Mesacol is a prescription medication primarily used in the treatment of inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn’s disease. It belongs to a class of drugs known as aminosalicylates, which work by reducing inflammation in the colon and rectum.

How Does Mesacol Work?

Mesacol contains the active ingredient mesalamine, which is believed to exert its therapeutic effects by inhibiting the production of inflammatory chemicals in the intestines. By reducing inflammation, Mesacol helps alleviate symptoms associated with IBD, including abdominal pain, diarrhea, and rectal bleeding.

Mesacol is available in various formulations, including tablets, delayed-release tablets, and rectal suppositories, allowing for tailored treatment approaches based on the severity and location of the inflammation within the gastrointestinal tract.

Precautions and Warnings with Mesacol

  • Allergic Reactions: Patients with a known hypersensitivity to mesalamine or any other ingredient in Mesacol should avoid its use.
  • Renal Impairment: Mesacol should be used with caution in patients with impaired renal function, as it may exacerbate existing kidney problems.
  • Hepatic Dysfunction: Patients with liver disease should use Mesacol with caution, as it may affect liver function.
  • Monitoring: Regular monitoring of kidney function, liver function, and blood cell counts may be necessary during Mesacol therapy.

Potential Risks and Adverse Effects

  • Mesalamine-Induced Acute Intolerance Syndrome (MIAIS): Mesacol may cause MIAIS, a rare but severe condition characterized by worsening of colitis symptoms, fever, and abdominal pain. Discontinue Mesacol immediately if MIAIS is suspected.
  • Mesalamine-Induced Nephrotoxicity: Mesacol may cause renal impairment, including interstitial nephritis and renal failure. Monitor renal function regularly during treatment.
  • Hypersensitivity Reactions: Severe allergic reactions, including anaphylaxis, have been reported with Mesacol use. Discontinue treatment and seek medical attention if signs of an allergic reaction occur.

Mesacol Side Effects

While Mesacol is generally well-tolerated, like any medication, it may cause side effects in some individuals. Side effects associated with Mesacol may include:

  • Blurred vision
  • Nausea and vomiting
  • Headache
  • Dizziness
  • Hair loss
  • Constipation
  • Dry mouth
  • Increased sweating
  • Acne
  • Burping
  • Heartburn
  • Chest pain
  • Shortness of breath
  • Vomiting blood

Mesacol Drug Interactions

Mesacol may interact with other medications, supplements, or substances, potentially affecting its effectiveness or increasing the risk of adverse effects. Some notable drug interactions with Mesacol include:

MedicationInteraction with Mesacol
Aspir 81 (Aspirin)Increased risk of gastrointestinal bleeding
Aspirin Low Strength (Aspirin)Increased risk of gastrointestinal bleeding
Benadryl (Diphenhydramine)Increased risk of drowsiness and dizziness
Calcium 600 D (Calcium / Vitamin D)Reduced absorption of calcium and vitamin D
CoQ10 (Ubiquinone)Reduced absorption of CoQ10
Cymbalta (Duloxetine)Increased risk of serotonin syndrome
Eliquis (Apixaban)Increased risk of bleeding
Fish Oil (Omega-3 Polyunsaturated Fatty Acids)Increased risk of bleeding
Flonase (Fluticasone Nasal)Increased risk of corticosteroid-related side effects
Humira (Adalimumab)Increased risk of immunosuppression and infection
Iron Sulfate (Ferrous Sulfate)Reduced absorption of iron
Lexapro (Escitalopram)Increased risk of serotonin syndrome
Lipitor (Atorvastatin)Increased risk of statin-related side effects
Metoprolol Succinate ER (Metoprolol)Increased risk of bradycardia and hypotension
MiraLAX (Polyethylene Glycol 3350)Increased risk of gastrointestinal side effects
Probiotic Formula (Bifidobacterium Infantis / Lactobacillus Acidophilus)Reduced effectiveness of probiotics
Protonix (Pantoprazole)Reduced absorption of mesalamine
Remicade (Infliximab)Increased risk of immunosuppression and infection
Singulair (Montelukast)Increased risk of adverse effects
Synthroid (Levothyroxine)Reduced absorption of levothyroxine
Tylenol (Acetaminophen)Increased risk of liver toxicity
Vitamin B12 (Cyanocobalamin)Reduced absorption of vitamin B12
Vitamin C (Ascorbic Acid)Increased risk of gastrointestinal side effects
Vitamin D2 (Ergocalciferol)Reduced absorption of vitamin D
Vitamin D3 (Cholecalciferol)Reduced absorption of vitamin D
Vyvanse (Lisdexamfetamine)Increased risk of cardiovascular side effects
Wellbutrin XL (Bupropion)Increased risk of seizures
Xanax (Alprazolam)Increased risk of CNS depression and respiratory depression
Zofran (Ondansetron)Increased risk of constipation
Zyrtec (Cetirizine)Increased risk of drowsiness and dizziness

Mesacol Strengths and Dosages

Available Strengths

  • Mesacol Tablets:
    • 400 mg
    • 800 mg
  • Mesacol Delayed-Release Tablets:
    • 400 mg
  • Mesacol Rectal Suppositories:
    • 500 mg

Recommended Dosages

  • Ulcerative Colitis:
    • Mild to moderate: Initial dosage of Mesacol tablets 400 mg, taken orally three times daily.
  • Moderate to severe: Initial dosage of Mesacol tablets 800 mg, taken orally three times daily.
  • Maintenance therapy: Dosage may be adjusted based on individual response, typically ranging from 1.6 to 4.8 grams per day.
  • Crohn’s Disease:
    • Mild to moderate: Initial dosage of Mesacol tablets 400 mg, taken orally three times daily.
  • Maintenance therapy: Dosage may be adjusted based on individual response, typically ranging from 2.4 to 4.8 grams per day.

Cost of Mesacol in America

As of the latest information, the following pricing details for Mesacol are available:

Mesacol 400 mg

Pack SizeQuantityPrice per Pill or UnitPrice
30 Tablet/s1US$ 0.73US$ 22.00
60 Tablet/s1US$ 0.63US$ 38.00
90 Tablet/s1US$ 0.58US$ 52.00

Mesacol 800 mg

Pack SizeQuantityPrice per Pill or UnitPrice
30 Tablet/s1US$ 0.83US$ 25.00
60 Tablet/s1US$ 0.75US$ 45.00
90 Tablet/s1US$ 0.69US$ 62.00

Mesacol CR 500Mg

Pack SizeQuantityPrice per Pill or UnitPrice
30 Tablet/s1US$ 1.00US$ 30.00
60 Tablet/s1US$ 0.90US$ 54.00
90 Tablet/s1US$ 0.85US$ 76.50

Mesacol OD 1200Mg

Pack SizeQuantityPrice per Pill or UnitPrice
30 Tablet/s1US$ 2.58US$ 77.40
60 Tablet/s1US$ 2.32US$ 139.32
90 Tablet/s1US$ 2.19US$ 197.37

Why is Mesacol so Expensive?

The pricing of Mesacol may be influenced by several factors, including:

  • Research and Development Costs: The development of Mesacol and similar medications involves substantial investment in research, clinical trials, and regulatory approval processes.
  • Manufacturing Expenses: The production and manufacturing of pharmaceutical products, including Mesacol, require specialized facilities and quality control measures, contributing to overall costs.
  • Limited Competition: Mesacol may face limited competition in the market, particularly if it is a patented or branded medication, which can influence pricing dynamics.
  • Insurance Coverage: Availability of insurance coverage and reimbursement policies may affect the out-of-pocket costs for patients obtaining Mesacol.

Mesacol Alternatives

While Mesacol is an effective treatment option for inflammatory bowel diseases, there may be alternative medications available that may offer similar therapeutic benefits:

  • Sulfasalazine (Azulfidine): Sulfasalazine is a medication that contains both a sulfa antibiotic (sulfapyridine) and mesalamine. It is commonly used in the treatment of inflammatory bowel diseases, including ulcerative colitis and Crohn’s disease. Sulfasalazine works by reducing inflammation in the gastrointestinal tract and is available in oral tablet form. It is often considered an alternative to Mesacol for patients who may not tolerate pure mesalamine formulations.
  • Balsalazide (Colazal): Balsalazide is a prodrug of mesalamine and is converted to mesalamine in the colon. It is indicated for the treatment of mild to moderate active ulcerative colitis. Balsalazide helps to reduce inflammation and symptoms associated with ulcerative colitis, such as diarrhea, rectal bleeding, and abdominal pain. It is available in oral capsule form and is typically taken multiple times daily.
  • Olsalazine (Dipentum): Olsalazine is structurally similar to sulfasalazine but does not contain the sulfa component found in sulfasalazine. It is metabolized into two molecules of mesalamine in the colon, where it exerts its anti-inflammatory effects. Olsalazine is indicated for the treatment of mild to moderate ulcerative colitis and is available in oral capsule form. Like other mesalamine-based medications, olsalazine is typically administered multiple times daily.
  • Asacol (Mesalamine): Asacol is another brand name for mesalamine, the active ingredient in Mesacol. Asacol is available in various formulations, including tablets and delayed-release tablets, and is used for the treatment of ulcerative colitis and Crohn’s disease. While Asacol may have slight differences in formulation or delivery method compared to Mesacol, they both contain mesalamine as the active ingredient and are used for similar indications.

FAQs of Mesacol

What are the common uses of Mesacol?

Mesacol is commonly used in the treatment of inflammatory bowel diseases, including ulcerative colitis and Crohn’s disease. It helps reduce inflammation in the colon and rectum, alleviating symptoms such as abdominal pain, diarrhea, and rectal bleeding.

How long does it take for Mesacol to start working?

The onset of action of Mesacol may vary among individuals. Some patients may experience symptom relief within a few days to weeks of starting treatment, while others may require longer durations for noticeable improvement.

Can Mesacol be taken with food?

Mesacol can typically be taken with or without food, as directed by a healthcare provider. However, some individuals may experience improved tolerance or reduced gastrointestinal side effects when taking Mesacol with food.

Are there any dietary restrictions while taking Mesacol?

There are generally no specific dietary restrictions associated with Mesacol use. However, individuals with inflammatory bowel diseases may benefit from following a well-balanced diet that is low in trigger foods and high in nutrients to help manage symptoms and support overall health.

Is it safe to consume alcohol while using Mesacol?

While moderate alcohol consumption may not directly interact with Mesacol, excessive alcohol intake may exacerbate gastrointestinal symptoms and increase the risk of side effects.

Can Mesacol be taken during pregnancy or breastfeeding?

The safety of Mesacol use during pregnancy and breastfeeding is not fully established. Pregnant or breastfeeding individuals should consult their healthcare provider before starting or continuing Mesacol therapy to weigh the potential risks and benefits.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

Product was successfully added to your cart!