Farxiga is a medication used to treat type 2 diabetes mellitus. It belongs to a class of drugs called SGLT2 inhibitors, which work by helping the kidneys remove glucose from the bloodstream through the urine. This helps lower blood sugar levels in people with diabetes.

How Does Farxiga Work?

Farxiga works by inhibiting the sodium-glucose co-transporter 2 (SGLT2) in the kidneys. This transporter is responsible for reabsorbing glucose back into the bloodstream from the urine. By blocking SGLT2, Farxiga promotes glucose excretion in the urine, leading to lower blood sugar levels.

Precautions and Warnings of Farxiga

Before starting Farxiga, it is important to consider the following precautions and warnings:

  • Kidney Function: Farxiga may cause or worsen kidney problems. It is not recommended for use in patients with severe kidney impairment or those on dialysis.
  • Dehydration: Farxiga can lead to dehydration, especially in elderly patients or those taking diuretics.
  • Hypotension: Farxiga may cause a drop in blood pressure, particularly when initiating treatment or increasing the dosage.
  • Genital Yeast Infections: SGLT2 inhibitors like Farxiga may increase the risk of genital yeast infections, particularly in women.
  • Ketoacidosis: Farxiga may increase the risk of ketoacidosis, a serious condition where the body produces high levels of blood acids called ketones.

Farxiga Side Effects

While Farxiga is generally well-tolerated, like any medication, it may cause side effects in some individuals.

Common Side Effects

  • Genital yeast infection
  • Respiratory infections, such as the common cold or the flu
  • Urinary tract infection
  • Increased urination
  • Back pain
  • Nausea
  • Increased cholesterol levels
  • Constipation

Serious Side Effects

  • Dehydration (low fluid level), which can cause other problems such as low blood pressure. Symptoms can include:
    • Dizziness
    • Feeling faint
    • Lightheadedness
    • Weakness, especially when you stand up
    • Fatigue
    • Thirst
  • Hypoglycemia (low blood sugar level), if Farxiga is used in combination with insulin or a sulfonylurea drug such as glipizide (Glucotrol). Symptoms can include:
    • Drowsiness
    • Headache
    • Confusion
    • Weakness
    • Hunger
    • Irritability
    • Sweating
    • Feeling jittery
    • Fast heart rate
  • Severe allergic reaction
  • Kidney damage
  • Serious urinary tract infections (UTIs)
  • Ketoacidosis
  • Fournier’s gangrene (necrotizing fasciitis of the perineum)

Drug Interactions With Farxiga

Farxiga may interact with other medications, supplements, or substances, potentially affecting its effectiveness or increasing the risk of adverse effects. Some notable drugs that may interact with Farxiga include:

CategoryExamples
Alpha Lipoic Acid
AndrogensTestosterone
Aspirin (ASA)
AntipsychoticsChlorpromazine, Clozapine, Olanzapine, Quetiapine (found in Seroquel), Risperidone
Bromocriptine
Buserelin
Ceritinib
Chloroquine
Dabrafenib
Danazol
Diabetes MedicationsChlorpropamide, Glyburide, Insulin, Metformin, Rosiglitazone (found in Avandamet)
Disopyramide
DiureticsFurosemide, Hydrochlorothiazide (found in Zestoretic), Triamterene
EstrogensConjugated Estrogen, Estradiol (Vagifem), Ethinyl Estradiol
Everolimus
Glucagon
GoserelinZoladex
Hepatitis C AntiviralsGlecaprevir and Pibrentasvir, Ledipasvir, Paritaprevir, Sofosbuvir, Velpatasvir
HIV Protease InhibitorsAtazanavir, Indinavir, Ritonavir (Norvir), Saquinavir
HydroxychloroquinePlaquenil
Lanreotide
LeuprolideLupron Depot
Mifepristone
Monoamine Oxidase Inhibitors (MAOIs)Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine (Parnate)
Niacin
Nilotinib
Octreotide
Oral CorticosteroidsDexamethasone, Hydrocortisone (found in Solu-Cortef), Prednisone
Pasireotide
Pegvisomant
Pentamidine
ProgestinsDienogest (Visanne), Levonorgestrel (found in Seasonique), Medroxyprogesterone, Norethindrone
Quinine
Quinolone AntibioticsCiprofloxacin, Levofloxacin (Levaquin)
Selective Serotonin Reuptake Inhibitors (SSRIs)Citalopram (found in Celexa), Fluoxetine (Prozac), Paroxetine (Paxil), Sertraline (Zoloft)
Sirolimus
Somatropin
Sulfonamide Antibiotics (“sulfas”)Sulfisoxazole, Sulfamethoxazole (found in Septra)
Sunitinib
Tacrolimus
Temsirolimus
Tramadol
Triptorelin
Vorinostat

Farxiga: Strengths and Dosages

Available Strengths

  • Farxiga 5 mg tablets
  • Farxiga 10 mg tablets
Recommended Dosage

The usual starting dose of Farxiga is 5 mg once daily, taken orally with or without food. For patients tolerating the 5 mg dose who require additional glycemic control, the dosage may be increased to 10 mg once daily.

Cost of Farxiga in America

The cost of Farxiga can vary depending on the dosage and quantity purchased:

Dosage (mg)Quantity (Tablets)Price (USD)
57$67.85
510$93.08
530$261.23
560$513.46
590$765.69
105$36.71
107$47.99
1010$64.92
1030$177.76
1090$516.28

Patients are encouraged to check with their local pharmacies, insurance providers, or explore patient assistance programs to determine the most cost-effective option for obtaining Farxiga.

Why is Farxiga so Expensive?

The cost of Farxiga in America can be significant, and several factors contribute to its high price:

  • Research and Development Costs: The development of pharmaceutical drugs, including Farxiga, involves extensive research, clinical trials, and regulatory approvals, which incur substantial costs. These expenses are often factored into the pricing of the medication.
  • Patent Protection: Farxiga is protected by patents, which grant the manufacturer exclusive rights to produce and sell the medication for a certain period. During this time, generic versions of the drug are not available, allowing the manufacturer to set higher prices.
  • Marketing and Advertising: Pharmaceutical companies invest heavily in marketing and advertising campaigns to promote their products, including Farxiga. These expenses contribute to the overall cost of the medication.
  • Insurance Coverage: The availability and extent of insurance coverage for Farxiga can vary, affecting out-of-pocket costs for patients. Some insurance plans may cover a portion of the medication’s cost, while others may require higher copayments or coinsurance.
  • Manufacturer Pricing Strategy: Pharmaceutical companies often employ pricing strategies based on factors such as perceived value, competitor pricing, and market dynamics, which can influence the cost of Farxiga.

Farxiga Alternatives

While Farxiga is a commonly prescribed medication for the treatment of type 2 diabetes, several alternative medications are available that may offer similar benefits. Some alternatives to Farxiga include:

  • Metformin (Glucophage): Metformin is often recommended as the first-line treatment for type 2 diabetes. It works by reducing glucose production in the liver and improving insulin sensitivity in the body.
  • Januvia (Sitagliptin): Januvia is a DPP-4 inhibitor that helps lower blood sugar levels by increasing the release of insulin and decreasing the production of glucose in the liver.
  • Invokana (Canagliflozin): Invokana is another SGLT2 inhibitor similar to Farxiga. It works by helping the kidneys remove glucose from the bloodstream through the urine, thereby lowering blood sugar levels.
  • Victoza (Liraglutide): Victoza is a GLP-1 receptor agonist that helps lower blood sugar levels by increasing insulin secretion, slowing gastric emptying, and reducing appetite.
  • Sulfonylureas (e.g., Glipizide, Glyburide): Sulfonylureas stimulate insulin secretion from the pancreas, helping lower blood sugar levels. They are often used in combination with other diabetes medications.
  • Thiazolidinediones (e.g., Pioglitazone, Rosiglitazone): Thiazolidinediones improve insulin sensitivity in the body and reduce glucose production in the liver, helping lower blood sugar levels.

Frequently Asked Questions About Farxiga

How rapid is weight loss with Farxiga?

The weight loss experienced with Farxiga can vary from person to person. While some individuals may notice weight loss within a few weeks of starting Farxiga, others may experience gradual weight loss over several months.

What is Farxiga used for?

Farxiga is used to treat type 2 diabetes mellitus in adults by helping to lower blood sugar levels. It belongs to a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors.

What is Farxiga 10 mg used for?

Farxiga 10 mg is used for the same purpose as Farxiga 5 mg, which is to treat type 2 diabetes mellitus in adults by helping to lower blood sugar levels. The 10 mg dosage may be prescribed based on individual needs and response to treatment.

How much water should you drink when taking Farxiga?

When taking Farxiga, it is recommended to drink plenty of fluids to prevent dehydration, especially if you experience increased urination as a side effect. Aim to drink at least eight glasses of water per day unless otherwise directed by your healthcare provider.

How much does Farxiga cost per month?

The cost of Farxiga per month can vary depending on factors such as dosage, quantity, pharmacy location, and insurance coverage.

What is Farxiga?

Farxiga is a medication used to treat type 2 diabetes mellitus in adults. It belongs to a class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors, which work by helping the kidneys remove glucose from the bloodstream through the urine.

How does Farxiga work?

Farxiga works by inhibiting a protein called SGLT2 in the kidneys, which helps to lower blood sugar levels by increasing the removal of glucose from the bloodstream through the urine. This mechanism of action helps to improve glycemic control in people with type 2 diabetes.

What happens if you stop taking Farxiga?

If you stop taking Farxiga suddenly, your blood sugar levels may increase, potentially leading to symptoms of hyperglycemia such as increased thirst, frequent urination, and fatigue. It’s essential to consult with your healthcare provider before discontinuing Farxiga or making any changes to your treatment plan.

How long does Farxiga stay in your system?

The elimination half-life of Farxiga is approximately 12 to 14 hours. This means that it takes about two to three days for Farxiga to be completely eliminated from your system after discontinuation. However, individual factors such as metabolism and kidney function may affect how long the drug stays in your body.

What drugs should not be taken with Farxiga?

Certain medications may interact with Farxiga, potentially affecting its effectiveness or increasing the risk of side effects. Some drugs that should not be taken with Farxiga include diuretics, insulin, sulfonylureas, and other medications that lower blood sugar levels.

Who makes Farxiga?

Farxiga is manufactured by AstraZeneca Pharmaceuticals LP, a global biopharmaceutical company headquartered in Cambridge, United Kingdom.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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