Tresiba, also known by its generic name insulin degludec, is a prescription medication approved for the treatment of type 1 and type 2 diabetes. It is a long-acting insulin analog that provides a continuous and steady release of insulin in the body, mimicking the basal insulin secretion found in individuals without diabetes.

Unlike short-acting or rapid-acting insulins that are taken before meals to manage postprandial glucose spikes, Tresiba is primarily used to regulate blood sugar levels between meals and overnight. It helps maintain a stable baseline of insulin in the body, which is crucial for optimal glycemic control.

Tresiba works by utilizing ultra-long fatty acid chains to form multi-hexamer complexes beneath the skin after injection. These complexes are gradually broken down, allowing for a slow and consistent release of insulin into the bloodstream. The prolonged action of Tresiba ensures that the insulin remains active for an extended period, reducing the risk of hypoglycemia and offering greater flexibility in dosing intervals.

The unique formulation of Tresiba provides a duration of action of up to 42 hours, which means that it can maintain a consistent insulin level beyond the traditional 24-hour period. This extended duration allows for more flexibility in scheduling injections, providing convenience for individuals with diabetes.

Tresiba FlexTouch is a modern insulin pen developed by Novo Nordisk, a leading pharmaceutical company specializing in diabetes care. This innovative insulin delivery system is designed to provide convenience, accuracy, and flexibility to people who require insulin for managing their blood sugar levels.

The Tresiba FlexTouch pens are prefilled with long-acting insulin degludec, which offers a basal insulin profile that lasts for up to 42 hours. This extended duration of action provides a steady release of insulin throughout the day, allowing for better blood sugar control and reducing the frequency of injections.

FlexTouch 100 Vs. FlexTouch 200

When deciding between Tresiba FlexTouch 100 and Tresiba FlexTouch 200, it is essential to consult with your healthcare provider. They will consider factors such as your insulin needs, dosage requirements, injection preferences, and overall diabetes management plan. Your healthcare provider will assess your specific situation and help determine which variant is most suitable for you.

Tresiba FlexTouch 100: Features and Benefits

Tresiba FlexTouch 100 is one of the variants of the Tresiba FlexTouch pen. It contains insulin degludec with a concentration of 100 units per milliliter (U-100). Here are some notable features and benefits of Tresiba FlexTouch 100:

Accurate Dosing

Tresiba FlexTouch 100 offers precise dosing increments, allowing individuals to administer insulin with accuracy and confidence. The pen is designed to deliver doses in 1-unit increments, ensuring precise control over insulin dosage.

Flexibility in Dosing

With Tresiba FlexTouch 100, individuals have the flexibility to adjust their insulin doses as per their healthcare provider’s recommendations. This enables personalized insulin management, taking into account factors such as lifestyle, diet, and exercise.

Ease of Use

Tresiba FlexTouch 100 features a user-friendly design, making it easy for individuals to administer their insulin injections. The pen has a simple push-button mechanism for dose selection and a clear dose display, allowing for convenient and hassle-free insulin administration.

Extended Duration of Action

Similar to Tresiba FlexTouch 200, Tresiba FlexTouch 100 provides a long-acting insulin profile, ensuring a prolonged release of insulin over an extended period. This allows for once-daily dosing, providing consistent basal insulin coverage.

Tresiba FlexTouch 200: Features and Benefits

Tresiba FlexTouch 200 is another variant of the Tresiba FlexTouch pen. It contains insulin degludec with a concentration of 200 units per milliliter (U-200). Let’s explore the features and benefits of Tresiba FlexTouch 200:

Reduced Injection Volume

Tresiba FlexTouch 200 offers a higher concentration of insulin degludec compared to Tresiba FlexTouch 100. This means that individuals can inject the same dose with a reduced injection volume, which may be beneficial for those who prefer or require smaller injection volumes.

Potential Lower Injection Frequency

Due to the higher concentration of insulin in Tresiba FlexTouch 200, some individuals may require fewer injections compared to Tresiba FlexTouch 100. This can be advantageous for those who prefer to minimize the number of injections they need to administer.


Tresiba FlexTouch 200 provides convenience for individuals who require higher insulin doses. With the higher concentration, they can achieve the necessary dosage with fewer units and injections, simplifying their insulin management routine.

Extended Duration of Action

Like Tresiba FlexTouch 100, Tresiba FlexTouch 200 also offers an extended duration of action, providing consistent and reliable basal insulin coverage for up to 42 hours. This contributes to stable blood sugar control throughout the day.

Key Differences

While both Tresiba FlexTouch 100 and Tresiba FlexTouch 200 offer similar benefits, they differ in insulin concentration, injection volume, and potential injection frequency. Here are the key differences between the two variants:

  1. Insulin Concentration: Tresiba FlexTouch 100 has a concentration of 100 units per milliliter (U-100), whereas Tresiba FlexTouch 200 has a concentration of 200 units per milliliter (U-200).
  2. Injection Volume: Tresiba FlexTouch 200 allows for reduced injection volume due to its higher insulin concentration, while Tresiba FlexTouch 100 requires a larger injection volume for the same dose.
  3. Injection Frequency: Depending on individual insulin requirements, Tresiba FlexTouch 200 may result in fewer injections compared to Tresiba FlexTouch 100 due to its higher insulin concentration.

Warnings and Precautions

Tresiba is a long-acting insulin analog used for the management of diabetes mellitus. While it is an effective medication for controlling blood sugar levels, it is essential to be aware of the warnings and precautions associated with its use. By understanding these aspects, individuals can ensure safe and effective usage of Tresiba while minimizing the risk of adverse effects.

Warnings for Using Tresiba

  • Hypoglycemia: Tresiba can cause low blood sugar levels, which can be potentially dangerous. Individuals should closely monitor their blood sugar levels and be aware of the symptoms of hypoglycemia, such as sweating, dizziness, confusion, and rapid heartbeat. Prompt treatment with a source of glucose is necessary to raise blood sugar levels if hypoglycemia occurs.
  • Hypokalemia: Tresiba may cause a decrease in potassium levels in the blood. This can lead to symptoms such as muscle weakness, fatigue, and irregular heartbeat. Regular monitoring of potassium levels and appropriate supplementation may be required.
  • Allergic Reactions: Some individuals may experience allergic reactions to Tresiba. Symptoms of an allergic reaction can include skin rash, itching, shortness of breath, and swelling of the face, lips, or tongue. If any of these symptoms occur, immediate medical attention should be sought.
  • Injection Site Reactions: Tresiba is administered via subcutaneous injection, and injection site reactions may occur. These reactions can manifest as redness, swelling, pain, or itching at the injection site. It is advisable to rotate injection sites and seek medical advice if persistent or severe reactions occur.
  • Fluid Retention and Heart Failure Risk: In some cases, Tresiba usage may lead to fluid retention, resulting in swelling or weight gain. This fluid retention can exacerbate underlying heart failure or increase the risk of heart failure in susceptible individuals. If you experience symptoms such as shortness of breath, rapid weight gain, or swelling of the extremities, consult your healthcare provider immediately.Individuals with liver or kidney impairment may require careful monitoring when using Tresiba. The dosage of Tresiba may need to be adjusted based on your specific condition. It is important to discuss your medical history and any pre-existing conditions with your healthcare provider before starting Tresiba.

Precautions for Using Tresiba

  • Renal or Hepatic Impairment: Individuals with renal or hepatic impairment may require dosage adjustments or closer monitoring when using Tresiba. It is crucial to consult a healthcare professional who can determine the appropriate dosage based on individual circumstances.
  • Hypersensitivity to Insulin: Individuals with a known hypersensitivity to insulin or any of the components in Tresiba should not use this medication. An alternative treatment option should be considered in such cases.
  • Pediatric Usage and Safety: Tresiba is approved for use in children aged one year and older with type 1 diabetes, and in adults with type 2 diabetes. Safety and effectiveness in pediatric patients below one year of age have not been established. If you have concerns about using Tresiba in children, consult your healthcare provider for guidance.

Side Effects

Tresiba, a prescription medication, is commonly used to control blood sugar levels in people with diabetes. While it is effective in managing diabetes, it’s important to understand the potential side effects that may occur during treatment.

Common Side Effects

When starting any medication, it’s crucial to be aware of the common side effects that may arise. Tresiba is generally well-tolerated by most individuals. However, some common side effects may occur during the initial stages of treatment. While these side effects are usually mild and temporary, it is important to discuss any persistent or bothersome symptoms with your healthcare provider. Here are some frequently encountered side effects associated with Tresiba: These are a few examples of common side effects:

  • Hypoglycemia: Tresiba can cause low blood sugar levels, leading to symptoms such as shakiness, dizziness, sweating, and confusion. It is important to monitor your blood sugar levels regularly and consult your healthcare provider if you experience persistent hypoglycemia.
  • Injection Site Reactions: Some individuals may experience redness, itching, or swelling at the injection site. These reactions are typically mild and resolve on their own.
  • Weight Gain: Weight gain is a potential side effect of Tresiba, although it varies among individuals. It’s essential to maintain a healthy lifestyle and monitor your weight while taking this medication.
  • Nasopharyngitis: Tresiba usage may increase the risk of developing a common cold. Symptoms include a runny or stuffy nose, sneezing, and sore throat. Rest and over-the-counter remedies can help manage these symptoms.
  • Headache
  • Nausea
  • Diarrhea

Rare Side Effects

In rare cases, individuals may experience more uncommon side effects while taking Tresiba. While uncommon, some individuals may experience rare side effects while using Tresiba. These side effects are less frequently observed but should still be recognized:

  • Allergic Reactions: In rare cases, Tresiba can cause allergic reactions, including itching, rash, swelling, or difficulty breathing. If you experience any of these symptoms, seek immediate medical attention.
  • Lipodystrophy: Prolonged use of Tresiba at the same injection site may lead to lipodystrophy, a condition characterized by the loss of fat tissue or the formation of fatty tissue masses. Rotate injection sites to minimize the risk of lipodystrophy.
  • Hypokalemia: Tresiba usage can rarely cause low levels of potassium in the blood. Symptoms may include muscle weakness, fatigue, and abnormal heart rhythms. Regular blood tests can help monitor potassium levels.
  • Visual Changes: In rare instances, Tresiba may affect vision. If you experience any changes in vision, consult your healthcare provider for further evaluation.

Severe Side Effects

While severe side effects are rare, they require immediate medical attention. If you experience any of the following side effects, seek emergency medical assistance:

  • Pancreatitis: Tresiba has been associated with pancreatitis, which is characterized by severe abdominal pain, nausea, and vomiting. Prompt medical intervention is necessary in such cases.
  • Hypersensitivity Reactions: Severe allergic reactions to Tresiba can occur, resulting in anaphylaxis. Symptoms may include difficulty breathing, chest tightness, rapid heartbeat, and swelling of the face, lips, or tongue. Call emergency services immediately if you experience these symptoms.

Managing and Minimizing Side Effects

To manage and minimize the side effects of Tresiba, follow these recommendations:

  1. Communicate with your healthcare provider: Inform your doctor about any side effects you experience while taking Tresiba.
  2. Follow the prescribed dosage: Ensure you are taking the correct dosage of Tresiba as instructed by your healthcare provider.
  3. Maintain a healthy lifestyle: Regular exercise, a balanced diet, and proper sleep can help manage side effects and improve overall well-being.
  4. Monitor blood sugar levels: Regularly monitor your blood sugar levels to ensure they remain within the target range. This will help identify any potential issues or side effects promptly.
  5. Attend regular check-ups: Visit your healthcare provider for routine check-ups and blood tests to monitor the effectiveness of Tresiba and identify any developing side effects.


Below, we will explore the various interactions that can occur with Tresiba, including drug interactions, herbal interactions, and food interactions. By understanding these interactions, you can ensure the safe and effective use of Tresiba while managing your diabetes.

Drug Interactions

When taking Tresiba, it’s crucial to be aware of potential drug interactions. Certain medications can affect the way Tresiba works or increase the risk of adverse effects. Some common medications that may interact with Tresiba include:

  • Insulin secretagogues (e.g., sulfonylureas)
  • Corticosteroids (e.g., prednisone)
  • Beta-blockers (e.g., propranolol)
  • Thiazolidinediones (e.g., pioglitazone)
  • Diuretics (e.g., hydrochlorothiazide)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)

Potential Effects of Drug Interactions

Drug interactions can have varying effects on Tresiba’s efficacy and safety. Some interactions may lead to increased blood sugar levels, requiring adjustments to your Tresiba dosage. Conversely, certain medications may enhance the effect of Tresiba, potentially causing low blood sugar levels (hypoglycemia). It is crucial to consult with your healthcare provider regarding any medications you are taking to ensure they are compatible with Tresiba.

Herbal Interactions

In addition to medications, herbal supplements can also interact with Tresiba. While herbal remedies are often seen as natural alternatives, they can still influence the effectiveness of Tresiba. Some popular herbal supplements known to interact with Tresiba include:

  • Ginseng
  • St. John’s Wort
  • Cinnamon
  • Fenugreek
  • Ginkgo Biloba

 Impact of Herbal Interactions

Herbal interactions with Tresiba can be complex and vary among individuals. For example, ginseng and fenugreek have been reported to lower blood sugar levels, potentially amplifying the effects of Tresiba and causing hypoglycemia. St. John’s Wort, on the other hand, may reduce Tresiba’s effectiveness, leading to higher blood sugar levels. It is crucial to inform your healthcare provider about any herbal supplements you are taking to prevent unwanted interactions.

Food Interactions

While food is an essential part of managing diabetes, certain foods can interact with Tresiba and affect blood sugar levels. It is important to be mindful of the following foods:

  • High-carbohydrate foods: Foods rich in carbohydrates, such as white bread, rice, and sugary snacks, can cause spikes in blood sugar levels when combined with Tresiba.
  • Alcohol: Consuming alcohol, especially in large quantities, can lead to low blood sugar levels and interfere with Tresiba’s effectiveness.
  • Grapefruit: Grapefruit and its juice can interfere with the metabolism of certain medications, including Tresiba, potentially leading to higher levels of the drug in the body.

Effects of Food Interactions

Food interactions with Tresiba can significantly impact its performance. By avoiding or limiting high-carbohydrate foods, alcohol, and grapefruit, you can help maintain stable blood sugar levels and ensure Tresiba works effectively to manage your diabetes. It is recommended to consult with a registered dietitian or your healthcare provider for personalized dietary recommendations.

Managing Interactions with Tresiba

  • Communication with Your Healthcare Provider: To ensure the safe and effective use of Tresiba, open and clear communication with your healthcare provider is vital. Inform them about all medications, herbal supplements, and dietary choices you are currently taking or planning to incorporate. Your healthcare provider can evaluate potential interactions and make necessary adjustments to your treatment plan.
  • Proper Medication Management and Timing: Proper medication management plays a crucial role in preventing interactions with Tresiba. Follow the prescribed dosage and administration instructions provided by your healthcare provider. Take Tresiba at the recommended times and avoid any alterations to the treatment plan without consulting your healthcare provider first.


Tresiba may vary depending on individual needs and the recommendation of a healthcare professional. It is important to follow the prescribed dosage and administration instructions carefully to ensure the best possible outcomes.

Initial Dosage

When initiating Tresiba treatment, the recommended starting dose may differ based on factors such as previous insulin therapy and the individual’s blood glucose goals. A healthcare professional will assess these factors and determine the appropriate initial dosage.

Titration and Adjustments

To achieve optimal blood sugar control, titration and dosage adjustments may be necessary. This involves regular monitoring of blood glucose levels and working closely with a healthcare professional to make appropriate changes to the Tresiba dosage. The goal is to find the right balance that keeps blood sugar levels within the target range.

Individualized Dosing

The dosing of Tresiba is highly individualized. Factors such as age, weight, kidney function, concomitant medications, and lifestyle choices may influence the dosing requirements. It is crucial to communicate openly with a healthcare professional to ensure the dosing of Tresiba is tailored to individual needs.

Time of Administration

Tresiba is designed to provide a long duration of action, offering flexibility in terms of the time of administration. It is important to establish a consistent dosing schedule and adhere to it as closely as possible. This helps maintain stable blood sugar levels throughout the day and night.


In the event of an insulin overdose, it’s important to recognize the signs and take appropriate actions. Symptoms of insulin overdose may include sweating, confusion, dizziness, weakness, and seizures. If you suspect an overdose, immediately contact emergency services or seek medical attention.

While it is important to take the prescribed dose of Tresiba to manage diabetes effectively, an overdose can lead to hypoglycemia, a condition characterized by low blood sugar levels. It is crucial to be aware of the signs and symptoms of hypoglycemia and take immediate action if an overdose is suspected.

If you suspect an overdose of Tresiba, it is important to take prompt action to raise blood sugar levels. This can be achieved by consuming a fast-acting source of glucose, such as fruit juice, candy, or glucose tablets. It is recommended to follow up with a healthcare professional for further guidance and monitoring.

Missed Dose

While adhering to the prescribed dosing schedule is important, occasionally, a dose of Tresiba may be missed. When a missed dose occurs, it is essential to understand the appropriate course of action to maintain blood sugar control.

Timing of the Missed Dose

The actions to be taken after a missed dose depend on the timing of the missed injection. If a dose is missed by only a few hours, the missed dose can be taken as soon as possible, and the regular dosing schedule can be resumed. However, if it has been a significant amount of time since the missed dose, it is best to consult with a healthcare professional for guidance on the appropriate steps to take.

Avoiding Double Dosing

It is crucial to avoid double dosing of Tresiba to compensate for a missed dose. Taking an excessive amount of Tresiba can increase the risk of hypoglycemia. If unsure about what to do after missing a dose, consulting with a healthcare professional is always the best course of action.


Tresiba FlexTouch pens are designed to deliver a long-acting insulin called Tresiba. These pens offer a precise and easy way to administer insulin, providing flexibility and convenience for diabetes management. Below, we go over some important notes of using the FlexTouch pens.

Preparing for Use

Before using a Tresiba FlexTouch pen, it’s essential to gather all the necessary supplies. These include the pen itself, a new needle, an alcohol swab, and a sharps container for proper disposal. Wash your hands thoroughly with soap and water to maintain good hygiene.

Administering Insulin with Tresiba FlexTouch Pens

  1. Choose an injection site. Common injection sites include the abdomen, thighs, and upper arms. Rotate the injection sites to prevent lipodystrophy (changes in fat distribution).
  2. Clean the injection site with an alcohol swab and allow it to dry. This helps minimize the risk of infection.
  3. Remove the pen cap and attach a new needle securely.
  4. Prime the pen by dialing two units and pressing the dose button. This ensures that the pen is ready for use and removes any air bubbles.
  5. Dial the desired dose. The dose selector on the pen allows you to choose the appropriate amount of insulin.
  6. Inject the needle into the chosen injection site at a 90-degree angle. Press the dose button fully to deliver the insulin.
  7. Keep the needle in the skin for a few seconds after delivering the dose to ensure that the full amount of insulin is injected.

After Using the Pen

After using the Tresiba FlexTouch pen, it’s crucial to follow these steps:

  1. Remove the needle and dispose of it safely in a sharps container. Do not recap the needle to avoid accidental needle sticks.
  2. Replace the pen cap to protect the needle and keep the pen clean.
  3. Store the pen according to the manufacturer’s instructions to maintain the integrity of the insulin.

Tips for Optimal Results

To ensure optimal results when using Tresiba FlexTouch pens, consider the following tips:

  • Consistency: Administer your insulin injections at the same time each day to establish a routine.
  • Communication: Stay in touch with your healthcare provider to discuss any concerns or adjustments needed in your insulin dosage.
  • Blood Sugar Monitoring: Regularly monitor your blood sugar levels and keep a record to track any patterns or changes.
  • Lifestyle Factors: Maintain a healthy lifestyle by eating a balanced diet, engaging in regular physical activity, and managing stress levels.


Proper storage of insulin is vital to maintain its effectiveness. If insulin is not stored correctly, it can degrade, lose its potency, and lead to inconsistent blood sugar control. Understanding the importance of proper storage ensures that you get the most out of your Tresiba.

  • Proper Storage Temperature for Tresiba: Tresiba should be stored in a refrigerator between 36°F and 46°F (2°C and 8°C). Avoid freezing the insulin as it can damage its structure and render it ineffective. Keep in mind that Tresiba should not be stored in the freezer compartment of the refrigerator.
  • Storage Duration and Expiration: Tresiba has a shelf life of up to 56 days when stored in a refrigerator. Always check the expiration date on the packaging and discard any unused Tresiba after it has expired. Using expired insulin can lead to unpredictable blood sugar levels.
  • Storing Tresiba in a Refrigerator: When storing Tresiba in a refrigerator, it is recommended to keep it away from the freezer compartment and any areas that might freeze, such as the back of the fridge. Store it in its original packaging to protect it from light exposure and ensure accurate expiration date tracking.
  • Traveling with Tresiba: Tips and Guidelines: When traveling with Tresiba, consider using a portable insulin cooler bag to keep it within the recommended temperature range. Make sure to pack extra Tresiba in case of unexpected delays. If you are traveling by air, keep your insulin with you in your carry-on luggage to prevent exposure to extreme temperatures in the cargo hold.
  • Protecting Tresiba from Light and Heat Exposure: Direct exposure to light and heat can degrade Tresiba and reduce its effectiveness. Store it in a cool, dark place, away from sunlight, stoves, microwaves, and other heat sources. Avoid leaving Tresiba in a hot car or near windows.


Proper disposal of medical waste, including Tresiba FlexTouch pens, is vital for the safety of individuals, healthcare professionals, and the environment. These pens are used to administer insulin to manage diabetes, and their safe disposal helps prevent accidental needle sticks and minimizes environmental impact.

Gather the Necessary Supplies

Before beginning the disposal process, ensure you have the following supplies:

  • Tresiba FlexTouch pen(s)
  • Puncture-resistant container (e.g., sharps container)
  • Disposable gloves (optional but recommended)
  • Alcohol swabs or disinfecting wipes

Prepare the Disposal Container

Choose a puncture-resistant container specifically designed for sharps disposal. These containers are available at pharmacies, medical supply stores, or you can inquire with your healthcare provider. Ensure the container has a tight-fitting lid to prevent accidental exposure to used needles.

Safely Remove the Needle

When the Tresiba FlexTouch pen is empty, it’s time to remove the needle. Follow these steps:

  • Unscrew the needle from the pen by twisting it counterclockwise.
  • Avoid touching the needle to minimize the risk of accidental injury or contamination.

Dispose of the Used Needle

Carefully place the used needle in the puncture-resistant container. Ensure the needle is fully inside the container and cannot cause harm to others. Never recap or bend the needle before disposal, as it increases the risk of injury.

Secure the Pen

After removing the needle, it’s essential to secure the Tresiba FlexTouch pen to prevent accidental use or needle sticks. Here’s what you should do:

  • Extend the pen’s dose dial until the “0” mark is visible, indicating it’s empty.
  • Replace the pen cap securely to cover the needle insertion point.

Properly Dispose

Now that the needle is safely disposed of and the pen is secured, it’s time to dispose of the Tresiba FlexTouch pen. Check local regulations or guidelines for proper disposal methods. Here are some options:

  • Many communities provide designated medical waste disposal services or drop-off locations. Research local resources to find the most convenient and environmentally friendly solution.
  • Some pharmacies or healthcare facilities may accept used Tresiba FlexTouch pens for proper disposal. Contact them to inquire about their policies.

Finalize the Disposal Process

Once you have properly disposed of the used Tresiba FlexTouch pen and needle, it’s important to finalize the disposal process. Follow these additional steps:

  • Secure the lid of the puncture-resistant container tightly to prevent spillage or accidental exposure.
  • Store the container in a safe and secure location, out of reach of children and pets.
  • When the container is full or according to local regulations, seal it completely and dispose of it through appropriate channels.

Tips for Safe Disposal of Tresiba FlexTouch Pens

To ensure the safe disposal of Tresiba FlexTouch pens, consider the following tips:

  1. Always use a sharps container or a puncture-resistant container with a secure lid for needle disposal.
  2. Do not dispose of Tresiba FlexTouch pens in the regular household trash without taking appropriate precautions.
  3. Follow your local waste management guidelines for disposing of sealed sharps containers.
  4. Keep sharps containers out of reach of children and pets.
  5. Educate others about the importance of proper disposal to prevent accidental needlesticks.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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