Octasa is a prescription medication used to treat and prevent flare-ups of ulcerative colitis and Crohn’s ileocolitis that is already under control.

Ulcerative Colitis, a condition that occurs when the colon and rectum get inflamed, is among the most common chronic diseases affecting Americans. Up to 9000 Americans live with this condition, requiring the need for treatment to manage it.

It contains the active substance mesalamine that acts on the affected area reducing inflammation in the colon, terminal ileum, and rectum.

How Does Octasa Work?

Octasa works by directly acting on the site of infection, decreasing inflammation in the lining of the colon, rectum, and ileum. It helps regulate inflammation by decreasing the production of prostaglandins and leukotrienes.

Prostaglandins affect the body’s inflammatory response, while leukotrienes are responsible for inflammation. By inhibiting the production of these substances, mesalamine helps to reduce inflammation and treat UC and Crohn’s ileocolitis.

Precautions and Warnings With Octasa

Octasa can cause adverse effects or worsen your conditions. It is important to check its precautions and warnings before starting to take the prescription and inform your doctor about any current condition you are suffering from for safe use.

  • Skin reactions: The use of Octasa has been linked to several skin diseases such as severe cutaneous reactions and Stevens-Johnson, which can be life-threatening.
  • Allergic Reactions: Before taking Octasa inform your doctor if you are allergic to the medication or its ingredients to prevent potential adverse reactions.
  • Mesalamine-Induced Acute Intolerance Syndrome: If you experience symptoms such as fever, headaches, and bloody diarrhea call your doctor immediately. These symptoms could indicate that you are having Mesalamine-induced acute intolerance syndrome.
  • Hypersensitivity: Patients having a pre-history of hypersensitivity reactions should avoid taking Octasa because they may be at risk of having anaphylaxis. The condition can manifest with inflammation of the heart, a disorder called
  • Reyes Syndrome: Patients who have received varicella virus vaccine in the past six weeks should avoid taking mesalamine due to the risk of having Reyes syndrome.
  • Kidney Conditions: Avoid taking Octasa if you are suffering from any kidney conditions, as it may cause kidney stones to develop. Discontinue the drug if you experience any signs of kidney problems.

Octasa Side Effects

While Octasa is generally well-tolerated, some people experience side effects while taking the medication. The side effects vary in severity and occurrence. Common side effects are usually manageable, while severe ones are rare and may require medical attention.

Common Side Effects

  • Cough
  • Fever
  • Blurred vision
  • Blood in your stool
  • Dizziness
  • Headache
  • Chills
  • Loss of appetite

Severe Side Effects

  • Difficulty breathing
  • Muscle aches and pains
  • Dark urine
  • Back pain
  • Swelling of your, legs and feet
  • Kidney conditions
  • Liver problems

Drug Interactions With Octasa

Understanding how Octasa interacts with other medications helps to ensure safe and effective treatment, specifically for patients suffering from colitis. Health providers can make informed decisions about medication selection, dosing adjustments, and monitoring strategies, which can help prevent potential risks and optimize therapeutic effects.

Drug Interaction
CyclosporineCombining cyclosporine (Restasis) with Octasa can cause kidney toxicity and increase blood pressure. Monitoring patients closely for signs of kidney dysfunction with symptoms such as changes in blood pressure may be necessary.
AzathioprineThe interaction between Octasa and azathioprine increases the risk of bone marrow suppression, which can result in decreased production of blood cells.
CorticosteroidsThe concurrent use of these medications may lead to the development of corticosteroid-related side effects such as high blood pressure, mood changes, fluid retention, and weight.
MethotrexateUsing methotrexate and Octasa concurrently may heighten the risk of having liver toxicity with symptoms such as dark urine, jaundice, and vomiting.
NaproxenTaking naproxen while using Octasa may cause gastrointestinal bleeding and ulcers accompanied by symptoms such as vomiting blood, stomach pain, and bloody stools.
Proton Pump Inhibitors (PPIs)Taking PPIs alongside Octasa reduces the absorption of Octasa, potentially diminishing its effectiveness.

Strengths and Dosages of Octasa

The dosage of the medicine can vary depending on its strength. The frequency of doses, intervals between doses, and duration of treatment are determined by specific medical conditions being addressed and the weight of the patient.

Weight Dosage No of Times a Day
Children weighing 17-33 kg40000mgTwo times per day
Children weighing 34-54kg1600mgTwo times per day
Adult weighing 55-90kg1600mgTwo times per day

For children below the age of 17 years, their dosage should be determined by a healthcare provider. Take the tablet whole with a glass of water or juice without breaking, chewing, or crushing it, because it has a coating designed to delay its onset or protect the medication from stomach acids.

Octasa is intended for long-term treatment. If your doctor agrees that Octasa is safe and beneficial for you, it will likely be part of your long-term regimen.

Octasa Alternatives

Several alternatives to Octasa exist, offering similar therapeutic benefits while potentially varying in efficacy, cost, and formulation. For patients seeking alternative treatment options, exploring these alternative drugs becomes imperative.

  • Mercaptopurine: 6-Mercaptopurine is an immunosuppressant that functions by suppressing immune response. It is frequently used alongside other medications to sustain remission in colitis and avert symptoms recurrence.
  • Olsalazine: It effectively manages mild to moderate colitis and serves as a preventive measure against flare-ups of the condition.
  • Sulfasalazine: Sulfasalazine contains a sulfa antibiotic and it operates by reducing inflammation within both the colon and intestines.
  • Other Medications: Apart from the listed alternative medications, there are other alternative drugs such as azathioprine, balsalazide, mesalamine, and infliximab.

FAQs of Octasa

What is Octasa?

Octasa is a prescription anti-inflammatory medication used in treating ulcerative colitis and Crohn’s ilecolitis. It contains the active ingredient mesalazine.

Octasa is a drug used in the management of ulcerative colitis, and Crohn’s ileocolitis, particularly during periods of remission to prevent flare-ups. Its active ingredient mesalamine, targets inflammation at the site of infection such as the ileum, rectum, and colon.

How does Octasa work?

Mesalazine functions by decreasing inflammation in the lining of the colon and rectum. It interferes with the production of inflammatory prostaglandin and other chemicals in the body like leukotriene B4 that are involved in the inflammatory process.

What do I need to know before using Octasa?

Before taking Octasa you need to know if you have allergies to the medication or if you have any liver or kidney problems.

What are the side effects of Octasa?

Octasa has side effects that include headache, rash, dizziness, chest pain, itching skin, vomiting, stomach pain, diarrhea, and muscle or joint pain.

Is it safe to take Octasa for a long time?

Long-term use of Octasa is safe, but your doctor should monitor your kidney and liver function throughout the treatment period. Regular check-ups are important when taking the medication because Octasa increases the risk of kidney and liver problems.

Is there any food or drink I need to avoid?

You can maintain your regular diet and fluid intake when taking Octasa. If you experience symptoms such as nausea and indigestion you should opt for simple meals and not alcohol or spicy foods.

How should I take Octasa?

Take Octasa before meals. Swallow the tablet as a whole with some liquid, do not chew, break, or crush it before swallowing.

What is the cost of Octasa in America?

In America, Octasa a medication that is commonly prescribed in the form of 400mg tablets, typically costs $113 for a 90-tablet supply. Alternatively, you might consider Mesalazine, its generic version, which is a little bit cheaper.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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