Mesacol treats conditions such as ulcerative colitis and Crohn’s disease, which are inflammatory bowel diseases (IBDs). Situations such as these can be highly uncomfortable and significantly impact daily life. Consequently, Mesacol becomes a vital option for patients seeking relief from persistent symptoms associated with these diseases. The medication relieves symptoms such as stomach pain, diarrhea, and rectal bleeding by blocking the production of certain chemicals that cause swelling.

Mesacol should be taken according to your doctor’s instructions. Your doctor will determine the dose and duration of treatment based on the severity of your condition. Take the prescribed amount only. For better results, take it at the same time every day. If you stop taking this medicine without consulting your doctor, your condition may worsen.

Some people may not be able to tolerate Mesacol. You should inform your doctor if you have liver or kidney problems. Inform the doctor about all medications you are taking to prevent side effects. Before taking this medicine, consult your doctor if you are pregnant or breastfeeding.

Currently, we offer Mesacol products through our partnering (and verified) pharmacies in Singapore and Mauritius.

Mesacol Vs. Mesacol OD

Mesacol, a renowned medication, is primarily used in the treatment of inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease. Its active ingredient, Mesalamine, is known for its anti-inflammatory properties that target the lining of the intestines. By doing so, Mesacol helps to alleviate symptoms like abdominal pain, diarrhea, and rectal bleeding.

Mesacol OD, which stands for “once-daily,” offers a convenient dosing regimen for patients. Similar to Mesacol, it contains Mesalamine as its active component. However, what sets it apart is the extended-release formulation. This allows for a gradual release of the medication in the digestive tract, ensuring a sustained therapeutic effect over the course of the day.

Dosage Frequency

One of the most notable differences between Mesacol and Mesacol OD is the dosing frequency. While standard Mesacol may require multiple doses throughout the day, Mesacol OD’s extended-release nature permits a single daily dose. This could enhance patient adherence to the treatment regimen.

Treatment Compliance

Due to its simplified dosing schedule, Mesacol OD could potentially lead to improved treatment compliance. Patients are more likely to adhere to a once-daily regimen compared to a multi-dose routine, ultimately contributing to better disease management.

Onset of Action

In terms of the onset of action, both Mesacol and Mesacol OD exhibit similar timelines. However, individual patient responses may vary. Some patients might experience relief sooner with one formulation over the other.

Flexibility in Routine

Mesacol allows for a flexible dosing schedule, making it suitable for patients who require tailored treatment approaches. On the other hand, Mesacol OD’s once-daily dosing might be preferable for individuals with busy lifestyles or those who prefer a set routine.


Mesacol is generally taken multiple times a day, with the specific dosage depending on the severity of the condition. The dosage can be tailored to individual patient needs, allowing for a more personalized approach. It is advisable to take Mesacol with meals to enhance its absorption and minimize potential stomach upset.

In contrast, Mesacol OD offers the advantage of once-daily dosing. This can simplify the medication schedule and enhance patient compliance. Patients can take Mesacol OD in the morning, preferably with breakfast, to ensure a steady release of the medication throughout the day. This convenience can be especially beneficial for individuals with busy lifestyles.


Mesacol’s absorption primarily occurs in the lower gastrointestinal tract. The active ingredient, mesalamine, targets the inflamed areas directly, aiding in reducing inflammation and alleviating symptoms. Proper administration, such as taking the medication with food, can enhance its absorption and effectiveness.

Mesacol OD’s extended-release formulation allows for gradual absorption over an extended period. The medication is designed to deliver mesalamine to the affected areas in a controlled manner, ensuring sustained relief. The convenience of once-daily dosing, combined with optimized absorption, makes Mesacol OD an attractive option for those seeking effective long-term management.

Pros and Cons of Mesacol


  1. Effective in Treating Inflammation: Mesacol has shown remarkable effectiveness in reducing inflammation in the body. This property makes it a valuable choice for conditions where inflammation plays a significant role.
  2. Localized Action: One of the key benefits of Mesacol is its targeted action. It primarily works on the colon, delivering the medication precisely where it’s needed the most. This can result in quicker relief and fewer systemic side effects.
  3. Minimal Systemic Absorption: Since Mesacol works locally, the systemic absorption of the medication remains minimal. This reduces the likelihood of widespread side effects that might occur with medications that have a broader reach.


  1. Limited Application: Mesacol’s efficacy is most notable in treating conditions related to the digestive tract. It might not be the most suitable option for health issues that don’t involve inflammation or the gastrointestinal system.
  2. Dosage Frequency: Some patients might find it inconvenient to take Mesacol multiple times a day due to its dosage frequency requirements. This can lead to decreased adherence to the treatment plan.

Pros and Cons of Mesacol OD


  1. Extended Release Formula: Mesacol OD features an extended-release formulation, allowing for less frequent dosing. This can greatly enhance patient compliance as they don’t need to take the medication as often.
  2. Convenient Dosage Schedule: Due to its extended-release nature, Mesacol OD offers a more convenient dosage schedule. This can lead to better patient adherence and overall treatment success.
  3. Broad Applicability: Unlike the traditional Mesacol, Mesacol OD’s extended-release mechanism enables it to be effective not only in gastrointestinal conditions but also in other inflammatory conditions.


  1. Delayed Onset of Action: While the extended-release feature is advantageous, it might result in a slower onset of action compared to the immediate-release Mesacol. Patients seeking rapid relief might find this to be a drawback.
  2. Potential for Overdose: The extended-release nature of Mesacol OD means that a higher amount of the medication is present in the body over an extended period. This increases the risk of accidental overdose if proper precautions are not taken.

Warnings and Precautions

Mesacol is a medication that can be incredibly beneficial for certain conditions, but it’s essential to be aware of the warnings and precautions associated with its use.

  • Consultation with a Medical Professional: Before starting Mesacol, consult with a qualified medical professional. This step is crucial to ensure that the medication is suitable for your specific health condition and won’t interact negatively with any other medications you might be taking.
  • Allergic Reactions: If you have a history of allergies or have experienced allergic reactions to medications in the past, it’s vital to inform your healthcare provider. Allergic reactions to Mesacol are rare but can occur. Watch out for symptoms like rash, itching, swelling, severe dizziness, or difficulty breathing.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, it’s essential to discuss the potential risks and benefits of Mesacol with your doctor. The medication’s effects on pregnancy and breast milk are not yet fully understood.
  • Kidney and Liver Function: Mesacol is processed by the kidneys and liver. If you have impaired kidney or liver function, your doctor may need to adjust the dosage to prevent any adverse effects. Regular monitoring of these functions may be required during the course of treatment.
  • Blood Disorders: If you have a history of blood disorders, such as bleeding problems or clotting disorders, your doctor needs to know about it. Mesacol can influence blood clotting factors, and adjustments to your treatment plan might be necessary.
  • Gastrointestinal Issues: Since Mesacol primarily targets the gastrointestinal tract, it’s crucial to inform your doctor if you have any existing gastrointestinal conditions. This includes conditions like Crohn’s disease or ulcerative colitis.
  • Monitoring and Follow-Up: Regular follow-up appointments with your healthcare provider are essential while using Mesacol. These appointments allow your doctor to monitor your progress, address any concerns, and make adjustments to your treatment plan if needed.
  • Side Effects: While side effects are not common with Mesacol, it’s important to be aware of potential symptoms. Common side effects include nausea, vomiting, headache, and mild stomach discomfort. If you experience severe or persistent side effects, contact your doctor.
  • Dosage Adherence: Adhering to the prescribed dosage schedule is crucial for the effectiveness of Mesacol. Avoid missing doses, and don’t adjust the dosage without consulting your doctor.

Side Effects

In the realm of gastroenterology, Mesacol has emerged as a significant medication for managing various inflammatory bowel diseases. However, like any pharmaceutical, Mesacol comes with a spectrum of potential side effects that users should be aware of.

Common Side Effects

  1. Gastrointestinal Distress: Some users may experience mild gastrointestinal discomfort, including nausea, vomiting, and diarrhea. These effects usually subside as the body adjusts to the medication.
  2. Headache and Dizziness: A commonly reported side effect, some individuals might encounter headaches and bouts of dizziness. Staying hydrated can help alleviate these symptoms.
  3. Abdominal Pain: Certain users might notice abdominal pain or cramping, which could be an indication of the body getting accustomed to the medication. Consulting a healthcare professional can provide reassurance.

Rare Side Effects

  1. Allergic Reactions: In rare instances, individuals may exhibit allergic reactions such as skin rash, itching, or swelling. If any of these symptoms manifest, seeking medical attention is imperative.
  2. Liver Function Abnormalities: A rare but potentially serious side effect involves changes in liver function. Regular monitoring of liver enzymes might be recommended by your healthcare provider.
  3. Blood Disorders: In a few cases, Mesacol might lead to changes in blood cell counts, affecting factors like clotting and immunity. This underlines the necessity of routine blood tests.

Severe Side Effects

  1. Pancreatitis: Though rare, pancreatitis can occur as a severe side effect of Mesacol. Symptoms like persistent abdominal pain, nausea, and vomiting require immediate medical intervention.
  2. Kidney Issues: Mesacol has been associated with kidney-related problems, including interstitial nephritis. Any changes in urinary patterns or kidney function warrant thorough medical evaluation.
  3. Lung Inflammation: Some individuals might experience inflammation of the lungs, leading to symptoms like persistent cough, chest pain, and difficulty breathing. Seeking medical attention is crucial to address this potential side effect.


Mesacol is a medication widely prescribed for the treatment of inflammatory bowel diseases, including ulcerative colitis and Crohn’s disease. As you embark on your journey with Mesacol, it’s crucial to understand its interactions with other substances, as they can impact its effectiveness and your overall health.

Drug Interactions

  1. Immunosuppressants: Combining Mesacol with immunosuppressant drugs might heighten the risk of immune system compromise. Consult your healthcare provider for personalized guidance if you are on immunosuppressive therapy.
  2. Blood Thinners: Interaction with blood-thinning medications can lead to increased bleeding tendencies. Regular monitoring of blood clotting parameters is crucial in such cases.
  3. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Concurrent use of NSAIDs and Mesacol could raise the likelihood of gastrointestinal complications. Your doctor might recommend alternative pain management strategies.

Herbal Interactions

  1. Aloe Vera: Known for its digestive benefits, aloe vera might counteract with Mesacol’s mechanisms. Prioritize open communication with your physician before integrating aloe vera supplements.
  2. Turmeric: While turmeric offers anti-inflammatory properties, it could potentially intensify the effects of Mesacol. Seek medical advice before using both concurrently.
  3. Garlic: Garlic supplements may interact with Mesacol, affecting its absorption. Monitoring your condition with your healthcare provider is crucial if you regularly consume garlic products.

Food Interactions

  1. Dairy Products: Calcium-rich dairy foods could hinder the absorption of Mesacol. Ensure a gap between consuming dairy and taking your medication.
  2. High-Fiber Foods: While a high-fiber diet is often recommended, it’s prudent to moderate the intake of high-fiber foods close to your Mesacol doses, as they could impact its effectiveness.
  3. Grapefruit: Grapefruit and its derivatives can interfere with drug metabolism, potentially affecting Mesacol’s efficacy. Your healthcare provider can advise you on safe consumption.


In the realm of managing inflammatory bowel diseases (IBD), Mesacol stands out as a prominent medication. To ensure the effective and safe utilization of Mesacol, it’s crucial to understand its dosing guidelines thoroughly.

Initial Dosing

When commencing Mesacol therapy, the initial dosing phase plays a pivotal role. Typically, the initial dosage varies depending on the patient’s medical condition and the severity of their symptoms. The recommended starting dose usually ranges between 800mg and 1600mg daily. This dose is commonly divided into two or three smaller administrations, spread across the day. Adhering to the prescribed schedule diligently from the outset sets the stage for the medication’s effectiveness.

Maintenance Dosing

After the initial phase, the maintenance dosing of Mesacol comes into focus. The purpose of maintenance dosing is to uphold the achieved therapeutic effects and further enhance them, if possible. For many patients, a daily dosage ranging between 400mg and 800mg proves effective in this stage. The healthcare provider, based on the patient’s response, might make adjustments to ensure an optimal balance between symptom management and minimizing side effects.

Missed Doses

In the course of any medical regimen, instances of missed doses can occur. When it comes to Mesacol, consistency is key, but occasional lapses shouldn’t induce undue worry. If a dose is inadvertently skipped, it’s generally advised to take it as soon as remembered, unless it’s almost time for the next scheduled dose. In that case, it’s better to skip the missed dose and continue with the regular dosing schedule. It’s important, however, to avoid doubling up on doses to compensate for a missed one.


While the dosing guidelines are meant to be followed diligently, it’s crucial to underscore the potential risks of overdose. Exceeding the recommended dosage can lead to adverse effects and complications. Symptoms of an overdose might include severe nausea, vomiting, confusion, and gastrointestinal distress. If there’s a suspicion of an overdose, immediate medical attention is warranted. Careful adherence to prescribed dosages is the primary defense against this potential risk.


Proper storage of medication, like Mesacol, is crucial to maintain its potency and safety.

  • Store in a Cool and Dry Place: To preserve the quality of Mesacol, keep it in a cool and dry environment. Avoid exposing it to direct sunlight, heat, or moisture, as these elements can degrade the medication over time.
  • Keep Away from Children and Pets: Ensure the safety of your loved ones by storing Mesacol out of reach of children and pets. A high shelf or a locked cabinet can be a suitable spot to prevent accidental consumption.
  • Original Packaging is Key: Always store Mesacol in its original packaging. The packaging is designed to provide optimal protection against external factors that can compromise the medication’s quality.
  • Check Expiry Dates: Regularly inspect your Mesacol medication for expiration dates. Expired medication can be ineffective and even harmful. Proper disposal of expired medication is equally important.
  • Avoid Bathroom Storage: Although it might seem convenient, the bathroom is not an ideal place to store medication due to the fluctuating humidity and temperature. Opt for a more stable environment.
  • Organize with a Medication Tracker: Consider using a medication tracker or an app to help you keep track of Mesacol doses and expiration dates. This can prevent any confusion and ensure timely replacements.
  • Consult Your Pharmacist: If you’re unsure about the proper storage of Mesacol, don’t hesitate to consult your pharmacist. They can provide valuable insights and address any concerns you might have.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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