Combigan is a prescription medicine that is used to treat eye pressure and the side effects of glaucoma. The drug combines two active ingredients, brimonidine and timolol, to help lower eye pressure. Each of the active ingredients has its own responsibility.

BrimonidineThis ingredient is an alpha agonist that works to encourage more fluids to flow out of the eye and reduces the production of fluid within the eye. This helps to relieve eye pressure.
TimololThis ingredient is a beta blocker that works to blog beta receptors in the eye, effectively reducing the amount of fluid in the eye and lowering eye pressure.

The two active ingredients work together to reduce fluid by inhibiting fluid production and encouraging fluid to flow better through the eye. The combined efforts effectively reduce eye pressure from glaucoma and other conditions.

Precautions and Warnings with Combigan

Speak to your doctor about your medical history as well as any medicines that you are currently using. Don’t just share prescriptions, but also discuss over-the-counter medicines, herbs, supplements, and vitamins. This information is important for your doctor to consider whether Combigan will be a good fit.

Work with your doctor to determine if Combigan would negatively impact you. It may not be the right fit for everyone. Be aware of the risks associated with Combigan and follow all instructions provided by your doctor.

If any of these statements apply to you, make sure your doctor is aware:

  1. You suffer from depression
  2. You have kidney or liver disease
  3. You have any allergies, including allergies to ingredients found in Combigan
  4. You have an existing disease that affects your blood vessels
  5. You suffer from asthma or a lung disease
  6. You have a history of heart disease or have been diagnosed with heart disease
  7. You have an overactive thyroid
  8. You have diabetes
  9. You have low blood pressure
  10. You suffer from any type of muscle weakness
  11. You are pregnant, trying to become pregnant, or breastfeeding

Combigan Side Effects

While Combigan works well for most people who use it, there are some potential side effects to be aware of. Most of these side effects are mild and will go away on their own. It may take a few days to a couple of weeks for them to resolve. If your side effects become severe or you are concerned about them, reach out to your doctor for safety.

Mild Side Effects

These are the mild side effects:

  • Bad taste in the mouth
  • Swelling and irritation of the eyelid
  • Burning, stinging, or itching of the eye
  • Abnormally large or red blood vessels in the eye
  • Dry eyes
  • Lack of energy

Serious Side Effects

There are some side effects that may be more serious. If you experience any of these, you need to speak to your doctor or seek medical care immediately.

These are the serious side effects:

  • Allergic reactions
  • Troubles breathing
  • Chest pain
  • Irregular heartbeat
  • Depression
  • Heavy muscle weakness (eyelid drooping)
  • Low blood pressure

Allergic Reaction

Signs of an allergic reaction include itchiness, flushing, and skin rash. When allergic reactions are more severe, they can lead to trouble breathing or heavy swelling. Get help quickly if these things occur.

Drug Interactions with Combigan

Combigan may cause some medicines to work less effectively. In addition, with certain medications, you may be at a higher risk for side effects or adverse effects when using Combigan. Speak to your doctor about everything you are taking. They may advise you to start or stop a medication while using Combigan. Do not adjust any medications or dosages without instructions to do so from your doctor.

Beta-blockers cover a wide variety of medications. Be sure to share them with your doctor. This includes any eye drops with beta-blockers that you may be using.

These are the medications that are most likely to interact with Combigan:

  • Digoxin
  • Digitalis
  • Reserpine
  • Antidepressants (amitriptyline, bupropion, clomipramine, doxepin, duloxetine, paroxetine, etc.)
  • MAO Inhibitors (linezolid, phenelzine, selegiline, etc.)
  • Beta Blockers (carvedilol, labetalol, nadolol, propranolol, etc.)
  • Heart and blood pressure medications (amlodipine, diltiazem, quinidine, verapamil, etc.)

Cost of Combigan in America

The cost of may vary for multiple reasons. The pharmacy that you use or the location you are in can impact the costs. In addition, the size of the bottle that you purchase may affect the cost. On average, Combigan costs $200-$300 for a 5ml bottle. There are additional sizes available, including a 10 ml and 15 ml option. These are more expensive and may range from $400-$650.

You may be able to reduce your out-of-pocket expenses by using a drug coupon or discount program. Look for options available to you to find the best savings. You may also be able to consider a generic form of brimonidine and timolol combination eye drops or an alternative that is cheaper.

Why Is Combigan So Expensive?

This prescription is so expensive because it is a name-brand medication. However, you will find that many specialty ophthalmic treatments are more expensive because of the market they are in. The market is smaller and the demand is much lower. This means the cost must be higher in order to cover all expenses to create, market, and test the drug.

Strengths and Dosages of Combigan

Combigan comes in just one strength that is solid across the board. In most cases, the dosage recommended is one drop to the affected eye twice per day. These doses are administered about 12 hours apart.

The bottles do come in different sizes, ranging from 5ml to 15ml. However, in each of these, the strength of the medicine remains the same. The breakout for the solution is .5% timolol and .2% brimonidine.

Combigan Alternatives

There are some alternative options that may be considered in place of Combigan. Speak with your doctor about the options to find the best fit.

FAQs of Combigan

What is Combigan?

Combigan is a dual-action ophthalmic eye treatment that is used to treat glaucoma and other conditions that cause intraocular eye pressure.

How Does Combigan Work?

Both of the active ingredients in Combigan help to reduce the fluid in the eye. One part helps to increase the flow of fluid, while the other works to prevent the buildup of flood.

How Long Can You Use Combigan?

Use Combigan for as long as your doctor prescribes it to you. There is no rule stating that you must stop or restart use after a specified time period.

Is There a Generic for Combigan?

There are generic options for Combigan. Look for Brimonidine Timolol to find the generic choices.

Who Makes Combigan?

Combigan is made by AbbVie Inc. and Allergan PLC. Allergan PLC is a subsidiary of AbbVie.

How Long is Combigan Good After Opening?

The bottle should be thrown out after four weeks from the opening date. You may also see an expiration date on your packaging. Do not use Combigan past this expiration date.

What Type of Glaucoma Does Combigan Treat?

Combigan is used to treat open-angle glaucoma as well as other disorders that cause ocular hypertension and pressure.

How Long Does it Take for Combigan to Work?

You should start to notice the effects of Combigan within 1-2 hours after you use the medication. Keep using this medicine as long as your doctor instructs you to.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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