Vagifem is a major estradiol-based product that is used to alleviate menopausal symptoms in aged women. It helps older women get relief from a condition called vaginal atrophy. Vaginal atrophy stems from a significant reduction in your body’s estrogen production. It leads to symptoms like vaginal dryness and itching.

Vagifem comes as vaginal inserts. The user will insert this tablet into the vagina to increase the levels of estrogen. A plastic applicator helps the user administer this tablet inside the vaginal cavity. It starts showing its effects usually in 2 to 4 weeks.

Precautions and Warnings with Vagifem

These are the most crucial precautions for Vagifem users. Before getting a Vagifem prescription, please tell your doctor if you have these conditions:

  • Thrombophilic disorders
  • History of hepatic impairment
  • An undiagnosed case of vaginal bleeding
  • Suffer from angioedema or are hypersensitive to Vagifem
  • A history of breast cancer or experience conditions like neoplasia

Vagifem Side Effects

You should always use vaginal estrogen and other products carefully, as per the instructions of the healthcare provider.

Common Side Effects

Some common side effects of Vagifem are:

  • Headache
  • Diarrhea
  • Tender breasts
  • Hair loss
  • Stomach pain
  • Back pain
  • Exhaustion

Major Side Effects

A few major side effects of Vagifem include:

  • Constipation
  • Pelvic Pressure
  • Memory loss
  • Weak eyesight
  • Depression or mood swings
  • Abnormal vaginal discharge
  • Fluid retention in your body

Drug Interactions with Vagifem

Vagifem affects how your body processes other drugs. Also, different drugs may change the way your body uses Vagifem. For this reason, you should tell your caregiver which drugs you are on before getting an estrogen recommendation.

It would help if you did not mix grapefruit juice with Vagifem as well because grapefruits may increase estrogen plasma concentrations. Also, please don’t use this drug when you’re breastfeeding as estradiol can decrease milk production and even pass into your breast milk, passing down to your infant and affecting them with the side effects of Vagifem.

In general, Vagifem is known to interact with these medicines:

Cost of Vagifem in America

Vagifem tablets (8 tablets, 10mcg dosage each) may cost around $189 at the lower end and more than $200 (usually around $282) at the higher end. The cost of Vagifem can be high, particularly for those without insurance. This high price point may be due to factors like a complex manufacturing process or a lack of widely available, equally effective alternatives.

Why is Vagifem so expensive?

Rigorous testing makes Vagifem safe and effective enough to be sold as a brand-name drug. Since the testing phase costs a lot, drug manufacturers can legally sell this drug exclusively for the next twenty years. Then, other brands can develop and sell generic versions. The specialized formulation and delivery will make this estradiol product highly costly without insurance.

However, if you’re paying for Vagifem or other estradiol products out of pocket, you may turn to services like MyRx Outlet, where it is available at a lower price than the average pharmacy.

Strengths and Dosages of Vagifem

Vagifem often comes in petite, round, white, film-coated, biconvex tablets with “NOVO 278” emblazoned on one side of the body. The diameter of each tablet is 6 millimeters. It usually has two dosages of 10mcg and 25mcg of estradiol.

Your doctor will prescribe you the strength tailored to your unique needs. Usually, women will get a starting dose of 10mcg. A typical user will take this drug daily for the first two weeks and then twice weekly. The second-most commonly starting dose is 25mcg. A doctor will prescribe you a dose based on your varying symptoms and medical history.

Surveys show that Vagifem treats the most bothersome symptoms of menopause in four weeks in older women. However, overdosing on Vagifem can lead to these health conditions:

  • Nausea
  • Drowsiness
  • Abdominal pain
  • Breast tenderness
  • Vaginal bleeding

Vagifem Alternatives

Vagifem is available primarily as a name-brand drug. However, you can also buy estradiol meds other than Vagifem if they cost less than the branded version. Some doctor-approved alternatives to Vagifem include:

Vagifem FAQ

What is Vagifem?

It’s an estrogen hormone used to treat menopause-like symptoms in or around the vagina. It contains estradiol in tiny amounts.

How long does it take for Vagifem to dissolve?

Vagifem takes several hours to dissolve and may as well liquefy itself completely in 24 hours.

How do you use Vagifem?

Users insert the Vagifem tablet inside the vagina by using a plastic applicator. Users begin this hormone replacement therapy (HRT) by taking a single dose of Vagifem daily for two weeks. Then, two tablets are used every week.

But your Vagifem dose will depend on your medical history. So, ask a doctor to prescribe you the right amount of Vagifem.

What is the difference between Vagifem and Imvexxy?

PrescriptionAtrophic urethritis and vaginitisAtrophic vaginitis and dyspareunia
Dosage10-microgram doses10-microgram to 4-microgram doses
CostGenerally more affordableGenerally more expensive
ApplicationInserted via a disposable plastic applicatorInserted usually via the user’s own hand
AbsorptionLower absorption levelsSystemic absorption
Safety IssuesEndometrial hyperplasia hasn’t been observed in usersLower cases of adverse reactions

How do you insert Vagifem?

You can insert this tablet into your vagina with the help of an applicator. You can ask your doctor to help you insert Vagifem. If you decide to do it yourself, then carefully read the USER INSTRUCTIONS before taking Vagifem.

How deeply do I insert Vagifem in the vagina?

You should insert the applicator as far into the vagina as comfortably possible (usually 8 to cm). For comfortable insertion of Vagifem, the applicator itself will guide you to the appropriate depth. You’ll want to insert it as far as feels comfortable without forcing it.

What if I miss a dose of Vagifem?

If you forget to take a dose of Vagifem, you may take it the moment you remember not taking it. If it’s almost time for the next dosage, then you can skip the missed dose. Don’t overdose to make up for the missed dose. Missing a dose of estradiol is safer than double-dosing on this med.

What if I take too much Vagifem?

Overdosing on estrogen products such as Vagifem (estradiol) can lead to these health conditions:

  • Nausea
  • Vaginal bleeding
  • Vaginal yeast infection

But Vagifem contains estradiol in low quantities, so the side effects aren’t that strong or serious. It’s better to be safe and tell your doctors about your medical history so they may recommend the correct dosage.

When should I stop using Vagifem?

You should stop using Vagifem when you notice these symptoms:

  • Headache that may feel like migraines
  • Yellowing of your skin
  • Yellowing of the sclera

What is Vagifem made from?

Vagifem contains an active ingredient called estradiol but also many other substances, such as:

  • Hypromellose
  • Lactose monohydrate
  • Maize starch and magnesium stearate
  • Hypromellose and macrogol 6000 (in its coating)

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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