Combigan (Brimonidine Tartrate, Timolol)
Combigan is a prescription combination eye drop used to lower elevated pressure inside the eye (intraocular pressure, or IOP) in patients with glaucoma or ocular hypertension when additional or replacement therapy is needed. It is an eye-pressure treatment and does not replace emergency care for sudden eye pain or sudden vision loss.
We only dispense medications with a valid prescription from a licensed prescriber.
All prescriptions are reviewed and verified before dispensing. Orders may be delayed or declined if prescription details are missing, do not match the patient information on file, appear altered, or are expired. We may also refuse service if we believe an order is intended for resale or redistribution.
What You Receive
- Combigan (or approved generic) in sealed manufacturer packaging
- Personalized prescription instructions based on your prescriber’s directions
- Medication information leaflet provided by the manufacturer
- Itemized invoice detailing your order
- Rx Required
From $37.00 – $139.99
Shipping & Delivery
- Shipped from licensed pharmacy partners
- Tracking information is provided once your order ships
Delivery times may vary based on location and prescription verification.
This page is for general information only and is not medical advice. For medical questions, please speak with your prescriber. See Sources & Methodology for how this information is reviewed and referenced.
Combigan Key Facts
What Combigan is
A prescription combination ophthalmic (eye) drop that contains:
Brimonidine tartrate, an alpha-adrenergic agonist
Timolol maleate, a beta blocker
What it’s used for
Combigan is used to reduce elevated eye pressure in patients with:
Glaucoma
Ocular hypertension
How it works
Combigan lowers eye pressure in two ways:
Brimonidine helps reduce fluid production in the eye and can increase fluid drainage
Timolol helps reduce fluid production in the eye
Combigan Safety Overview
Combigan contains timolol (a beta blocker), so even though it is an eye drop, some effects can still affect the rest of the body. Important risks include breathing problems, slow heart rate, low blood pressure, and worsening heart failure in susceptible patients.
Combigan Warnings & Precautions
Contact your prescriber if you have wheezing, fainting, shortness of breath, or a very slow pulse.
Do not use Combigan if:
- You have asthma or a history of asthma
- You have severe COPD
- You have certain serious heart rhythm problems (such as sinus bradycardia, second- or third-degree AV block without a pacemaker)
- You have overt heart failure or cardiogenic shock
- You have a known allergy to brimonidine, timolol, or product ingredients
- You are treating a child under 2 years of age
Key warnings to know
- Systemic beta-blocker effects can occur even with eye drops
- Breathing problems may worsen in people with asthma or severe COPD
- Slow heart rate, low blood pressure, or heart block can occur
- Heart failure symptoms can worsen in some patients
- Eye allergy reactions, eye redness, or irritation can occur
- Use caution if you have depression, circulation problems, diabetes, or thyroid disease
- If using more than one eye drop, separate doses by at least 5 minutes
Side Effects and When to Get Help
Most side effects happen in or around the eye, such as redness, burning, stinging, dryness, or blurred vision. Because Combigan contains timolol, some people can also have whole-body effects such as slow heart rate, dizziness, or breathing symptoms. Get urgent help for chest pain, severe shortness of breath, fainting, or facial or throat swelling.
Possible side effects may include
- Eye redness
- Burning or stinging after use
- Itching or eye irritation
- Dry eye
- Blurred vision
- Drowsiness or fatigue
- Dizziness
- Dry mouth
- Slow heart rate (in some patients)
Get urgent help right away for
- Severe shortness of breath or wheezing
- Fainting or near-fainting
- Chest pain or very slow heart rate
- Severe eye pain or sudden vision changes
- Swelling of the face, lips, tongue, or throatSwelling of the face, lips, tongue, or throat
Interactions
Combigan interaction risk is mainly related to the timolol component (beta-blocker effects) and the brimonidine component (alpha-agonist effects). Always review your full medication list with your prescriber, including heart medicines, blood pressure medicines, antidepressants, and other eye drops.
Interactions to review with your prescriber may include
- Other beta blockers (eye drops or oral medicines), because heart rate and blood pressure effects can add up
- Calcium channel blockers (such as verapamil or diltiazem), because slow heart rate or low blood pressure risk can increase
- Digoxin or other medicines that slow heart rate
- Blood pressure medicines, because blood pressure lowering effects may increase
- MAO inhibitors and some antidepressants, which may affect brimonidine response
- CNS depressants (such as sedatives or alcohol), because drowsiness may increase
- Other eye drops, which should be timed properly (at least 5 minutes apart)
Combigan Drug Facts
| Category | Details |
|---|---|
| Brand Name | Combigan |
| Drug Class | Alpha-adrenergic agonist + beta-adrenergic receptor blocker (combination ophthalmic drop) |
| Indication | Reduction of elevated intraocular pressure in glaucoma or ocular hypertension requiring adjunctive or replacement therapy |
| Dosage Forms | Ophthalmic solution (eye drops) |
| Strengths | 0.2% brimonidine tartrate / 0.5% timolol maleate (2 mg/mL brimonidine tartrate and 5 mg/mL timolol) |
| Administration Timing | 1 drop in the affected eye(s) twice daily, about 12 hours apart |
| Contact Lens Guidance | Remove soft contact lenses before use and wait at least 15 minutes before reinserting (based on preservative guidance) |
| Who should not use it | Asthma, severe COPD, certain serious heart rhythm/heart failure conditions, children under 2, or product allergy |
| Storage | Store at controlled room temperature. Keep bottle tightly closed and avoid contaminating the dropper tip |
| Alternatives | Alphagan P (brimonidine), timolol eye drops, dorzolamide/timolol, brinzolamide/brimonidine, prostaglandin analogs such as latanoprost (prescriber-selected based on IOP goals) |
Helpful Information
How To Buy Combigan Online
1
Select Your Prescribed Combigan Dosage & Strength
Choose the strength and quantity that matches your prescription, then add it to your cart. Orders are limited to a 90-day supply per fill.
2
Complete Checkout
Ensure your shipping and contact information is correct so your order can be processed without delays.
3
Submit Your Combigan Prescription
Upload your prescription at checkout. If you need a transfer, provide your prescriber or current pharmacy details and we will request it on your behalf.
Prescription & Dispensing Standards
- Prescription required for all orders and reviewed for pharmacy and regulatory compliance
- Dispensed by licensed pharmacy partners
- Orders are held if information is missing, unclear, or does not match.
- No substitutions without prescriber approval, and no controlled substances.
Our Guarantee
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Combigan at a discounted rate, call 1-888-551-2467.
FAQs
What is Combigan used for?
Combigan is used to lower elevated eye pressure in patients with glaucoma or ocular hypertension when one medicine alone is not enough or a replacement combination is appropriate.
How often do I use Combigan?
The usual labeled dose is 1 drop in the affected eye(s) twice daily, about 12 hours apart. Follow your prescription directions.
Can Combigan affect my body even though it is an eye drop?
Yes. Because it contains timolol, some people can have whole-body beta-blocker effects such as slow heart rate, dizziness, or breathing symptoms.
Can I use Combigan with other eye drops?
Yes, in many cases. If you use more than one eye drop, separate them by at least 5 minutes unless your prescriber gives different instructions.
Can I wear contact lenses with Combigan?
Combigan contains a preservative. Remove soft contact lenses before use and wait at least 15 minutes before putting them back in, unless your prescriber tells you otherwise.
Ordering & Prescription FAQs
Do I need a prescription?
Yes, a prescription is required. Refills depend on what your prescriber authorizes.
How do I submit my prescription?
You can upload it through our Upload Prescription page, email it to info@myrxoutlet.com, or fax it to 1-888-230-1245. If you need a prescription transfer, just let us know at checkout and include your pharmacy or prescriber contact details.
When is my payment processed?
Your payment is processed only after your prescription and order have been reviewed and approved by our licensed pharmacy team. Once everything is confirmed, we’ll process payment and prepare your order for shipping.
What happens if my prescription can’t be verified?
Your order may be placed on hold or declined if prescription details are missing, don’t match, are expired, or can’t be confirmed.
Sources
FDA Prescribing Information, COMBIGAN (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%
https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021398s006lbl.pdf
AbbVie Canada, COMBIGAN Product Monograph (PDF)
DailyMed, Brimonidine tartrate and timolol maleate ophthalmic solution drug label information
https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=brimonidine%20timolol%20ophthalmic%20solution
Mayo Clinic, Brimonidine and timolol (ophthalmic route) drug information
https://www.mayoclinic.org/drugs-supplements/brimonidine-and-timolol-ophthalmic-route/description/drg-20071372