Estring® is a soft, flexible vaginal device that ensures the uniform release of estradiol, a form of estrogen. This vital hormone plays a significant role in regulating many physiological functions. However, its concentration tends to decline as women approach menopause.

Estring® provides hormone supplementation to counteract this hormonal void and primarily addresses the genitourinary discomforts associated with menopause. Estring® can treat issues like vaginal dryness, stinging, itchiness, and pain during intimacy.

Warnings and Precautions

It is always important to inform your doctor about your health history, hypersensitivities, and any medications you currently take before starting to use Estring®.

Additional precautions and recommendations include being aware of unusual sensations, itching, irritation, or other issues after inserting the device. Seek medical advice if you have any concerns. Also, be sure to maintain regular gynecological check-ups while using Estring®.

Possible Side Effects

Estring® is a hormonal treatment. Therefore, there is potential for the following side effects:

  • Vaginal discharge: Some users may have an elevated level of vaginal secretion.
  • Vaginal discomfort: Temporary irritation, itching, or a burning sensation may be felt after positioning the Estring® device.
  • Breast sensitivity: Instances of breast sensitivity or discomfort have been noted among users of Estring®.
  • Gastrointestinal discomfort: Nausea has been reported as an occasional adverse effect.
  • Water retention: Hormonal variations might induce water retention or bloating.
  • Hypersensitivity or allergic reactions: Symptoms like skin irritation, itching, inflammation or swelling of the face or lips, and difficulty breathing indicate a potential allergic response. Immediate medical assistance is vital for acute and severe symptoms.

Knowledge about these side effects and timely communication with your doctor or other healthcare provider is critical for safe and effective treatment with Estring®.

Potential Drug Interactions

As with all medications, there is the potential for interactions with other drugs and related side effects. Although Estring® has a primarily localized effect, other medications might affect its effectiveness. In addition, the risk of undesired effects might increase when combined with other drugs. Specific treatments, such as certain antifungal agents or other vaginal products, might interact with Estring®. You must check with your medical provider about all other medications or supplements you’re using to ensure there are no surprise interactions.

Why was Estring® Developed?

Estring® emerged in response to the need for a targeted and efficient way to treat menopausal symptoms, particularly urogenital atrophy. This condition is characterized by changes in and around the vaginal area due to reduced estrogen levels during menopause.

The rationale for the development of Estring® involved:

Addressing Menopausal Symptoms

Menopause signifies a natural phase in a woman’s life marked by a gradual reduction in estrogen production. This hormonal transition may bring a range of uncomfortable and distressing symptoms, including vaginal dryness, irritation, itching, and pain during sexual intimacy. Estring® was designed to alleviate these symptoms by directly delivering estrogen to the affected vaginal tissues.

Providing Tailored Treatment

Traditional hormone replacement therapies (HRT) typically involve systemic estrogen supplementation, which can elicit broader physiological effects but, at the same time, increase potential side effects. Estring®, on the other hand, was designed to provide localized treatment. Limiting exposure to exogenous hormones reduces the potential risks linked to increased estrogen levels.

How was Estring® Developed?

The development of Estring® was based on the following three factors.

Intravaginal Ring (IVR) Technology: Estring® is provided as an IVR designed to steadily dispense a controlled and consistent low dose of estradiol, a variant of estrogen, over an extended period. This IVR mechanism allows the gradual and uninterrupted release of estrogen, delivering it directly to the vaginal tissues that need it the most.

Clinical Investigation: The effectiveness of Estring® was validated through extensive clinical research, which also provided pivotal studies necessary to ensure its safety. These clinical studies generated important insights regarding Estring’s insertion process and subsequent effects.

Urogenital Atrophy Management: The design of Estring® was derived from the specific focus on addressing urogenital atrophy, a prevailing menopausal symptom. This condition emerges via changes in the vaginal and vulvar tissues, leading to symptoms ranging from mild discomfort to significant pain. The configuration of Estring® is strategically designed to address these changes and associated symptoms effectively.

How Does Estring® Work?

Once positioned in the vagina, Estring® releases a continuous, set amount of estradiol over ninety days. The hormone permeates the vaginal lining directly and also enters the circulatory system. This focused drug distribution ensures that the vaginal tissues receive the hormone supplementation needed to revitalize and preserve their function.

Reasons to Choose Estring®

  • Longevity: After insertion, Estring® remains functional for three months, bypassing the requirement for daily dosing.
  • Targeted effects: The activity of Estring® is focused on menopausal vaginal symptoms by delivering hormones precisely where needed.
  • Measured hormone treatment: Estring® releases a continuous and controlled low dose of estradiol, reducing the likelihood of complications associated with intensive systemic hormone therapies.
  • Ease of use: Many women find the Estring® vaginal device convenient and easy to use. Once in place, it provides worry-free treatment until the replacement of the ring at three months.


Insertion and removal of Estring® are simple, following these steps:

  • Wash your hands thoroughly.
  • Find a comfortable position by elevating one leg while standing or lying down.
  • Squeeze the ring between your thumb and forefinger.
  • Gently insert the ring as deep as possible while remaining comfortable.
  • Follow a similar process for the removal of the device.

The Estring® device remains active for three months. After this period, removing the ring and replacing it with a new one if you are continuing treatment is essential.


There are several important factors regarding the safe storage of Estring® to protect others from unintended hormonal exposure and ensure the long-term preservation of the therapeutic agent.

  • Temperature: Store Estring® at room temperature, ideally between 68°F and 77°F (20°C to 25°C). Avoid keeping this medication where it could be exposed to high temperatures.
  • Keep out of reach of children: Ensure the device is kept in an area that is not accessible to children or pets.
  • Check expiration: Before use, confirm Estring® hasn’t surpassed its recommended timeframe for usage by checking its expiration date.

Estring® Dosages

Estring® is a vaginal device that delivers the hormone estradiol. Every Estring® device holds 2 mg of estradiol. Upon vaginal placement, it continuously releases approximately 7.5 mcg of estradiol every 24 hours for three months. The soft and flexible format of Estring® makes it easy to insert and remove and comfortable to use.

Cost and Availability

Estring® can be accessed predominantly through a medical prescription. The cost might fluctuate depending on geographic location, type of insurance, and your chosen pharmacy. For accurate pricing details, it is best to contact your health insurer or pharmacy directly.

As of the time of writing (September 2023), a single Estring® vaginal ring (90 days of treatment) was available for between $500-600 per ring (as a cash payment without insurance). If covered by insurance, the cost to the patient could be significantly lower, depending on deductibles and co-payments associated with individual insurance plans.

Estring has become a popular medication that Americans buy online from Canada. MyRx Outlet offers Estring at fraction of the cost (compares to local US pharmacies).

Other Options Beyond Estring®

Currently, there are no generic versions of Estring® available. While estradiol (the active ingredient in Estring®) is available in various formulations that include some generic versions, there is no generic alternative to the Estring® vaginal ring format.

Estring® is a favored option and format for many people, but alternative types of treatments are also available for postmenopausal vaginal discomfort. These include:

  • Vaginal ointments and tablets: Typically, these contain estrogen and are used directly in the vaginal area.
  • Oral hormone replacement therapy involves consuming estrogen or applying it via dermal patches, which is disseminated systemically through the bloodstream. This type of treatment addresses a broader range of postmenopausal issues but also has an expanded set of associated risks.
  • Hormone-free hydrating agents and lubricants: These are designed to reduce dryness and discomfort without using hormones.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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