Lialda is a prescription medication indicated for the induction of remission in patients with active, mild to moderate ulcerative colitis (UC) and for the maintenance of remission of UC. It belongs to a class of drugs known as aminosalicylates, which are thought to exert their therapeutic effects by inhibiting the production of inflammatory mediators in the colon.

How Does Lialda Work?

The active ingredient in Lialda is mesalamine, which is formulated in a delayed-release tablet designed to deliver the medication to the colon, where it exerts its anti-inflammatory effects. Mesalamine is believed to inhibit the activity of inflammatory enzymes and cytokines, thereby reducing inflammation and symptoms associated with UC.

Lialda works locally in the colon and is not absorbed systemically significantly, minimizing the risk of systemic side effects commonly associated with corticosteroids or immunosuppressants. By targeting inflammation in the colon, Lialda helps to alleviate symptoms such as diarrhea, rectal bleeding, and abdominal pain, allowing patients to achieve and maintain remission from UC.

Precautions and Warnings with Lialda

Contraindications

  • Lialda is contraindicated in patients with a known hypersensitivity to mesalamine, salicylates, or any other formulation components.
  • Patients with severe renal impairment or renal failure should not use Lialda.

 Special Precautions for Use

  • Patients with a history of allergic reactions to sulfasalazine should use Lialda with caution.
  • Monitoring for renal function should be considered in patients with pre-existing renal impairment or those at risk of renal dysfunction.
  • Lialda should be used with caution in patients with pre-existing liver disease.
  • Patients with a history of gastrointestinal obstruction or severe ulcerative colitis should use Lialda with caution and under the supervision of a healthcare professional.

Warnings for Specific Populations

  • Pregnancy: Lialda should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus.
  • Lactation: It is not known whether mesalamine is excreted in human breast milk. Due to the potential for adverse reactions in nursing infants, a decision should be made whether to discontinue breastfeeding or discontinue Lialda therapy, taking into account the importance of the drug to the mother.

Liadla Side Effects

While Liadla is generally well-tolerated, like any medication, it may cause side effects in some individuals. Side effects associated with Lialda may include:

Mild Side Effects

  • Flatulence (passing gas)
  • Abnormal liver function test results, which could be a sign of liver problems
  • Abdominal pain
  • Diarrhea
  • Headache
  • Hair loss
  • Itchiness
  • Upset stomach
  • Back pain or joint pain
  • Fatigue
  • Mild allergic reaction

Serious Side Effects

  • Liver problems, including liver failure in people who already have liver problems. Symptoms can include:
    • Jaundice (yellowing of your skin or the whites of your eyes)
    • Pain in the right side of your upper abdomen
  • Mesalamine-induced acute intolerance syndrome. Symptoms can be hard to tell apart from a flare-up of ulcerative colitis, but they may include:
    • Abdominal pain or cramping
    • Bloody diarrhea
    • Fever
    • Headache
    • Rash
  • Kidney problems, including kidney failure and kidney stones. Symptoms can include:
    • Passing less urine than usual
    • Swollen ankles, feet, or legs
    • Shortness of breath
    • Nausea
    • Pain in your abdomen, back, or pelvis
    • Frequent need to urinate, but passing only small amounts of urine
    • Blood in your urine
  • Pancreatitis (inflammation of your pancreas). Symptoms can include:
    • Nausea and vomiting
    • Diarrhea
    • Abdominal swelling and tenderness
    • Fever
  • Skin rashes, including severe rashes from Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS). Symptoms can include:
    • Rash that peels or has blisters
    • Fever
    • Body aches
  • Severe allergic reaction

Drug Interactions With Lialda

Lialda may interact with other medications, supplements, or substances, potentially affecting its effectiveness or increasing the risk of adverse effects. Some notable drug interactions with Lialda include:

  • Amlodipine (Norvasc)
  • Aspirin
  • Aspirin Low Strength (aspirin)
  • Atorvastatin (Lipitor)
  • Azathioprine
  • Clonazepam
  • Cymbalta (duloxetine)
  • Folic acid
  • Furosemide
  • Gabapentin
  • Humira (adalimumab)
  • Levothyroxine (Synthroid)
  • Lisinopril
  • Losartan
  • Metformin
  • Multivitamin
  • Nexium (esomeprazole)
  • Omeprazole
  • Pantoprazole
  • Prednisone
  • Protonix (pantoprazole)
  • Sertraline (Zoloft)
  • Singulair (montelukast)
  • Tramadol
  • Trazodone
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zyrtec (cetirizine)

Strengths and Dosages of Lialda

Available Strengths

Lialda is available in the form of delayed-release oral tablets (1.2 grams).

Recommended Dosages

The recommended dosage of Lialda for the induction of remission in patients with active, mild to moderate ulcerative colitis is four 1.2-gram tablets (total daily dose of 4.8 grams) taken once daily with a meal for a duration determined by the healthcare provider.

For maintenance of remission in patients with ulcerative colitis, the recommended dosage of Lialda is two 1.2-gram tablets (total daily dose of 2.4 grams) taken once daily with a meal for a duration determined by the healthcare provider.

Administration Instructions

  • Lialda tablets should be swallowed whole and should not be crushed, chewed, or broken.
  • The tablets should be taken with a meal to facilitate delivery of the medication to the colon and reduce the risk of gastrointestinal side effects.
  • Patients should always adhere to the prescribed dosage and regimen as directed by their healthcare provider.

Cost of Lialda in America

At this time of writing, reports the cost for Lialda oral delayed release tablet 1.2 g to be approximately $1,192 for a supply of 120 tablets.

Patients are encouraged to check with their local pharmacies, insurance providers, or explore patient assistance programs to determine the most cost-effective option for obtaining Lialda.

Why is Lialda so Expensive?

  • Research and Development Costs: Pharmaceutical companies invest significant resources in research, clinical trials, and regulatory processes to develop and bring a medication like Lialda to market. These expenses contribute to the overall cost of the medication.
  • Patent Protection: Lialda may be protected by patents, which grant exclusivity to the manufacturer for a certain period, allowing them to recoup their investment and maintain profitability.
  • Limited Competition: Depending on the market, Lialda may face limited competition from generic alternatives, allowing the manufacturer to maintain higher pricing.
  • Manufacturing and Distribution Expenses: The production and distribution of pharmaceuticals involve costs related to raw materials, manufacturing facilities, quality control measures, and distribution channels, which can contribute to the pricing of the medication.

Lialda Alternatives

While Lialda is an effective medication for inducing and maintaining remission in patients with ulcerative colitis, several alternative treatment options may be available:

  • Sulfasalazine: Another aminosalicylate medication, sulfasalazine, is commonly used in the treatment of ulcerative colitis. It works similarly to Lialda but may have a different side effect profile.
  • Other Mesalamine Formulations: Various mesalamine formulations, including different dosages and delivery mechanisms such as enemas or suppositories, may be used as alternatives to Lialda depending on the severity and location of the disease.
  • Corticosteroids: Corticosteroids such as prednisone may be used to induce remission in patients with moderate to severe ulcerative colitis. However, long-term use may be limited by their side effect profile.
  • Immunomodulators: Immunomodulatory medications such as azathioprine or 6-mercaptopurine may be used in patients who do not respond to or cannot tolerate aminosalicylates or corticosteroids.

FAQs of Lialda

What is Lialda?

Lialda is a prescription medication used for the induction and maintenance of remission in patients with mild to moderate ulcerative colitis (UC). It contains mesalamine as its active ingredient and works by reducing inflammation in the colon.

What happens if you take Lialda without food?

Taking Lialda without food may increase the risk of gastrointestinal side effects such as nausea, abdominal pain, or diarrhea. It is recommended to take Lialda with a meal to help reduce these side effects and ensure optimal absorption of the medication.

How long do Lialda side effects last?

The duration of Lialda side effects can vary depending on individual factors and the specific side effect experienced. In general, mild side effects may resolve within a few days to a couple of weeks after starting treatment.

How does Lialda work?

Lialda works by delivering mesalamine, an anti-inflammatory medication, directly to the colon. Mesalamine inhibits the production of inflammatory mediators and helps reduce inflammation in the colon, thereby relieving symptoms associated with ulcerative colitis.

How long does it take for Lialda to work?

The onset of action of Lialda may vary among individuals. Some patients may experience symptom improvement within a few weeks of starting treatment, while others may require several weeks for the full therapeutic effect to be realized.

Who makes Lialda?

Lialda is manufactured by Shire US Inc., a subsidiary of Takeda Pharmaceutical Company Limited.

How long does Lialda stay in your system?

The elimination half-life of Lialda is approximately 12 hours. This means that it takes about 12 hours for half of the medication to be cleared from the body. However, complete elimination may take several days.

What time of day should I take Lialda?

Lialda is typically taken once daily with a meal. The specific time of day for taking Lialda may vary among individuals based on their preferences and lifestyle.

What is the difference between Lialda and mesalamine?

Lialda is a brand-name medication that contains mesalamine as its active ingredient. Mesalamine is also available under other brand names and generic formulations. The difference between Lialda and other mesalamine products may lie in factors such as dosage form, dosing regimen, and inactive ingredients.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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