects, such as decreased libido ejaculatory disorders, and sexual dysfunction. |
| Ketoconazole | Ketoconazole is a medication that can inhibit the enzymes that metabolize Finasteride, leading to increased blood levels and side effects such as liver toxicity and hormonal imbalances. |
| Oxybutynin | Oxybutynin, used to treat overactive bladder, can increase the side effects of Finasteride, such as urinary retention and difficulty urinating. |
| Tamsulosin | Tamsulosin when combined with Finasteride can lead to hypotension, dizziness, and fainting, especially when starting treatment. |
Strengths and Dosages of Finasteride
Always follow the guidance of your prescriber when taking any medication.
| Age | Strengths and dosage of Finasteride | No.of times per day | |
| Hair loss | Benign prostate hyperplasia | ||
| Adult | 1mg | 5mg | Once daily |
The dose, form, and frequency of taking finasteride will depend on several factors, including your age, the condition being treated, the severity of your condition, other medical conditions you have, and how you react to the first dose.
Take a tablet with a full glass of water once a day at the same time each day, with or without meals. Follow all directions on your prescription label and read the medication guide or instruction sheet thoroughly.
Finasteride Alternatives
Not everyone can tolerate Finasteride or find it effective. For patients seeking different treatment options, several alternatives are available that target the same conditions through various mechanisms. These alternatives range from other pharmaceutical options to natural supplements and lifestyle changes, each with its own benefits and potential side effects.
Alternatives of Finasteride include:
- Propecia
- Topical ketoconazole
- Dutasteride
- Mesoridien
- Flomax
- Minoxidil
- Spironolactone
- Tamsulosin
- Saw palmetto
- Biotin
- Viviscal
Finasteride FAQs
How do you reduce the side effects of Finasteride?
You can reduce the side effects of Finasteride by considering dose adjustments under your doctor’s guidance, maintaining a healthy lifestyle, and scheduling regular check-ups to help monitor your condition. Taking finasteride with food can also help to prevent stomach upset.
How long does Finasteride take to work?
It will take approximately six months for Finasteride to work fully in patients suffering from an enlarged prostate and about 3 to 6 months for people with hair loss to experience significant improvement.
Does Finasteride shrink the prostate?
Yes. The medication can shrink the prostate by about 25%.
How long does Finasteride stay in your system?
Finasteride will take about 30 hours to clear from your system after taking your last dose.
How effective is Finasteride?
Finasteride is generally a very effective medication in treating hair loss and benign prostatic Hyperplasia. Approximately 9 in 10 men have experienced slow or a complete stop in hair loss after taking the medication.
How long after stopping Finasteride will my hair fall out?
After stopping Finasteride, expect hair loss to resume after a few weeks
How much Finasteride should I take for hair loss?
Typically, the hair loss dosage of Finasteride is 1 mg once per day.
How common are Finasteride side effects?
Finasteride side effects are relatively uncommon but they can occur.
How long after stopping Finasteride will the side effects stop?
Once you stop taking Finasteride, it will take two weeks for the side effects to subside.
When is the best time to take Finasteride?
You can take Finasteride at any time of day, as long as you take it around the same time each day.
IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.
