Qtern is a prescription medication that combines two active ingredients: dapagliflozin and saxagliptin. It is mainly used to treat type 2 diabetes in adults. The combination of these two drugs helps in controlling blood sugar levels effectively. Dapagliflozin belongs to a class of medications called SGLT2 inhibitors, while saxagliptin falls under the DPP-4 inhibitor class.

Qtern is specifically designed for adults who have been diagnosed with type 2 diabetes. It is not intended for people with type 1 diabetes or those with diabetic ketoacidosis. If you have a history of severe kidney problems or are allergic to any of the active ingredients in Qtern, this medication may not be suitable for you. Always consult your healthcare provider to determine if Qtern is the right choice for managing your diabetes.

Type 2 Diabetes

Type 2 Diabetes is a chronic metabolic disorder characterized by high blood glucose levels (hyperglycemia) resulting from the body’s ineffective use of insulin. Insulin is a hormone produced by the pancreas that helps regulate blood sugar levels. In Type 2 Diabetes, the body either doesn’t produce enough insulin or becomes resistant to its effects.

Type 2 Diabetes develops due to a combination of genetic and lifestyle factors. While genetics can predispose individuals to the condition, lifestyle choices play a crucial role in its development. The primary causes of Type 2 Diabetes include:

  1. Genetics: Family history of Type 2 Diabetes can increase the risk of developing the condition.
  2. Obesity: Excess body weight, especially abdominal fat, is a significant risk factor.
  3. Physical Inactivity: Lack of regular physical activity can contribute to insulin resistance.
  4. Unhealthy Diet: A diet high in refined carbohydrates, sugary beverages, and saturated fats increases the risk.
  5. Age: The risk of Type 2 Diabetes increases with age, particularly after 45 years.


  1. Frequent Urination: Increased need to urinate, especially at night.
  2. Excessive Thirst: Feeling constantly thirsty and unable to quench it.
  3. Unexplained Weight Loss: Losing weight without trying can be a warning sign.
  4. Fatigue: Feeling tired and lacking energy throughout the day.
  5. Blurred Vision: Vision may become blurry due to high blood sugar levels.
  6. Slow Healing: Cuts and wounds taking longer to heal.

Warnings and Precautions

If you or a loved one is taking Qtern for diabetes management, it’s crucial to be aware of potential risks and necessary safety measures.

  1. Consult Your Healthcare Provider: Always consult your healthcare provider before starting or discontinuing Qtern. They can assess your medical history and current conditions to determine if it’s safe for you.
  2. Not Suitable for Type 1 Diabetes: Qtern is only suitable for type 2 diabetes patients and should not be used by individuals with type 1 diabetes.
  3. Allergies to Ingredients: Inform your doctor if you have allergies to dapagliflozin, saxagliptin, or any other ingredients in Qtern.
  4. Kidney Function Tests: Regularly monitor kidney function as Qtern may affect kidney health.
  5. Increased Urination: Qtern may cause increased urination. Stay hydrated to prevent dehydration.
  6. Ketoacidosis Risk: Watch out for symptoms of ketoacidosis, such as nausea, vomiting, abdominal pain, and difficulty breathing. Seek immediate medical attention if you experience these symptoms.
  7. Pancreatitis Warning: Pay attention to signs of pancreatitis, such as severe abdominal pain that may spread to your back. Seek medical help if you suspect pancreatitis.
  8. Heart Failure: Individuals with a history of heart failure should use Qtern with caution. Monitor heart health regularly.
  9. Low Blood Sugar (Hypoglycemia): Be aware of the signs of low blood sugar, including sweating, dizziness, confusion, and trembling. Always keep a source of sugar on hand to raise blood sugar levels if needed.
  10. Joint Pain: Some patients may experience joint pain while taking Qtern. Inform your doctor if you encounter this symptom.
  11. Frequent Infections: Qtern may increase the risk of urinary tract infections. Report any signs of infection to your doctor.
  12. Skin Rashes: If you develop a severe rash while using Qtern, discontinue use and seek medical advice.
  13. Hypersensitivity Reactions: Watch for signs of hypersensitivity reactions, such as swelling of the face, lips, tongue, or throat. Seek immediate medical attention in such cases.
  14. Increased Cholesterol Levels: Qtern may elevate cholesterol levels. Monitor your cholesterol regularly.
  15. Lactic Acidosis: Rare cases of lactic acidosis have been reported with Qtern use. Inform your doctor if you experience muscle pain, difficulty breathing, or stomach discomfort.
  16. Drug Interactions: Inform your healthcare provider about all the medications, supplements, or herbal products you are taking, as they may interact with Qtern.
  17. Pregnancy and Breastfeeding: Consult your doctor before using Qtern during pregnancy or breastfeeding.
  18. Pediatric Use: Qtern is not recommended for use in pediatric patients.
  19. Geriatric Considerations: Geriatric patients may be more prone to side effects. Caution is advised in this population.
  20. Driving and Machinery: Qtern may cause dizziness or drowsiness. Avoid activities that require alertness until you know how it affects you.
  21. Alcohol Consumption: Limit alcohol intake while on Qtern, as it may increase the risk of hypoglycemia.
  22. Storage and Expiry: Store Qtern as per the manufacturer’s instructions and check the expiration date before use.
  23. Emergency Contact: Keep a list of emergency contacts with you in case of severe reactions.
  24. Lifestyle Factors: Maintain a healthy lifestyle with balanced nutrition and regular exercise while using Qtern.
  25. Discontinuation: Never stop or change the dosage of Qtern without consulting your doctor.

Side Effects

While Qtern proves beneficial for many individuals, it is essential to recognize that like any medication, it may also cause side effects.

Common Side Effects

  1. Frequent Urination: One of the common side effects of Qtern is increased urination due to the presence of dapagliflozin, which encourages the excretion of glucose in the urine.
  2. Genital Infections: Some patients using Qtern may experience genital yeast infections or urinary tract infections, primarily resulting from increased sugar levels in the urinary tract.
  3. Nasopharyngitis: Nasopharyngitis, commonly known as the common cold, may occur as a mild side effect in some individuals using Qtern.
  4. Headaches: Headaches are a common occurrence among individuals initiating Qtern therapy. Usually, they are temporary and subside as the body adapts to the medication.
  5. Low Blood Sugar (Hypoglycemia): While Qtern itself is not known to cause hypoglycemia, when taken in combination with other diabetes medications like insulin or sulfonylureas, there is a slight risk of low blood sugar.
  6. Diarrhea: Some individuals may experience diarrhea as a side effect of Qtern, often during the initial stages of treatment.

Rare Side Effects

  1. Ketoacidosis: In rare cases, patients using Qtern may develop ketoacidosis, a serious condition where the body produces high levels of blood acids called ketones. This may occur in individuals with insufficient insulin levels.
  2. Allergic Reactions: Although rare, some individuals may experience allergic reactions to Qtern, which may manifest as skin rashes, itching, swelling, or difficulty breathing. Immediate medical attention is necessary in such cases.
  3. Pancreatitis: There have been rare reports of pancreatitis in individuals using Qtern. Symptoms may include severe abdominal pain, nausea, and vomiting.
  4. Acute Kidney Injury: In isolated cases, Qtern may lead to acute kidney injury, characterized by a sudden decrease in kidney function. This condition requires immediate medical intervention.
  5. Bone Fractures: Some studies suggest that SGLT2 inhibitors like dapagliflozin may increase the risk of bone fractures, although the association with Qtern is yet to be definitively established.

Severe Side Effects

  1. Cardiovascular Events: While Qtern itself is not known to cause cardiovascular events, it is essential to consider individual risk factors, especially in patients with a history of heart diseases.
  2. Fournier’s Gangrene: In very rare instances, SGLT2 inhibitors have been associated with Fournier’s gangrene, a potentially life-threatening bacterial infection affecting the genital or perineal area.
  3. Dehydration: Qtern may lead to dehydration, particularly in elderly patients or those taking diuretics, increasing the risk of adverse effects on kidney function.
  4. Urinary Tract Obstruction: Although rare, some individuals may experience urinary tract obstruction due to increased urine production with Qtern.
  5. Hypersensitivity Reactions: Severe allergic reactions to Qtern may occur in rare cases, resulting in anaphylactic shock, a medical emergency requiring immediate treatment.


While Qtern can be highly effective in treating diabetes, it’s essential to be aware of potential interactions with other drugs, herbs, and certain foods. Understanding these interactions will ensure that you can safely incorporate Qtern into your diabetes management plan without adverse effects.

Drug Interactions

  1. Insulin and Other Diabetes Medications: Combining Qtern with other diabetes medications or insulin may increase the risk of hypoglycemia (low blood sugar). Your healthcare provider will carefully adjust the dosages to prevent this complication.
  2. Diuretics (Water Pills): Diuretics can reduce blood pressure and lead to dehydration. When taken with Qtern, there might be an increased risk of low blood pressure and kidney problems. Regular monitoring is essential.
  3. Beta-Blockers: These medications are commonly prescribed for heart conditions. When taken with Qtern, they may mask some symptoms of hypoglycemia, making it challenging to detect and treat low blood sugar levels.
  4. Certain Antifungal Medications: Some antifungal drugs, such as ketoconazole, itraconazole, and fluconazole, may interfere with the breakdown of Qtern in the body, potentially leading to higher drug levels.
  5. Blood Pressure Medications: Qtern can have a mild diuretic effect, and when combined with other blood pressure medications, it may lead to a more significant decrease in blood pressure. Close monitoring is essential to prevent complications.

Herbal Interactions

  1. Ginseng: Ginseng may lower blood sugar levels. Combining it with Qtern could lead to hypoglycemia. Monitor your blood sugar levels regularly and inform your healthcare provider if you notice any significant changes.
  2. Aloe Vera: Aloe vera supplements may also lower blood sugar levels, and when taken with Qtern, it might amplify this effect.
  3. Garlic: Garlic is known for its various health benefits, but it may also affect blood sugar levels. Caution should be exercised when using garlic supplements with Qtern.
  4. Cinnamon: Cinnamon, often used to add flavor to foods, has been studied for its potential blood sugar-lowering effects. When used with Qtern, it may lead to additional reductions in blood sugar levels.

Food Interactions

  1. Alcohol: Consuming alcohol while taking Qtern can increase the risk of hypoglycemia. Alcohol can interfere with the liver’s ability to release stored glucose, leading to low blood sugar levels.
  2. Grapefruit: Grapefruit and its juice contain compounds that can affect the way Qtern is metabolized in the body, potentially leading to higher drug levels.
  3. High-Carbohydrate Foods: Large quantities of high-carbohydrate foods can raise blood sugar levels. When taking Qtern, it’s essential to maintain a balanced diet and monitor carbohydrate intake.
  4. Caffeinated Beverages: Caffeine can affect blood sugar levels and may interact with Qtern’s action. Moderation is key when consuming caffeinated beverages.
  5. Sugary Snacks: Consuming sugary snacks without proper meal planning may lead to spikes in blood sugar levels, making it challenging to manage diabetes effectively.


To ensure you use Qtern effectively and safely, it’s essential to understand the dosing guidelines for different situations.

Initial Dosing

When beginning treatment with Qtern, it’s crucial to follow the appropriate initial dosing recommendations. The initial dosing may vary depending on several factors, such as the patient’s current medications, renal function, and individual response to treatment.

It is recommended to take one tablet of Qtern orally once daily. Each tablet contains the combination of 10 mg dapagliflozin and 5 mg saxagliptin. The medication can be taken with or without food, but it’s best to take it around the same time every day to establish a routine.

The initial dose helps the body adapt to the medication and minimizes the risk of potential side effects. It is important to keep a close eye on blood glucose levels during this phase, as it allows healthcare providers to assess the patient’s response to the treatment.

Maintenance Dosing

After the initial dosing phase, the patient will transition into the maintenance dosing stage. Maintenance dosing is crucial for achieving and sustaining stable blood sugar levels over the long term. In this phase, the dosage typically remains the same as the initial dose, but adjustments may be made depending on the individual’s response to treatment and any changes in their health status.

The maintenance dose is generally one tablet of Qtern (10 mg dapagliflozin/5 mg saxagliptin) taken once daily. Adherence to the dosing schedule is essential for the medication to be effective in managing diabetes.

During the maintenance phase, regular check-ups with a healthcare provider are recommended to monitor the patient’s progress and make any necessary adjustments to the dosage or treatment plan.

Missed Dose

While it’s crucial to adhere to the dosing schedule, there might be instances when a dose of Qtern is missed. In such cases, it’s essential to follow specific guidelines to ensure the continuity of treatment and prevent any adverse effects on blood glucose control.

If a dose of Qtern is missed, the patient should take it as soon as they remember. However, if it is almost time for the next scheduled dose, it is advisable to skip the missed dose and resume the regular dosing schedule. It’s important not to take a double dose to make up for the missed one.

If the patient is unsure about what to do after missing a dose or if they have any concerns, they should contact their healthcare provider for guidance.


An overdose of Qtern can be dangerous and requires immediate medical attention. It’s crucial to be vigilant and take preventive measures to avoid an accidental overdose.

If an overdose is suspected, emergency medical help should be sought without delay. Common signs of an overdose may include severe hypoglycemia (low blood sugar levels), dizziness, confusion, fainting, or difficulty breathing.

Preventing overdose is essential, and patients should strictly adhere to the prescribed dosage and never take more Qtern than recommended by their healthcare provider.


Proper storage of Qtern is crucial to preserve its efficacy and prevent any potential harm.

  1. Store at Room Temperature: Keep Qtern at room temperature between 68°F and 77°F (20°C and 25°C) away from direct heat and light.
  2. Keep Away from Moisture: Protect Qtern from moisture by storing it in a tightly closed container.
  3. Avoid Extreme Temperatures: Do not store Qtern in places with extreme temperatures, such as in a refrigerator or a car during hot summer days.
  4. Keep Out of Reach of Children: Store Qtern in a secure location, out of reach of children, to prevent accidental ingestion.
  5. Follow the Expiration Date: Always check the expiration date on the packaging and do not use Qtern if it has expired.
  6. Do Not Repackage: Keep Qtern in its original container, and do not transfer it to smaller containers or pill organizers.
  7. Discard Damaged Pills: If you notice any damage, discoloration, or unusual odor on Qtern tablets, do not use them; instead, contact your pharmacist.
  8. Avoid Sun Exposure: Store Qtern away from direct sunlight, as exposure to sunlight may affect its potency.
  9. Keep in a Cool, Dry Place: Choose a cool, dry place away from the bathroom and kitchen sink to store Qtern.
  10. Follow Package Instructions: Adhere to any specific storage instructions provided on the Qtern package.
  11. Do Not Freeze: Do not freeze Qtern, as extreme cold can alter its effectiveness.
  12. Store Away from Appliances: Avoid storing Qtern near appliances that generate heat, such as stoves or radiators.
  13. Maintain Original Packaging: Keep Qtern in its original blister pack or bottle with the label intact for proper identification.
  14. Keep It Sealed: Always reseal the Qtern container immediately after use to maintain its integrity.
  15. Check for Clumping: Examine Qtern tablets regularly for clumping, and do not use if they have adhered together.
  16. Consult Pharmacist or Healthcare Provider: If you have any doubts about storage or handling, consult your pharmacist or healthcare provider.
  17. Away from Pets: Ensure that Qtern is stored away from pets to prevent accidental ingestion.
  18. Monitor Storage Conditions: Regularly monitor the storage conditions to ensure they remain appropriate.
  19. Keep It Dry: Protect Qtern from humidity and dampness, as moisture can reduce its effectiveness.
  20. Dispose of Expired Medication Properly: When Qtern reaches its expiration date, dispose of it following proper medication disposal guidelines.
  21. Store in Original Container: Store Qtern in its original packaging, which is designed to protect it from external factors.
  22. Keep It in a Dark Place: Shield Qtern from light exposure by storing it in a dark place or using a light-resistant container.
  23. Avoid Glass Containers: Opt for plastic or non-glass containers to store Qtern to avoid potential breakage.
  24. Properly Seal Bottles: Ensure that Qtern bottles are tightly sealed to prevent moisture and air exposure.
  25. Store Away from Medication with Similar Names: Avoid storing Qtern near medications with similar names to prevent mix-ups.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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