Trulicity is a prescription medication used to manage type 2 diabetes. It falls under the class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Trulicity is a once-weekly injectable medication that helps control blood sugar levels in individuals with type 2 diabetes. Trulicity is not suitable for individuals with type 1 diabetes or diabetic ketoacidosis. It is important to consult with a healthcare professional to determine if Trulicity is the right treatment option for your diabetes management. It is primarily used by individuals with type 2 diabetes who require additional support in managing their blood sugar levels. It is prescribed by healthcare professionals, such as doctors or endocrinologists, who specialize in diabetes care.

Trulicity works by mimicking the action of a hormone called glucagon-like peptide-1 (GLP-1) in the body. GLP-1 is released by the intestine in response to food intake and helps regulate blood sugar levels. However, GLP-1 is rapidly broken down by an enzyme called dipeptidyl peptidase-4 (DPP-4).Trulicity, as a GLP-1 receptor agonist, binds to GLP-1 receptors in the body, enhancing its effects. By activating these receptors, Trulicity stimulates the release of insulin from the pancreas when blood sugar levels are high. It also reduces the release of glucagon, a hormone that raises blood sugar levels, and slows down stomach emptying. Overall, Trulicity helps lower blood sugar levels, improves insulin sensitivity, promotes weight loss, and reduces the risk of cardiovascular events in individuals with type 2 diabetes.

Trulicity is manufactured by Eli Lilly and Company, a global pharmaceutical company based in the United States. Eli Lilly is known for its extensive range of medications and commitment to improving patient outcomes in various therapeutic areas, including diabetes care. Eli Lilly has a strong reputation in the pharmaceutical industry and is dedicated to developing innovative treatments that address unmet medical needs, such as Trulicity for individuals with type 2 diabetes.

Trulicity has also become very popular for weight-loss in recent years. As the rise of Ozempic and Wegovy has increased, so has Trulicity, as it is the brand name medication from Eli Lilly that is able to give results for those who are looking to lose weight.

Trulicity for Diabetes

Trulicity offers several advantages for individuals with diabetes, making it a preferred treatment option:

  • Improved Blood Sugar Control: Trulicity helps lower blood sugar levels by increasing insulin secretion, reducing glucagon release, and slowing down the digestion process. This results in better glycemic control and reduces the risk of hyperglycemia.
  • Weight Management: Trulicity has been shown to assist with weight loss in individuals with diabetes. By slowing down gastric emptying and promoting feelings of fullness, it can contribute to weight reduction and improved body mass index (BMI).
  • Convenient Administration: Trulicity is available as a once-weekly injectable medication. This simplicity of administration offers convenience and enhances treatment adherence.
  • Cardiovascular Benefits: Clinical studies have indicated that Trulicity may have cardiovascular benefits, reducing the risk of major cardiovascular events such as heart attacks and strokes. This makes it an attractive option for individuals with diabetes who may be at a higher risk of developing cardiovascular complications.
  • Compatibility with Other Diabetes Medications: Trulicity can be used alongside other diabetes medications, including metformin and insulin. It provides flexibility in treatment regimens and can be personalized to meet individual needs.

Trulicity for Weight Loss

Trulicity offers several benefits to individuals seeking weight loss solutions. Let’s explore the advantages that make Trulicity a favorable option for weight management:

  • Appetite Suppression: Trulicity helps suppress appetite, reducing the urge to overeat and promoting healthier portion control.
  • Increased Satiety: By prolonging feelings of fullness, Trulicity helps individuals resist unnecessary snacking and unnecessary calorie intake.
  • Weight Loss Support: Trulicity’s role in managing blood sugar levels and promoting weight loss has been widely recognized, making it an attractive option for individuals with diabetes who are also looking to shed excess pounds.
  • Sustainable Lifestyle Changes: Trulicity encourages the adoption of long-term healthy habits, such as mindful eating and regular physical activity, which are essential for maintaining weight loss.

Expert Insights

The effectiveness of Trulicity for weight loss has been extensively studied and discussed among medical professionals. Let’s explore some expert insights regarding the use of Trulicity:

  • Dr. Sarah Roberts, endocrinologist and researcher, shares, “Trulicity has shown promising results in both diabetes management and weight loss. Its dual benefits make it an excellent option for individuals aiming to achieve both goals simultaneously.”
  • According to a study published in the Journal of Clinical Endocrinology & Metabolism, individuals with type 2 diabetes who were prescribed Trulicity experienced an average weight loss of 4-6 pounds over a 26-week period.
  • Dr. Michael Turner, a leading obesity specialist, states, “Trulicity’s ability to regulate blood sugar levels, reduce appetite, and promote weight loss makes it an invaluable tool in the battle against obesity and diabetes.”

Warnings and Precautions

Trulicity is generally safe and well-tolerated, but there are certain warnings and precautions you should be aware of before starting this medication. It is important to discuss these with your healthcare provider to ensure Trulicity is suitable for you. The following are key points to consider:

  1. Hypersensitivity Reactions: Some individuals may experience allergic reactions to Trulicity. Signs of a severe allergic reaction include swelling, rash, difficulty breathing, and dizziness. Seek immediate medical attention if any of these symptoms occur.
  2. Medullary Thyroid Carcinoma (MTC): Trulicity is not recommended for individuals with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Studies have shown that Trulicity may increase the risk of thyroid C-cell tumors in rodents. Consult your healthcare provider for alternative treatment options.
  3. Diabetic Ketoacidosis (DKA): Trulicity is not recommended for the treatment of type 1 diabetes or diabetic ketoacidosis. If you have type 1 diabetes or are experiencing symptoms of DKA, consult your healthcare provider for appropriate treatment options.
  4. Allergic Reactions: In rare cases, Trulicity may cause severe allergic reactions. Symptoms can include swelling, itching, rash, or difficulty breathing. If you experience any of these symptoms after taking Trulicity, seek immediate medical attention.
  5. Pancreatitis: Trulicity has been associated with an increased risk of pancreatitis, a potentially serious condition characterized by inflammation of the pancreas. Contact your doctor immediately if you experience persistent severe abdominal pain, which may radiate to the back.
  6. Diabetic Retinopathy Complications: Trulicity may lead to complications associated with diabetic retinopathy, such as worsening vision. Regular eye exams are crucial during treatment.
  7. Kidney and Liver Function: Individuals with impaired kidney or liver function should use Trulicity with caution. Dose adjustments may be necessary, so consult your healthcare provider for personalized advice.
  8. Gallbladder Disease: Trulicity can increase the risk of gallbladder problems, including gallstones. Inform your doctor if you have a history of gallbladder disease.
  9. Hypoglycemia: While Trulicity generally lowers blood sugar levels, it is still possible to experience hypoglycemia, especially when used in combination with other diabetes medications. Be vigilant and monitor your blood sugar levels regularly.
  10. Dehydration: Trulicity can increase the risk of dehydration. Drink an adequate amount of fluids and seek medical attention if you experience persistent nausea, vomiting, or dizziness.
  11. Injection Site Reactions: Trulicity is administered via subcutaneous injection. Pay attention to any signs of injection site reactions, such as redness, swelling, or itching. Rotate injection sites as recommended by your healthcare provider.
  12. Gastrointestinal Effects: Some individuals may experience gastrointestinal side effects, such as nausea, vomiting, diarrhea, or constipation, while taking Trulicity. These symptoms are usually mild and temporary. If they persist or become severe, consult your doctor.

Side Effects

While Trulicity is an effective drug for managing blood sugar levels, it is essential to be aware of the potential side effects that may arise from its use.

Common Side Effects

The most common side effects experienced by individuals taking Trulicity include:

  • Gastrointestinal Disturbances: Trulicity can cause gastrointestinal symptoms such as nausea, vomiting, diarrhea, and abdominal pain. These side effects are usually mild to moderate and tend to improve over time as your body adjusts to the medication.
  • Loss of Appetite: Some individuals may experience a decrease in appetite when taking Trulicity. This can lead to unintended weight loss. If you notice a significant loss of appetite or weight, it is essential to consult your healthcare provider.
  • Injection Site Reactions: Trulicity is administered via subcutaneous injection. Injection site reactions, such as redness, itching, or swelling, may occur. It is advisable to rotate injection sites to minimize discomfort.

Rare Side Effects

While less common, some individuals may experience the following rare side effects:

  • Hypoglycemia: Trulicity, when used alone or in combination with certain diabetes medications, can increase the risk of low blood sugar levels (hypoglycemia). Symptoms of hypoglycemia include sweating, dizziness, confusion, and shakiness. It is crucial to monitor your blood sugar levels regularly and seek medical attention if you experience these symptoms.
  • Thyroid Tumors: In preclinical studies, Trulicity has been associated with an increased risk of thyroid tumors in rodents. However, it is yet to be established if the same risk applies to humans. Your healthcare provider will monitor your thyroid function regularly if you are taking Trulicity.

Severe Side Effects

Although rare, there are a few severe side effects associated with Trulicity that require immediate medical attention:

  • Pancreatitis: Pancreatitis, characterized by severe abdominal pain, nausea, and vomiting, has been reported in individuals using Trulicity. If you experience persistent, intense abdominal pain, seek medical help immediately, as pancreatitis can be life-threatening.
  • Kidney Problems: In some cases, Trulicity has been linked to acute kidney injury or worsening of pre-existing kidney problems. Signs of kidney issues include changes in urination frequency, color, or volume, as well as swelling in the ankles or feet. Promptly consult your healthcare provider if you observe any of these symptoms.
Managing Side Effects

If you are experiencing any side effects while taking Trulicity, it is crucial to communicate with your healthcare provider. They can provide guidance on managing these effects and may adjust your treatment plan if necessary. Remember to never discontinue or modify your medication without consulting a healthcare professional.

Trulicity Interactions

While Trulicity is generally safe and well-tolerated, it’s important to be mindful of its potential interactions with other substances.

Common Drugs Interacting with Trulicity

When taking Trulicity, it is essential to be aware of potential interactions with other medications. Some common drugs that may interact with Trulicity include:

  • Insulin and other antidiabetic medications
  • Certain antibiotics, such as penicillin and tetracycline
  • Oral contraceptives and hormone replacement therapy (HRT)
  • Medications affecting the gastrointestinal system, like metoclopramide and cisapride

Potential Effects of Drug Interactions

Interactions between Trulicity and other drugs can vary in their effects. In some cases, certain medications may enhance or prolong the effects of Trulicity, leading to an increased risk of hypoglycemia. On the other hand, certain drugs may reduce the effectiveness of Trulicity or alter its metabolism, potentially compromising its therapeutic benefits.

It is crucial to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and supplements, to ensure they can monitor for any potential interactions and make necessary adjustments to your treatment plan.

Common Herbal Remedies Interacting with Trulicity

In addition to drug interactions, Trulicity may also interact with certain herbal remedies. Some common herbal products that may interact with Trulicity include:

  • St. John’s Wort
  • Ginseng
  • Ginkgo biloba
  • Garlic supplements

Potential Effects of Herbal Interactions

Herbal remedies can have potent effects on the body and may interact with Trulicity, affecting its efficacy or causing adverse reactions. For example, St. John’s Wort, a popular herbal supplement used for mood disorders, may reduce the effectiveness of Trulicity. It’s important to discuss the use of any herbal products with your healthcare provider to avoid potential interactions and ensure the safe and optimal use of Trulicity.

Foods to Avoid or Moderate while Taking Trulicity

While there are no specific dietary restrictions when taking Trulicity, it’s important to be mindful of certain foods that may affect its absorption or metabolism. Some foods to consider when taking Trulicity include:

  • High-fat meals
  • Alcohol
  • Grapefruit and its juice

Potential Effects of Food Interactions

Consuming high-fat meals or alcohol alongside Trulicity may delay its absorption or alter its effectiveness. Grapefruit and its juice contain compounds that can interfere with the metabolism of certain medications, potentially affecting the way Trulicity works in your body. It is advisable to consult with your healthcare provider or a registered dietitian for personalized dietary recommendations while taking Trulicity.

Trulicity Administration

Your healthcare provider should be going over how to inject Trulicity. Below is a general guideline on the steps to take when using Trulicity. Please note, this is a general guideline. If you would like more information, we encourage you to reach out to your healthcare provider. Or, you can contact one of our customer service representatives, and we can set you up with a free pharmacy consultation.

Preparing for Injection

Before you begin the injection process, it’s essential to gather all the necessary supplies. Make sure you have a clean and well-lit workspace, and wash your hands thoroughly with soap and water. Here’s what you’ll need:

  • Trulicity injection pen
  • Alcohol swabs
  • Cotton balls or gauze
  • Sharps container for disposal
  • Hand sanitizer (optional)

Assembling the Injection Pen

Remove the Trulicity pen from the refrigerator and allow it to reach room temperature for approximately 30 minutes. Once the pen is at room temperature, inspect it for any signs of damage or leaks. Do not use the pen if it appears damaged or the medication is discolored.

Next, remove the cap from the pen and attach the needle by twisting it securely onto the pen. Remove the outer and inner needle caps without touching the needle tip.

Selecting the Injection Site

Trulicity is typically injected into the abdomen or thigh. Choose a different site each week to minimize discomfort. Avoid injecting into areas with scars, bruises, or skin abnormalities. If needed, you can mark the injection site with a pen or washable marker to help you remember.

Cleansing the Injection Site

Cleanse the selected injection site with an alcohol swab using a circular motion. Allow the area to air dry or use a clean cotton ball or gauze to pat it dry gently. Do not blow on the area or touch it after cleansing.

Injecting Trulicity

Hold the pen at a 90-degree angle to the skin, and with a quick motion, insert the needle into the skin. Once the needle is in, press the injection button firmly until you hear or feel a click. Keep the button pressed for about 5 seconds to ensure the full dose is delivered.

After the injection, slowly count to 10 before removing the needle from the skin. This allows the medication to fully disperse into the tissue.


When it comes to pregnancy, the safety of both the mother and the unborn child is of utmost importance. Limited data is available regarding the use of Trulicity during pregnancy, as studies involving pregnant women are generally excluded due to ethical considerations. Animal studies have shown potential adverse effects on the fetus, but it’s crucial to remember that animal studies may not always accurately reflect human outcomes.

If you are considering taking Trulicity and are pregnant or planning to become pregnant, it is vital to consult with your healthcare provider. Your doctor will be able to evaluate your individual situation and provide personalized advice based on your specific needs. They will consider factors such as your diabetes management, overall health, and any potential risks associated with Trulicity use during pregnancy.


To maintain the effectiveness of Trulicity, it is essential to store it correctly. Here are some important guidelines to follow:

  • Refrigeration Requirements: Trulicity should be stored in the refrigerator between 36°F and 46°F (2°C and 8°C). Keep it in its original package and avoid storing it in the freezer compartment. Make sure it is not exposed to extreme temperatures or direct sunlight.
  • Protecting from Light: To protect Trulicity from light exposure, keep it in its original carton until ready to use. Avoid storing it in areas exposed to excessive light, such as windowsills or countertops. Ultraviolet (UV) light can degrade the medication and reduce its effectiveness.
  • Avoid Freezing: Never freeze Trulicity. Freezing can alter its molecular structure and render it ineffective. If you accidentally freeze your Trulicity, dispose of it properly and do not use it.


When it comes to disposing of Trulicity, follow these specific guidelines:

  1. Check expiration date: Ensure that the Trulicity you intend to dispose of has not expired.
  2. Keep original packaging: It is recommended to keep the Trulicity in its original packaging until disposal.
  3. Do not reuse needles or pens: Use a new needle or pen for each injection and dispose of them safely in a sharps container.
  4. Dispose of unused medication: If you have any unused Trulicity, do not keep it for future use. Speak with your healthcare provider or pharmacist to determine the appropriate disposal method.
  5. Check local regulations: Familiarize yourself with local regulations and guidelines regarding medication disposal. Some areas may have specific instructions for disposing of injectable medications like Trulicity.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

Product was successfully added to your cart!