Adcirca is the brand name for the generic drug tadalafil. It belongs to a class of medications called phosphodiesterase type 5 (PDE5) inhibitors. While it is more commonly known for its use in treating erectile dysfunction under the brand name Cialis, Adcirca is specifically approved to treat pulmonary arterial hypertension.

The active ingredient in Adcirca is tadalafil. It is available in various dosage strengths, and the appropriate dosage is determined by the prescribing healthcare provider based on the patient’s condition and medical history.

This medication is primarily used to improve exercise ability in people with pulmonary hypertension. It works by relaxing and widening the blood vessels in the lungs, which helps reduce blood pressure and improves blood flow, making it easier for the heart to pump blood through the lungs. It exerts its therapeutic effects by inhibiting the enzyme PDE5, which is responsible for breaking down cyclic guanosine monophosphate (cGMP). By inhibiting PDE5, Adcirca increases cGMP levels, leading to smooth muscle relaxation and vasodilation in the pulmonary arteries.

Adcirca is prescribed to adult patients diagnosed with pulmonary arterial hypertension. It is not intended for use in children or adolescents. Patients suffering from PAH often experience symptoms such as shortness of breath, fatigue, chest pain, and dizziness.

Numerous clinical trials have demonstrated the efficacy of Adcirca in improving exercise capacity and hemodynamic parameters in patients with pulmonary arterial hypertension. Studies have shown that Adcirca can significantly increase the distance covered during the six-minute walk test, a standard assessment of exercise capacity in PAH patients.

Adcirca vs. Cialis

Adcirca is specifically approved for the treatment of pulmonary arterial hypertension, while Cialis is indicated for the management of erectile dysfunction.

The recommended dosage of Adcirca for pulmonary arterial hypertension is different from the dosages available for Cialis in treating erectile dysfunction. It’s essential to follow the prescribed dosage for each medication carefully.

Cialis typically starts working within 30 to 60 minutes after ingestion, while Adcirca’s onset of action may vary based on individual response. Both medications have varying durations of action, with Cialis lasting longer.

While Adcirca and Cialis are generally well-tolerated, they may cause side effects such as headaches, indigestion, back pain, and nasal congestion. It is crucial to consult a healthcare professional before starting any medication to ensure they are safe for you based on your medical history and current health condition.

The choice between Adcirca and Cialis depends on several factors, including the individual’s medical history, the severity of erectile dysfunction, and personal preferences. It is essential to discuss these factors with a healthcare professional who can provide personalized recommendations.

Indications for Adcirca

Adcirca is approved for the treatment of Pulmonary Arterial Hypertension (PAH) and Benign Prostatic Hyperplasia (BPH). As with any medication, it is crucial to follow healthcare providers’ instructions and be aware of potential side effects and drug interactions. If you have any concerns or questions about Adcirca’s usage, consult a qualified healthcare professional for personalized advice.

Pulmonary Arterial Hypertension (PAH)

Pulmonary Arterial Hypertension (PAH) is a severe condition characterized by high blood pressure in the arteries that supply the lungs. This leads to an increased workload on the heart, resulting in various symptoms such as shortness of breath, fatigue, and chest pain. Adcirca has been approved by health authorities as a medication to manage PAH effectively.

Benign Prostatic Hyperplasia (BPH)

Benign Prostatic Hyperplasia (BPH) is a non-cancerous enlargement of the prostate gland, commonly affecting aging men. This condition can lead to difficulties in urination, causing frequent and urgent needs to urinate, weak urine flow, and incomplete bladder emptying. Adcirca has been found to improve symptoms related to BPH and aid in the management of this condition.

Warnings and Precautions

Adcirca is a medication that is used to treat specific medical conditions, such as pulmonary arterial hypertension (PAH), benign prostatic hyperplasia (BPH), and erectile dysfunction (ED). While it can provide significant benefits, it is essential to be aware of the potential warnings and precautions associated with this drug to ensure safe and effective usage.

Medical History and Current Medications

Discuss your complete medical history with your doctor, especially if you have a history of heart problems, liver or kidney disease, or a recent stroke. Additionally, inform your doctor about all the medications you are currently taking, including over-the-counter drugs and herbal supplements. Some medications can interact with Adcirca and cause adverse effects.


Adcirca is not suitable for everyone. It is contraindicated in individuals taking nitrates or guanylate cyclase stimulators, as it can lead to a dangerous drop in blood pressure. Additionally, those with severe liver or kidney impairment should avoid Adcirca.

Pregnancy and Breastfeeding

Adcirca should not be used during pregnancy unless explicitly prescribed by a doctor. It is unknown whether the medication passes into breast milk, so breastfeeding mothers should consult their healthcare provider before using Adcirca.

Allergic Reactions

Individuals with a known hypersensitivity to Adcirca’s active ingredient, tadalafil, or any other components of the drug should avoid its use. Allergic reactions can manifest as skin rashes, itching, swelling, severe dizziness, and difficulty breathing. If any allergic symptoms occur, immediate medical attention is necessary.

Cardiovascular Risks

Adcirca can lead to a drop in blood pressure, which may cause dizziness, fainting, or even a heart attack in some individuals. Patients with pre-existing cardiovascular conditions, such as heart disease, stroke, or arrhythmias, must exercise caution when using Adcirca. It is crucial to inform your doctor about any history of heart problems before initiating treatment.

Nitrate Therapy

The concomitant use of Adcirca with nitrates or nitric oxide donors is contraindicated, as it can cause a significant drop in blood pressure. Avoid using Adcirca if you are already taking medications containing nitrates.


Adcirca can cause hypotension (low blood pressure), especially when taken in combination with other medications like nitrates. To avoid adverse effects, patients should refrain from taking nitrates while using Adcirca. Moreover, patients must follow their physician’s guidance regarding the appropriate dosage and timing of Adcirca.


Priapism, a prolonged and painful erection lasting more than four hours, is a severe side effect associated with Adcirca use. Patients experiencing priapism should seek immediate medical attention to prevent potential long-term damage to the penis.

Vision and Hearing Loss

In rare cases, Adcirca has been linked to sudden vision and hearing loss. Patients who experience any changes in vision or hearing while taking the medication should discontinue its use and consult a healthcare professional promptly.

Liver and Kidney Impairment

Patients with severe kidney or liver impairment should use Adcirca with caution, as the medication’s clearance may be reduced in these individuals. Dose adjustments may be necessary to ensure safety and efficacy.

Pulmonary Veno-Occlusive Disease (PVOD)

Adcirca is not recommended for patients with pulmonary veno-occlusive disease (PVOD) due to the potential risk of worsening the condition. Inform your doctor if you have or suspect you have PVOD before starting Adcirca.

Pregnancy and Breastfeeding

Adcirca is not recommended during pregnancy due to potential risks to the unborn baby. If you are pregnant or planning to become pregnant, discuss alternative treatment options with your healthcare provider. Similarly, it is essential to consult your doctor if you are breastfeeding, as Adcirca may pass into breast milk.

Pediatric Use

Adcirca is not approved for use in children and adolescents. The drug’s safety and efficacy have not been established in this age group, and its use in pediatric patients is not recommended. Before administering Adcirca to any patient, healthcare providers must thoroughly assess the individual’s medical history and take note of any pre-existing conditions, allergies, or potential drug interactions.

Driving and Operating Machinery

Adcirca may cause dizziness and visual disturbances. If you experience these side effects, refrain from driving or operating heavy machinery until you are certain about your ability to perform these tasks safely.

Side Effects

Below, we have categorized the side effects of Adcirca into three sections: common, rare, and severe. It’s important to note that not everyone will experience these side effects, and some individuals may not experience any at all. Always consult with your healthcare provider if you have concerns about the side effects of Adcirca.

Common Side Effects

  1. Headache: One of the most common side effects of Adcirca is a mild to moderate headache. This discomfort is often short-lived and can be alleviated with over-the-counter pain relievers.
  2. Flushing: Some patients may experience facial flushing or redness due to increased blood flow. This effect is generally harmless and transient.
  3. Indigestion: Adcirca may cause gastrointestinal disturbances, such as indigestion or an upset stomach. Taking the medication with a meal can help mitigate this side effect.
  4. Muscle Pain: In some cases, individuals may experience muscle pain or back pain while taking Adcirca. Gentle stretching and warm compresses can provide relief.
  5. Nasal Congestion: Adcirca might lead to a stuffy or runny nose. This side effect usually subsides on its own without medical intervention.

Rare Side Effects

  1. Vision Changes: Although rare, some patients have reported changes in vision while on Adcirca. This may include blurred vision, sensitivity to light, or a temporary loss of vision. If you experience any visual disturbances, seek immediate medical attention.
  2. Hearing Impairment: Another infrequent side effect is hearing loss or ringing in the ears. If you notice any changes in your hearing, consult your healthcare provider.
  3. Priapism: Priapism is a potentially serious condition characterized by prolonged and painful erections. While rare, it requires immediate medical attention to prevent complications.
  4. Allergic Reactions: Some individuals may be hypersensitive to Tadalafil and experience allergic reactions. Symptoms may include rash, itching, swelling, severe dizziness, or difficulty breathing. Seek emergency medical help if any allergic reactions occur.

Severe Side Effects

  1. Chest Pain: Severe chest pain or angina can be a serious side effect of Adcirca. If you experience chest discomfort while taking this medication, seek immediate medical attention.
  2. Fainting: Adcirca may lead to episodes of fainting or loss of consciousness. If you faint or feel dizzy, inform your healthcare provider immediately.
  3. Shortness of Breath: Difficulty breathing or shortness of breath is a severe side effect that warrants prompt medical evaluation.
  4. Irregular Heartbeat: Adcirca can sometimes cause irregular heart rhythms. If you experience palpitations or an irregular heartbeat, contact your doctor promptly.
  5. Swelling: Severe swelling in the extremities or sudden weight gain could indicate fluid retention. Notify your healthcare provider if you notice significant swelling.
  6. Severe Allergic Reactions: Although rare, severe allergic reactions can occur. These may manifest as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat. Seek emergency medical help if you experience any of these symptoms.


Adcirca is a valuable medication for managing pulmonary arterial hypertension, but it is essential to be cautious of potential interactions. Always consult your healthcare provider before starting Adcirca or making changes to your treatment plan. By being proactive and informed, you can ensure safe and effective usage of this medication.

Drug Interactions

Adcirca may interact with various drugs, including prescription medications and over-the-counter remedies. It’s essential to be cautious when combining Adcirca with other drugs to avoid adverse effects or reduced efficacy. Here are some common drug interactions with Adcirca:

Interactions with Nitrates

Nitrates are commonly used to treat chest pain (angina) and other heart-related conditions. Combining Adcirca with nitrates can lead to a dangerous drop in blood pressure, which may result in fainting or even life-threatening complications. Patients should never use Adcirca while taking nitrates or riociguat.

Alpha-Blockers and Adcirca

Alpha-blockers are prescribed to manage high blood pressure and certain prostate conditions. When used in combination with Adcirca, they can cause a sudden decrease in blood pressure, leading to dizziness and lightheadedness. It is crucial to consult a healthcare professional before using these medications together.

Antifungal Medications

Certain antifungal medications, such as ketoconazole and itraconazole, can increase the levels of Adcirca in the blood, leading to an elevated risk of adverse effects. Physicians may need to adjust the Adcirca dosage when prescribed alongside these medications.

Antihypertensive Medications

Combining Adcirca with other antihypertensive drugs may lead to excessive blood pressure reduction, causing dizziness or fainting. Inform your healthcare provider of all medications you are taking to prevent potential complications.

Antibiotics and Tadalafil

Some antibiotics, particularly erythromycin and clarithromycin, can interfere with Adcirca’s metabolism, potentially leading to increased drug levels in the body. Patients on these antibiotics should inform their doctors if they are using Adcirca.

Protease Inhibitors

Protease inhibitors are used to treat HIV and hepatitis C. They can significantly increase the concentration of Adcirca in the blood, potentially leading to an increased risk of adverse effects. Adjusting the Adcirca dosage may be necessary if a patient is taking protease inhibitors.

CYP3A4 Inhibitors

Adcirca is metabolized by the CYP3A4 enzyme. Concurrent use of CYP3A4 inhibitors, such as some antifungal medications and HIV protease inhibitors, can increase Adcirca’s blood levels, potentially leading to adverse effects. Your healthcare provider will monitor your response closely if you must take these drugs together.

Combining Adcirca with Other Drugs

If you are taking medications not listed above, it is still crucial to inform your healthcare provider. Your doctor can assess potential interactions and adjust the dosages accordingly. Remember never to start or stop any medication without consulting a healthcare professional.

Herbal Interactions

Herbal products, though often considered natural, can still interact with medications, including Adcirca. It’s crucial to be cautious and consult your healthcare provider before using any herbal remedies while taking Adcirca. Here are some herbal interactions to be aware of:

St. John’s Wort and Adcirca

St. John’s Wort is a popular herbal supplement used to manage depression and anxiety. When taken with Adcirca, it can accelerate the breakdown of the medication, reducing its effectiveness. Patients on Adcirca therapy should avoid using St. John’s Wort.

Gingko Biloba

Ginkgo Biloba is believed to improve memory and cognitive function. Nonetheless, combining it with Adcirca can lead to increased bleeding risk, especially in individuals taking blood-thinning medications. Therefore, caution should be exercised when using both substances simultaneously.


Ginseng is commonly used to boost energy and enhance cognitive function. However, when combined with Adcirca, it may increase the risk of adverse effects, particularly related to blood pressure. It’s advisable to avoid using ginseng while taking Adcirca.


Echinacea, widely used for immune system support, may alter Adcirca’s metabolism, affecting its effectiveness. Patients should inform their healthcare providers about their echinacea use.

Saw Palmetto

Saw palmetto, a herb used for prostate health, may interact with Adcirca in ways that affect its efficacy. Patients using Adcirca should seek medical advice before taking saw palmetto.

Food Interactions

Food can also interact with Adcirca, affecting its absorption and effectiveness. Understanding food interactions can help you get the most out of your Adcirca treatment. Here are some food-related interactions:

Grapefruit and Tadalafil

Grapefruit juice can inhibit the breakdown of Adcirca in the body, leading to higher levels of the medication. This can intensify the side effects and increase the risk of adverse reactions. Patients on Adcirca should avoid consuming grapefruit or its juice.

High-Fat Meals

High-fat meals can delay the absorption of Adcirca, reducing its effectiveness. It is advisable to take Adcirca on an empty stomach or with a light meal to ensure optimal absorption and therapeutic benefits.

Alcohol Consumption

Alcohol can lower blood pressure, just like Adcirca. Combining the two may result in excessive blood pressure reduction, leading to dizziness and lightheadedness. It is advisable to limit alcohol consumption while using Adcirca.

Caffeine and Adcirca

Caffeine can increase heart rate and blood pressure. Using caffeine while on Adcirca may amplify these effects, potentially causing discomfort. Patients should moderate their caffeine intake while using Adcirca.

Calcium-Rich Foods

Calcium-rich foods, such as dairy products, can interfere with Adcirca’s absorption. It is recommended to avoid taking Adcirca with calcium-rich meals.

Adcirca is a valuable medication for treating pulmonary arterial hypertension and benign prostatic hyperplasia. However, its interactions with other drugs, herbs, and foods can impact its effectiveness and your overall health. By being vigilant about potential interactions and following the safety measures mentioned, you can ensure the safe and efficient use of Adcirca in your treatment plan.

Quick Tips for Avoiding Adcirca Interactions

To minimize the risk of adverse interactions with Adcirca, consider the following tips:

  • Inform your healthcare provider about all medications, herbs, and supplements you are taking.
  • Never combine Adcirca with nitrates or riociguat.
  • Exercise caution when using Adcirca with alpha-blockers or protease inhibitors.
  • Avoid using St. John’s Wort, ginseng, and ginkgo biloba while on Adcirca therapy.
  • Refrain from consuming grapefruit or high-fat meals when taking Adcirca.


To ensure the effectiveness and safety of Adcirca, it is crucial to follow the prescribed dosing instructions provided by your healthcare professional. The typical starting dose is 40 mg (two 20 mg tablets) once daily. However, your doctor may adjust the dosage based on your individual response and medical condition.

Taking Adcirca: Important Points to Remember

  1. Consistency is Key: Take Adcirca at the same time each day to maintain a consistent level of the drug in your system.
  2. Avoid Grapefruit: Grapefruit and grapefruit juice can interact with Adcirca, potentially increasing the risk of side effects. Avoid consuming grapefruit products while on this medication.
  3. Missed Dose: If you forget to take a dose, take it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.
  4. Storage: Store Adcirca at room temperature, away from moisture and heat. Keep the medication out of the reach of children and pets.
  5. Use with Caution: If you have liver or kidney problems, discuss your condition with your doctor before starting Adcirca.


Proper storage of Adcirca is crucial to maintain its effectiveness and ensure its safety for consumption. In this article, we will provide you with a step-by-step guide on how to store Adcirca to maximize its shelf life and potency.

The first step in storing Adcirca is to carefully read the label and check the expiration date. Ensure that you are using the most current medication and that it is not past its expiration date. Expired medications may lose their effectiveness and can pose potential health risks.

Adcirca should be stored in a cool, dry place away from direct sunlight and heat sources. Avoid storing the medication in the bathroom or near the kitchen sink, as moisture and humidity can degrade the drug’s potency over time. Fluctuations in temperature can compromise the integrity of Adcirca. Therefore, it is essential to store the medication at a consistent room temperature. Avoid leaving it in areas that are subject to extreme temperatures, such as near windows or heating vents.

Always keep Adcirca in its original container with the lid tightly closed. The container is specifically designed to protect the medication from external factors that may affect its stability. Do not transfer the pills to a different container unless instructed by a healthcare professional.

Keep Adcirca out of reach of children and pets. The medication should only be taken under the supervision of a healthcare provider and should never be accessible to curious hands or paws.

Freezing Adcirca can cause irreversible damage to the medication. Ensure it is stored in a place where the temperature does not drop below freezing.


IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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