Avandamet is a diabetes medication that mixes two other medications, metformin and rosiglitazone. It’s used with exercise and a proper diet to control blood sugar levels for patients with type 2 diabetes. It’s not used for type 1. It takes just a few minutes to start lowering blood sugar. It’s often used by diabetic patients who have little control over their blood sugar and who can’t use other oral diabetes drugs.

This medication is part of a drug class called thiazolidinediones. Avandamet works by assisting insulin in working better, so the body’s cells can more easily receive glucose. Metformin, one of the active ingredients, causes the liver to make less glucose and makes it easier for glucose to get into various body tissues.

When patients can control their blood glucose levels, it can help delay or even prevent diabetes complications like blindness and heart disease. It can take two to three months for this medication’s full effects to be seen. It isn’t used in patients who are taking insulin.

Precautions and Warnings of Avandamet

Don’t take this medication if you are allergic to its ingredients. It’s also best not to use this drug if you are pregnant and breastfeeding. If you have a current serious infection, and trauma to your body, or have recently had surgery, your doctor likely won’t prescribe you this medication.

Ensure that your doctor knows all about your medical history, including any conditions you currently have. This is especially true if you have any history of lactic acidosis, have chronic or acute metabolic acidosis, or have heart failure. If you have type 1 diabetes, this isn’t the medication for your disease. If you have severely reduced function of the liver, kidney disease, or your kidneys function poorly, don’t use this medication. If you have severe dehydration, consume a lot of alcohol, or you have cardiovascular collapse or any condition that causes lowered blood oxygen levels, don’t take this medication.

If you have a test coming up that requires you to get contrast materials that include iodine in an intravenous injection, you may have to stop taking this medication for 48 hours before the test. Talk to your doctor about this test and get instructions for temporarily stopping the medication.

Avandamet can cause you to develop a severe health problem called lactic acidosis. If you get this condition, you may have an uneven or fast heartbeat, nausea and vomiting, muscle weakness or pain, dizziness, trouble breathing, feeling seriously tired or weak, stomach pain, or a cold or numb feeling in your legs and arms. This condition is more likely if you drink a lot of alcohol, have kidney or liver disease, or you’re 65 or older.

Bone fractures are possible in the feet, hands, or the upper arm. Women are more likely to have this complication. Women can also have their periods start up again after they had been gone for an extended period because of a medical condition. If this happens, be sure to use effective birth control. This medication shouldn’t be used if you’re breastfeeding. It’s also not for use in patients who are under 18.

Avandamet Side Effects

Several side effects may occur while you take this medication. Some may only last a few days to a few weeks as your body adjusts to taking the medication.

Common Side Effects

Some of the common side effects can include:

  • Nausea or upset stomach
  • Weight gain
  • Diarrhea
  • Vomiting
  • Tasting something metallic or unpleasant
  • Constipation
  • Stomach pain

Serious Side Effects

There are some side effects that are more serious and should be reported to your doctor as soon as you can. These include:

  • Muscle weakness or tenderness
  • Symptoms of fluid retention – rapid weight gain or swelling in the extremities
  • Symptoms of anemia – pale skin, fast heartbeat, being very tired or weak
  • Symptoms of low blood sugar – fatigue, dizziness, sweating, trembling, drowsiness, hunger, shakiness, headache
  • Symptoms of liver problems – stomach pain, dark urine, nausea, vomiting, loss of appetite, yellowing of the eyes or skin
  • Unexpected spotting or vaginal bleeding in those who use oral birth control pills
  • Changes to your vision

Severe Side Effects

If you have any of these symptoms, you need to stop taking the medication and get emergency medical care:

  • Chest pain
  • Symptoms of a heart attack – shortness of breath, sweating, anxiety, fear, sudden pain in the neck, jaw, back, arms, shoulder, or chest
  • Symptoms of a serious allergic reaction – swelling in your face or in your mouth, shortness of breath, or hives
  • Symptoms of fluid accumulating in your lungs – serious shortness of breath that gets even worse when you lie down
  • Symptoms of heart failure – getting easily fatigued, short of breath, or swelling in the feet or ankles
  • Symptoms of swelling or fluid in the back part of the eye – decreased vision or blurry vision

Drug Interactions With Avandamet

There are a number of other drugs that can have a bad interaction with Avandamet. Your doctor needs to know everything you take, even if it’s something over the counter. There are many other drugs that aren’t recommended to pair with Avandamet. There are also a number of drugs that aren’t recommended but may be used together when it’s needed, including aspirin and ciprofloxacin.

Some of the medications that can interact badly include:

  • Acetrizoic acid
  • Ethiodized oil
  • Iobitridol
  • Iodamide
  • Iodoxamic acid
  • Ipodate
  • Metrizoic acid
  • Metrizamide
  • Tyropanoate Sodium

Strengths and Dosages of Avandamet

The two medications that make up Avandamet are found in this medication at various strengths. All of them are oral tablets. There is a strength that has 4 mg of rosiglitazone and 500 mg of metformin. There is a 2 mg rosiglitazone and 500 mg metformin. Then there is a 2 mg rosiglitazone with 1,000 mg metformin, and a 4 mg rosiglitazone and 1,000 mg metformin. The maximum dosage is 8 mg rosiglitazone and 2,000 mg metformin every day. Often, a smaller dose is started and then the strength goes up over time.

Rosiglitazone/Metformin
Avandamet tablets:2 mg/500 mg

4 mg/500 mg

2 mg/1,000 mg

4 mg/1,000 mg

FAQs of Avandamet 

What is Avandamet?

This is a medication for the treatment of type 2 diabetes. It’s often prescribed for patients who have tried other oral diabetes medications that didn’t work for them or had too many side effects.

What are the active ingredients in Avandamet?

There are two of them: metformin and rosiglitazone. Each is a type of diabetes drug that helps the body to use its insulin better.

Is there a generic for Avandamet ?

No, there is no generic of Avandamet.

When was this medication approved?

It was first approved in 2002.

Can you drink alcohol with Avandamet?

No, it’s best not to drink any alcohol while you’re taking it. Consuming alcohol with this medication can make it more likely that you’ll develop a severe condition called lactic acidosis.

Can I take Avandamet if I just had surgery?

No, it’s not recommended in patients who have recently had surgery.

Can I breastfeed while taking Avandamet?

No, it’s not recommended for breastfeeding mothers.

Can Avandamet make you gain weight?

Yes, this is one of the possible side effects. If you take it and have rapid weight gain, your doctor needs to know about it right away.

How long does it take for Avandamet to work?

It goes to work in minutes. However, it doesn’t get to its full effectiveness until about two to three months of taking it daily.

Are there alternatives to Avandamet?

There are many other diabetes medications on the market that treat type 2 diabetes. One of these is metformin, one of the active ingredients in Avandamet. Other alternatives for treatment include Mounjaro, Rybelsus, Victoza, Semaglutide and Januvia.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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