Mezavant is a prescription medication primarily used to manage mild to moderately active ulcerative colitis. It falls under the category of aminosalicylates, which are anti-inflammatory drugs used to alleviate symptoms of inflammatory bowel diseases.

Mezavant contains an active ingredient called mesalazine, also known as 5-aminosalicylic acid (5-ASA). This compound acts locally in the colon, where it exerts its anti-inflammatory effects. Mesalazine is thought to work by inhibiting the production of inflammatory chemicals in the colon, thus reducing inflammation and allowing the affected tissues to heal.

Mezavant is specifically designed for individuals diagnosed with mild to moderately active ulcerative colitis, a type of inflammatory bowel disease that affects the colon and rectum. It is not intended for use in other types of IBD, such as Crohn’s disease.

Ulcerative Colitis

Ulcerative Colitis is a type of inflammatory bowel disease that primarily affects the colon and rectum. It falls under the category of autoimmune diseases, where the body’s immune system mistakenly attacks the gastrointestinal tract, leading to chronic inflammation. This chronic inflammation causes irritation, swelling, and the development of open sores or ulcers in the inner lining of the colon and rectum.

The condition can vary in severity, with some individuals experiencing mild symptoms and others facing more severe and frequent flare-ups. While the exact cause of Ulcerative Colitis remains unknown, research suggests a combination of genetic, environmental, and immune system factors play a role in its development.

Ulcerative Colitis can present with a range of symptoms, which may vary from person to person. Some of the common signs and symptoms include:

  1. Abdominal Pain and Cramping: Individuals with Ulcerative Colitis often experience abdominal pain and cramping, particularly during flare-ups.
  2. Diarrhea: Chronic diarrhea is a hallmark symptom of this condition. The stool may contain blood or mucus.
  3. Rectal Bleeding: Blood in the stool is a common indicator of inflammation and ulcers in the rectum.
  4. Urgency to Defecate: A sudden and strong urge to have a bowel movement is another common symptom.
  5. Weight Loss: Chronic inflammation and malabsorption can lead to unintended weight loss.
  6. Fatigue: Persistent inflammation and frequent bowel movements can cause fatigue and weakness.
  7. Loss of Appetite: Reduced appetite and difficulty in eating may occur during active disease phases.
  8. Fever: Some individuals may experience fever during flare-ups.


The exact cause of Ulcerative Colitis is still not fully understood, but several factors may contribute to its development. These include:

  1. Genetics: Family history plays a significant role, as individuals with a family member having IBD are at a higher risk.
  2. Immune System Dysfunction: An abnormal immune response may lead to inflammation in the colon.
  3. Environmental Triggers: Certain environmental factors, such as diet, stress, and infections, might trigger or worsen symptoms.
  4. Age and Ethnicity: Ulcerative Colitis is more common in people between 15 and 30 years old and those of Ashkenazi Jewish descent.

Warnings and Precautions

While it can be effective in managing symptoms and improving patients’ quality of life, it is essential to understand the potential warnings and precautions associated with this medication.

  1. Consult Your Healthcare Provider: Before starting Mezavant, consult your healthcare provider to discuss your medical history, current medications, and any potential interactions or contraindications.
  2. Allergic Reactions: If you are allergic to salicylates or mesalamine products, do not take Mezavant, as it can trigger severe allergic reactions.
  3. Pregnancy and Breastfeeding: Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the safety of Mezavant during pregnancy and lactation is not fully established.
  4. Pediatric Use: Mezavant’s safety and effectiveness in children have not been extensively studied, so its use in pediatric patients should be carefully evaluated.
  5. Renal Impairment: If you have kidney problems, your doctor may adjust the dosage or consider alternative treatments, as Mezavant is primarily eliminated through the kidneys.
  6. Liver Dysfunction: People with liver diseases should exercise caution while using Mezavant, and regular liver function tests may be necessary.
  7. Hypersensitivity Reactions: Monitor for signs of hypersensitivity reactions, such as rash, fever, and difficulty breathing, and discontinue Mezavant if these symptoms occur.
  8. Lung Inflammation: Mezavant may cause lung inflammation in rare cases. Seek immediate medical attention if you experience breathing difficulties or chest pain.
  9. Interactions with Other Medications: Inform your doctor about all the medications, vitamins, and supplements you are taking, as Mezavant may interact with certain drugs, such as azathioprine or 6-mercaptopurine.
  10. Mesalamine-Induced Acute Intolerance Syndrome: If you experience worsening symptoms, cramping, or bloody diarrhea, discontinue Mezavant immediately, as it may indicate mesalamine-induced acute intolerance syndrome.
  11. Blood Disorders: Mezavant can affect blood cell counts, so regular blood tests may be necessary to monitor for any blood-related issues.
  12. Sun Sensitivity: Mezavant can increase your sensitivity to the sun. Take precautions and use sunscreen when going outdoors.
  13. Vaccination: Consult your healthcare provider before getting vaccinated while on Mezavant, as it may interfere with certain vaccines.
  14. Infection Risk: Mezavant may suppress your immune system, increasing the risk of infections. Stay vigilant for signs of infection and seek medical attention if needed.
  15. Gastrointestinal Disorders: If you have a history of gastrointestinal disorders, inform your doctor, as Mezavant may aggravate certain conditions.
  16. Sulfite Sensitivity: Mezavant contains sulfites, which can trigger allergic reactions in susceptible individuals.
  17. Pancreatitis: If you experience severe abdominal pain, discontinue Mezavant and seek immediate medical attention, as it may be a sign of pancreatitis.
  18. Lactose Intolerance: Mezavant tablets contain lactose. If you are lactose intolerant, discuss alternative formulations with your doctor.
  19. Cardiac Risks: Individuals with a history of heart problems should use Mezavant with caution, as it may increase the risk of heart-related issues.
  20. Bone Marrow Suppression: Mezavant may suppress bone marrow function, leading to a decreased production of blood cells. Regular blood tests can monitor for this side effect.
  21. Monitoring during Therapy: Your doctor may schedule regular check-ups to monitor your response to Mezavant and any potential side effects.
  22. Withdrawal of Therapy: Do not stop Mezavant abruptly without consulting your doctor, as it may worsen your condition.
  23. Asthma and Aspirin Sensitivity: Mezavant may worsen asthma or sensitivity to aspirin. Discuss your medical history with your doctor.
  24. Central Nervous System Effects: In rare cases, Mezavant may cause central nervous system side effects, such as headaches or dizziness.
  25. Storage and Handling: Store Mezavant at the recommended temperature and protect it from moisture and light.

Side Effects

While it is effective in managing these conditions, like any medication, it may cause side effects. Understanding these side effects is crucial for patients and healthcare providers to make informed decisions about treatment options.

Common Side Effects

  1. Headache: A frequently reported side effect of Mezavant is mild to moderate headaches. These headaches typically subside over time as the body adjusts to the medication.
  2. Nausea and Vomiting: Some patients may experience nausea and vomiting, especially during the initial weeks of treatment. Taking Mezavant with food or adjusting the dosage may help alleviate these symptoms.
  3. Abdominal Discomfort: Mezavant can cause mild abdominal discomfort, including cramps and bloating. This usually resolves on its own, but if the discomfort is severe or persistent, consult a healthcare professional.
  4. Fatigue: Feeling tired or fatigued is a common side effect that may occur during Mezavant treatment. Adequate rest and maintaining a healthy lifestyle can help manage fatigue.
  5. Joint Pain: A small percentage of patients may experience joint pain or muscle aches while taking Mezavant. This side effect is usually mild and transient.
  6. Skin Rash: Some individuals may develop a mild skin rash that may itch or cause irritation. Contact your healthcare provider if the rash becomes severe or bothersome.
  7. Diarrhea or Constipation: Changes in bowel movements are common with Mezavant use. Patients may experience diarrhea or, conversely, constipation. Staying hydrated and eating a balanced diet can help regulate bowel movements.

Rare Side Effects

  1. Allergic Reactions: Although rare, some individuals may experience allergic reactions to Mezavant, characterized by hives, difficulty breathing, or swelling of the face, lips, tongue, or throat. Seek immediate medical attention if any signs of an allergic reaction occur.
  2. Liver Problems: In rare cases, Mezavant may affect liver function. Symptoms of liver problems include jaundice (yellowing of the skin or eyes), dark urine, and persistent fatigue. Prompt medical evaluation is essential if these symptoms arise.
  3. Pancreatitis: Mezavant may rarely lead to inflammation of the pancreas, causing severe abdominal pain and discomfort. If you experience persistent or severe abdominal pain, seek medical help immediately.
  4. Blood Disorders: Some patients may experience changes in blood cell counts, leading to anemia or other blood-related issues. Regular blood tests can help monitor and manage these rare side effects.
  5. Lung Inflammation: There have been isolated reports of lung inflammation (pneumonitis) associated with Mezavant use. If you experience unexplained shortness of breath or cough, contact your healthcare provider promptly.

Severe Side Effects

  1. Mesalamine-Induced Nephrotoxicity: In rare cases, Mezavant may cause kidney damage, leading to nephrotoxicity. Symptoms include decreased urine output, swelling in the legs, and fatigue. Immediate medical attention is necessary if these symptoms arise.
  2. Serious Skin Reactions: Mezavant may rarely cause severe skin reactions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis. These conditions require urgent medical intervention.
  3. Anaphylaxis: Although extremely rare, Mezavant may trigger a severe and life-threatening allergic reaction known as anaphylaxis. Signs include difficulty breathing, swelling, and a sudden drop in blood pressure. Seek emergency medical help if anaphylaxis is suspected.
  4. Worsening of Ulcerative Colitis: In some cases, Mezavant may paradoxically worsen symptoms of ulcerative colitis. If you notice a sudden worsening of symptoms, inform your healthcare provider promptly.
  5. Cardiovascular Events: There have been rare reports of cardiovascular events, such as heart attacks or strokes, in patients taking Mezavant. Patients with a history of cardiovascular disease should be closely monitored during treatment.


While Mezavant can be highly effective in managing these conditions, it’s crucial to be aware of its potential interactions with other drugs, herbs, and foods.

Drug Interactions

  1. Anti-coagulants: Combining Mezavant with blood thinners like Warfarin may increase the risk of bleeding. Regular monitoring and dosage adjustments may be necessary.
  2. Azathioprine and 6-Mercaptopurine: These medications, commonly used to treat inflammatory bowel diseases, may interact with Mezavant, leading to increased toxicity levels. Your doctor will carefully monitor your response to these drugs if they are prescribed together.
  3. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Taking NSAIDs while on Mezavant can increase the risk of kidney problems and gastrointestinal bleeding. Your doctor may recommend alternatives for pain relief.
  4. Probenecid: Co-administration of Probenecid with Mezavant may delay the excretion of Mesalazine, leading to higher blood levels. Regular monitoring is crucial in such cases.
  5. Sulfa Drugs: As Mezavant contains a sulfa moiety, using other sulfa-containing medications can increase the risk of allergic reactions.

Herbal Interactions

  1. Aloe Vera: Aloe Vera has natural anti-inflammatory properties, which may potentially interact with Mezavant, leading to increased effects. Monitoring is necessary if using both.
  2. St. John’s Wort: This herbal remedy is known to induce drug-metabolizing enzymes, which can reduce Mezavant’s concentration in the body, making it less effective.
  3. Turmeric: Turmeric also possesses anti-inflammatory properties and might interact with Mezavant. Monitor your response if using both.
  4. Garlic: Garlic supplements may increase the risk of bleeding when taken alongside Mezavant. Caution is advised, especially if you are already on anticoagulants.
  5. Echinacea: Echinacea’s immune-stimulating effects may interfere with Mezavant’s action. It’s best to avoid this herbal remedy while on Mezavant.

Food Interactions

  1. Dairy Products: Calcium-rich foods, such as milk and dairy products, may reduce Mezavant’s absorption. Take Mezavant at least one hour before or two hours after consuming dairy.
  2. Grapefruit: Grapefruit and its juice can inhibit drug-metabolizing enzymes, potentially increasing Mezavant’s concentration and adverse effects. Avoid grapefruit while on Mezavant.
  3. High-Fat Meals: High-fat meals can slow down Mezavant’s absorption, leading to delayed effects. It’s best to take Mezavant on an empty stomach or with a light meal.
  4. Alcohol: Alcohol can irritate the gastrointestinal tract, just like Mezavant. Combining the two may lead to increased stomach upset and other gastrointestinal issues.
  5. Caffeine: Caffeine can also irritate the gastrointestinal tract and may worsen side effects when taken with Mezavant. Limit caffeine intake to reduce potential problems.


Using this medication safely and effectively requires a clear understanding of the dosing guidelines.

Initial Dosing

When starting Mezavant, the initial dosing may vary depending on your individual condition and your healthcare provider’s recommendations. Typically, the standard initial dose is 2.4 grams per day, taken as four 0.375-gram tablets once daily with food. Always follow your doctor’s instructions and do not change the dosage without consulting them.

Maintenance Dosing

Once your symptoms are under control, your doctor may recommend a maintenance dose to keep your condition in remission. The usual maintenance dose for Mezavant is 2.4 grams per day, taken as two 1.2-gram tablets twice daily with food. Again, adherence to your doctor’s advice is essential for maintaining your progress.

Missed Dose

If you accidentally miss a dose of Mezavant, take the missed dose as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the missed one and resume your regular dosing schedule. Never take a double dose to make up for the missed one, as it can lead to adverse effects.


An overdose of Mezavant can be dangerous and may lead to severe side effects. If you suspect you or someone else has taken more than the recommended dose, seek immediate medical attention. Symptoms of an overdose may include severe stomach pain, nausea, vomiting, fever, rapid breathing, or unresponsiveness.

In case of a Mezavant overdose, prompt medical intervention is crucial. Contact emergency services or go to the nearest hospital immediately. Be prepared to provide information on the amount of medication taken and any symptoms experienced. Medical professionals will take appropriate actions to address the situation and minimize potential harm.


If you or someone you know is prescribed Mezavant, it’s crucial to handle and store the medication correctly.

  1. Storage Temperature: Keep Mezavant at room temperature, ideally between 68°F and 77°F (20°C to 25°C).
  2. Avoid Moisture: Protect the medication from excessive moisture by storing it in a dry place.
  3. Original Packaging: Keep Mezavant in its original blister packaging until you are ready to use it.
  4. Away from Light: Store Mezavant away from direct sunlight and fluorescent lighting to maintain its stability.
  5. Do Not Freeze: Do not freeze Mezavant as extreme temperatures can affect its effectiveness.
  6. Child-Proof Container: Store Mezavant in a child-proof container or a secure location to prevent accidental ingestion.
  7. Keep in Bathroom: Avoid storing Mezavant in the bathroom or any other humid environment.
  8. Proper Seal: Ensure that the blister pack is tightly sealed after each use.
  9. Avoid Extreme Temperatures: Do not store Mezavant near heat sources, such as radiators or stoves.
  10. Keep Out of Reach: Store Mezavant out of reach of pets and children.
  11. Check Expiry Date: Regularly check the expiration date and discard any expired medication.
  12. Avoid Pill Crushers: Do not crush or break Mezavant tablets unless advised by a healthcare professional.
  13. Medicine Cabinet: Store Mezavant in a cool, dry place away from the reach of children and pets.
  14. Medication Information: Keep the medication information leaflet with the medicine for reference.
  15. Avoid Humidity: Prevent Mezavant from exposure to high humidity or moisture.
  16. Prescription Label: Keep the original prescription label on the medication packaging.
  17. Store at Room Temperature: Maintain a stable room temperature for storing Mezavant.
  18. Medication Records: Keep a record of your Mezavant dosage and any side effects experienced.
  19. Discard Damaged Tablets: Dispose of any damaged or discolored tablets safely.
  20. Travel Containers: Use travel containers specifically designed for medications while on the go.
  21. Avoid Pill Splitters: Do not split Mezavant tablets unless instructed by your doctor.
  22. Medication History: Share your medication history with your healthcare provider to avoid any potential interactions.
  23. Avoid Humid Areas: Do not store Mezavant near sinks or in the bathroom where humidity levels are high.
  24. Medication Reviews: Regularly review your Mezavant dosage with your doctor to ensure its efficacy.
  25. Store in Dry Place: Keep Mezavant in a dry place to prevent moisture-induced damage.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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