Methazolamide is a carbonic anhydrase inhibitor medication used to treat glaucoma. This disease damages the optic nerves of a person’s eyes, generally caused by fluid built-up or increased pressure inside the eye. Glaucoma can lead to vision loss when left untreated. The medication works by inhibiting the enzyme carbonic anhydrase, which is commonly found in eye tissue.

Within the eye, carbonic anhydrase works to produce aqueous humor. This fluid fills the front part of a person’s eye. In glaucoma, this fluid overfills, leading to pressure and other issues from the extra fluid. With Methazolamide, the production of aqueous humor is suppressed to achieve reduction of the intraocular pressure that is occurring.

The high pressure within the eye associated with glaucoma often leads to damage of the optic nerve and therefore vision loss. As a result, Methazolamide works to prevent this damage by reducing the pressure. Reducing the pressure protects the optic nerve and preserves vision in the process.

Precautions and Warnings with Methazolamide

If you have concerns about taking Methazolamide or want to know if it will be a good choice for your needs, the best thing to do is speak to your doctor about the option. Be sure to discuss your medical history and any allergies so the doctor can properly advise you.

If you have an allergy to Methazolamide or any type of sulfonamide medication, you should avoid using Methazolamide. Here are some additional precautions and warnings to be aware of.


Liver or Kidney IssuesIndividuals with liver or kidney issues may use Methazolamide, but they may need special monitoring or dosage adjustments
Electrolyte ImbalanceCertain electrolytes, specifically sodium, chloride, and potassium, may be affected and become imbalanced. This should be monitored closely for individuals with heart failure or kidney disease
Sulfa Drug AllergyMethazolamide is a derivative of sulfonamide, so anyone with a history of sulfa drugs like sulfonamide antibiotics should use with caution or avoid use
Metabolic AcidosisMetabolic acidosis is an imbalance of the body’s pH levels Methazolamide could cause this occurrence. Symptoms to be aware of include confusion, fatigue, irregular heartbeat, and rapid breathing.
Eye IrritationMethazolamide is typically used in eyedrop form for the primary treatment of glaucoma. You may experience eye irritation. If you experience issues like redness, irritation, or other eye-related problems, consult with your doctor.
Pregnant or BreastfeedingThere are very few studies of Methazolamide used while breastfeeding or pregnant and safety has not been established. If you are pregnant, breastfeeding, or planning to become pregnant, check with your doctor before use
Drug InteractionsMethazolamide may interact with other medications so be sure to confer with your doctor regarding any prescriptions, herbal products, or over-the-counter products you may be using

Using products such as cannabis or alcohol can contribute to excessive dizziness or drowsiness caused by Methazolamide. Methazolamide may make a person more sensitive to the sun, therefore limiting sun time and avoiding tanning booths is recommended.

Be proactive by checking with your doctor before taking Methazolamide to ensure it is a good choice for your health needs. Understanding inactive ingredients is also important as these could trigger allergic reactions or other side effects too. If you have any of the following issues, consult with your doctor before use.

  • Liver disease
  • Kidney problems
  • Hyperthyroidism
  • Gout
  • Diabetes (be sure to mention any diabetic medications you are taking)
  • Mineral imbalances
  • Adrenal gland problems
  • Breathing issues (lung infections, COPD, emphysema, etc.)

Methazolamide Side Effects

There are many different potential side effects to be aware of. One of the most common is that Methazolamide can make you dizzy or drowsy with use. Many people who use Methazolamide will not experience serious side effects and may experience no side effects at all.

If you do experience something serious, be sure to contact your doctor immediately and stop using it while you determine the next steps. Your doctor may advise continued use for mild side effects but will typically stop the medication for severe side effects.

Mild Side Effects

In most cases, mild side effects are most common. These include:

  • Drowsiness
  • Dizziness
  • Fatigue
  • Frequent urination
  • Change in taste preferences
  • Loss of appetite
  • Vomiting
  • Diarrhea
  • Tingling or pain in hands and feet

Serious Side Effects

If you experience a more serious side effect or you experience mild side effects that get worse or do not resolve, talk to your doctor right away. These are the more serious side effects reported:

  • Hives
  • Rash
  • Itching
  • Peeling skin
  • Long-lasting loss of appetite
  • Extreme nausea
  • Extreme fatigue
  • Ringing of ears
  • Abnormal bleeding or bruising
  • Flu-like symptoms
  • Fever, sore throat, chills, and signs of an infection
  • Muscle weakness or fatigue
  • Seizures
  • Difficulty swallowing or breathing
  • Stomach pain (upper right of stomach)
  • Yellowing of skin or eyes

Allergic Reactions

Finally, while allergic reactions are uncommon, they can happen. Symptoms such as a rash, itching, swelling, and trouble breathing are common signs of allergic reactions. If the reaction is not severe, reach out to your doctor. However, if you have a severe reaction, seek medical care immediately.

Drug Interactions with Methazolamide

It is possible that Methazolamide may react with certain medications, particularly certain diuretics, corticosteroids, and anticonvulsants. Speak with your doctor about any pre-existing health conditions, your health history, and all medications (including over the counter, herbs, and prescriptions). The interaction for most of these is the ability for Methazolamide to affect how the medication works or increase the risk of certain side effects.

The most common elements that interact with Methazolamide are memantine and methenamine.

Strengths and Dosages of Methazolamide

Do not use more than your doctor prescribes and follow their directions exactly for the best outcomes.

Methazolamide is typically taken as either eye drops or oral tablets. The dosage will vary depending on the method of administration.

  • Oral Tablets: typical adult dosage ranges from 50-100mg taken 2-3 times per day
  • Eye drops: The strength is approximately 1% and usage is typically 1 drop inserted into the eye 2-3 times per day

Methazolamide Alternatives

The choice of the right treatment may depend on your medical history as well as any reactions or allergies that are known. Work with your healthcare provider for the most appropriate treatment option.

There are alternative options that may be used in place of Methazolamide.

  • Alternative Carbonic Anhydrase Inhibitors
  • Prostaglandin Analogs
  • Rho Kinase Inhibitors
  • Alpha Agonists
  • Beta Blockers
  • Surgery

FAQs Of Methazolamide

What is the Proper Storage Method for Methazolamide?

Methazolamide should be stored in the original container. Keep out of reach of children and keep the lid tightly closed. Avoid excessive heat or moisture for storage purposes.

What Should I Do if I Miss a Dose of Methazolamide?

If you miss a dose, you may take that dose as soon as you remember unless it is nearly time for your next dose. If it is close to the next dose, just skip the dose and continue the dosage following your normal dosage schedule.

Does Methazolamide Need to Be Taken with Food?

You may take Methazolamide with or without food. Taking it with food or at mealtimes may help reduce nausea or the risk of an upset stomach.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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