Mezavant is a branded version of the generic drug, mesalamine, a 5-aminosalicylic acid (5-ASA) drug commonly used to manage the symptoms associated with ulcerative colitis, Crohn’s Disease, and other inflammatory bowel diseases (IBD).

Mezavant is a potent anti-inflammatory drug specifically designed to reduce the colorectal inflammation associated with ulcerative colitis, and the greater gastrointestinal inflammation found with Crohn’s Disease.

An extended-release delivery system ensures that the medication is gradually released throughout the length of the gastrointestinal tract and colon, where the active ingredient, mesalazine, acts as an inhibitor, blocking a naturally occurring inflammatory chemical at the cellular level.

Mezavant Side Effects

While Mezavant is generally well-tolerated by most patients in the short term, adverse effects are possible at any stage and may become more likely the longer the drug is used.

Common Side Effects

Some patients have reported symptoms associated with indigestion when taking Mezavant.

Patients have also reported the following common side effects:

.Abdominal Pain

  • Cramps
  • Change In Blood Pressure
  • Constipation
  • Mild Diarrhea
  • Light-Headedness
  • Weakness
  • Ear Ache
  • Sore Throat
  • Lethargy
  • Tremors
  • Nausea & Vomiting
  • Back Pain

Severe Side Effects

These side effects may be indicative of a more serious health concern. Seek guidance from a healthcare professional if you experience any of the following side effects

  • Burning Pain the Anus
  • Fever
  • Rapid Heartrate
  • Pounding Heartbeat
  • Butterfly-shaped Rash On Face Or Arms
  • Rectal Bleeding
  • Numb Extremities
  • Severe Headache
  • Severe Abdominal Pain
  • Unexplained Bruises
  • Changes in Vision
  • Worsening of ANY Symptom

Symptom Clusters

These symptoms may be significant if they occur with other symptoms:

  • Anemia: Feeling light-headed, unusually tired, and weak, pale skin, difficulty catching breath
  • Kidney Damage: Feeling the urge to urinate more frequently (especially during the night) but producing less urine, blood in urine
  • Infection: Fever, or chills, difficulty catching breath, extended period of dizziness, headache, neck ache, unexplained weight loss, listlessness
  • Liver Damage:  Nausea, vomiting, and diarrhea with loss of appetite and weight loss. Jaundice (Yellow color to the skin or eyes) dark-colored urine, pale-colored stools, skin rash, itching
  • Lung Inflammation: Fever, coughing, difficulty catching breath, chest pain, wheezing
  • Kidney Stones: Blood in urine, feeling an increased urge to urinate, pain in the groin or lower back

Urgent Side Effects

The following side effects are rare but have the potential to be life-threatening. If you experience any of the following symptoms, stop taking Mezavant and seek immediate medical attention.

  • Life-Threatening Allergic Reaction: Shortness of breath, difficulty breathing, nausea and vomiting, facial swelling, throat swollen, stomach cramps
  • Acute Intolerance Syndrome: Abdominal cramps or severe abdominal discomfort, bloody diarrhea, fever
  • Inflammation Around the Heart: Coughing, fatigue, fever, shortness of breath
  • Pancreatitis: Abdominal pain in upper left quadrant, back pain, rapid heartbeat, distended abdomen, fever
  • Serious Skin Reaction: Skin rash, flushed skin, blistering around the eyes or mouth, peeling skin, joint pain, fever
  • Pressure in the Brain: Severe headache (worse with eye movement), seeing flashes of light, vision loss, nausea, ringing in the ears

Mezavant Contraindications

Allergic reactions are possible with any drug. Be sure to let your doctor know if you have experienced an allergic reaction to medication in the past.

Additionally, if you have experienced any of the following health concerns, your doctor may opt to prescribe an alternative medication.

  • Previous inflammation around the heart
  • Previous allergic reaction to Mezavant, mesalazine, or sulphasalazine
  • Restriction or blockage of the stomach
  • History of skin conditions like atopic dermatitis or atopic eczema
  • History of severe skin reactions to substances

Mezavant Strengths And Dosages

Mezavant is available in 1200 mg gastro-resistant, prolonged-release tablets.

Treatment PhaseStrength/FormTypical Dose
Induction/Pre-Remission1200mg DR or ER2400mg – 4800mg once daily
Maintenance/Remission1200mg DR or ER

 

2400mg once daily

Additional Administration Information

There are a few important instructions to remember when taking Mezavant

  • Mezavant should be taken with a meal to increase absorption.
  • Do not chew, split, or crush Mezavant tablets. Pills should be swallowed intact with a full glass of water.
  • If you miss a dose simply carry on with your regular dosing schedule. DO NOT take more than your usual dosage amount.

Mezavant Pricing

Mezavant prices can vary depending on your location, and pharmacy pricing. and the pharmacy you choose. Health insurance or membership in a pharmacy discount plan may reduce the cost of the drug significantly.

The prices quoted here reflect the current average retail price with no health insurance or discount reductions. At the time of this writing, the average reported cost for a bottle of 360 tablets was $554.95, or ~$1.54 per pill.

Mezavant Alternatives

Yes, there are alternatives to Mezavant if you are looking for different treatments for ulcerative colitis. Mesalazine, the active ingredient in Mezavant, is also available in several other formulations that may differ in dosages and administration schedules. It’s important for you to consult your healthcare provider to determine if an alternative medication would be effective for your specific needs.

Brand NameFormulaStrength
PentasaSlow Release (SR)500 mg & 1000mg
AsacolDelayed Release (DR)400mg & 800mg
LialdaMMX Multi Matrix System (MMX)1200mg

Each of these medications has its own unique profile, and your doctor can help you compare these options.

Keep in mind that while all these drugs serve a similar purpose, they may have different side effects or interactions. It’s imperative to discuss these aspects with your healthcare provider before making any changes to your treatment regimen.

Additionally, non-medication-based strategies such as dietary modifications and stress management techniques may help to reduce the severity of the disorder and allow you to stop taking medications

Frequently Asked Questions About Mezavant

Do you still have questions we haven’t answered? We have compiled a list of the most common questions we receive. You may find your answers here.

What conditions is Mezavant prescribed for?

Mezavant is primarily used to treat mild to moderate ulcerative colitis, a type of inflammatory bowel disease that affects the colon. It is also used to manage the symptoms of Crohn’s Disease..

Does Mezavant have any common side effects?

Yes, it may cause side effects like headache, stomachache and nausea. Like most drugs in this class, it can be damaging to the kidneys and liver, so it is important to watch for any outward signs of illness like jaundice, or dark urine.

How does Mezavant differentiate from steroids?

Both corticosteroids and Mezavant work to reduce inflammation in the colon and GI tract. However, they use slightly different methods of action to achieve the desired effect. Steroids, while effective, carry a much higher risk of adverse effects with continued use. Mezavant delivers the same level of efficacy with a better safety profile.

What type of drug class does Mezavant belong to?

Mezavant belongs to the drug class known as aminosalicylates, which are compounds that help reduce inflammation in the lining of the colon.

How long does it typically take for Mezavant to take effect?

The time it takes for Mezavant to make a marked impact on the level of inflammation and associated discomfort will differ from patient to patient. However, many patients notice an improvement in their symptoms within a few weeks of starting treatment.

Can long-term Mezavant use have adverse effects on liver health?

Long-term use of Mezavant does have the potential to damage the liver. Therefore, it’s recommended to have regular liver function tests while on the medication to ensure your liver remains healthy.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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