Xiidra is a prescription medication used to treat various eye conditions, such as dry eye syndrome, allergic conjunctivitis, and meibomian gland dysfunction. It is an ophthalmic solution that helps relieve the symptoms associated with these conditions, providing much-needed comfort and relief for individuals experiencing eye discomfort.

Xiidra works by targeting and inhibiting a specific molecule called lymphocyte function-associated antigen-1 (LFA-1). LFA-1 is involved in the inflammatory response that occurs in the eyes of individuals with certain eye conditions. By inhibiting LFA-1, Xiidra helps reduce inflammation and alleviate the symptoms associated with dry eyes, allergic conjunctivitis, and meibomian gland dysfunction.

Individuals suffering from dry eye syndrome, allergic conjunctivitis, and meibomian gland dysfunction can greatly benefit from using Xiidra. If you experience symptoms such as dryness, itching, redness, and discomfort in your eyes, Xiidra may provide the relief you need. It is always important to consult with your healthcare provider to determine if Xiidra is the right choice for your specific condition.

Warnings and Precautions

While Xiidra can provide relief for many individuals, it’s essential to understand the safety considerations to ensure optimal use and minimize potential complications.

  1. Consult Your Healthcare Provider: Before starting any new medication, it is crucial to consult your healthcare provider. They will evaluate your medical history and determine if Xiidra is the right choice for you. Openly discuss any pre-existing conditions, allergies, or medications you are currently taking to ensure your safety.
  2. Allergic Reactions: Xiidra contains certain ingredients that may cause an allergic reaction in some individuals. If you have a known allergy to any components of Xiidra, inform your healthcare provider immediately. They will guide you on alternative treatment options to manage your dry eye symptoms effectively.
  3. Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, it is important to discuss the use of Xiidra with your healthcare provider. Limited research is available regarding the effects of Xiidra on pregnancy and breastfeeding. Your healthcare provider will weigh the potential benefits against the risks and advise you accordingly.
  4. Children and Adolescents: Xiidra’s safety and effectiveness in children and adolescents have not been established. Therefore, it is not recommended for use in this age group without proper medical guidance.
  5. Other Medical Conditions: Inform your healthcare provider about any other medical conditions you have, such as eye infections, injuries, or surgeries. These factors may affect the suitability of Xiidra for your specific situation.
  6. Contact Lenses: If you wear contact lenses, it is important to remove them before applying Xiidra. Wait at least 15 minutes after using the medication before reinserting your contact lenses.

Side Effects

While Xiidra offers relief to many individuals, it’s crucial to be aware of the potential side effects that may arise from its use.

Common Side Effects

  • Eye irritation and discomfort
  • Blurred vision
  • Unpleasant taste sensation
  • Watery eyes
  • Eye redness

Rare Side Effects

  • Eye pain
  • Eye discharge
  • Sensitivity to light
  • Eye swelling
  • Eye infection

Severe Side Effects

  • Severe eye pain or discomfort
  • Swelling or redness around the eyes
  • Changes in vision
  • Eye discharge accompanied by pain
  • Signs of an allergic reaction, such as hives, rash, itching, swelling, or difficulty breathing


As with any medication, it’s important to understand the potential interactions that may occur when using Xiidra.

Drug Interactions with Xiidra:

  • Antibiotics: Some antibiotics, such as erythromycin and clarithromycin, may interact with Xiidra. These medications can affect the metabolism of Xiidra, leading to an increased risk of side effects. It is advisable to inform your healthcare provider about any antibiotics you are currently taking.
  • Antihistamines: Antihistamines like diphenhydramine or cetirizine can potentially cause drowsiness and may interact with Xiidra, amplifying its sedative effects. If you are using antihistamines, consult your doctor to determine the best approach for managing dry eye symptoms.
  • Immunosuppressants: Xiidra may interact with immunosuppressant medications like cyclosporine, tacrolimus, or mycophenolate mofetil. These drugs can affect the efficacy of Xiidra and may require adjustment of dosages or careful monitoring. Always inform your healthcare provider about your current medications.
  • Glaucoma Medications: If you are using medications for glaucoma, such as timolol or latanoprost, it is essential to inform your eye doctor or ophthalmologist about your Xiidra use. They can guide you on managing both conditions effectively and minimize any potential interactions.

Herbal Interactions with Xiidra:

  • St. John’s Wort: St. John’s Wort, a popular herbal supplement used for depression, can affect the metabolism of certain medications, including Xiidra. This interaction may lead to reduced effectiveness or increased side effects. Consult your doctor before using St. John’s Wort alongside Xiidra.
  • Ginkgo Biloba: Ginkgo Biloba, commonly used for cognitive enhancement, has anticoagulant properties. Combining it with Xiidra, which may also have a mild anticoagulant effect, may increase the risk of bleeding. Speak with your healthcare provider if you are using Ginkgo Biloba and considering Xiidra.
  • Echinacea: Echinacea, often used to boost the immune system, may interact with Xiidra and potentially alter its effectiveness. It is advisable to consult your doctor before using Echinacea alongside Xiidra.

Food Interactions with Xiidra:

  • Grapefruit: Grapefruit and its juice contain compounds that can interfere with the metabolism of medications. Although there is no specific evidence of grapefruit interactions with Xiidra, it is generally advisable to avoid consuming large amounts of grapefruit or grapefruit juice while using any medication, including Xiidra.
  • Alcohol: Drinking alcohol in moderation is generally considered safe while using Xiidra. However, excessive alcohol consumption can cause dehydration and worsen dry eye symptoms. It’s best to consume alcohol in moderation and ensure you stay hydrated.

How to Use

Using Xiidra correctly is crucial for effective, safe, and optimal treatment.

  1. Wash Your Hands: Before handling Xiidra or touching your eyes, it’s essential to wash your hands thoroughly. Use mild soap and warm water, and dry your hands with a clean towel or air dryer.
  2. Open the Xiidra Vial: Gently tap the vial to ensure the solution is well-mixed. Then, twist off the cap of the vial, taking care not to touch the tip of the vial or let it come into contact with any surfaces.
  3. Tilt Your Head Back: Tilt your head back slightly and look up toward the ceiling. Use a mirror if it helps you to see your eye more clearly.
  4. Pull Down Your Lower Eyelid: With one hand, gently pull down your lower eyelid to create a small pocket.
  5. Apply Xiidra: Hold the vial upside down and squeeze it gently to release a single drop into the pocket formed by your lower eyelid. Avoid blinking or squeezing your eyes tightly while applying the medication.
  6. Close Your Eye: Close your eye gently and press your finger against the inner corner of your eye for about one minute. This helps prevent the medication from draining into your tear ducts too quickly.
  7. Repeat for the Other Eye: Repeat steps 3 to 6 for your other eye.
  8. Recap the Vial: After using Xiidra, recap the vial tightly and dispose of it properly. Do not reuse vials to avoid contamination.


Proper dosing is crucial when using Xiidra for the treatment of dry eye disease.

Initial Dosing for Xiidra

When initiating treatment with Xiidra, the recommended dosage is one drop in each eye twice daily, approximately 12 hours apart. It is important to carefully follow the instructions provided by your healthcare provider or the medication’s packaging. Remember to wash your hands before instilling the eye drops to maintain proper hygiene.

Maintenance Dosing for Xiidra

After the initial dosing period, your healthcare provider may adjust the dosage based on your response to treatment. The maintenance dosage for Xiidra typically involves using one drop in each eye twice daily, approximately 12 hours apart, as an ongoing regimen. It is important to continue using Xiidra as prescribed, even if your symptoms improve. Consult your doctor if you have any concerns or questions about your maintenance dosage.

Missed Dose

If you accidentally miss a dose of Xiidra, don’t panic. Simply instill the missed dose as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Avoid doubling the dose to make up for the missed one, as it may lead to unintended side effects. Consistency in dosing is important for maintaining the effectiveness of the medication.


It is crucial to use Xiidra strictly according to the prescribed dosage. Using more than the recommended amount of Xiidra can increase the risk of side effects without providing additional benefits. If you accidentally use more than the prescribed dose, seek immediate medical attention or contact a poison control center. Be sure to store Xiidra out of the reach of children to prevent accidental ingestion.


To maintain the efficacy of Xiidra and ensure its safety, proper storage is vital.

  • Storing Xiidra at the Right Temperature: One crucial factor in storing Xiidra is maintaining the appropriate temperature. The ideal temperature range for storing Xiidra is between 36°F (2°C) and 46°F (8°C). It is important to note that freezing Xiidra should be strictly avoided, as it can alter the medication’s properties and render it ineffective. Proper temperature regulation is crucial during both storage and transportation of Xiidra. Ensure that the medication is stored in a cool and dry place, away from direct sunlight and heat sources like radiators or ovens. Avoid leaving Xiidra in a hot car or any location where the temperature exceeds the recommended range.
  • Keeping Xiidra Away from Light: Exposure to light can degrade the active ingredients in Xiidra, reducing its effectiveness. Therefore, it is essential to protect Xiidra from direct sunlight and other sources of bright light. To do so, keep the medication in its original packaging, which is designed to provide adequate protection from light. If the original packaging is damaged, transfer the Xiidra to a dark-colored, light-resistant container. Ensure that the container is tightly sealed to prevent any light exposure. Remember to label the container clearly with the medication’s name, expiration date, and any other pertinent information.
  • Avoiding Exposure to Moisture: Moisture can also impact the stability and efficacy of Xiidra. To prevent moisture-related issues, store Xiidra in a dry environment. Avoid storing it in bathrooms, near sinks, or any other location prone to high humidity. Additionally, ensure that the cap or lid of the Xiidra container is tightly closed after each use to prevent moisture from entering. In case the Xiidra container comes into contact with water or any other liquid, it is recommended to discard the medication and obtain a new supply. Using Xiidra that has been compromised by moisture can be potentially harmful and may not provide the intended therapeutic effects.
  • Handling Xiidra with Care: Proper handling of Xiidra is essential to maintain its sterility and prevent contamination. Always wash your hands thoroughly before handling the medication to minimize the risk of introducing bacteria or other impurities. When using Xiidra, avoid touching the tip of the dropper or the opening of the container to any surface, including your eyes. This helps prevent contamination and preserves the sterility of the medication. If the dropper or container becomes dirty or contaminated, replace it with a new one to ensure the safety and effectiveness of the medication.
  • Storing Xiidra Away from Children: As with all medications, it is crucial to store Xiidra out of reach of children and pets. Xiidra contains active ingredients that can be harmful if ingested. Store the medication in a secure cabinet or a high shelf where children cannot access it. By doing so, you can prevent accidental ingestion and ensure the safety of your loved ones.


Take-Back Programs

Many communities and pharmacies have medication take-back programs to facilitate the proper disposal of medications. These programs provide a safe and convenient way to dispose of expired or unwanted medications, including Xiidra.

Prescription Drug Drop-Off Sites

Prescription drug drop-off sites are established locations where you can safely dispose of your unused or expired medications. Check with your local pharmacy or law enforcement agency to find the nearest drop-off site in your area.

Mail-Back Programs

Some drug manufacturers or pharmacies offer mail-back programs, allowing you to send back unused or expired medications for proper disposal. Contact the manufacturer of Xiidra or your local pharmacy to inquire about such programs.

Mixing with Unappealing Substances

To prevent accidental ingestion or misuse, you can mix Xiidra with unappealing substances like coffee grounds or cat litter. Seal the mixture in a plastic bag and dispose of it in the regular trash.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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