Evotaz is a drug used to treat HIV infection among patients. This drug is mostly used in combination with other medications to ensure complete effectiveness.

HIV has been a worldwide health issue for some time now. According to the WHO, approximately 0.7% of adults have HIV/AIDS globally.

Medications like Evotaz are effective in treating HIV. While Evotaz does not cure this infection, it helps infected people live a better and longer life by reducing the viral load.

The medication combines two active ingredients, atazanavir which is a protease inhibitor that helps prevent the virus from producing and replicating, and cobicistat which inhibits the breakdown of atazanavir in the body to ensure higher levels of atazanavir are maintained to continuously fight HIV.

How Does Evotaz Work?

Evotaz uses a double-action system to fight the virus. It contains Atazanavir, a protease inhibitor that works by blocking a type of enzyme referred to as HIV protease which plays a crucial role in the replication of HIV in the body. By blocking the enzyme, Atazanavir prevents the virus from dividing itself into many copies hence slowing the diffusion of the HIV infection.

On the other hand, cobicistat, the pharmacokinetic enhancer, prevents certain enzymes in the liver from breaking down Atazanavir. This process increases the level of atazanavir in your blood, helping it to remain effective for a long period at a high concentration.

The combination of these ingredients helps prevent HIV infection by blocking the viral replication of HIV in your body hence reducing its impact on the immune system.

Evotaz: Precautions and Warnings 

Before starting Evotaz, it is important to be aware of certain precautions and warnings associated with the medication. This is essential for ensuring the safe and effective use of Evotaz in the treatment of HIV infection.

  • Hemophilia: Individuals suffering from hemophilia A and B are more likely to experience increased bleeding when taking Evotaz medication. Before being given the medication inform your doctor if you are suffering from hemophilia.
  • Fat Redistribution: Prolonged usage of Evotaz medication may alter how fat is redistributed in your body causing some parts of the body to change shapes such as the stomach area, breast enlargement, and dorsocervical fat pad.
  • Cardiovascular Diseases: Evotaz may cause regular heart rhythm, potentially leading to symptoms such as seizures and fainting, and could lead to sudden death.
  • Liver and Kidney Function: If you are suffering from any liver or kidney conditions inform your doctor before taking the medication as these conditions could cause a build-up of Evotaz in the body increasing the risk of adverse side effects.
  • Diabetes Mellitus: HIV-infected patients taking Evotaz may experience a new development of diabetes mellitus or it can worsen the condition of existing diabetes mellitus. Tell your doctor if you are suffering from diabetes or taking any diabetic medications.
  • Renal Impairment: Evotaz increases the risk of having acute renal failure. In case you experience symptoms like decreased urine output, no urine production at all, or seizures and chest pains, discontinue the medication immediately and seek medical assistance.
  • Driving and Operating Heavy Machinery: This medication causes dizziness or you could feel lightheaded. Be cautious when driving or operating heavy machinery when taking Evotaz.

Evotaz Side Effects

Understanding the potential side effects of Evotaz is crucial for patients and healthcare providers to ensure safe and effective management of health conditions. As with any medication, Evotaz may be associated with certain side effects that can be either common or severe, including:

Common Side Effects

  • Hives
  • Insomnia
  • Decrease or increase in appetite
  • Decreased urination
  • Blurred vision
  • Dizziness
  • Vomiting

Severe Side Effects

  • Slurred speech
  • Weight changes
  • Swollen glands
  • Painful or difficult urination
  • Swollen of the feet and legs
  • Unusual bruising or bleeding

Drug Interactions With Evotaz

Evotaz may interact with other medications, potentially altering their effectiveness or increasing the risk of side effects. By being aware of the interactions, individuals can work with the healthcare team to optimize the treatment plan and minimize the risks associated with combining medications.

Drug Interaction
SildenafilThe interaction of sildenafil (Viagra) and Evotaz can increase the concentration of erectile dysfunction medication in the bloodstream potentially leading to an increased risk of side effects like headache and vision changes.
Immunosuppressants (Tacrolimus)Combining immunosuppressant medications like tacrolimus and Evotaz increases the risk of toxicity and side effects such as increased susceptibility to infections and high blood pressure.
OxycodoneThe interaction of these two medications increases the concentration of Oxycodone in the bloodstream, which leads to an increased risk of confusion and respiratory depression.
FluconazoleEvotaz increases levels of antifungal medications like fluconazole (Diflucan) in the blood potentially intensifying side effects like nausea, liver toxicity, and vomiting.
Statins (Atorvastatin)The combination of atorvastatin (found in Lipitor) and Evotaz may cause side effects such as muscle pain, and weakness.

Evotaz Strengths and Dosages

The ideal dose of Evotaz for treating HIV is one tablet per day, which should be taken around the same time every day.

Age Dosage No. of Times a Day
Children and AdultsI tablet contains Aranavir 300mg and Cobicistat 150mgOne tablet per day

Children below 35kg should not use the medication unless advised otherwise by a doctor. Take the medication with food, swallowing the tablet whole without breaking, crushing, or chewing it.

Cost of Evotaz America

The price of a 30-day supply of Evotaz medication oral tablets (300mg-150mg) can vary, but generally, it costs around $1,700. The price fluctuates depending on the pharmacy you choose and your location.

The medication is solely available as a brand-name medication, with no generic alternative currently on the market.

Evotaz Alternatives

Alternative medications of Evotaz work through various mechanisms to inhibit different stages of the HIV lifecycle, ultimately reducing the viral load in the body and slowing the progression of the disease. They include:

  • Atripla: Atripla is a combination of three different drugs efavirenz, tenofovir disoproxil fumarate, and emtricitabine. The medication inhibits the activity of the enzyme reverse transcriptase, which HIV needs to replicate. This prevents the virus from multiplying and reduces its ability to spread in the body.
  • Prezcobix: It is a combination of darunavir which prevents HIV from replicating by interfering with the protease enzyme, which is necessary for the virus to assemble new viral particles, and cobicistat, which boosts the effectiveness of the medication by inhibiting its breakdown in the body.
  • Other Medications: Other alternative medications include: Descovy, Complera, Tivicay, Symfi, Stribid, Isentress, and Genvoya.

FAQs About Evotaz

How does Evotaz work?

Evotaz works by combining a protease inhibitor atazanavir and cobisistat. Atazanavir stops the virus from making more copies, while cobicistat slows down how quickly the body gets rid of atazanavir.

What are the side effects of Evotaz?

The frequently experienced side effects of Evotaz are yellowing of the skin and rash, dizziness, irregular heartbeats, increased blood sugar, and the occurrence of liver or gallbladder problems.

How do I use Evotaz?

Evotaz is taken once a day orally with food as directed by the doctor and needs to be taken exactly as prescribed. A patient is advised to stay under the care of a health provider while taking the medication.

What if I miss the Evotaz medication for a long period of time?

Missing this medication for a long period may make you more vulnerable to serious effects. If you miss a medication avoid taking two doses to make up for the missed dose. As soon as you remember, take the next dose immediately to ensure consistency. Remember to inform your doctor about the medications missed to advise you.

Can I use Evotaz with other medications for HIV?

This medication can be used with multiple medications which include antibiotics, antifungal drugs, and medications that usually affect liver enzymes. However, this should only happen under the instructions of your healthcare provider to avoid potential interactions.

Can Evotaz cure HIV?

This type of medication is not used to cure HIV but it is used to reduce the viral load which in turn increases the life span of an individual and reduces the risk of HIV transmission.

Can I switch to Evotaz from using another medication?

Yes. Switching to this medication is advised to take place under the guidance of your healthcare provider after they have keenly assessed your condition and ensured the medication is appropriate for you. You are advised to keep a record of all the medications that you take and present them to your caregiver for evaluation before prescribing you with Evotaz.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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