Menopausal women use different drugs to treat vasomotor symptoms, such as hot flashes, night sweats, etc. (experienced by around 8 out of 10 females). One of these drugs is called Divigel or estradiol. This color, odorless gel comes in small sachets. Users apply it on their upper thighs to absorb it into their bloodstream.

Divigel works by delivering estradiol (estrogen) to your bloodstream, overcoming a lack of this essential hormone in your body. It helps your body manage the significant symptoms of menopause. This drug has been around since 2007.

Precautions and Warnings with Divigel

These are the most important precautions for Divigel users:

  • Avoid using Divigel if you’re pregnant
  • Divigel may lead to uterine cancer in some women
  • Be mindful of kids and pets around you because Divigel can cause the below-mentioned side effects if they touch the skin where you’ve applied the drug.
  • If you have a history of heart attack or cancer, please don’t use Divigel
  • Tell your doctor if you have a history of vaginal bleeding, asthma, epilepsy, lupus, kidney disease, migraines, etc.

Share your medical history with your doctor so they may determine if Divigel is the right drug for you. This will help you avoid the major side effects of this medicine.

Divigel Side Effects

Some common side effects of Divigel are:

Common Side Effects

  • Headaches or dizziness
  • Breast pain or tenderness
  • Abnormal vaginal discharge
  • Vaginal itching or spotting
  • Nausea, vomiting, and stomach cramps

Major Side Effects

  • Blood clots
  • Jaundice
  • Mental confusion
  • Constipation or weight loss
  • Stomach swelling and tenderness

Advanced Side Effects

Drug Interactions with Divigel

Divigel affects how your body processes other drugs. Also, different drugs may change the way your body uses Divigel. For this reason, you should tell your caregiver which drugs you are on before getting an estradiol recommendation.

It would help if you did not mix grapefruit juice with Divigel as well because grapefruits may increase estrogen plasma concentrations in your body.

In general, Divigel is known to interact with these medicines:

Cost of Divigel in America

Divigel comes in a box of sachets containing the same dosage as Divigel. Buying a box may cost you between $187 and $214 without insurance. In other words, the average cost of a box of Divigel is somewhere over $200, while a single sachet (1 gm of 1 mg/gm) costs around $7. Estradiol products can range in price, with pharmacists estimating a high of $520 and a low of $300.

Why is Divigel so Expensive?

Rigorous testing makes Divigel safe and effective enough to be sold as a brand-name drug. Since the testing phase costs a lot, drug manufacturers can legally sell this drug exclusively for the next twenty years. Then, other brands can develop and sell generic versions. This is why the prices of this medicine can be really high.

However, if you’re paying for Divigel or other estradiol products out of pocket, you should turn to services like MyRx Outlet, where Divigel is often available at a lower price than the average pharmacy. That’s how you get estradiol at an affordable rate.

Strengths and Dosages of Divigel

It’s available in five dosages ranging from 0.25mg to 1.25mg, but it’s safer always to begin your hormone therapy with the lowest dosage. The higher the dosage, the more severe its side effects.

Your doctor will prescribe you the strength tailored to your unique needs. Usually, women will get a starting dose of 0.25mg. A typical user will take this drug once per day, applying Divigel on their upper thighs.

Overdosing on Divigel can lead to tender breasts, pain in your abdomen, drowsiness, vaginal bleeding, nausea, vomiting, etc.

Divigel clear, colorless gel that comes in a packet with this information:

  • Dosage
  • Divigel name
  • Manufacturer name
  • Batch number
  • Expiry date

Divigel Alternatives

Divigel is available primarily as a name-brand drug. However, you can also buy conjugated estrogen gels other than Divigel if they cost less than the branded version. Some doctor-approved Divigel alternatives are:

Divigel FAQs

What is Divigel?

Divigel relieves menopausal symptoms in older women (hot flashes, night sweats, etc.). It’s an estrogen gel that’s rubbed on your skin and then absorbed into your bloodstream.

How to use Divigel?

You should squeeze the contents of the packet entirely on your thigh and rub it for maximum absorption. You can also apply this gel to your right thigh on odd days and your left thigh on even days.

How much Divigel should I use in a day?

Divigel comes in many dosages, ranging from 0.25mg to 1.25mg. However, it’s best to use 0.25 dosage on yourself every day.

How long does Divigel take to show its effects?

Divigel starts showing its effects in as early as two weeks. In 12 weeks, it’ll help you get rid of most hot flashes and provide quick relief from the major symptoms of menopause.

Is Divigel a natural item?

Estradiol is a naturally occurring hormone found in females, and it’s the active ingredient used in the making of Divigel. It’s the main form of estrogen ovaries produced in women of childbearing age.

When is the best time to apply for Divigel?

You can apply Divigel whenever you’re most comfortable. It doesn’t matter whether you apply it during the day or night. However, it’d best to use it right after bathing, and you don’t have to rub it on your skin aggressively since it’ll get absorbed in a few minutes.

Can I take a shower after applying Divigel?

No, you shouldn’t take a shower immediately after using Divigel. Wait at least an hour before entering a swimming pool or bathing in your house. Give estradiol ample time to absorb in your skin.

What are some side effects of using Divigel?

Some common side effects of Divigel are:

  • UTIs
  • Joint pain
  • Blood clots
  • Leg cramps
  • Bladder irritability

Should I use Divigel on my face?

Please don’t put Divigel on your face. Also, it shouldn’t be rubbed on breasts or genitalia. Only use this medicine on your upper thighs and wash your hands thoroughly after applying it.

What food should you avoid when taking Divigel?

Like other estrogen hormones, you shouldn’t drink grapefruit use when using Divigel.

Does Divigel affect your mood?

Yes, Divigel is known to cause stress and anxiety among some users. If you are suffering from sudden mood swings after using Divigel, please inform your doctor right away.

What are the differences between Divigel and Estradiol?

UseTreats menopausal symptomsTreats menopausal symptoms
FormulaGelTransdermal spray
Concentration0.1% estradiol concentrationDepends on the dosage
ApplicationApplied on the skin as a gelApplied on the skin as a spray
TimingYou should apply Divigel on your thighs once a dayYou can spray Evamist on your skin 1 to 3 times a day
SafetyHigher doses can be harmfulNeeds to be kept away from children
Drying TimeIt takes a few minutes to dry on your skinDries quickly with no messy residue


IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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