Actoplus MET is a medication given to people with type 2 diabetes to help manage their blood sugar levels. This medication contains two active ingredients, pioglitazone and metformin, that can stave off complications stemming from type 2 diabetes like heart attack, stroke, or kidney damage.

Precautions and Warnings with Actoplus

You’ll also need to stop taking this medication before certain surgeries or procedures. Any x-ray or scanning procedure where a medical professional would use iodinated contrast could be a problem when taking this medication. Inform your doctor or dentist you’re taking Actoplus MET before undergoing any procedure or surgery.

Since Actoplus MET contains two different medications, discussing how your body could potentially react to these medications is vital. You should also let your doctor know if you’ve had any of the following issues before you start an Actoplus MET regimen:

  • Breathing problems, including asthma
  • Kidney disease
  • Heart disease
  • Liver disease
  • Swelling (edema)
  • Blood problems, including anemia
  • Bladder cancer

Side Effects of Actoplus 

While this medication typically won’t cause low blood sugar, it can occur in some patients who are taking additional diabetes medications like insulin. Prevent low blood sugar by maintaining a healthy eating schedule and abstaining from drinking large amounts of alcohol.

Common Side Effects

Most of these symptoms should dissipate within the first few days or weeks of treatment. Tell your doctor if symptoms return after the first few days, especially stomach-related symptoms, as this could indicate lactic acidosis. The most common side effects of Actoplus MET include:

  • Sore throat
  • Muscle pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Weakness
  • Tooth problems
  • A metallic taste in your mouth

Serious Side Effects

Anyone experiencing these side effects should seek immediate professional medical help. Serious side effects of Actoplus MET are:

  • Vision problems, like blurred vision
  • Bone fracture
  • Red-colored urine
  • Frequent or painful urination
  • Other signs of liver disease, like constant nausea or yellowing eyes/skin

Drug Interactions With Actoplus

Multiple drugs could cause shifts in blood sugar levels. This can make it much harder to manage, so don’t stop or start any medications without talking to your doctor first.

Check your blood sugar often, and let your doctor know right away if you develop symptoms of high or low blood sugar. Diet and exercise can often help offset some of the blood sugar issues that occur when taking multiple medications.

Actoplus MET is known to interact with the following drugs:

  • Gemfibrozil
  • Rifampin (Rifadin)
  • Metoprolol
  • Propanolol

Strengths and Dosages of Actoplus

Actoplus MET has two different dosages, one for pioglitazone and the other for metformin. Most doctors start their patients with a 15mg/500mg dose twice daily.

FAQs of Actoplus

How do you take Actoplus?

The recommended way to take this medication is with meals to decrease the chance of developing stomach problems. Most patients will take this medication once or twice daily.

How does Actopluswork?

Pioglitazone and metformin work together to help the body respond appropriately to the insulin naturally produced. Metformin will also lower the amount of sugar your digestive tract absorbs and how much your liver makes.

When should you take Actoplus?

You can take this medication at any time of the day, but doctors recommend you try and take it at the same time each day.

Are there any risks associated with Actoplus?

This medication could potentially increase your risk for bladder cancer, usually if you’ve taken it consistently for more than 12 months. Let your doctor know if you experience any signs of bladder cancer.

What should you do if you miss a dose of Actoplus?

Take your next dose whenever you remember, unless you’re getting close to the time of your next dose, then wait and take your dose as usual. Do not take an additional dose to make up for missing one.

What is the cost of Actoplus in America?

The average cost of Actoplus MET at a pharmacy is roughly $631 for 60 tablets, which is generally a 30-day supply. The price could potentially vary significantly based on your insurance or pharmacy choice.

Are there alternatives to Actoplus?

Metformin, an active ingredient in Actoplus MET, can be taken by itself as an alternative, as it improves how the body handles insulin. Ozempic is another alternative since it lowers blood sugar and glucagon secretion from the liver.

Are there generic options for Actoplus?

The generic version of Actoplus MET is simply pioglitazone HCL/metformin HCL.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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