Combigan is a medication that is commonly prescribed for the treatment of glaucoma and ocular hypertension. Glaucoma is a group of eye conditions that can cause damage to the optic nerve, leading to vision loss. Ocular hypertension, on the other hand, refers to high pressure within the eye, which can also increase the risk of developing glaucoma. Combigan belongs to a class of drugs called beta-blockers and alpha agonists, and it works by reducing the production of fluid in the eye and increasing the drainage of fluid from the eye.

Combigan is a prescription eye drop medication that contains two active ingredients: brimonidine tartrate and timolol maleate. Brimonidine tartrate is an alpha-2 adrenergic agonist, and timolol maleate is a beta-blocker. These two ingredients work together to lower the pressure within the eye and reduce the risk of optic nerve damage.

Combigan is primarily used to treat two eye conditions: glaucoma and ocular hypertension. Glaucoma is a progressive eye disease characterized by increased intraocular pressure, which can damage the optic nerve and result in vision loss. Ocular hypertension, on the other hand, refers to higher than normal pressure within the eye without any signs of optic nerve damage or vision loss.

By reducing the pressure within the eye, Combigan helps to prevent further damage to the optic nerve and preserve vision. It is important to note that Combigan is not a cure for glaucoma or ocular hypertension, but rather a treatment that helps manage these conditions and prevent further deterioration.


Yes, there are generic versions of Combigan available through MyRx Outlet. Generic medications are bioequivalent to their brand-name counterparts, meaning they have the same active ingredients and are expected to produce the same therapeutic effects. Generic versions of Combigan typically contain brimonidine tartrate and timolol maleate in the same concentrations as the brand-name medication.

It is crucial to follow the warnings and precautions to ensure safe and appropriate use. By discussing your medical history, allergies, and other relevant information with your healthcare provider, you can minimize the risks and maximize the benefits of Combigan. Remember, your eye health is essential, and proper care is necessary to maintain optimal vision.

Generic medications are often more affordable than brand-name drugs, making them a cost-effective option for patients. Please refer to your doctor if you are able to use a generic.

Warnings and Precautions

Follow the instructions provided by your healthcare professional regarding the use of Combigan. Use the medication exactly as prescribed, including the recommended dosage and frequency. Do not use more or less of the medication unless advised by your doctor.

  • Allergies and Sensitivities: Talk to your doctor about any known allergies or sensitivities you may have, especially to brimonidine, timolol, or any other ingredients in Combigan. Inform your healthcare provider if you have a history of allergic reactions to medications or any other substances.
  • Medical Conditions: Inform your doctor about any existing medical conditions, including but not limited to heart disease, lung disease, diabetes, thyroid problems, or circulation disorders. Combigan may interact with certain medical conditions, and your doctor needs to evaluate the potential risks and benefits before prescribing this medication.
  • Children and Elderly: Combigan safety and effectiveness in children have not been established. Consult with your child’s pediatrician before considering the use of this medication in pediatric patients. Elderly patients may be more sensitive to the effects of Combigan. Careful monitoring is required to ensure appropriate dosage and to detect any potential adverse reactions.
  • Eye Conditions: Combigan is specifically intended for use in the eyes. Avoid using it in any other part of the body. If you have any eye conditions other than glaucoma or ocular hypertension, discuss them with your healthcare provider. Certain eye conditions may require additional precautions or adjustments to the treatment plan.
  • Eye Infections or Surgeries: If you have an eye infection or are scheduled for any eye surgeries, inform your doctor before starting Combigan. In some cases, the use of Combigan may need to be temporarily suspended during eye infections or certain surgical procedures.

Side Effects

If any side effect raises concerns or becomes bothersome, it is crucial to consult a healthcare professional promptly. While Combigan is generally well-tolerated, it is important to be aware of the potential side effects associated with its use.

Common Side Effects

  • Eye redness: A common side effect of Combigan is temporary eye redness, which usually subsides on its own within a short period.
  • Stinging or burning sensation: Some individuals may experience a mild stinging or burning sensation upon instilling Combigan eye drops.
  • Blurred vision: Blurry vision may occur immediately after administering Combigan, but it typically resolves quickly.
  • Dry eyes: Combigan can cause temporary dryness in the eyes, leading to discomfort and a gritty sensation.
  • Itchy or watery eyes: Itching or excessive tearing of the eyes can occur as a result of Combigan use.

Rare Side Effects

  • Eye irritation: In rare cases, Combigan may cause persistent eye irritation, including redness, itching, and inflammation.
  • Eye swelling: Although uncommon, some individuals may experience eyelid or eye swelling due to an allergic reaction to Combigan.
  • Eye discharge: Rarely, Combigan can lead to the formation of eye discharge, such as crusts or sticky secretions.
  • Sensitivity to light: A small number of patients may develop increased sensitivity to light while using Combigan eye drops.
  • Conjunctivitis: While rare, Combigan has been associated with the development of conjunctivitis, commonly known as pink eye.

Severe Side Effects

  • Allergic reactions: In some rare instances, individuals may experience severe allergic reactions to Combigan, characterized by swelling of the face, lips, or tongue, difficulty breathing, and hives. If any of these symptoms occur, immediate medical attention is essential.
  • Changes in heart rate: Combigan contains timolol, which can affect heart rate. In rare cases, it may cause a significant decrease in heart rate or worsen pre-existing heart conditions. Patients with a history of heart problems should consult their healthcare provider before using Combigan.
  • Low blood pressure: Combigan has the potential to lower blood pressure. Individuals who already have low blood pressure or are taking medications to lower blood pressure should exercise caution and discuss the risks with their doctor.
  • Respiratory problems: Rarely, Combigan may lead to breathing difficulties, especially in individuals with a history of asthma or other respiratory conditions. Immediate medical attention should be sought if experiencing shortness of breath, wheezing, or chest tightness.
  • Corneal and retinal disorders: Although extremely rare, there have been isolated reports of corneal and retinal disorders associated with the use of Combigan. These conditions may cause vision changes, eye pain, or vision loss. Any abnormalities should be promptly reported to an eye specialist.

Drug Interactions

It is important to be aware of potential drug interactions with Combigan to ensure safe and effective use of the medication. It is crucial to inform your healthcare provider about all the medications, including prescription, over-the-counter, and herbal supplements, that you are taking before starting Combigan. They can evaluate the potential drug interactions and adjust your treatment plan accordingly to ensure your safety and optimize the effectiveness of Combigan.

Here are some important points to consider:

  • Monoamine Oxidase Inhibitors (MAOIs): Combigan should not be used with MAOIs or within 14 days of discontinuing their use. Combining Combigan with MAOIs can lead to severe cardiovascular reactions such as hypertension or hypotension.
  • Beta-Blockers and Calcium Channel Blockers: Combigan contains timolol, a non-selective beta-blocker. Combining it with other systemic beta-blockers (such as Tenormin),  or calcium channel blockers may enhance their effects, potentially leading to additive side effects such as bradycardia (slow heart rate) or hypotension (low blood pressure). Close monitoring of heart rate and blood pressure is advised if using Combigan alongside these medications.
  • Antihypertensive Medications: Combigan can cause a decrease in blood pressure. When used in combination with other antihypertensive medications, such as ACE inhibitors, ARBs, or diuretics, it may result in further lowering of blood pressure. Regular monitoring of blood pressure is essential when Combigan is used along with other antihypertensive drugs.
  • Digitalis Glycosides Combigan: specifically the brimonidine component, may potentiate the cardiac effects of digitalis glycosides like digoxin. Patients taking Combigan along with digitalis glycosides should be closely monitored for signs of digitalis toxicity, such as nausea, vomiting, dizziness, or irregular heart rhythms.
  • Oral Beta-Blockers: Combigan contains timolol, a beta-blocker. When used concurrently with oral beta-blockers, systemic absorption and the risk of systemic side effects may increase. Close monitoring for systemic side effects, such as low blood pressure, slow heart rate, or exacerbation of asthma, is recommended if using Combigan with oral beta-blockers.
  • Alpha-2 Agonists: Combigan contains brimonidine, an alpha-2 adrenergic agonist. Concurrent use with other alpha-2 agonists, such as clonidine, may result in additive effects on blood pressure and heart rate. Patients using Combigan along with alpha-2 agonists should be monitored for changes in blood pressure and heart rate.
  • Tricyclic Antidepressants (TCAs) and Monoamine Oxidase Inhibitors (MAOIs): Combigan should be used cautiously in patients using TCAs or MAOIs due to the potential for increased systemic effects, including hypotension or bradycardia. Regular monitoring of blood pressure and heart rate is advised when combining Combigan with TCAs or MAOIs.


Combigan is available in the form of eye drops, which makes it convenient and easy to use. The medication comes in two dosage strengths:

  1. Combigan 0.2%/0.5% (brimonidine tartrate 0.2% and timolol maleate 0.5%)
  2. Combigan 0.2%/0.25% (brimonidine tartrate 0.2% and timolol maleate 0.25%)

Recommended Dosage

The dosing regimen for Combigan may vary depending on the severity of your condition and individual factors. As mentioned throughout this page, please contact your healthcare provider for any and all questions related to your taking this medication. Each person is different and your healthcare professional will be able to determine what is best for you in regards to taking this medication. However, the standard recommended dosage for most patients is as follows:

  1. Instill one drop of Combigan into the affected eye(s) twice daily.
  2. It is important to maintain a consistent dosing schedule and follow your healthcare provider’s instructions precisely.

Administrative Tips

To ensure the optimal effectiveness of Combigan and minimize the risk of contamination or infection, it is essential to follow these administration tips:

  • Wash your hands thoroughly before handling the eye drops.
  • Tilt your head back and pull down the lower eyelid to create a small pocket.
  • Squeeze the prescribed number of drops into the pocket without touching the eye or surrounding areas.
  • Close your eyes gently for a minute or two to allow the medication to be absorbed.
  • If you are using other eye drops, wait at least 5 minutes between each application to prevent potential interactions.


Proper storage conditions play a vital role in maintaining the efficacy of medications. When it comes to storing Combigan, it’s essential to adhere to specific guidelines to ensure its stability and safety. Here are some key points to keep in mind:

  • Temperature: Combigan should be stored at room temperature, preferably between 68°F (20°C) and 77°F (25°C). It’s crucial to avoid exposing the medication to extreme heat or cold, as it can affect its chemical composition and potency.
  • Humidity: High humidity can cause moisture to accumulate in medication containers, leading to degradation. It is recommended to store Combigan in a dry environment to maintain its quality. Avoid storing it in areas such as the bathroom, where humidity levels tend to be higher.
  • Light Exposure: Combigan should be protected from direct sunlight and excessive light exposure. Exposure to light can break down the active ingredients in the medication and reduce its effectiveness. Store Combigan in a dark place, such as a drawer or cabinet, to shield it from light.
  • Original Packaging: Keep Combigan in its original packaging until it is ready to be used. The packaging is designed to protect the medication from external factors that may affect its stability. If the original packaging becomes damaged or compromised, consider transferring the medication to an airtight container.
  • Airtight Container: If you need to transfer Combigan to a different container, ensure that it is airtight and provides adequate protection from moisture and light. Choose a container that is specifically designed for storing medications to maintain their integrity.
  • Keep Out of Reach of Children and Pets: As with any medication, it’s crucial to keep Combigan out of the reach of children and pets. Store it in a secure location, preferably in a locked cabinet or high shelf, to prevent accidental ingestion or misuse.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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