Trelegy Ellipta, a medication for controlling COPD and asthma issues, provides complete respiratory therapy with 3 components in one inhaler, namely:

  • Fluticasone Furoate: As an inhaled corticosteroid, this component reduces airway inflammation. Fluticasone furoate reduces COPD and asthma symptoms including coughing and wheezing by reducing inflammation.
  • Umeclidinium: Umeclidinium is a long-acting anticholinergic. It works by relaxing airway muscles, which opens them and makes breathing easier. This approach is critical for COPD patients because it tackles one of the main reasons for airflow restriction.
  • Vilanterol: Vilanterol is a long-acting beta-agonist It widens airways by relaxing their muscles, increasing airflow. This method relieves shortness of breath.

The Trelegy Ellipta Synergy

The combined power of these three components makes Trelegy Ellipta strong and highly effective. Fluticasone furoate fights inflammation, umeclidinium relaxes airway muscles, and vilanterol expands them. They treat many respiratory distress symptoms, providing a more complete response than separate drugs.

Trelegy Ellipta does more than treat respiratory disorders. Understanding its composition and how these factors function together can help people grasp its potential to relieve COPD and asthma symptoms over time.

How Does Trelegy Ellipta Work?

Trelegy Ellipta’s multidimensional method of action helps manage COPD and asthma. Here’s how the drug operates.

Inhaled Corticosteroid (ICS): Fluticasone Furoate

Target: Trelegy Ellipta contains fluticasone furoate, an inhaled corticosteroid (ICS) that targets airway inflammation.

Action: ICSs like fluticasone furoate suppress bronchial tube inflammation, edema, and mucus production.

The result: It reduces inflammation, making breathing easier and lowering coughing and wheezing.

Long-Acting Anticholinergic: Umeclidinium

Target: Relaxes airway muscles.

Action: This relaxation dilates COPD patients’ airways, making breathing easier.

The result: Umeclidinium improves airway obstruction, a major COPD symptom, by relaxing muscles.

Long-Acting Beta-Agonist: Vilanterol

Target: Vilanterol expands bronchial airways as a LABA.

Action: It relaxes airway muscles, opening them and increasing airflow.

The result: Vilanterol improves lung function and shortness of breath by expanding airways.

Precautions and Warnings

Before taking Trelegy Ellipta, you need to understand its risks and side effects. Here is a brief but a detailed overview:

Allergic Reactions

Precaution: It is highly recommended to consult your doctor before using Trelegy Ellipta if you have allergies to its components or related medications.

Importance: Allergies can result to complications ranging from mild skin rashes to serious respiratory issues. Understanding your potential allergy risks can help you avoid these complications.

Respiratory Infections

Precaution: Trelegy Ellipta may raise the risk of respiratory infections such as pneumonia and bronchitis.

Importance: Report infection symptoms including fever, cough, and increased mucus production to your doctor.

Ocular Effects

Precaution: Long-term usage of inhaled corticosteroids like fluticasone furoate may cause ocular issues such as glaucoma or cataracts.

Importance: Trelegy Ellipta users should have regular eye exams to monitor and manage eye issues.

Bone Health

Precaution: Prolonged use of corticosteroids, even inhalation, may affect your bone density.

Importance: Talk to your doctor about your bone health, especially if you have osteoporosis or other risk factors.

Withdrawal Symptoms

Precaution: Abruptly quitting Trelegy Ellipta may cause withdrawal symptoms, including breathing difficulties and worsened COPD symptoms.

Importance: Follow your doctor’s instructions when stopping or changing medications to avoid withdrawal symptoms.

Pregnancy and Breastfeeding

Precaution: Trelegy Ellipta safety during pregnancy and breastfeeding is uncertain. Consult your doctor if you are  pregnant or nursing.

Importance: Your healthcare practitioner can help you balance the potential benefits and risks.

Other Medications

Precaution: Please inform your healthcare practitioner of all medications, vitamins, and herbal products you are taking. There’s a higher possibility that Trelegy will interact with some of them.

Importance: Trelegy Ellipta must not interact negatively with other drugs. This ensures maximum effectiveness and safety.

Safe and effective Trelegy Ellipta administration requires awareness of these risks and warnings. Always talk to your doctor to discuss issues and make sure your treatment plan aligns with your circumstances.

Side Effects

Trelegy Ellipta can effectively treat COPD and asthma, but like any medicine, it may cause negative effects.

Many Trelegy Ellipta users tolerate it well with few or no negative effects. You must notify your doctor of any side effects. They can advise on side effects and therapy changes.

Remember that Trelegy Ellipta may help manage COPD and asthma better than it hurts. Individual responses may vary, so open communication with your doctor is crucial for improving treatment and protecting your health.

A complete list of adverse effects, ranked by prevalence, is as follows:

Common Side Effects (May Affect 1 in 10 People)

  • Upper Respiratory Tract Infections: These may include colds, sore throats, and sinusitis.
  • Headache: Early treatment may cause mild to moderate headaches.
  • Back Pain: Back pain may occur during or after the use of Trelegy. If this condition becomes worse, please reach out to your doctor for further instructions.
  • Throat Irritation: This mostly manifests as scratchiness or dryness of the throat.

Uncommon Side Effects (Up to 1 in 100 People May Experience them)

  • Oral Thrush: Long-term usage of inhaled corticosteroids such fluticasone furoate may cause oral fungal infections. It is therefore recommended that you rinse your mouth after every dose to reduce this risk.
  • Increased Heart Rate: Trelegy Ellipta may cause tachycardia, a condition characterized by an increased heart rate.
  • Tremor: Mild hand trembling may be experienced but it’s quite uncommon among Trelegy users
  • Muscle Cramps: Some Users may experience muscle pain.

Rare Side Effects (May Affect 1 in 1000 People)

  • Allergic reactions: Trelegy Ellipta can cause serious allergic reactions, but they are rare. If you get skin rash, itching, swelling, severe dizziness, or trouble breathing, see a doctor.
  • Paradoxical Bronchospasm: Breathing problems can worsen shortly after taking the inhaler. Though rare, it demands rapid medical attention.
  • Eye Problems: Long-term usage of inhaled corticosteroids such as fluticasone furoate may raise the risk of glaucoma and cataracts.

Drug Interactions

Drug interactions must be considered to use Trelegy Ellipta safely. These interactions can reduce medication efficacy, increase side effects, or cause unforeseen problems. The following drugs and substances may interact with Trelegy Ellipta, along with their side effects:

Other Inhaled Medications:

Interaction: Combining inhaled drugs, especially ones with comparable components like long-acting beta-agonists or inhaled corticosteroids (such as Breo  and Anoro), may lead to side effects and problems.

An explanation: Multiple inhalation drugs with overlapping components can cause overdosing and side effects. Your doctor will carefully assess the need for several inhalation drugs and adapt your treatment plan.

Antifungal Medications (Azoles)

Interaction: Ketoconazole, itraconazole, and voriconazole may raise Trelegy Ellipta component levels in the body, increasing negative effects.

An explanation: Azoles can interfere with hepatic drug breakdown, raising blood Trelegy Ellipta levels. This may increase adverse effects and problems. To avoid drug interactions, your doctor will closely monitor your medication regimen and modify dosages.

HIV Protease Inhibitors

Interaction: Ritonavir and lopinavir/ritonavir may raise Trelegy Ellipta component levels, increasing negative effects.

An explanation: HIV protease inhibitors, like azoles, impede Trelegy Ellipta metabolism, increasing body concentrations. This greater exposure may enhance side effects. Your doctor will oversee your medication and provide specific advice.


Interaction: Non-selective beta-blockers, such as Betoptic, Carvedilol and Terormin may counteract Trelegy Ellipta’s broncho dilatory actions, exacerbating respiratory symptoms.

An explanation: Beta-blockers can block bronchodilators like Trelegy Ellipta’s long-acting beta-agonist. Interference may limit COPD or asthma treatment effectiveness. Your doctor will monitor your respiratory state if you take a beta-blocker with Trelegy Ellipta and may make modifications.


Interaction: When used with Trelegy Ellipta, some diuretics (loop diuretics) like furosemide, might cause low potassium levels in the body.

An explanation: Loop diuretics and Trelegy Ellipta may increase potassium loss. Poor potassium levels can cause muscle weakness, abnormal heartbeats, and other health concerns. Your doctor will check potassium levels and adjust medication as needed.

Additional Considerations

Herbal Supplements: Herbal supplements may interact with Trelegy Ellipta. According to PubMed Central, some herbal products may impair Trelegy Ellipta’s efficacy. Discuss herbal products with your doctor to ensure therapeutic compatibility.

Smoking and Smoke Exposure: Smoking can impair Trelegy Ellipta’s efficacy. If you smoke or are routinely exposed to smoke, talk to your doctor for proper management and therapy changes.

Open communication with your doctor about all drugs, supplements, and substances is crucial. They can identify potential interactions, advise on medication management, and assure your safety and well-being while using Trelegy Ellipta. Never modify your medicine without consulting your doctor.

Strengths and Doses

Trelegy Ellipta comes in various strengths and dosages to meet the demands of COPD and asthma patients. The severity of your disease and your doctor’s advice determines strength and dosage. Strengths and doses are shown below:

Trelegy Ellipta: Lowest Strength

Trelegy Ellipta’s lowest strength includes 92 mcg fluticasone furoate, 55 mcg umeclidinium, and 22 mcg vilanterol each inhalation. It is usually recommended to COPD and asthma patients who need a lower maintenance dose.

Trelegy Ellipta: Mid-Range Strength

The mid-range strength of Trelegy Ellipta involves 184 mcg fluticasone furoate, 55 mcg umeclidinium, and 22 mcg vilanterol per inhalation. This level is indicated for moderate to severe COPD or asthma.

Trelegy Ellipta 232/55/22 mcg: Greatest Strength

Trelegy Ellipta’s greatest strength involves 232 mcg fluticasone furoate, 55 mcg umeclidinium, and 22 mcg vilanterol per inhalation. It is designated for severe COPD or asthma symptoms that require a stronger medicine.

Dosage Instructions

Trelegy Ellipta is a medicine that you breathe in and should be used once a day, or as your doctor advises.

Your health care provider will figure out the exact dosage, including the number of inhalations, based on your situation and treatment goals.

To effectively treat your symptoms, it’s important to carefully follow the dosage directions.


The drug is delivered using the Ellipta inhaler. You should keep track of the number of doses left in your inhaler so that you can refill when it runs out. Your doctor will give you comprehensive inhaler instructions. Proper inhaler technique helps medication reach your lungs.

Adjustments to Treatment

Your healthcare provider may adjust Trelegy Ellipta strength or dosage to ensure optimal symptom control. Consult your doctor before changing your dosage or frequency, as this can affect treatment efficacy.

Trelegy Ellipta’s strengths and doses enable customized treatment strategies. To ensure that your drug regimen matches your health condition and controls your COPD or asthma symptoms, you must regularly communicate with your doctor.


To effectively treat COPD and asthma, you must use Trelegy Ellipta correctly. This step-by-step guide will help you use Trelegy Ellipta accurately and confidently:

  • Step 1: Inhaler Check. Make sure your Trelegy Ellipta inhaler is intact and has your medication on a blister strip. Examine the expiration date.
  • Step 2: Before Inhaling. Hold the inhaler with the mouthpiece facing you and the cover closed. No need to shake the inhaler before use.
  • Step 3: Open the Inhaler. Slide the cover down to reveal the mouthpiece. This loads Trelegy Ellipta for inhalation.
  • Step 4: Exhale Fully. Before inhalation, fully exhale away from the inhaler to empty your lungs.
  • Step 5: Inhale Medication. Form a tight seal by placing the mouthpiece between your teeth and lips. Forcefully inhale through the mouthpiece while pressing the inhaler’s side button. This punctures an inhaler blister, releasing the drug as a fine powder for inhalation.
  • Step 6: Hold Your Breath. Remove the inhaler from your mouth after inhaling the medication, but do not exhale immediately. Hold your breath for 5–10 seconds to let the drug into your lungs.
  • Step 7: Exhale Slowly. Gently exhale through your mouth.
  • Step 8: Close the Inhaler. To close the inhaler, slide the cover up until it clicks into place . The inhaler is sealed for next usage.
  • Step 9: Rinse Your Mouth. To reduce the possibility of oral thrush, rinse your mouth with water or mouthwash after using Trelegy Ellipta. Do not swallow the rinse.
  • Step 10: Clean the Inhaler. Wipe the mouthpiece with a dry tissue to maintain cleanliness. Avoid submerging the inhaler.
  • Step 11: Store the Inhaler. Keep your Trelegy Ellipta inhaler cool, dry, and out of direct sunlight and moisture. Keep it away from kids.
  • Step 12: Adhere to Your Healthcare Provider’s Instructions. Follow your specified dosage and regimen. Consult your doctor before changing your dose.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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