Jentadueto is a diabetes medication that contains two active ingredients – linagliptin and metformin. Each of these ingredients is used for controlling adult diabetics’ blood glucose levels. When a patient has diabetes, they often have high blood glucose levels that can cause a host of health problems. It’s important to keep blood sugar levels under control, and that’s what this medication can do.

Linagliptin is a medication that is classified as a DPP-4 inhibitor. It causes the intestines to release more incretin. This hormone causes insulin levels to go up whenever the patient has high blood sugar such as just after eating a meal. The other active ingredient, metformin, is classified as an oral hypoglycemic. It lowers the amount of glucose that the liver makes and helps glucose get into the body’s tissues. It’s an especially helpful drug for diabetics who are overweight.

This drug is supposed to be used along with eating a healthy diet and getting enough exercise. It’s sometimes used when other diabetes medications haven’t been enough to keep blood glucose levels under control. This medication may be taken on its own, or it may be taken with another diabetes medication.

Precautions and Warnings of Jentadueto

If you have type 1 diabetes, don’t take this medication. If you are allergic to any of the ingredients in it, tell your doctor, and don’t take Jentadueto. You also shouldn’t take it if you have any severe infections, you’re about to have surgery, or there is any trauma to your body. If you’re going to have surgery that will cause you not to eat or drink normally, you shouldn’t take this medication.

Patients who have severe dehydration or drink a lot of alcohol shouldn’t use Jentadueto. It also shouldn’t be used if you’re getting radiologic testing that uses contrast that contains iodine. If you have a history of suffering from lactic acidosis or metabolic acidosis or you’ve had diabetic ketoacidosis that came with a coma or without, make sure your doctor knows about it. Also tell your doctor if you have any disease that comes with your tissues not getting enough oxygen.

If you have reduced kidney function or you’re suffering from liver function that’s severely reduced, tell your doctor and don’t take this medication. If you don’t have good control over your blood glucose levels, this medication shouldn’t be taken as the only diabetes medication that you use.

It’s possible to get lactic acidosis with this medication, which is when too much acid builds up in the body. If you’re 65 or older or have heart failure or have had a heart attack, you are more likely to have this happen. This is a serious condition that can cause problems like organ failure. If you have the symptoms of this condition, it’s essential to get help right away. The symptoms can include belly pain, irregular heartbeat, dizziness, trouble breathing, and tiredness.

Rarely, patients who take this medication have developed pancreatitis. Some of the symptoms that patients commonly have with this condition include nausea, vomiting, fever, and pain in the upper stomach. If you get these symptoms, tell your doctor immediately.

If you’ve had kidney or heart problems recently, make sure your doctor knows. This can cause patients to develop heart failure while on this medication. If you have sudden weight gain, tiredness, trouble breathing, or swelling, tell your doctor right away. You may need emergency medical care.

Jentadueto can also cause you to have levels of vitamin B12 that are too low. This can eventually lead to anemia. If you take this medication and get muscle problems, low energy, numbness or tingling in your feet and hands, or dizziness, tell your doctor. You should be monitored while you take this medication to check your B12 levels.

Jentadueto Side Effects

There are many side effects that may happen when taking this medication. Many people don’t have side effects while others have only mild effects. If you have severe effects, make sure your doctor knows about it. You may need to have your dosage changed or to be moved to a different diabetes medication.

Common Side Effects

Some of the common side effects include:

  • Diarrhea
  • Gas
  • Bloating
  • Heartburn
  • Cough
  • Increased sunlight sensitivity
  • Constipation
  • Stuffy nose
  • Runny nose
  • Loss of appetite
  • Sore throat
  • Having a metallic taste in the mouth
  • Nausea
  • Mouth ulcers

Serious Side Effects

There are also more serious side effects that you need to tell your doctor about right away and possibly get immediate medical attention. These side effects are much more rare, and they should be attended to right away:

  • Loss of coordination
  • Rash or hives
  • Lower thyroid function that may come with tiredness, constipation, being more cold-sensitive, and weight gain
  • Erosions of the skin or blisters
  • Serious joint pain
  • Symptoms of an infection – severe diarrhea, long-lasting dizziness, fever and chills, stiff neck, shortness of breath, or headache
  • Symptoms of anemia – pale skin, shortness of breath, dizziness, being unusually weak or tired
  • Symptoms of damage to muscles – muscle pain with no obvious cause, brown urine, weakness or tenderness of the muscles
  • Signs of low blood sugar – slurred speech, sweating, mood swings, shaking, vision changes, headache, or fast heartbeat
  • Vomiting

Drug Interactions With Jentadueto 

There are many other drugs that can create a bad interaction with Jentadueto. There are many other medications that can interact but that may be used if the doctor sees that the benefits outweigh the risks. For this reason, make sure your doctor knows everything that you’re taking, even if it’s over-the-counter or an herbal supplement. Some of these include:

  • Diatrizoate
  • Lobitridol
  • Acetrizoic acid
  • Iodamide
  • Iopamidol
  • Iopromide
  • Iothalamate
  • Ioxaglate
  • Iotroxic acid
  • Ipodate
  • Tyropanoate sodium
  • Metrizoic acid
  • Metrizamide

Jentadueto Strengths and Dosages

There are three strengths of this medication, and all are oral medications. The strength of each of them is measured both by how much linagliptin is in it as well as how much metformin. There is a tablet that is 2.5 mg/1000 mg, one that is 2.5 mg/850 mg, and one that is 2.5 mg/500 mg.

Jentadueto containing Linagliptin and Metformin:2.5 mg/500 mg
Jentadueto containing Linagliptin and Metformin:2.5 mg/850 mg
Jentadueto containing Linagliptin and Metformin:2.5 mg/1000 mg

Cost of Jentadueto in America

A supply of 60 tablets is about $550. You may pay more or less depending on the pharmacy you choose, any coupon cards that you use, and your health insurance policy if any. If you have commercial health insurance, the manufacturer of Jentadueto makes a coupon card that lowers the co-pay price to $10. There are also other coupon cards that people can use for other discounts, especially if they don’t have health insurance.

Your health insurance will dictate much of the price you’ll pay. If you haven’t met your deductible, you may pay a high price for this medication. Or, you may only have a set co-pay to pay. If you’ve met your out-of-pocket maximum for the year, you will likely pay nothing for this medication.

Why Is Jentadueto So Expensive?

While a generic of this medication has been approved by the FDA, it isn’t commercially available yet. The manufacturer of Jentadueto still has the patent on the formulation and can set the price high. This is often done because of the high cost of developing a drug and bringing it to market.

Jentadueto Alternatives

There is a wide selection of diabetes medications that could be used as alternatives to Jentadueto. These include Janumet, Mounjaro, Metformin, Zepbound, and Glumetza. Your doctor will determine the right medication needed for your specific medical condition. This will often depend on how well your blood sugar is controlled, whether you’re having complications from diabetes, and other factors.

FAQs of Jentadueto 

What is Jentadueto?

Jentadueto is a diabetes medication that has two active ingredients to help diabetics have better control over their condition. The medication includes Linagliptin and Metformin.

What Is Jenadueto used for?

It’s used to help the body better use its insulin so that blood sugar levels can be lowered.

What is the difference between Jentadueto and Jentadueto XR?

Jentadueto XR is an extended-release version of Jentadueto. It has the same basic ingredients and the same half-life, but it releases the medication more slowly and steadily.

Can you use this medication while pregnant or breastfeeding?

This medication is not recommended during these items because Metformin can be risky to a baby. Make sure your doctor knows that you’re pregnant or breastfeeding before you use this medication.

Can you drink alcohol while taking this medication?

Small amounts might be ok if allowed by your doctor. However, drinking heavily while on this medication can cause serious problems and make your blood sugar harder to control.

Who is the manufacturer of Jentadueto?

Boehringer Ingelheim Pharmaceuticals, Inc. is the manufacturer.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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