Divigel (Estradiol Gel)
Divigel is a prescription estrogen gel applied to the skin once daily. It is used to treat moderate to severe vasomotor symptoms due to menopause (such as hot flashes) in appropriate patients.
We only dispense medications with a valid prescription from a licensed prescriber.
All prescriptions are reviewed and verified before dispensing. Orders may be delayed or declined if prescription details are missing, do not match the patient information on file, appear altered, or are expired. We may also refuse service if we believe an order is intended for resale or redistribution.
What You Receive
- Divigel in sealed manufacturer packaging
- Personalized prescription instructions based on your prescriber’s directions
- Medication information leaflet provided by the manufacturer
- Itemized invoice detailing your order
- Rx Required
This page is for general information only and is not medical advice. For medical questions, please speak with your prescriber. See Sources & Methodology for how this information is reviewed and referenced.
Divigel Key Facts
What Divigel is
Divigel is a topical estradiol (estrogen) gel for skin application. It comes in single-dose foil packets and dries on the skin after application.
What it’s used for
Divigel is indicated for the treatment of moderate to severe vasomotor symptoms due to menopause.
How it works
Divigel delivers estradiol through the skin into the bloodstream to help reduce menopausal hot flashes and related vasomotor symptoms.
Divigel Safety Overview
Divigel has important estrogen-related risks, including a boxed warning about endometrial cancer risk with unopposed estrogen in women with a uterus.
Divigel Warnings & Precautions
Your prescriber may review your bleeding history, clot risk, liver history, and upcoming surgery/immobilization before and during treatment.
Do not use Divigel if:
- You have unusual or unexplained vaginal bleeding
- You currently have or have had breast cancer
- You have estrogen-dependent cancer
- You currently have or previously had blood clots (DVT/PE), stroke, or heart attack
- You have liver impairment or liver disease
- You have had an anaphylactic reaction, angioedema, or hypersensitivity to Divigel
- You have certain known thrombophilic disorders (such as protein C, protein S, or antithrombin deficiency)
Key warnings to know
- In women with a uterus, estrogen alone can increase endometrial cancer risk; report vaginal bleeding after menopause promptly
- Divigel may increase the risk of blood clots and stroke; stop and seek medical care if these are suspected
- Your prescriber may tell you to stop Divigel before certain surgeries or prolonged immobilization
- Do not wash the application site for at least 1 hour after applying (washing earlier can lower estradiol exposure)
- Let the gel dry fully and avoid skin-to-skin contact with the application site until dry to reduce transfer to others
- Keep children and pets away from exposed application sites
- Divigel is alcohol-based and flammable until dry; avoid fire, flame, or smoking until it dries
- Sunscreen or other topical lotions may affect estrogen exposure (the specific effect on Divigel has not been fully evaluated in clinical trials)
Side Effects and When to Get Help
Divigel can cause side effects that range from mild to serious. Common effects are often manageable, but symptoms such as abnormal bleeding, clot symptoms, or allergic reactions need urgent medical attention.
Possible side effects may include
- Irregular vaginal bleeding or spotting
- Breast tenderness
- Vaginal yeast infection
- Upper respiratory infection or cold-like symptoms
- Headache or nausea
- Mild skin/application-site irritation (uncommon)
Get urgent help right away for
- Unusual vaginal bleeding after menopause
- Signs of a blood clot, stroke, or heart attack (such as chest pain, sudden shortness of breath, severe leg pain/swelling, sudden severe headache, or speech/vision changes)
- Severe allergic reaction symptoms (such as swelling of the face, lips, or tongue, trouble breathing, or hives)
- New breast lumps
- Yellowing of the skin/eyes or other serious liver-related symptoms
Interactions
Divigel has important interaction considerations because estradiol is partly metabolized by CYP3A4. Some medicines and products can increase or decrease estrogen levels and may change effectiveness or side effects.
Interactions you should discuss with your prescriber include
- CYP3A4 inducers such as St. John’s wort, phenobarbital, carbamazepine, and rifampin
- CYP3A4 inhibitors such as erythromycin, clarithromycin, ketoconazole, itraconazole, and ritonavir
- Grapefruit juice
- New prescription medicines, OTC products, or herbal supplements that may affect hormone levels
- Sunscreen or topical lotions used on/near the application site (may affect estrogen absorption/exposure)
- Prescription, OTC, and herbal products that may increase bleeding risk
Divigel Drug Facts
| Category | Details |
|---|---|
| Brand Name | Divigel |
| Drug Class | Estrogen hormone therapy (topical estradiol) |
| Indication | Treatment of moderate to severe vasomotor symptoms due to menopause |
| Dosage Forms | Topical gel in single-dose foil packets |
| Strengths | 0.25 g, 0.5 g, 0.75 g, 1.0 g, 1.25 g packets (delivering 0.25 mg, 0.5 mg, 0.75 mg, 1.0 mg, 1.25 mg estradiol) |
| Boxed Warning | Endometrial cancer risk with unopposed estrogen in women with a uterus |
| Who should not use it | Unexplained vaginal bleeding, certain cancers, active/history of clots or stroke/MI, liver disease, hypersensitivity, certain thrombophilic disorders |
| Administration Timing | Usually once daily around the same time; apply to the upper thigh (right or left, alternating sides), allow to dry before dressing |
| Storage | Store at room temperature 20 to 25°C (68 to 77°F |
| Alternatives | Estradiol patch (Climara, Vivelle-Dot), estradiol gel (EstroGel), oral estradiol (Estrace) |
Helpful Information
How To Buy Divigel Online
1
Select Your Prescribed Divigel Dosage & Strength
Choose the strength and quantity that matches your prescription, then add it to your cart. Orders are limited to a 90-day supply per fill.
2
Complete Checkout
Ensure your shipping and contact information is correct so your order can be processed without delays.
3
Submit Your Divigel Prescription
Upload your prescription at checkout. If you need a transfer, provide your prescriber or current pharmacy details and we will request it on your behalf.
Prescription & Dispensing Standards
- Prescription required for all orders and reviewed for pharmacy and regulatory compliance
- Dispensed by licensed pharmacy partners
- Orders are held if information is missing, unclear, or does not match.
- No substitutions without prescriber approval, and no controlled substances.
Our Guarantee
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Divigel at a discounted rate, call 1-888-551-2467.
FAQs
What is Divigel used for?
Divigel is used to treat moderate to severe menopausal vasomotor symptoms, such as hot flashes.
Where should I apply Divigel?
Divigel is applied once daily to the skin of either the right or left upper thigh, alternating sides to help reduce irritation. Do not apply it to the face, breasts, irritated skin, or in/around the vagina.
How long should I wait before washing or swimming after applying Divigel?
Do not wash the application site for at least 1 hour after applying Divigel. The patient instructions also note the site should be dry before dressing or swimming.
What should I do if I miss a dose of Divigel?
Do not double the next dose. If your next dose is less than 12 hours away, skip the missed dose and resume your regular schedule the next day. If it is more than 12 hours until your next dose, apply the missed dose and resume your normal dosing the next day.
Can Divigel transfer to another person or pet?
Yes, accidental transfer can happen if someone touches the application site before it is fully dry. Let the gel dry completely, wash your hands after applying, and avoid direct contact with the treated area until dry.
Ordering & Prescription FAQs
Do I need a prescription?
Yes, a prescription is required. Refills depend on what your prescriber authorizes.
How do I submit my prescription?
You can upload it through our Upload Prescription page, email it to info@myrxoutlet.com, or fax it to 1-888-230-1245. If you need a prescription transfer, just let us know at checkout and include your pharmacy or prescriber contact details.
When is my payment processed?
Your payment is processed only after your prescription and order have been reviewed and approved by our licensed pharmacy team. Once everything is confirmed, we’ll process payment and prepare your order for shipping.
What happens if my prescription can’t be verified?
Your order may be placed on hold or declined if prescription details are missing, don’t match, are expired, or can’t be confirmed.
Sources
FDA Prescribing Information / Patient Information, DIVIGEL (estradiol gel), for topical use
https://www.accessdata.fda.gov/drugsatfda_docs/label/2026/022038s017lbl.pdf
DailyMed Drug Label, DIVIGEL- estradiol gel
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=59e610dc-883e-4f07-9ec6-a5841b0bf9fb