Motegrity is a prescription medication that’s used to treat cases of chronic idiopathic constipation. This serotonin-4 receptor agonist exists in tablet form and is only confirmed as safe for adults to use. Adults who have struggled with constipation for three consecutive months can take one Motegrity tablet every 24 hours.

This oral drug is typically used to relieve constipation after one has first attempted other medications, like laxatives. Upon ingestion, Motegrity helps the stomach and intestines properly digest food so that it can easily move through the bowels.

Unlike other medications used to treat constipation, Motegrity works by causing natural movements of the colon muscle. Each person’s colon muscle must undergo natural or artificial stimulation in order for the bowels to properly move. Stiff or congested colon muscles are ultimately what leads to constipation.

With Motegrity, adults who’ve suffered constipation should notice some relief within three to four days.

Precautions and Warnings with Motegrity

Before you begin using Motegrity, you should schedule an appointment with your doctor to discuss any medications you’re currently on, along with the symptoms of constipation you’re experiencing.

If you are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed, you should inform your doctor before taking Motegrity. Any kidney complications, mood problems, thoughts of suicide, or run-ins with depression should also be disclosed to your doctor before you start taking Motegrity.

You should not take Motegrity if you suffer from intestinal wall conditions (such as tears, ulcerative colitis, or Crohn’s disease), bowel blockages, or tears in your stomach. If you suffer an allergic reaction (rashes, breathing problems, facial swelling, or itching) after taking this prescription medication, you should discontinue use.

Motegrity side effects

Motegrity, like all medications, comes with potential side effects.

Mild Side Effects

Mild side effects may clear up as your body gets used to this prescription drug:

  • Dizziness
  • Fatigue
  • Headache
  • Nausea
  • Gas/bloating
  • Diarrhea
  • Stomach pain

Severe Side Effects

If you notice severe side effects after taking Motegrity, you should immediately inform your doctor. If you believe you’re having a medical emergency, call 911 right away. Most people who take Motegrity do not experience severe side effects.

Severe side effects of Motegrityinclude the following:

  • Extreme allergic reactions
  • Thoughts/talk/actions of suicide
  • Irregular/fast heartbeat

Strengths and dosages of Motegrity

Motegrity is an oral tablet that’s available in 1mg and 2mg strengths. You can take this prescription drug with or without food or drink. At this time, it is unknown if splitting or crushing motegrity impacts its effectiveness. You should take the tablet at the same time each day by swallowing it whole.

If you forget a daily dose of Motegrity, be sure to take it as soon as possible. If you’re almost due for your next daily dose, do not take an extra dose to make up for the missed one. Extra doses of motegrity may increase your likelihood of experiencing heightened or severe side effects.

Motegrity Alternatives

There is no general alternative to Motegrity. However, traditional laxatives and other medicines for constipation can be used as alternatives. These medications include the following:

  • Linzess
  • Amitiza
  • Miralax
  • Senna
  • Dulcolax
  • Biscolax

FAQs of Motegrity

What is Motegrity?

Motegrity is a prescription drug and serotonin receptor agonist used to treat constipation lasting for three or more months.

How does Motegrity work?

Motegrity works by causing colon contractions. These contractions then cause food to make its transition through the digestive tract, which generates necessary bowel movement and relieves constipation.

How long does Motegrity stay in your system?

Motegrity stays in your system for five days following your most recent dose.

How long does it take for Motegrity to start working?

Clinical studies have shown that 28% of people who’ve taken Motegrity have experienced faster bowel movements within one week. The first bowel movement after one’s initial dose of Motegrity has been known to occur within one to five days.

How do I take Motegrity?

Motegrity is a tablet that should be taken once per day, at the same time each day. This tablet should also be swallowed whole, as it’s unknown if splitting or crushing the tablet may hurt its effectiveness.

How fast does Motegrity work?

According to clinical studies, 28% of people who’ve taken Motegrity have noticed improved bowel movements within one week. Other people consuming this drug may require more or less time before Motegrity begins to work for them.

How long can you take Motegrity?

When taking Motegrity, you should regularly check in with your doctor. Your doctor will be able to provide specific information on how long you can safely take Motegrity.

What time of day should you take Motegrity?

You should take Motegrity at any time during the day, but at the same time each day. The time you pick to take Motegrity should be a time that you can easily remember.

Who makes Motegrity?

Motegrity is made by Takeda Pharmaceutical Company.

What is the cost of Motegrity in America (without insurance)?

A one-month supply of 1mg – 2mg Motegrity costs about $589 without insurance at most pharmacies across the United States.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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