Pentasa is a brand name for the drug mesalamine, which belongs to the class of medications known as aminosalicylates. It is primarily used to manage the symptoms of mild to moderate ulcerative colitis and mild to moderate Crohn’s disease. Mesalamine acts locally in the gastrointestinal tract to reduce inflammation and provide relief from the discomfort associated with IBD.

Pentasa exerts its therapeutic effects through its active ingredient, mesalamine, which has anti-inflammatory properties. The exact mechanism of action is not fully understood, but it is believed that mesalamine works by inhibiting the production of inflammatory substances, such as prostaglandins and leukotrienes, which play a crucial role in the inflammatory response in the digestive tract.

When Pentasa is administered orally, the medication reaches the colon and the terminal ileum (the last part of the small intestine) where it exerts its anti-inflammatory effects. By reducing inflammation, Pentasa helps in controlling the symptoms of ulcerative colitis and Crohn’s disease, such as abdominal pain, diarrhea, rectal bleeding, and urgency.

Pentasa is commonly prescribed for individuals diagnosed with ulcerative colitis or Crohn’s disease. These are chronic inflammatory conditions of the gastrointestinal tract that can significantly impact a person’s quality of life. Pentasa is particularly effective in managing mild to moderate disease activity and preventing flare-ups.

The medication is used by a diverse group of individuals, including:

  • Patients with Ulcerative Colitis: Ulcerative colitis primarily affects the colon (large intestine) and the rectum, leading to inflammation and ulceration of the inner lining of the digestive tract. Patients with ulcerative colitis may experience symptoms such as abdominal pain, bloody diarrhea, weight loss, and fatigue. Pentasa is often prescribed to induce and maintain remission in these patients.
  • Patients with Crohn’s Disease: Crohn’s disease is a chronic inflammatory condition that can affect any part of the digestive tract, from the mouth to the anus. Common symptoms include abdominal pain, diarrhea, fatigue, and weight loss. Pentasa is frequently used to manage mild to moderate Crohn’s disease and prevent relapses.
  • Those with Mild to Moderate Disease Activity: Pentasa is most effective in individuals with mild to moderate disease activity. It helps alleviate symptoms and maintain periods of remission, reducing the frequency and intensity of flare-ups.
  • Patients Seeking a Well-Tolerated Medication: Pentasa is generally well-tolerated by most individuals. It offers a favorable safety profile, making it a suitable choice for patients who may have experienced adverse effects with other medications or those who require long-term therapy.
  • Individuals Aiming for Localized Treatment: As a locally acting medication, Pentasa primarily targets the inflamed areas of the digestive tract without significantly affecting the rest of the body. This feature makes it an attractive option for those seeking targeted treatment with minimal systemic effects.
  • Pediatric Patients: Pentasa is also prescribed to pediatric patients with IBD. It provides a reliable treatment option for children and adolescents suffering from ulcerative colitis or Crohn’s disease.
  • Pregnant and Breastfeeding Women: For pregnant or breastfeeding women with IBD, Pentasa may be considered a safer option compared to certain other medications. However, the decision to use Pentasa during pregnancy or while breastfeeding should be made in consultation with a healthcare provider.
  • Individuals Unresponsive to Other Treatments: Some patients may not respond adequately to other medications commonly used for IBD treatment. Pentasa can be a viable alternative in such cases, offering a chance for symptom relief and disease management.

Warnings and Precautions

While it can be highly effective, it’s essential to be aware of the warnings and precautions associated with its usage.

  1. Allergic Reactions: If you have known allergies to mesalamine or any other ingredients in Pentasa, inform your doctor immediately.
  2. Mesalamine Sensitivity: Patients with a sensitivity to mesalamine may experience worsening symptoms. Monitor for any adverse reactions.
  3. Kidney Function: Regularly assess kidney function during Pentasa treatment, as it may affect renal health.
  4. Liver Function: Check liver function periodically, especially for patients with pre-existing liver conditions.
  5. Pediatric Use: Use Pentasa in pediatric patients only as directed by a healthcare professional.
  6. Geriatric Use: Elderly patients may require dose adjustments, as kidney function tends to decline with age.
  7. Gastrointestinal Obstruction: Avoid using Pentasa in patients with pyloric stenosis or any history of gastrointestinal obstruction.
  8. Interstitial Nephritis: Pentasa use has been associated with interstitial nephritis. Watch for symptoms like fever, rash, and eosinophilia.
  9. Blood Disorders: Pentasa can affect blood cell counts, so monitor for signs of anemia, leukopenia, or thrombocytopenia.
  10. Mesalamine-Induced Acute Intolerance Syndrome: Discontinue Pentasa if signs of acute intolerance syndrome appear.
  11. Pregnancy and Breastfeeding: Consult your doctor before taking Pentasa if you are pregnant or breastfeeding.
  12. Fertility: Pentasa does not affect fertility in men or women, but consult your healthcare provider if you have concerns.
  13. Monitoring During Therapy: Regularly monitor for any changes in symptoms and drug efficacy during Pentasa treatment.
  14. Immunizations: Inform your healthcare provider about Pentasa usage before receiving any vaccinations.
  15. Driving and Operating Machinery: Pentasa may cause dizziness, so exercise caution when driving or operating machinery.
  16. Withdrawal of Corticosteroids: Do not abruptly stop corticosteroid therapy, as it may worsen your condition.
  17. Lactose Intolerance: Pentasa tablets contain lactose, so consider alternative formulations for lactose-intolerant patients.
  18. Treatment Failure: If your condition does not improve or worsens, consult your doctor for alternative treatments.
  19. Use in Patients with Hepatic Impairment: Use Pentasa with caution in patients with hepatic impairment.

Side Effects

Common Side Effects

  • Headache: A frequent but temporary side effect of Pentasa is a mild headache.
  • Nausea and Vomiting: Some individuals may experience feelings of nausea or vomiting, especially during the initial days of treatment.
  • Abdominal Discomfort: Patients may encounter mild abdominal discomfort, which should improve over time.
  • Diarrhea: Diarrhea is another common side effect, but it often diminishes as the body adjusts to the medication.
  • Fatigue: Feeling tired or fatigued is a possibility with Pentasa use, but rest and proper hydration can help alleviate this.

Rare Side Effects

  • Allergic Reactions: Some individuals may develop allergic reactions to Pentasa, leading to symptoms such as hives, rash, itching, or swelling of the face, tongue, or throat.
  • Liver Problems: In rare cases, Pentasa can affect liver function, leading to symptoms like jaundice, dark urine, or persistent abdominal pain.
  • Blood Disorders: Pentasa may cause changes in blood cell counts, resulting in symptoms such as unexplained bruising, bleeding, or weakness.

Severe Side Effects

  • Pancreatitis: Pentasa may cause inflammation of the pancreas, leading to severe abdominal pain, nausea, and vomiting.
  • Pericarditis: Some individuals may experience inflammation of the pericardium, the membrane surrounding the heart, resulting in chest pain and difficulty breathing.
  • Interstitial Nephritis: In rare instances, Pentasa can lead to interstitial nephritis, characterized by symptoms like decreased urination and swelling.
  • Severe Allergic Reactions: Anaphylaxis, a severe allergic reaction, may occur rarely, causing breathing difficulties and a sudden drop in blood pressure.


As with any medication, Pentasa can interact with other drugs, herbal supplements, and even certain foods, potentially affecting its efficacy or causing adverse effects.

Drug Interactions

  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Combining NSAIDs with Pentasa may increase the risk of kidney problems and gastrointestinal bleeding.
  • Azathioprine and 6-Mercaptopurine: Concurrent use of these drugs with Pentasa can elevate the risk of bone marrow suppression.
  • Methotrexate: Pentasa can reduce the elimination of methotrexate from the body, leading to increased toxicity.
  • Probenecid: Probenecid can reduce the excretion of Pentasa, potentially leading to increased blood levels of the drug.
  • Warfarin: Pentasa may interact with warfarin, an anticoagulant, affecting its blood-thinning effect and increasing the risk of bleeding.

Herbal Interactions

  • St. John’s Wort: This herbal supplement can decrease the effectiveness of Pentasa, leading to increased inflammation in IBD.
  • Aloe Vera: Aloe Vera may have a laxative effect, which could worsen symptoms in individuals with IBD.
  • Garlic: Garlic supplements may increase the risk of bleeding when combined with Pentasa.
  • Ginseng: Ginseng can affect the immune system, potentially altering the response to Pentasa treatment.

Food Interaction

  • Dairy Products: Calcium-rich foods like milk and cheese can reduce the absorption of Pentasa. It’s best to take Pentasa at least one hour before or two hours after consuming dairy.
  • Fatty Foods: High-fat meals might slow down the absorption of Pentasa, leading to a delayed response.
  • Grapefruit Juice: Grapefruit juice can interfere with drug metabolism and may affect Pentasa’s efficacy.


When using Pentasa, it’s crucial to follow the dosing guidelines to ensure optimal effectiveness and safety.

Initial Dosing

When starting Pentasa, the initial dosing is essential for achieving the desired therapeutic effects. The standard initial dose is usually determined based on the condition being treated and the patient’s individual characteristics. Typically, the initial dosing for adults with mild to moderate ulcerative colitis is 1 g four times daily. For Crohn’s disease patients, the initial dose might be higher, usually around 1 g to 1.5 g four times a day.

Maintenance Dosing

Once the initial phase is completed, the maintenance dosing of Pentasa is necessary to sustain remission and prevent disease relapse. The typical maintenance dose for adults with ulcerative colitis is 500 mg to 1 g four times daily. For those with Crohn’s disease, the maintenance dose ranges from 1 g to 2 g four times daily

Missed Dose

If you accidentally miss a dose of Pentasa, take it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Avoid taking double doses to compensate for the missed one, as this may lead to adverse effects.


An overdose of Pentasa can be potentially harmful and should be avoided at all costs. If you suspect an overdose or experience symptoms such as severe stomach pain, vomiting, fast heartbeat, or difficulty breathing, seek immediate medical attention or contact your local poison control center.


To get the best results from this medication, it is crucial to follow the ideal storing guidelines.

  1. Storage Temperature: Pentasa should be stored at room temperature, typically between 68°F and 77°F (20°C to 25°C).
  2. Avoid Extreme Temperatures: Keep Pentasa away from direct sunlight and avoid exposing it to extreme temperatures, such as heat or freezing cold.
  3. Original Packaging: Store Pentasa in its original blister packaging until you are ready to use it. This helps protect the medication from moisture and ensures its stability.
  4. Moisture and Humidity: Avoid storing Pentasa in a humid environment, such as a bathroom, as moisture can compromise the medication’s integrity.
  5. Out of Reach of Children: Keep Pentasa out of the reach of children and pets to prevent accidental ingestion.
  6. Closed Container: Always keep the container tightly closed when not in use to maintain the medication’s efficacy.
  7. Do Not Repackage: Refrain from transferring Pentasa to another container or pillbox, as it might reduce its effectiveness.
  8. Separate from Food and Beverages: Store Pentasa away from food, beverages, and pet food to prevent contamination.
  9. Medication Organizer: If you use a medication organizer, ensure it is clean and dry before placing Pentasa in it.
  10. Away from Electronics: Avoid storing Pentasa near electronic devices, as exposure to magnetic fields could affect the medication’s quality.
  11. Travelling with Pentasa: When traveling, keep Pentasa in its original packaging and carry it in a cool, dry place in your bag. Avoid leaving it in a hot car or exposed to sunlight for extended periods.
  12. Medication Expiration: Always check the expiration date on Pentasa’s packaging and discard any expired medication promptly.
  13. Pharmacy Instructions: Follow any specific storage instructions provided by your pharmacist or healthcare professional.
  14. Storage Duration: If you have any leftover Pentasa after completing your treatment, ask your pharmacist about the appropriate storage duration.
  15. Incompatible Containers: Never store Pentasa in containers previously used for other medications to prevent cross-contamination.
  16. Monitoring Storage Conditions: Regularly check the storage conditions to ensure they meet the recommended guidelines.
  17. Proper Disposal: Dispose of any unused or expired Pentasa properly following local regulations and guidelines.
  18. Backup Supply: Consider having a backup supply of Pentasa in case of emergencies or unexpected events.
  19. Keep Track of Usage: Maintain a record of your Pentasa usage to ensure you don’t miss any doses and to manage your supply effectively.
  20. Pharmacist Consultation: If you have any doubts or questions about storing Pentasa, consult your pharmacist for personalized advice.
  21. Educate Caregivers: If you have a caregiver assisting you with medication management, ensure they are aware of the proper storage guidelines for Pentasa.
  22. Follow Healthcare Provider’s Advice: Always follow your healthcare provider’s instructions regarding Pentasa usage, storage, and dosage.
  23. Medication Safety Tips: Familiarize yourself with general medication safety tips to ensure you maintain a safe and efficient medication storage system.
  24. Avoid Freezing Pentasa Suppositories: If you are prescribed Pentasa suppositories, do not freeze them as it may affect their effectiveness.
  25. Store Away from Pets: Ensure that your pets cannot access the area where you store Pentasa to avoid accidental ingestion.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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