Delzicol (mesalamine) belongs to a class of drugs called aminosalicylates, which are used to treat gut inflammation. It helps to treat and prevent flare-ups of ulcerative colitis, a type of inflammatory bowel disease (IBD). An autoimmune disorder, ulcerative colitis causes swelling and ulcers in the colon and rectum due to your immune system attacking your gut.

As a result of ulcerative colitis, Delzicol reduces inflammation. As a result of its ability to block cyclooxygenase (COX) and inhibit prostaglandin production in the colon, it is thought to have anti-inflammatory properties. Prostaglandins (a group of lipids) and COX both contribute to inflammation.

As a delay-release capsule, Delzicol dissolves only at a pH of 7 or greater, which means the drug is released directly into the terminal ileum and colon beyond, where it has an anti-inflammatory effect.

As of 2013, Delzicol has been approved by the Food and Drug Administration (FDA). Delzicol has since been approved as a generic drug.

Warnings and Precautions

In the pursuit of maintaining optimal gastrointestinal health, Delzicol serves as an essential medication. However, it’s crucial to be well-informed about the potential warnings and precautions associated with its usage. By understanding and adhering to these guidelines, you can make the most of Delzicol’s benefits while minimizing any potential risks.

  • Consultation with Healthcare Professional: Before initiating any medication regimen, including Delzicol, it’s imperative to consult a qualified healthcare professional. A licensed medical practitioner can evaluate your individual medical history, potential allergies, and existing medications to ensure that Delzicol is a suitable option for you.
  • Allergic Reactions: Be vigilant about any allergic reactions that might occur upon taking Delzicol. If you experience symptoms such as hives, difficulty breathing, swelling of the face, lips, tongue, or throat, discontinue usage immediately and seek medical attention.
  • Kidney Function Monitoring: Regular monitoring of kidney function is essential while taking Delzicol. Your healthcare provider might recommend periodic blood tests to assess how well your kidneys are functioning. This precaution helps in identifying any adverse effects on kidney health.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the usage of Delzicol with your healthcare provider. They can weigh the potential benefits against the risks and determine the most appropriate course of action for your specific situation.
  • Pre-existing Medical Conditions: Inform your healthcare provider about any pre-existing medical conditions you have, such as liver disease or gastrointestinal disorders. Delzicol’s safety and efficacy can be influenced by these factors, so your medical professional can make informed decisions regarding your treatment.
  • Drug Interactions: Be cautious about potential drug interactions when taking Delzicol. Certain medications might adversely interact with Delzicol, affecting its effectiveness or leading to unwanted side effects. Always inform your healthcare provider about any other medications, supplements, or herbal remedies you are taking.
  • Dosage Adherence: Adhering to the prescribed dosage is vital to ensure the medication’s effectiveness and your safety. Avoid altering the dosage without consulting your healthcare provider, as doing so can result in suboptimal treatment outcomes or potential health risks.
  • Side Effects Monitoring: Keep a close watch for any side effects that might arise while taking Delzicol. Common side effects can include diarrhea, nausea, headache, or abdominal discomfort. Should you experience any persistent or severe side effects, promptly communicate with your healthcare provider.
  • Geriatric Considerations: If you are an older adult, your body’s response to medications might differ. Your healthcare provider will carefully assess the dosage and monitor any potential effects to ensure your well-being.
  • Storage Guidelines: Properly store Delzicol as per the manufacturer’s recommendations. Store it at room temperature, away from moisture and heat, to maintain its potency and safety.

Side Effects

Delzicol is a medication prescribed for the treatment of inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease. While it offers relief and improved quality of life for many individuals, it’s essential to be aware of potential side effects that can occur.

Common Side Effects

  1. Gastrointestinal Distress: Some individuals may experience mild gastrointestinal discomfort, including bloating, gas, and stomach cramps.
  2. Headache: A common side effect is occasional headaches, which typically subside as the body adjusts to the medication.
  3. Nausea and Vomiting: Delzicol can cause mild nausea, leading to occasional vomiting in some cases.
  4. Skin Reactions: Skin rash or mild irritation may occur as a result of taking Delzicol.

Rare Side Effects

  1. Allergic Reactions: In rare instances, individuals may develop allergic reactions such as hives, itching, or swelling of the face, lips, or tongue.
  2. Liver Function Changes: Delzicol can affect liver enzymes, leading to rare cases of elevated liver function tests.
  3. Blood Disorders: There have been reports of rare cases of blood disorders, including decreased white blood cell counts, which can affect the body’s immune response.

Severe Side Effects

  1. Pancreatitis: Although uncommon, severe abdominal pain that radiates to the back could indicate pancreatitis, a serious condition requiring medical attention.
  2. Kidney Problems: Some individuals may experience decreased kidney function or changes in urine output, which should be promptly reported to a healthcare professional.
  3. Serious Allergic Reactions: While rare, severe allergic reactions like anaphylaxis can occur, leading to difficulty breathing, rapid heartbeat, and a drop in blood pressure.


Delzicol is a medication used to treat various gastrointestinal conditions. Understanding its interactions with other drugs, herbs, and foods is crucial to ensuring its effectiveness.

Drug Interactions

  • Antacids: Combining Delzicol with antacids might reduce its effectiveness. It’s advisable to space out the intake of these substances to avoid diminished results.
  • Azathioprine and Mercaptopurine: Delzicol may enhance the effects of these medications, potentially leading to toxicity. Consult your healthcare provider before taking them together.
  • Probenecid: Concurrent use of Delzicol and probenecid may lead to increased levels of Delzicol in the body, potentially resulting in adverse effects.

Always inform your doctor about all the medications you’re taking, including over-the-counter drugs, supplements, and herbal remedies, to avoid potential interactions.

Herbal Interactions

  • Aloe Vera: Aloe vera may accelerate the absorption of Delzicol, possibly leading to an increased risk of side effects.
  • Ginseng: Ginseng could potentially reduce the effectiveness of Delzicol by affecting its absorption or metabolism. Consult your healthcare provider before using them together.
  • St. John’s Wort: This herb is known to interact with numerous medications, including Delzicol. It might decrease Delzicol’s efficacy, leading to inadequate symptom management.

Food Interactions

  • Dairy Products: Dairy foods, particularly high-calcium ones, might interfere with Delzicol’s absorption. It’s recommended to take Delzicol either an hour before or two hours after consuming dairy.
  • Grapefruit: Grapefruit and its juice contain compounds that can inhibit the enzymes responsible for breaking down Delzicol, potentially leading to increased drug levels in the body.
  • High-Fat Meals: Delzicol absorption could be delayed when taken with high-fat meals. Opt for a balanced diet to ensure optimal absorption.


Delzicol is a medication known for its effectiveness in treating certain gastrointestinal conditions. To ensure its optimal results and prevent any adverse effects, it’s crucial to adhere to the dosing guidelines.

Initial Dosing

When initiating Delzicol treatment, a precise dosing regimen is crucial. The recommended dosage for adults is usually two 400 mg capsules, taken three times daily for a total daily dose of 2.4 grams. This initial phase sets the tone for your treatment journey. It’s advised to take these doses approximately six hours apart to maintain consistent levels of the medication in your system.

Maintenance Dosing

Once the initial phase is completed, the maintenance dosing strategy comes into play. At this juncture, the dosage is generally adjusted based on your response to the treatment and your healthcare provider’s guidance. The aim is to strike the right balance between symptom management and minimizing potential side effects.

The typical maintenance dose for Delzicol is often reduced to two 400 mg capsules, taken twice daily, yielding a total daily dose of 1.6 grams. Adhering to this regimen is vital to sustain the positive effects of the medication and maintain stability in your digestive health.

Missed Doses

In the course of your treatment journey, there might be instances where a dose of Delzicol is inadvertently missed. In such cases, it’s important not to panic, but rather to take appropriate action. If you remember within two hours of the missed dose, it’s recommended to take the missed dose. However, if more than two hours have passed, it’s advised to skip the missed dose and resume your regular dosing schedule.


While the dosing guidelines for Delzicol offer therapeutic benefits, it’s imperative to exercise caution to prevent an overdose situation. In case of accidental ingestion of a significantly higher dose than recommended, seek medical attention immediately. Symptoms of an overdose may include severe stomach pain, vomiting, and rapid breathing.


Proper storage is essential to maintaining the potency of Delzicol and ensuring that it remains safe for consumption.

  1. Temperature Control: Store Delzicol at room temperature, preferably between 68°F to 77°F (20°C to 25°C). Avoid exposing the medication to extreme temperatures, such as direct sunlight or freezing conditions.
  2. Humidity Considerations: Keep Delzicol in a dry environment. High humidity levels can lead to the deterioration of the medication’s quality.
  3. Protection from Light: Protect the medication from light by storing it in its original container. Light exposure can contribute to the breakdown of the active ingredients.
  4. Designate a Storage Space: Choose a designated storage area that is cool, dry, and away from direct sunlight.
  5. Avoid Bathroom Storage: While it may be convenient, the bathroom is not an ideal location due to humidity and temperature fluctuations.
  6. Keep Away from Children and Pets: Store Delzicol out of reach of children and pets to prevent accidental ingestion.
  7. Follow Dispensing Instructions: Adhere to the dispensing instructions provided by your healthcare provider or pharmacist. This ensures you are taking the correct dosage and using the medication as directed.
  8. Check Expiry Dates: Always check the expiration date on the packaging before taking Delzicol. Expired medication may not provide the intended benefits and could potentially be harmful.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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