Trelegy Ellipta is a medication prescribed for the treatment of severe Chronic Obstructive Pulmonary Disease. It contains three active ingredients, vilanterol, fluticasone furoate, and umeclidinium bromide, that work together to manage symptoms triggered by asthma and COPD, such as chronic bronchitis and emphysema.

The medication is prescribed to adults whose condition cannot be well managed by long-acting beta-2 agonists or inhaled corticosteroids alone.

How Does Trelegy Work?

Trelegy Ellipta uses a 3-power combination of vilanterol, fluticasone furoate, and umeclidinium bromide to treat asthma and COPD. These three active ingredients work as follows:

  • Fluticasone: This is a corticosteroid that helps to prevent irritation and reduce inflammation in the walls of the lungs, keeping the airways open for easy breathing.
  • Vilanterol: A bronchodilator that relaxes lung muscles, keeping the airways open. Works best for conditions where airways are narrow and inflamed.
  • Umeclidinium: Categorized as an anticholinergic that inhibits the action of acetylcholine, resulting in bronchodilation effects.

Precautions and Warnings with Trelegy

Certain situations and conditions can prevent you from using Trelegy Ellipta safely and effectively. Talk with your doctor about these conditions and determine the risks of using Trelegy Ellipta before starting your dose.

  • Liver Conditions: Liver conditions prevent the breakdown of Trelegy Ellipta, which may lead to the accumulation of the drug in the body and increase the risk of adverse side effects. Inform your doctor if you have liver failure before taking Trelegy Ellipta.
  • Thyroid Disorders: Patients suffering from thyroid disorders, such as thyroid tumors, may experience worsening of the condition if they use Trelegy Ellipta. Before beginning the medication, you should consult your doctor if you have thyroid disorders.
  • Glaucoma: Prolonged usage of Trelegy Ellipta may lead to the new development of eye problems like glaucoma or worsen existing eye problems. Notify your doctor if you are suffering from any eye conditions before using the drug.
  • Bladder Conditions: Trelegy Ellipta may cause pain when urinating or increase the adverse effects of bladder problems.
  • Driving and Operating Heavy Machinery: Avoid driving or operating heavy machinery when under the medication of Trelegy Ellipta because it causes dizziness and drowsiness.
  • Thrush Infections: Since Trelegy Ellipta is inhaled, it may cause mouth and throat infections. After using the medication, rinse your mouth thoroughly and spit out to prevent thrust infection.
  • Heart Conditions: Trelegy Ellipta may cause certain heart conditions, such as a heart attack or high blood pressure, to worsen. If you are suffering from heart problems, inform the doctor before taking the medication.

Trelegy Side Effects

You may experience side effects after taking Trelegy Ellipta. These unwanted effects can be either standard, which is usually temporary, or severe, which rarely occurs in patients but can be fatal. In case you have severe side effects, seek medical attention as soon as possible

Common Side Effects

  • Headache
  • Bronchitis
  • Pneumonia
  • Fungal infection in the throat and mouth
  • Upper respiratory tract infection like the common cold
  • Diarrhoea

Severe Side Effects

  • Increased blood pressure
  • Decreased adrenal gland function
  • Fast or irregular heartbeats
  • Eye conditions such as glaucoma
  • Severe allergic reactions
  • Weakened bones

Trelegy Drug Interactions

Several medications may interact with Trelegy Ellipta and potentially cause unwanted effects or reduce the efficacy of either drug. Tell your doctor if you are taking any other prescription or over-the-counter medications, vitamins, or supplements to avoid interactions.

Antifungal medicationsThe interaction between Trelegy Ellipta and antifungal medications such as itraconazole (Sporanox) may cause an increase in the risk of cardiovascular effects such as high blood pressure.
Monoamine Oxidase InhibitorsThe interaction between Trelegy Ellipta and MAOIs like vilanterol causes an increase in cardiovascular effects such as irregular heartbeats and hypertension.
Beta-blockersBeta-blocker medications may interfere with the effectiveness of Trelegy Ellipta in managing the symptoms of COPD.
Anticholinergic MedicationWhen these two medications interact, it may increase the risk of side effects such as dry mouth, urinary retention, and blurred vision.
CarbamazepineInteraction between these two medicines may tamper with the effectiveness of Trelegy Ellipta and slow down the symptoms of COPD.
Other corticosteroidsConcurrent use of Trelegy Ellipta with other corticosteroids increases the risk of developing adrenal suppression and osteoporosis.

Trelegy Strengths and Dosages

When determining the dosage of Trelegy Ellipta, doctors consider factors like the patient’s condition, asthma therapy, and the severity of the condition. Usually, patients start with a minimum medication dosage and slowly adjust it as prescribed by a doctor until they reach the effective dosage that adequately responds to the sickness.

Trelegy Ellipta is not usually prescribed to children unless advised by the doctor. After using this medication, rinse your mouth thoroughly with clean water to avoid fungal infection in the mouth and throat.

Age Condition Minimum Dosage Maximum Dosage # of times a day
AdultAsthma100mcg200mcgOnce per day (one inhalation)
AdultCOPD100mcgDoes not have a maximum dosageOnce per day (one inhalation)

Trelegy Alternatives

Some frequently prescribed alternatives to Trelegy Ellipta include a range of inhalers and combination therapies tailored to treat asthma and COPD. The medications may vary depending on factors like the severity of the condition and individual medical needs. Some common alternatives include:

  • Advair Diskus: A type of inhaler with the active ingredients fluticasone and salmeterol. This drug is given as a dose of 1 inhalation twice a day for treating symptoms of asthma and COPD.
  • Dulera: This medication is only used to treat asthma in adults and children aged five years.
  • Other Medications: Other alternative medications include Breo Ellipta, Anoro Ellipta, and Symbicort.

FAQs of Trelegy

Can Trelegy Ellipta cause weight gain?

No. This medication does not make you gain weight. Adding weight can be a side effect of corticosteroids that are swallowed in pill form.

What are some of the alternative medications of Trelegy Ellipta?

Some alternative medications to treat COPD include Dulera, Anoro Ellipta, Symbicort, Spiriva Respimat, and Breo Ellipta.

Is Trelegy Ellipta used to treat asthma?

Yes. Trelegy Ellipta is prescribed to adults who have asthma for long-term use. This medication does not provide quick relief for sudden breathing issues and should not be used as a replacement for a rescue inhaler.

Can Trelegy Ellipta be used as a nebulizer?

Yes. All three medications in the inhaler come in a version that can be used with a nebulizer.

Does Trelegy Ellipta stop wheezing?

The medication is prescribed for long-term use and helps to manage and prevent asthma symptoms, including wheezing, coughing, and shortness of breath.

Why should I rinse my mouth after using Trelegy?

Washing your mouth after using the inhaler prevents you from having an oral thrush inside your throat and mouth.

What are the side effects of Trelegy Ellipta?

The common unwanted effects of Trelegy Ellipta include headaches, diarrhea, nausea, pneumonia, fungal infection in the mouth and throat, and cardiovascular diseases.

What is the cost of Trelegy Ellipta in America?

Trelegy Ellipta is currently sold under its brand name; no generic version is available. The cost for the 100mcg medication is $332 for a supply of 28 inhalation powders. The above price applies to individuals who pay out of pocket and not for medical insurance coverage.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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