Angeliq is a medication that is used to reduce the symptoms of menopause. Women commonly have these symptoms when their bodies are not producing adequate amounts of estrogen.  Women who are experiencing menopause usually have instances of flushing or perspiration on their face and upper body. These are known as hot flashes. This medication also helps relieve the symptoms of vaginal discomfort like dryness, burning sensations, and itching in this area.

Angeliq is a combination of two types of hormones- an estrogen and a progestin. The estrogen is estradiol and the progestin is drospirenone. Estradiol replenishes your body with estrogen that is lost due to menopause. It also helps relieve hot flashes and vaginal dryness. Drospirenone is added to protect the uterus from damage and help prevent uterine cancer.

Precautions and Warnings with Angeliq

You should not take Angeliq if you are allergic to the active ingredients of drospirenone, estradiol, or even spironolactone. Always tell your pharmacist or doctor if you have any kind of allergies. Angeliq may also contain some inactive ingredients which could cause allergic reactions or other problems.

Using this medication may make you feel lightheaded or dizzy. Do not take alcohol or use marijuana if you are on this drug. Since the use of this drug can raise potassium levels, talk to your physician or chemist before taking salt or potassium supplements.

You may also develop vision problems if you wear contact lenses or are nearsighted. Contact your eye doctor if you experience these difficulties.

Do not take this drug if you get pregnant. You should inform your doctor immediately if this happens.  You should not take Angeliq as a means of preventing dementia, stroke, or heart disease.

You should consult with your doctor or pharmacist before taking this medication. Be sure to tell them about your medical history.

Do not take this medication if you are suffering from or have experienced any of the following symptoms in the past:

  • Adrenal gland problems
  • Diabetes
  • Asthma
  • Blood clotting disorders, like a  protein S or protein C deficiency
  • Breast, ovary, or uterine cancer
  • Current/history of blood clots in the eyes, lungs, or legs
  • Family medical history of blood clots, breast lumps, or cancer
  • Gallbladder disease
  • Heart attack
  • Heart disease
  • Family or personal history of angioedema, a swelling disorder
  • Obesity
  • Heart failure
  • High blood cholesterol and fat or triglyceride level
  • High blood pressure
  • Hypoparathyroidism
  • Lupus
  • Hypothyroidism- an underactive thyroid
  • Kidney disease
  • Liver disease
  • Mental/mood disorders such as depression and memory loss
  • Migraine headaches
  • Porphyria- a certain metabolic disorder
  • Seizures
  • Stroke
  • Mineral imbalance – such as high or low calcium blood level, high potassium blood level, or low sodium blood level
  • Uterus problems such as uterine fibroids and endometriosis
  • Vaginal bleeding of unknown cause
  • Yellowing of the eyes or skin during pregnancy or with past estrogen use

Angeliq Side Effects

Be sure to discuss these side effects with your doctor or pharmacist immediately, especially if they last for a long time or get progressively worse.

Some of the side effects of taking this medication include the following:

  • Bloating
  • Dizziness
  • Breast tenderness
  • Change in vaginal discharge
  • Headache
  • Nausea
  • Increased or decreased interest in sex
  • Changes in sleep patterns
  • Irritability
  • Lightheadedness
  • Stomach upset
  • Weight changes

Drug Interactions with Angeliq

Angeliq affects how your body processes other drugs. Also, different drugs may change the way your body uses Angeliq. For this reason, you should tell your caregiver which drugs you are on before getting an estrogen recommendation.

It would help if you did not mix grapefruit juice with Angeliq as grapefruits may increase estrogen plasma concentrations. Also, don’t use this drug when you’re breastfeeding since Angeliq can decrease milk production and even pass into breast milk.

Known Interactions

It is known that Angeliq has interactions with these drugs:

  • Aromatase inhibitors, like exemestane and anastrozole
  • Atazanavir/cobicistat (such as Evotaz)
  • Tamoxifen
  • Corticosteroids, like prednisone
  • Ospemifene
  • Fezolinetant
  • Warfarin
  • Raloxifene
  • Tizanidine
  • Tranexamic acid

Potassium Interactions

Since drospirenone is likely to increase the level of potassium in your body, consult with your doctor if you take other products or drugs that also raise potassium, like

  • Aliskiren
  • Angiotensin receptor blockers such as losartan and heparin
  • ACE inhibitors like enalapril and lisinopril
  • NSAIDs such as ibuprofen and naproxen.
  • Pills like spironolactone, eplerenone and triamterene reduce water in the body.

Estrogen Interactions

The use of other medications can also affect how estrogen works and the removal of estrogen from your body. Some of these drugs include:

Strengths and Dosages of Angeliq

The following are the recommended dosages for this drug:

StrengthDosage
0.25 mg/0.5 mgOnce daily
0.5mg/1 mgOnce daily

Your doctor will prescribe you the dosage according to your condition. You should take the drug at the same time each day so that it becomes a habit and you don’t miss a dose. In case you do miss a dose, don’t worry.  You can skip the dose if you are more than 12 hours late for it. Just take your regular dose the next day, but do not take two doses at the same time to make up for it.

Angeliq Alternatives

Angeliq is available primarily as a name-brand drug. However, you can also buy conjugated estrogens (CEs) other than Angeliq if they cost less than the branded version. Some doctor-approved Angeliq alternatives are:

Angeliq FAQs

What is Angeliq used for?

Angeliq is a drug that is primarily used for the control of menopausal symptoms.  These include vaginal itching, dryness, and night sweats. It’s a form of estrogen therapy for older females. A female experiences these symptoms when her body stops producing adequate amounts of estrogen.

How is Angeliq usually administered?

Angeliq is a drug that is taken by mouth. You should take the drug with the strength and dosage recommended by your doctor. The usual dosage is one tablet per day. Your doctor will prescribe the dosage required depending on your present condition and medical history.

What happens if you miss a dose?

If you miss a dose of Angeliq, don’t worry. You can take the dose up to 12 hours late. If you miss this as well, just take the normal dose the next day. It would be best if you did not try to take two doses at once as it can cause adverse reactions.

What happens if you overdose on Angeliq?

If you accidentally take an overdose of Angeliq, get to a doctor or emergency treatment center as soon as possible. You may experience abnormal vaginal bleeding, or nausea and vomiting that does not stop.

In case of a serious overdose, the person may become unconscious or experience breathing difficulties. Contact the nearest poison treatment center immediately to deal with this situation.

What are some side effects of Angeliq?

Users of this medication may get skin blotches, especially if exposed to the sun. You may also get spotting or have irregular menstrual cycles. You may also get headaches. Mental confusion and mood swings are also common. People have also reported stomach pain and weight gain as a consequence of taking this drug.

What are some recommended lifestyle changes while using Angeliq?

It would help if you did not smoke or drink alcohol while taking this medication. Eat well-balanced meals that have sufficient amounts of calcium and Vitamin D. You should make every effort to reduce stress. Eat meals low in fat and salt. You should lose weight to control or prevent high blood pressure and high cholesterol. It will also help in controlling diabetes and preventing strokes and heart disease. Keeping your mind active with mental exercises to prevent dementia.

What are some other things you can do to prevent vaginal discomfort?

It is recommended to keep your body temperature cool. This will help manage hot flashes. You can drink cool beverages, use a fan, or dress lightly and in layers. Don’t eat spicy foods. Learn relaxation techniques and exercise to reduce hot flashes. Use vaginal lubricants while having intercourse.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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