Eylea (aflibercept) is a prescription medication used in the treatment of various eye conditions, primarily neovascular (wet) age-related macular degeneration (AMD), diabetic macular edema (DME), and macular edema following retinal vein occlusion (RVO). It belongs to a class of drugs known as vascular endothelial growth factor (VEGF) inhibitors.

Eylea works by blocking the activity of VEGF-A, a protein that promotes the growth of abnormal blood vessels in the eye. By inhibiting VEGF-A, Eylea helps reduce the leakage and growth of these abnormal blood vessels, thereby slowing down the progression of the underlying eye condition and preserving vision.

Precautions and Warnings with Eylea

  • Intraocular Inflammation: Eylea injection may result in intraocular inflammation, which can manifest as increased intraocular pressure (IOP), anterior chamber cells, and flare.
  • Endophthalmitis and Retinal Detachments: Proper aseptic injection techniques should be utilized when administering Eylea to minimize the risk of endophthalmitis and retinal detachments.
  • Arterial Thromboembolic Events: Serious, sometimes fatal, arterial thromboembolic events (ATEs) have been reported following Eylea administration.
  • Increased Intraocular Pressure: Eylea may cause an increase in intraocular pressure (IOP), which can lead to glaucoma or worsen preexisting glaucoma.
  • Cerebrovascular Accident: Cerebrovascular accidents, including strokes, have been reported in patients receiving Eylea.
  • Hypersensitivity Reactions: Hypersensitivity reactions, including anaphylaxis, have been reported following Eylea administration.

Eylea Side Effects

While Eylea is generally well-tolerated, like any medication, it may cause side effects in some individuals. Side effects associated with Eylea may include:

Mild Side Effects

  • Changes to your vision for a time after the injection
  • Red spot on the surface of an eye caused by bleeding from a minor blood vessel
  • Eye pain
  • Eye redness
  • Seeing floaters (small squiggly lines or moving spots in your vision)
  • Feeling like something is in your eye
  • Watery eyes
  • Vitreous detachment (a condition in which the jelly-like substance inside your eyeball pulls away from your retina)
  • Eyelid swelling

Serious Side Effects

  • Cataracts (a type of eye problem). Symptoms can include:
    • Blurry or cloudy vision
    • Trouble seeing at night
    • Seeing colors as faded
    • Increased sensitivity to glare
    • Double vision in the affected eye
  • Allergic reaction
  • Increased intraocular pressure (pressure in your eye)
  • Endophthalmitis (infection inside the eyeball)
  • Detached retina (separation of the retina from the back of the eye)
  • Increased risk of blood clots that could lead to a heart attack or stroke

Eylea Strengths and Dosages

Please follow your prescribers instructions when intaking any medication you are prescribed.

Available Strengths

Eylea is available as a sterile, preservative-free solution for intravitreal injection in single-dose vials. Each vial contains either 40 mg/mL (2 mg/0.05 mL) or 100 mg/mL (2 mg/0.02 mL) of aflibercept.

Recommended Dosages

The recommended dosage of Eylea varies depending on the indication:

  • Neovascular (Wet) Age-Related Macular Degeneration (AMD): The recommended dosage is 2 mg administered by intravitreal injection every 4 weeks for the first 12 weeks, followed by 2 mg administered every 8 weeks thereafter.
  • Diabetic Macular Edema (DME): The recommended dosage is 2 mg administered by intravitreal injection every 4 weeks.
  • Macular Edema Following Retinal Vein Occlusion (RVO): The recommended dosage is 2 mg administered by intravitreal injection every 4 weeks.

Cost of Eylea in America

At this time of writing, the cost for Eylea intravitreal solution (40 mg/mL) to be approximately $1,958 for a supply of 0.05 milliliters

Patients are encouraged to check with their local pharmacies, insurance providers, or explore patient assistance programs to determine the most cost-effective option for obtaining Eylea.

If this is your first time using MyRx Outlet, you can save 10% on your first order by using the discount code MYRX10 at checkout.

Eylea Alternatives

While Eylea is a widely prescribed medication for various eye conditions such as neovascular (wet) age-related macular degeneration (AMD), diabetic macular edema (DME), and macular edema following retinal vein occlusion (RVO), there are several alternative treatment options available:

  • Lucentis (ranibizumab): Lucentis is another anti-VEGF medication approved for the treatment of neovascular (wet) age-related macular degeneration (AMD), diabetic macular edema (DME), and macular edema following retinal vein occlusion (RVO).
  • Avastin (bevacizumab): Avastin is not FDA-approved specifically for ocular conditions, but it is sometimes used off-label as an alternative anti-VEGF treatment for neovascular AMD, DME, and RVO.
  • Steroid Injections: Corticosteroid medications such as triamcinolone acetonide may be used to treat macular edema associated with conditions like diabetic retinopathy and uveitis.
  • Laser Therapy: Laser photocoagulation or photodynamic therapy (PDT) may be used as alternative treatment options for certain eye conditions, such as diabetic retinopathy and choroidal neovascularization.
  • Surgical Interventions: In some cases, surgical interventions such as vitrectomy or retinal detachment repair may be necessary to treat advanced eye conditions or complications that do not respond to medical or laser treatments.

FAQs of Eylea

If you are a current customer and have ordered Eylea from us before, feel free to contact us and we can set you up with a free pharmacy consultation with one our licensed pharmacists.

What is Eylea used for?

Eylea is used to treat various eye conditions, including neovascular (wet) age-related macular degeneration (AMD), diabetic macular edema (DME), and macular edema following retinal vein occlusion (RVO).

How is Eylea administered?

Eylea is administered by intravitreal injection, which means it is injected directly into the eye. The injection is typically performed by a qualified healthcare professional in a clinical setting.

How often do I need to receive Eylea injections?

The dosing frequency of Eylea injections may vary depending on the specific eye condition being treated. For neovascular AMD, the recommended dosing schedule is typically every 4 weeks for the first 12 weeks, followed by every 8 weeks thereafter. For DME and RVO, injections may be administered every 4 weeks.

What are the common side effects of Eylea?

Common side effects of Eylea may include conjunctival hemorrhage, eye pain, cataract, vitreous floaters, and increased intraocular pressure.

How long does it take for Eylea to start working?

The onset of action of Eylea may vary depending on the individual and the specific eye condition being treated. Some patients may experience improvement in their symptoms shortly after starting treatment, while others may require several injections before seeing significant results.

Does Eylea cure eye conditions?

Eylea is not a cure for eye conditions such as neovascular AMD, DME, or RVO. However, it can help slow down the progression of these conditions and preserve vision over time when used as directed by your healthcare provider.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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