Adcirca, also known as tadalafil, is a prescription medication available at MyRx Outlet and is used specifically to treat pulmonary arterial hypertension (PAH). This is a common condition that causes abnormally high blood pressure in the arteries of the lungs, making it harder for your heart to pump blood through your lungs and deliver the essential oxygen to the rest of your body. Africa helps both men and women to improve their exercise capacity and increase blood flow to particular parts of the body.

Adcirca tackles high blood pressure in the lungs by targeting a cellular process that regulates blood vessel relaxation. There are tiny muscles wrapped around your lung blood vessels with an enzyme called PDE5 making it hard for blood to flow through freely. Adcirca is a PDE5 inhibitor and it prevents the enzyme from clamping down the muscles, helping it relax. This wider passage allows blood to flow through the lungs more easily, reducing the pressure that was building up. More oxygen reaches your body’s cells and it allows you to breathe better during exercises and build stamina.

Precautions and Warnings with Adcirca

Adcirca stems from a group of phosphodiesterase 5 inhibitors (PDE-5i) and should not under any circumstances be used without your doctor’s prescription. Adcirca can interact dangerously with certain medications, particularly nitrates and guanylate cyclase stimulators. When these ingredients combine with Adcirca, they can cause a sudden and severe drop in blood pressure. So it’s also important to avoid nitrates for at least 48 hours after your last dose of Adcirca. If you have any allergies, especially a known severe allergy to tadalafil (the active ingredient in Adcirca), you should not take this medication.

There is also a possibility of patients experiencing acute chest pain(angina) after consuming Adcirca, so get medical attention as soon as possible if it happens. Like other PDE-5 inhibitors, Adcirca can also temporarily decrease your blood pressure. Before prescribing, your doctor should assess if your underlying heart conditions will have side effects when paired with Adcirca. Sudden vision loss or hearing problems are also a possible effect of this drug. In a rare but possible occurrence, men consuming Adcircia may experience an erection lasting more than four hours. Stop using Adcirca immediately if this happens and seek medical attention.

Adcirca Side Effects

Adcirca, like any medication, can cause side effects. It’s important to be aware of both serious and common side effects so you can take action if needed.

Severe Side Effects

  • Signs of an allergic reaction (hives, trouble breathing, swelling).
  • Heart attack symptoms (chest pain, pressure, pain radiating to jaw or shoulder, nausea, sweating).
  • Sudden vision changes or loss.
  • Ringing in the ears or sudden hearing loss.
  • Painful erection lasting longer than 4 hours (priapism).
  • Loss of vision.
  • Prolonged erection (lasting more than 4 hours).
  • Signs of low blood pressure (dizziness, lightheadedness, nausea, blurred vision, rapid breathing, fainting).
  • Fluid buildup in the lungs (fatigue, shortness of breath, bluish skin).

Common Side Effects

  • Muscle pain (back, arms, jaw).
  • Blurred vision.
  • Chest pain, discomfort, tightness.
  • Chills, cold sweats, confusion.
  • Dizziness, fainting, lightheadedness upon standing.
  • Irregular heartbeat.
  • Increased erection.
  • Nausea, nervousness.
  • Pain in arms, jaw, back, or neck.
  • Sweating, tiredness, weakness.

Rare Side Effects

  • Painful or prolonged erection.
  • Blistering, peeling skin, cough, diarrhea.
  • Difficulty speaking, double vision, fast heartbeat.
  • Severe headache, hives, rash.
  • Joint or muscle pain, numbness or tingling.
  • Red, swollen skin, vision changes.
  • Sores in mouth or on lips, stomach pain.
  • Swelling of feet or lower legs.

Drug Interactions with Adcirca

For those of you not aware, a drug interaction occurs when a medication you consume reacts with another substance in your body. This reaction can change the way one or both substances work. While taking Adcircia for Pulmonary Arterial Hypertension, you have to be aware of these potential drug interactions.

Major Interactions (Avoid Completely)

  • Other PDE5 Inhibitors: Don’t combine Adcirca with other indicator medicines in the same class (e.g., Viagra, Levitra). This can worsen side effects.
  • Nitrates: Medications like nitroglycerin used for chest pain can cause a dangerous drop in blood pressure when taken with Adcirca.
  • Alpha-Blockers: Both Adcircia, which is a PDE5 inhibitor, and alpha-adrenergic blocking agents are vasodilators and they are used to lower the blood pressure levels. But if combined together, these vasodilators will create an additive effect that can cause more harm than good.

Moderate Interactions (Use with Caution)

  • Allergies: If you have a known allergy to tadalafil or experience symptoms like:
    • Hives, rash, itching, swelling under your skin (usually in your eyelids, lips, hands, or feet)
    • Difficulty breathing, swelling of your mouth, tongue, or throat
    • Feeling faint or lightheaded
  • Poppers: Poppers are recreational inhaled drugs that contain nitrates like amyl nitrate or butyl nitrate so they should not be taken together with Adcirca.

Other Interactions to Consider

  • Alcohol: While not life-threatening, excessive alcohol can worsen the blood pressure-lowering effects of Adcirca and may affect its absorption.
  • Grapefruit: Avoid interacting grapefruit with Adcirca is able to boost the concentration levels of Ciatus in your body.
  • Certain Medications: Antifungal medications (e.g., ketoconazole), HIV protease inhibitors, some antibiotics (e.g., clarithromycin), and other medications affecting CYP3A4 enzymes can interact with Adcirca.

Strengths and Dosages of Adcirca

Adcirca (tadalafil) is available in 20mg tablets for the treatment of Pulmonary Arterial Hypertension (PAH) only.

Recommended Dosage

  • PAH: 40mg (two 20mg tablets) taken once daily, with or without food. Dividing the dose throughout the day is not recommended.

Important: Adcirca is not for erectile dysfunction (ED) or benign prostatic hyperplasia (BPH). Different medications like Cialis (tadalafil) are available for these conditions with varying strengths and dosages (see table below for reference).

Dosage Table

Condition Medication StrengthDosage Notes
PAHAdcirca, Alyq, Tadliq20mg tablets40mg (2 x 20mg tablets) once dailyDo not split or divide tablets.
ED(As Cialis or generic)Cialis, generic2.5mg, 5mg, 10mg, 20mg tabletsVaries depending on use (PRN or once-daily). See table for details.May require dose adjustments with certain medications.
BPH(As Cialis or generic)Cialis, generic5mg tablets5mg once dailyMay be used in combination with finasteride for BPH.

Adcirca Alternatives

Here are some of the most common alternatives to Adcirca that you will find on the market:

  • Viagra: Sildenafil, commonly known as Viagra is one of the known alternatives to Adcirca used for the treatment of erectile dysfunction. Sildenafil belongs to the same class of phosphodiesterase (PDE) inhibitors and it helps to boost exercise abilities in adults with PAH or high blood pressure.
  • Revatio: Similar to Sildenafil, Revatio also helps relax the constricted blood vessels inside the body by targeting blood flow to a specific part. Revatio is primarily prescribed for PAH while Sildenafil is prescribed mainly for erectile dysfunction in men.
  • Epoprostenol (Flolan): Epoprostenol is a prostacyclin analog. Prostacyclins are naturally occurring substances in the body that help to relax blood vessels and prevent blood clotting. In PAH, the lungs’ blood vessels are narrower which it harder for the heart to pump blood through. Epoprostenol helps to relax these blood vessels, which improves blood flow and reduces strain on the heart.

FAQs of Adcirca

What is Adcirca?

Adcirca (tadalafil) is a prescription medication used to treat pulmonary arterial hypertension (PAH). PAH is a condition that causes high blood pressure in the arteries that carry blood from your heart to your lungs. Adcirca helps to relax the muscles in the walls of your lungs’ blood vessels, allowing blood to flow more easily and reducing strain on your heart.

How long does Adcirca take to work?

You may start to feel some improvement in your exercise ability within a few weeks of taking Adcirca. However, it can take up to 3 months to see the full benefits of the medication.

How long does Adcirca stay in the system?

The amount of time Adcirca stays in your system can vary depending on factors like your age, kidney function, and liver function.  In general, it can take several days for the medication to be completely eliminated from your body.

How does Adcirca Work?

Adcirca medications work by increasing blood flow in certain parts of the body by relaxing the muscles in the walls of blood vessels. In the lungs, this relaxation allows blood to flow more easily, reducing pressure and improving symptoms of PAH.

How should I use Adcirca?

  • Adcirca comes in 20mg tablets and is typically taken once daily, with or without food.
  • Swallow the tablets whole. Do not split, crush, or chew them.
  • It’s important to take Adcirca consistently at the same time each day, as prescribed by your doctor.
  • Do not take more Adcirca than your doctor prescribes.
  • Be sure to tell your doctor about all the medications, vitamins, and herbal supplements you are taking before starting Adcirca.

Who makes Adcirca?

The manufacturer of Adcirca is Eli Lilly and Company. Adcirca itself is a brand name, with tadalafil being the generic medication.

Who should not take Adcirca?

You should not take Adcirca if you:

  • Are allergic to tadalafil or any other ingredients in Adcirca
  • Have recently had a heart attack or stroke
  • Have severe low blood pressure
  • Take nitrates (medications used to treat chest pain)
  • Take certain medications, including alpha-blockers, some antibiotics, antifungal medications, and HIV protease inhibitors.

Can women use Adcirca?

Adcirca is not approved for use in women. There are other medications available to treat PAH in women. Talk to your doctor about the best treatment option for you.

Is there any food or drink I need to avoid with Adcirca?

Grapefruit juice can interact with Adcirca and increase the amount of medication in your system. It’s best to avoid grapefruit juice while taking Adcirca. Excessive alcohol consumption can also worsen the blood pressure-lowering effects of Adcirca.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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