Linzess (Linaclotide)
Linzess is a prescription oral capsule used to treat certain constipation-related conditions, including IBS-C and chronic idiopathic constipation in adults. It is also approved for certain pediatric patients with IBS-C or functional constipation, depending on age.
We only dispense medications with a valid prescription from a licensed prescriber.
All prescriptions are reviewed and verified before dispensing. Orders may be delayed or declined if prescription details are missing, do not match the patient information on file, appear altered, or are expired. We may also refuse service if we believe an order is intended for resale or redistribution.
What You Receive
- Linzess (or approved substitute) in sealed manufacturer packaging
- Personalized prescription instructions based on your prescriber’s directions
- Medication information leaflet provided by the manufacturer
- Itemized invoice detailing your order
- Rx Required
From $59.95 – $167.32
Shipping & Delivery
- Shipped from licensed pharmacy partners
- Tracking information is provided once your order ships
Delivery times may vary based on location and prescription verification.
This page is for general information only and is not medical advice. For medical questions, please speak with your prescriber. See Sources & Methodology for how this information is reviewed and referenced.
Linzess Key Facts
What Linzess is
Linzess is a prescription medicine that contains linaclotide. It is a guanylate cyclase-C (GC-C) agonist and comes as an oral capsule.
What it’s used for
Linzess is used for:
IBS-C in adults and pediatric patients 7 years of age and older
Chronic idiopathic constipation (CIC) in adults
Functional constipation (FC) in pediatric patients 6 years of age and older
How it works
Linzess works locally in the intestines by activating GC-C receptors, which increases intestinal fluid and helps move stool through the gut more easily.
Linzess Safety Overview
Linzess has an important boxed warning for serious dehydration in children younger than 2 years old.
Linzess Warnings & Precautions
Another key warning is severe diarrhea, which may require stopping the medication and rehydration.
Do not use Linzess if:
- The patient is less than 2 years of age
- You have a known or suspected mechanical gastrointestinal obstruction
Key warnings to know
- Serious dehydration risk in pediatric patients less than 2 years old (boxed warning)
- Severe diarrhea can happen and may require stopping treatment and rehydration
- Accidental ingestion by children can be dangerous
- Store Linzess securely and out of reach of children
- Contact your prescriber if symptoms become severe or unusual
Side Effects and When to Get Help
Diarrhea is the most common side effect of Linzess and can sometimes be severe. Most side effects are stomach-related, but severe diarrhea or severe abdominal symptoms need urgent attention.
Possible side effects may include
- Diarrhea
- Gas
- Abdominal pain
- Abdominal bloating or distension
Get urgent help right away for
- Severe diarrhea, especially if it is persistent or worsening
- Severe stomach-area pain, especially with bright red blood in stool or black/tarry stools
Interactions
The FDA label notes no formal drug-drug interaction studies were conducted, and clinically meaningful interactions are not expected through common CYP enzymes or transporters because systemic exposure is negligible. You should still review your full medication list with your prescriber.
Interactions you should discuss with your prescriber include
- Prescription medicines
- Over-the-counter medicines
- Vitamins
- Herbal supplements
- Other constipation medicines or laxatives
Linzess Drug Facts
| Category | Details |
|---|---|
| Brand Name | Linzess |
| Drug Class | Guanylate cyclase-C (GC-C) agonist |
| Indication | IBS-C (adults, pediatric 7+); CIC (adults); FC (pediatric 6+) |
| Dosage Forms | Oral capsules |
| Strengths | 72 mcg, 145 mcg, 290 mcg |
| Administration Timing | Once daily, empty stomach, at least 30 minutes before a meal |
| Boxed Warning | Serious dehydration risk in children <2 years; do not use in patients <2 years or with known/suspected mechanical GI obstruction |
| Storage | Room temperature; keep in original bottle; protect from moisture; keep tightly closed; keep desiccant in bottle |
| Missed Dose | Skip missed dose; take next dose at regular time; do not take 2 doses at once |
| Alternatives | Trulance (plecanatide), Amitiza (lubiprostone), Ibsrela (tenapanor) |
Helpful Information
How To Buy Linzess Online
1
Select Your Prescribed Linzess Dosage & Strength
Choose the strength and quantity that matches your prescription, then add it to your cart. Orders are limited to a 90-day supply per fill.
2
Complete Checkout
Ensure your shipping and contact information is correct so your order can be processed without delays.
3
Submit Your Linzess Prescription
Upload your prescription at checkout. If you need a transfer, provide your prescriber or current pharmacy details and we will request it on your behalf.
Prescription & Dispensing Standards
- Prescription required for all orders and reviewed for pharmacy and regulatory compliance
- Dispensed by licensed pharmacy partners
- Orders are held if information is missing, unclear, or does not match.
- No substitutions without prescriber approval, and no controlled substances.
Our Guarantee
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Linzess (or approved substitute) at a discounted rate, call 1-888-551-2467.
FAQs
What is Linzess used for?
Linzess is used for IBS-C in adults and pediatric patients 7 years and older, CIC in adults, and functional constipation in pediatric patients 6 years and older.
How should I take Linzess?
Take Linzess once daily on an empty stomach at least 30 minutes before a meal, at approximately the same time each day. Swallow the capsule whole (do not crush or chew).
What if I miss a dose of Linzess?
Skip the missed dose and take your next dose at the regular time. Do not take 2 doses at the same time.
Can I open the Linzess capsule if I cannot swallow it?
Yes. The label includes instructions for opening the capsule and administering it with applesauce or water for patients who cannot swallow capsules whole.
What side effect should I watch for most closely?
Diarrhea is the most common side effect and can be severe. Stop Linzess and contact your healthcare provider right away if you get severe diarrhea.
Ordering & Prescription FAQs
Do I need a prescription?
Yes, a prescription is required. Refills depend on what your prescriber authorizes.
How do I submit my prescription?
You can upload it through our Upload Prescription page, email it to info@myrxoutlet.com, or fax it to 1-888-230-1245. If you need a prescription transfer, just let us know at checkout and include your pharmacy or prescriber contact details.
When is my payment processed?
Your payment is processed only after your prescription and order have been reviewed and approved by our licensed pharmacy team. Once everything is confirmed, we’ll process payment and prepare your order for shipping.
What happens if my prescription can’t be verified?
Your order may be placed on hold or declined if prescription details are missing, don’t match, are expired, or can’t be confirmed.
Sources
FDA Prescribing Information / Medication Guide, LINZESS (linaclotide) capsules
https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/202811s022lbl.pdf
DailyMed Drug Label / Medication Guide, LINZESS (linaclotide) capsule
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=09beda19-56d6-4a56-afdc-9a77b70b2ef3