Simbrinza is a prescription ophthalmic eye drop treatment that treats ocular hypertension and open-angle glaucoma. The medication is specifically used to treat any disorder that causes elevated intraocular pressure, also referred to as IOP.

Simbrinza has two active ingredients that fall into two separate categories. The active ingredient works together to reduce fluid product in the eye and inherently help to lower intraocular eye pressure in the process. These are the two active ingredients. The drug has two active ingredients.

BrinzolamideCarbonic anhydrase Inhibitor that works to reduce the production of fluid in the eye
Brimonidine TartrateSelective alpha-2 adrenergic agonist that decreases production of fluid while increasing drainage of fluid from the eye

Precautions and Warnings with Simbrinza


Providing your doctor with accurate information will ensure you get the best treatment possible. It also helps to prevent issues related to your medical history or other medications that you may be taking as well.

If you have allergies to brinzolamide or brimonidine tartrate, you should not take this medication. If you have allergies to any of the inactive ingredients, it may not be a good fit for you either.

Speak to your doctor about your medical history. Be sure to share with them any history of eye issues or surgeries. Let your doctor know anything that you are taking, including these items:

  • Over-the-counter drugs
  • Prescriptions
  • Supplements
  • Vitamins
  • Herbs


While using Simbrinza, you may experience dizziness or drowsiness. Avoid driving or operating heavy machinery if you experience these issues. Wait until you know how Simbrinza will affect you before driving or participating in activities that require you to be alert.

Simbrinza is not recommended for children under 2 years old.

If you are pregnant, planning to become pregnant, or breastfeeding, consult with your doctor before using Simbrinza. It is unknown whether it could have any negative effects and should only be taken when needed during these times.

When using Simbrinza do not touch the dropper directly to your eye. Do not let the dropper touch your hands or any other surface as it may become contaminated. If you have any of these health issues, be sure to share them with your doctor:

  • Kidney disease
  • Liver disease
  • History of stroke or blood clots
  • Depression
  • Narrow-angle glaucoma
  • Low or high blood pressure
  • Congestive heart failure
  • Coronary artery disease

Simbrinza Side Effects

Side effects may vary. The most common side effect is temporary blurry vision or dry eyes. However, it is possible to experience other side effects as well as more severe side effects.

Common Side Effects

These are the most common side effects that may occur.

  • Drowsiness
  • Tiredness
  • Itchiness of the eye
  • Dry eyes
  • Temporary blurred vision
  • Redness or irritation
  • Discharge from eye
  • Dry mouth
  • Dizziness
  • Headaches

Serious Side Effects

If you experience a lasting side effect or one that makes you worry, consult with your doctor right away. If your side effects begin as minor but worsen or do not go away, you need to reach out to your doctor quickly.

More serious side effects are as follows:

  • Irregular heartbeats (quickened or slowed)
  • Pain to the eye or eyelid
  • Burning sensations
  • Swelling of the eye
  • Extreme light sensitivity
  • Changes to vision
  • Fainting
  • Allergic reactions (rash, hives, difficulty breathing, etc.)

Drug Interactions with Simbrinza

Simbrinza may interact with other medications, supplements, or herbs. It is important to speak to your doctor about everything you are taking. Do not start, stop, or adjust your dosage without first speaking to your doctor. Using Simbrinza could affect how other medications work. You may also experience more serious side effects when used with certain medications.

Check labels of all allergy or cough and cold products for ingredients that may be known to cause drowsiness.

Let your doctor know if you are using any of these products that may cause drowsiness:

  • Antihistamines (cetirizine, diphenhydramine, etc.)
  • Cannabis products
  • Sleep or anxiety medication (alprazolam, zolpidem, diazepam, etc.)
  • Muscle relaxers
  • Opioid pain relief (codeine)

Simbrinza Cost in America

There are certain factors that may affect what you pay for Simbrinza in America. The prices vary depending on the pharmacy as well as your location. On average, Simbrinza costs anywhere from $200-$300 without any insurance or discounts.

You may be able to take advantage of a drug discount or coupon plan to help save money on the expense. You may also be able to find generic options or alternatives that are less expensive. Speak to your doctor about these options to see if they have any recommendations.

Why Is Simbrinza Expensive?

Most eye treatment medications cost a lot more than traditional medications you may be used to. The reason for this is because they are so specialized. Eye treatments have to be specially made for the eye and they are not a high-demand market. While they may be common in the eye care industry, it is a significantly smaller market than treating everyday health conditions.

The costs associated with research, testing, development, and marketing are much higher. In addition, when you purchase a brand-name option, it tends to be more expensive as well.

Strengths and Dosages of Simbrinza

When you are prescribed Simbrinza, your doctor will provide specific instructions for use. Follow the instructions that are provided in order to get the best results. Do not take this medication longer than is recommended and do not take extra doses. You should not use Simbrinza while wearing contact lenses.

In most cases, you will use one drop in the affected eye twice per day. The strength is 1% brinzolamide and .2% brimonidine.

Simbrinza Alternatives

There are some alternative solutions to Simbrinza. Work with your provider to determine the best choice.

FAQs of Simbrinza

How Many Drops of Simbrinza are in an 8ml Bottle?

As a rule of thumb, there are approximately 20 drops per milliliter of solution. In an 8ml bottle, this would be approximately 160 drops.

How Does Simbrinza Work?

Simbrinza has two active ingredients. Both ingredients work to reduce intraocular pressure of the eye with a similar approach. They help to decrease fluid production to lower intraocular pressure and increase eye drainage.

 Who Makes Simbrinza?

Simbrinza is made by Alcon Laboratories, Inc. This is a division of Novartis.

How Long Does Simbrinza Stay in Your System?

It is estimated that Simbrinza could stay in your system for up to 111 days. However, this depends on how long it is used and how your body receives the medication as well.

How Can You Save Money on Simbrinza?

Simbrinza can be costly. If you have health insurance, this may cover some of the cost of the medication. If you do not have insurance or need additional savings, you may be able to save money through a discount drug or coupon program. These programs can generally save a good amount from the total cost. You may be able to use a generic option or an alternative to Simbrinza.

 Is Drowsiness a Side Effect of Simbrinza?

Yes, drowsiness is one of the most common side effects of using Simbrinza. You should not drive or participate in activities that require focus until you know how Simbrinza is going to affect you in this way.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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