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OsmoPrep (Sodium Phosphate)
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OsmoPrep is a laxative that cleans the bowel before certain procedures, such as colonoscopy. This medicine cleans your colon by causing diarrhea.
The medicine is available in a oral (tablet) form. It contains sodium biphosphate and sodium phosphate. The latter draws large amounts of water into the colon, which causes watery stools, cleans the intestines, and helps the doctor to clearly see your colon.
OsmoPrep may be prescribed to treat conditions other than those mentioned above. This medicine is not recommended for weight loss or constipation due to the possibility of severe side effects.

Precautions and Warnings with Osmoprep
OsmoPrep should not be taken by patients with an allergy to sodium phosphate and sodium biphosphate.
The effects of this medicine on pregnant and breastfeeding women are unknown. Expecting and nursing mothers should consult with their healthcare providers before taking it.
Warnings
This medicine should not be taken by those who have:
- Gastric bypass surgery
- Stomach stapling
- Toxic megacolon or ulcerative
- Perforated bowel
- Bowel obstruction
- Kidney disease
Precautions
You should inform your healthcare provider if you have had any of these conditions before starting your treatment with Osmoprep:
- Cardiovascular diseases
- Dehydration
- Electrolyte imbalance
- Seizures
- Gastroesophageal reflux disease (GERD)
- Stomach surgery
- Intestinal disorder (inflammatory bowel disease or ulcerative colitis)
- Trouble swallowing
- Withdrawal from alcohol or drug addiction
Kidney Disease
Osmoprep has been linked to kidney diseases. Be sure to mention to your prescriber if you are:
- Over 55 years of age
- Have dehydration, cardiovascular and abdominal problems
- Taking medicines to treat cardiovascular disease, high blood pressure, or certain NSAIDs

OsmoPrep Side Effects
This is not the complete list of the Osmoprep. These side effects vary from patient to patient and not everyone taking this medication may experience these reactions.
Experiencing side effects means you should not stop taking the medicine. Contact your healthcare provider if you are having any of these symptoms. Your doctor will guide you in managing the side effects of Osmoprep. They may also change the dosage or remove this medication from the treatment plan, if these side effects worsen your condition or persist.
In case of serious side effects, stop taking the medicine and seek immediate medical attention.
You should stop taking OsmoPrep and seek medical assistance if you get an allergic reaction (swelling on your face, lips, tongue, or throat hives along with dizziness, wheezing, difficulty breathing, and hives) to it.
Mild Side Effects
- Vomiting
- Nausea
- Bloating
Serious Side Effects
- Dizziness
- Headache
- Seizures (convulsions or black-out)
- Little to no urination
- Irregular heart function
- Severe stomach/abdominal pain
- Rectal bleeding or red stools
- No bowel movement after taking this medicine

Drug Interactions with OsmoPrep
Certain medications may reduce the efficacy of OsmoPrep when taken together. These interactions can also put you at risk of serious side effects.
You should address your concerns about the possible interactions with Osmoprep before taking the medicine.
You should share the list of the any medications (this includes: prescription, over-the-counter, supplements, and hormonal drugs) you are taking along with your daily consumption of alcohol, caffeine, or street drugs for safe and effective treatment.
Your healthcare provider may recommend you make dietary and lifestyle changes for safe and effective use of the medicine.
The drugs/medication that could interact with this medicine are:
- Abilify (aripiprazole)
- Cymbalta (duloxetine)
- Baclofen
- Acetaminophen
- Amitriptyline
- Amoxicillin
- Cipro (ciprofloxacin)
- Augmentin (amoxicillin/clavulanate)
- Nexium (esomeprazole)
- Trazodone
- Lorazepam
- Benadryl (diphenhydramine)
- Benzonatate
- Doxycycline
- Folic Acid
- Lyrica (pregabalin)
- Gabapentin
- Ibuprofen
- Prednisone
- Xanax (alprazolam)
- Metformin

Strengths and Dosages of OsmoPrep
Osmoprep contains the following (active and inactive) ingredients and can be found in these strengths:
| Active Ingredients | Strengths | Inactive Ingredients |
| Sodium Phosphate, Monobasic, Monohydrate, | 1.102 g in 1.5 g | Polyethylene Glycol 8000 |
| Sodium Phosphate, Dibasic, Anhydrous | 0.398 g in 1.5 g | Magnesium Stearate |
Contact your healthcare provider if you do not understand the directions provided to you.
Drink plenty of water before, during, and after taking this medicine to avoid getting dehydrated. Avoid milk, liquids that are colored red or purple, and juice with pulp, or alcoholic beverages.
Carefully follow your doctor’s dosing instructions about the timing of this medication and your procedure.
Dosage
Get in touch with your healthcare provider if you missed a dose or could not finish the required doses before your procedure. Avoid taking more than the recommended dose of this medicine.
The recommended dose of OsmoPrep for colon cleansing in adult patients is:
- The evening before the procedure: Four tablets with eight ounces of liquids every 15 minutes for a total of 20 tablets.
- On the day of the procedure: Four tablets with eight ounces of liquids every 15 minutes for a total of 12 tablets three to five hours before.

OsmoPrep Alternatives
Your healthcare provider will prescribe OsmoPrep after judging that the benefits of the medicine are higher than the risk of interactions and side effects.
The below-mentioned alternatives have their pros and cons, and you should not switch to different versions of this medication without your doctor’s approval.
Your healthcare provider may remove OsmoPrep from your treatment plan and prescribe alternative versions of the medicine if your condition worsens.
The alternatives to this medicine are:
- MiraLAX
- Magnesium Oxide
- Bisacodyl
- Erythromycin
- Dulcolax
- Docusate
- Colace
- MoviPrep

FAQs of OsmoPrep
What does OsmoPrep treat?
OsmoPrep is used to cleanse the colon before a colonoscopy procedure. It helps clear the intestines of the stool, making it easier for the doctor to see the inside of the colon during the exam.
How big are OsmoPrep tablets?
OsmoPrep tablets are small, oval-shaped, and typically about the size of an average pill, making them easy to swallow.
When is the best time to take Osmoprep?
The best time to take OsmoPrep is usually the day before your colonoscopy, following a specific schedule provided by your doctor. Typically, this involves taking the first dose in the evening and the second dose a few hours later.
How long does it take for OsmoPrep to work?
OsmoPrep usually starts working within 30 minutes to 6 hours after the first dose. It is important to stay near a bathroom during this time as the medication will cause frequent bowel movements.
How long does OsmoPrep stay in your system?
OsmoPrep generally stays in your system for about 24 hours. However, the active ingredients are usually eliminated from your body through bowel movements within a few hours after the last dose.
What are the common side effects of OsmoPrep?
Common side effects of OsmoPrep include nausea, bloating, abdominal pain, and vomiting. Most side effects are mild and resolve on their own, but you should contact your doctor if they persist or worsen.
Can I eat or drink before taking OsmoPrep?
It is recommended to follow a clear liquid diet the day before your colonoscopy and to avoid solid foods. Your doctor will provide specific instructions on what you can eat or drink before and after taking OsmoPrep.
Is OsmoPrep safe for everyone to use?
OsmoPrep is not suitable for everyone. It should not be used by individuals with certain medical conditions, such as kidney disease, heart failure, or electrolyte imbalances. You should always consult your doctor before using OsmoPrep to ensure it is safe for you.
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IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.