Fragmin works by preventing the formation of blood clots during blood kidney dialysis and certain types of surgeries. This, in turn, helps to reduce the risks connected with clot formation, such as heart attack and pulmonary embolism.

The drug prevents blood clot formation by inhibiting thrombin, an enzyme that promotes coagulation and regulates hemostasis.

The medication can also be used to stop the growth of blood clots already formed by preventing the activation of clotting factors such as thrombin, which helps it convert fibrinogen into fibrin during blood clot formation.

Precautions and Warnings of Fragmin

  • Risk of Bleeding: If you have unusual bruising or blood in the urine, you should not use the medication because it increases the risk of bleeding profusely.
  • Spinal Anesthesia: Patients undergoing spinal surgeries may be at risk of severe conditions. For instance, Fragmin can cause excessive bleeding, which can result in chronic paralysis.
  • Allergic Reactions: If you are allergic to latex or its compounds, talk to your doctor before administering the drug, as it can trigger certain allergic conditions such as vomiting and nausea.
  • Children: Keep Fragmine away from children and never administer it to newborn babies below one month of age.
  • Other medications: Tell your doctor if you are taking any other drugs, including those you bought. Certain medications, like aspirin, which is used to thin your blood, can increase the effects of the other medications.
  • Avoid Traumatic Events: Take precautions to prevent injury which might cause excessive internal or external bleeding.

Fragmin Side Effects

Like any other medication, Fragmin can cause side effects in some patients. Stop using Fragmin and contact your doctor if you experience any unusual or severe side effects.

Common Side Effects

  • Bleeding
  • Irritation
  • Swelling around the place of injection
  • Redness
  • Bruise

Severe Side Effects

  • Painful skin lesions
  • Hair loss
  • Bruising in the spine
  • Bleeding in your brain

Fragmin Drug Interactions

Fragmin is a popular DVT treatment. When combined with certain medicines, this drug can prove disastrous. Therefore, you should talk to your doctor before combining Fragmin with other medications, including:

  • Abciximab: A medicine that prevents harmful blood clots. It complements aspirin and heparin. When used with Fragmin, Abciximab might cause severe bleeding.
  • Acebutolol: Manages hypertension and associated problems in adults. Acebutolol increases hyperkalemia risk when used with Fragmin.
  • Acemetacin: Effective for pain and inflammation. Fragmin combined with acemetacin can cause severe bleeding and hemorrhage.
  • Aspirin: Effective and reliable for pain and fever relief. When used with Fragmin, aspirin can induce severe bleeding. Unless prescribed by your doctor, do not use aspirin with fragmin.
  • Antiplatelet Supplements: Antiplatelet supplements like garlic, ginkgo biloba, and fish oil may increase bleeding risk with Fragmin.
  • A few antibiotics: Cephalosporins and penicillins may increase Fragmin hemorrhage.

Please talk about potential interactions with your doctor or pharmacist before using Fragmin.

Fragmin Strengths and Dosages

Fragmin comes in different strengths and dosages used to treat different medical conditions. The following table lists Fragmin’s strengths and dosages.

Strength (IU)Dosage (for prevention of deep vein thrombosis)Dosage (for treatment of deep vein thrombosis or pulmonary embolism)
2,5002,500 IU subcutaneously once daily200 IU/kg subcutaneously once daily, up to 18,000 IU daily
5,0005,000 IU subcutaneously once daily200 IU/kg subcutaneously once daily, up to 18,000 IU daily
7,5007,500 IU subcutaneously once daily200 IU/kg subcutaneously once daily, up to 18,000 IU daily
10,0005,000 IU subcutaneously once daily200 IU/kg subcutaneously once daily, up to 18,000 IU daily


In the case of chemotherapy-induced thrombocytopenia, Fragmin dose should be adopted as follows:

For patients with platelet counts between 50,000 and 100,000/mm3, the daily dose of Fragmin should be reduced by 2,500 IU until the platelet count recovers to 100,000/mm3 and above.

For patients with platelet counts below 50,000/mm3, Fragmin should be discontinued until the platelet count recovers above 50,000/mm3.

Doctors may adjust dosages based on patient considerations like severity and medical history. Following your doctor’s instructions and the drug label’s dose information is vital.

Alternatives to Fragmin

Fragmin is not the only drug of its kind. Other drugs can still serve its purpose well. These include:


This is yet another effective prescription drug that works well against deep vein thrombosis and other related conditions, which is found in the brand medication Lovenox. It is administered through an injection done under the skin. With Enoxaparin, you do not need to do routine blood tests. However, close monitoring of patients is required in order to avoid excessive bleeding


Xarelto (rivaroxaban) prevents blood clots by blocking Factor Xa, an enzyme involved in clotting. It’s prescribed for atrial fibrillation, DVT, PE, and DVT/PE prevention.

Although Xarelto reduces clots, it can increase the risk of excessive bleeding. However, Andexxa (andexanet alfa) can reverse its anticoagulant effects in extreme bleeding or emergency surgery.

Patients taking Xarelto must know its benefits and hazards and follow their doctor’s orders for safe use.


This antithrombotic drug prevents reactions that cause blood clots by deactivating thrombin and factor Xa.

FAQs of Fragmin

What happens if I overdose?

Fragmin overdose is hazardous and can be life-threatening if not attended to early enough. Therefore, it is advised to promptly reach out for medical attention if you suspect you or someone else has overdosed Fragmin.

What do I need to avoid while using Fragmin?

Unless directed otherwise by your doctor, you should not use aspirin with Fragmin as it increases the risk of bleeding. Also, avoid activities that expose you to injuries and other bleeding risks.

What do I do in case I miss a dose?

If you miss a dose, don’t panic. Take the dose as soon as possible. Please skip the missed dose if the next dose is less than 2 hours away. Taking two doses at the same time or close intervals may lead to excessive bleeding.

Can I drink alcohol while on Fragmin?

Fragmin (dalteparin) can increase bleeding risk, which is risky if you fall or hit your head while drinking. Discuss alcohol safety with your doctor before drinking.

What is the cost of Fragmin in America?

A few factors, including the drugstore, the dosage, and the area of residence, determine the cost of Fragmin in America. Depending on the drugstore, the Fragmin subcutaneous solution (2500 intl units/0.2 mL) costs $401 for 2 milliliters. Insurance policies do not apply to the quoted price.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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