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Papaverine (Injection)
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Papaverine is a medicine that treats conditions with blood circulation problems and helps your blood flow through veins and arteries. The medicine also treats conditions causing spasms of smooth muscle such as chest pain, heart attack, or stomach and gallbladder disorders.
Your healthcare provider may prescribe Papaverine to treat conditions other than those mentioned above.
It is available in oral or injectable solution.
Precautions and Warnings with Papaverine
The effects of Papaverine on an unborn baby are unknown. You should tell your healthcare provider if you are pregnant or plan to become pregnant while taking the medication.
It is unknown if the medicine passes into a nursing baby through breast milk. You should inform your doctor if you are breastfeeding while taking Papaverine.
Papaverine is not recommended as a sexual aid for patients with erectile dysfunction (impotence). If the medicine is injected into the penis, it may cause a painful or prolonged erection that may require surgery.
You should not take Papaverine if you have a cardiovascular condition called “Atrioventricular (AV) block.”
You should inform your healthcare providers if you have a history of the following conditions:
- Liver disease
- Glaucoma
- High blood pressure
- Heart disease
Papaverine Side Effects
This is not the complete list of side effects that may occur when taking Papaverine. It varies from patient to patient, and not everyone may experience them.
Common or mild side effects are temporary and go away on their own as the body adjusts to Papaverine during the treatment. You should inform your healthcare provider if you are experiencing serious side effects of the medicine.
Your healthcare provider may change the dose or switch to an alternative if the side effects persist.
You may experience side effects while taking the medicine. You should stop the medicine if you have allergic reactions (swelling, respiratory problems, and hives) after a dose.
Mild Side Effects
- Fatigue
- General ill feeling
- Abdominal issues (diarrhea, constipation, nausea, and loss of appetite)
- Headache
- Dizziness or spinning sensation
- Drowsiness
- Increased sweating
- Skin rash
Serious Side Effects
- Swelling, redness, or pain where Papaverine was injected
- Severe tingling
- Muscle weakness
- Severe headache
- Vision changes
- Loss of appetite
- Extreme drowsiness
- Jaundice
- Irregular heart function
- Dark urine
- Respiratory issues
- Anxiety
- Clay-colored stools
- Pounding in your neck or ears
- Upper stomach pain
Drug Interaction with Papaverine
You should share the list of the products (prescription, over-the-counter, supplement, or hormonal drugs) and your daily intake of alcohol, nicotine, caffeine, and street drugs for safe and effective treatment.
Remember, your healthcare provider will prescribe Papaverine after judging that its benefits are higher than the risk of drug interactions or side effects.
There are certain medicines that can reduce the efficacy of Papaverine when they are taken together. These drug interactions may put you at risk of serious side effects or worsen your condition.
The medicines which may interact with Papaverine are:
- Aspirin
- Adrenalin (epinephrine)
- Benadryl (diphenhydramine)
- Celebrex (celecoxib)
- Cialis (tadalafil)
- CoQ10 (ubiquinone)
- Eliquis (apixaban)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flonase (fluticasone nasal)
- L-Arginine (arginine)
- Metoprolol
- MiraLAX (polyethylene glycol 3350)
- Neurontin (gabapentin)
- Paracetamol (acetaminophen)
- Prilosec (omeprazole)
- Tylenol (acetaminophen)
- Viagra (sildenafil)
- Vitamin B1, B12, B6, C, D3 and K1
- Xarelto (rivaroxaban)
Papaverine Cost in America Without Insurance
A 20-milliliter Papaverine (30 mg/mL) injectable solution will set you back between $341 to $392, whereas a 2 mL vial of 30 mg/mL costs around $63.85 without insurance in the United States.
Papaverine is expensive in the United States as it is produced by few manufacturers in the country and this allows them to set high prices. The manufacturing process requires research and development costs for pharmaceutical companies which are reflected in the price.
It is a branded medicine and they are expensive than their generic counterparts.
Strengths and dosages of Papaverine
Papaverine is available in oral tablets and injections
It active ingredients include papaverine hydrochloride, while the inactive ingredients include edetate disodium, sodium citrate, citric acid, monohydrate, and water.
Papaverine should be taken exactly as prescribed by your healthcare provider or according to the instructions on the description label.
| Forms | Quantity | Dosage Frequency | Additional Information |
| Extended-release capsules | 150 mg | Every twelve hours | The dose can be increased to 150 mg every eight hours or 300 mg every twelve hours. |
| Tablets | 100 to 300 mg | Three to five times a day | – |
| Injection | 1 to 4 mL | Every three hours | Two doses may be given 10 minutes apart in treating cardiac extrasystoles |
The capsule and tablets should be swallowed whole. You should not crush, break, or chew before swallowing. You may mix the contents with jam or jelly and swallow without chewing if the capsule is too large to swallow.
If you have missed a dose of this oral form of the medicine, it should be taken as soon as possible. You should skip the missed dose and go back to your regular dosing schedule if it’s time for the next one. You should not double dose to make up for the missed one.
Papaverine Alternatives
Your healthcare provider may switch your treatment plan from Papaverine to other versions of the medicines as they have the same functions.
You must consult with your doctor or healthcare provider before switching to these alternatives. Your physician can assist you in understanding the risks associated with these above-mentioned medicines.
Your doctor may remove Papaverine if the drug interactions or side effects worsen your condition.
- Edex
- Cialis
- Alprostadil
- Vardenafil
- Caverject
- Viagra
FAQs of Papaverine
What is Papaverine used for?
Papaverine is prescribed to improve blood flow in patients with blood circulation problems. It relaxes blood vessels, making it easier for blood to flow through the body. It is also used to treat conditions that cause muscle spasms, such as chest pain and certain gastrointestinal issues.
How is Papaverine administered?
Papaverine can be administered orally in tablet or extended-release capsule form or via injection in a clinical setting. The oral tablets are typically taken three to five times a day, while the extended-release capsules are taken every 8-12 hours.
What are the common side effects of Papaverine?
Common side effects include nausea, dizziness, flushing, headache, and gastrointestinal issues such as constipation or diarrhea. More severe side effects may include jaundice, irregular heartbeat, or severe allergic reactions.
Can Papaverine be taken during pregnancy or breastfeeding?
The effects of Papaverine during pregnancy and breastfeeding are not well-studied. It is essential to discuss with a healthcare provider if you are pregnant or planning to become pregnant or if you are breastfeeding before taking this medication.
What precautions should be taken before using Papaverine?
Before taking Papaverine, inform your doctor if you have any allergies or heart conditions (such as AV block) or are taking other medications. It may cause drowsiness or dizziness, so caution is advised when driving or operating machinery.
What should I do if I miss a dose of Papaverine?
If you are taking Papaverine orally and miss a dose, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
What happens if I overdose on Papaverine?
An overdose of Papaverine can lead to symptoms such as extreme drowsiness, dizziness, vomiting, and fast heartbeats. In case of an overdose, seek emergency medical assistance immediately.
Are there any drug interactions with Papaverine?
Papaverine may interact with other medications, particularly those affecting heart rhythm or blood pressure. It is crucial to inform your healthcare provider about all medications you are taking to avoid potential interactions.
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At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Papaverine at a discounted rate, call 1-888-551-2467.
IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.
