Akynzeo combines two active ingredients: netupitant and palonosetron. During chemotherapy, Akynzeo prevents nausea and vomiting caused by the treatment. In addition to this medicine, dexamethasone is commonly given as a steroid.

Patients who receive chemotherapy, a potent cancer treatment, often experience these distressing symptoms, making their already challenging fight against the disease even more difficult. Furthermore, Akynzeo might benefit patients undergoing surgery or other medical procedures.

Aktynzeo affects the body by targeting the receptors responsible for causing nausea and vomiting. One of the active ingredients in this medication is netupitant, which blocks the action of neurokinin, a substance in the brain that causes nausea and vomiting. Palonosetron, the second active ingredient, complements this effect by inhibiting serotonin receptors in the gut and brain responsible for nausea and vomiting. As a result of this dual-action approach, Akynzeo can make a formidable defense against these unwanted side effects.

In a comparative study, Akynzeo demonstrated superiority over traditional anti-nausea medications, reaffirming its position as a game-changer. The combination of active ingredients sets it apart, providing comprehensive and lasting relief from nausea and vomiting.

Warnings and Precautions

Akynzeo is a medication used to manage chemotherapy-induced nausea and vomiting (CINV). While it can be highly effective in providing relief, it’s essential to be aware of its potential warnings and precautions to ensure safe and successful treatment.

  • Allergic Reactions: An important warning associated with Akynzeo is the possibility of allergic reactions. If you experience symptoms such as hives, rash, itching, swelling, or difficulty breathing, seek medical attention promptly.
  • Heart Conditions: Individuals with certain heart conditions should exercise caution when using Akynzeo. Discuss your medical history thoroughly with your doctor, especially if you have a history of irregular heartbeat or heart-related issues.
  • Liver Problems:If you have liver problems or a history of liver disease, your healthcare provider needs to be informed. Akynzeo’s metabolism can be influenced by liver function, necessitating proper monitoring.
  • Pregnancy and Breastfeeding: Pregnant or breastfeeding individuals should consult their healthcare professionals before using Akynzeo. Limited studies are available on its effects during these conditions.
  • Driving and Machinery: Akynzeo can induce dizziness or drowsiness. It’s advisable to avoid driving or operating heavy machinery until you’re certain about how the medication affects you.
  • Pediatric Use: The safety and efficacy of Akynzeo in children haven’t been well-established. It’s typically not recommended for pediatric use without proper medical guidance.
  • Elderly Patients: Elderly patients may experience a heightened sensitivity to the effects of Akynzeo. Close monitoring for any adverse effects is crucial for this demographic.

Side Effects

While this drug brings relief to many, it’s important to acknowledge the potential side effects that might accompany its benefits.

Common Side Effects

  1. Mild Fatigue: Some individuals may experience mild fatigue, which is often transient and fades as the body adjusts to the medication.
  2. Headache: Headaches can occur as a result of the medication’s impact on blood vessels and circulation. These are usually short-lived and manageable.
  3. Constipation: Akynzeo might lead to temporary constipation in some cases. Maintaining hydration and a balanced diet can help alleviate this symptom.
  4. Dizziness or Lightheadedness: A slight sense of dizziness or lightheadedness might be observed in certain individuals, especially during the initial days of treatment.

Rare Side Effects

  1. Allergic Reactions: Although rare, allergic reactions to Akynzeo are possible. These reactions might include skin rashes, itching, swelling, and even difficulty in breathing. Immediate medical attention is necessary if any of these symptoms arise.
  2. Electrolyte Imbalance: In isolated cases, Akynzeo could disturb the balance of electrolytes in the body, potentially leading to irregular heartbeats and muscle weakness.

Severe Side Effects

  1. QT Prolongation: One of the more severe side effects is the lengthening of the QT interval in the heart’s electrical cycle. While this is uncommon, it can predispose individuals to dangerous arrhythmias.
  2. Liver Complications: Although rare, some individuals might experience elevated liver enzymes or other signs of liver dysfunction. Regular monitoring is crucial to detect and manage such issues promptly.
  3. Serotonin Syndrome: In extremely rare cases, Akynzeo usage could trigger serotonin syndrome, a potentially life-threatening condition characterized by agitation, hallucinations, rapid heartbeat, and elevated body temperature.


Akynzeo is a medication that offers relief to individuals dealing with chemotherapy-induced nausea and vomiting. Understanding its interactions with other drugs, herbs, and food is crucial for a safe and effective treatment journey.

Drug Interactions

  1. Anticoagulants: Combining Akynzeo with anticoagulants might increase the risk of bleeding. Close monitoring is essential.
  2. Antiarrhythmics: Certain antiarrhythmic medications could experience altered effects when interacting with Akynzeo. Consult your healthcare provider.
  3. Antiemetics: Using multiple antiemetic drugs concurrently with Akynzeo might lead to enhanced effects, necessitating a dosage adjustment.
  4. Antidepressants: Some antidepressants such as  Prozac and Paxil are a risk to your health with this medicaiton.

Herbal Interactions

  1. Ginger: As both Akynzeo and ginger have antiemetic properties, combining them might intensify the effects. Discuss this combination with your doctor.
  2. St. John’s Wort: This herbal remedy could potentially reduce the effectiveness of Akynzeo. Openly communicate your herbal supplement use with your healthcare provider.

Food Interactions

  1. High-Fat Meals: Akynzeo’s absorption can be affected by high-fat meals. It’s advisable to maintain a consistent diet during your treatment period.
  2. Grapefruit: Grapefruit and its juice might interfere with the metabolism of Akynzeo. Consulting your doctor about grapefruit consumption is recommended.


To harness Akynzeo’s full potential, it’s crucial to adhere to precise dosing guidelines.

Initial Dosing

When commencing Akynzeo therapy, proper initial dosing is key. The recommended dosage for adults is one capsule, containing netupitant 300 mg and palonosetron 0.5 mg, taken orally, approximately an hour before the start of chemotherapy or surgery. This single-dose regimen provides a potent antiemetic effect, ensuring patients can face these procedures with confidence.

Maintenance Dosing

To sustain the benefits of Akynzeo, a carefully planned maintenance dosing schedule should be followed. For patients undergoing multiple chemotherapy cycles or undergoing surgery over several days, a regimen of one capsule daily is recommended. It’s advised to take the capsule at approximately the same time each day to maintain consistent plasma levels of the medication and maximize its efficacy.

Missed Doses

In the hustle and bustle of medical routines, missed doses can occur. If a patient forgets to take their Akynzeo capsule at the designated time, it’s recommended to take the missed dose as soon as they remember. However, if it’s close to the time for the next scheduled dose, patients should skip the missed dose and continue with their regular dosing schedule. It’s important not to double up on doses to compensate for a missed one, as this could lead to unwanted side effects.


Preventing overdose is of paramount importance when using Akynzeo. Exceeding the recommended dosage can result in adverse effects and complications. If an overdose is suspected, immediate medical attention should be sought. Symptoms of overdose may include severe headache, constipation, and an irregular heartbeat. Remember, the prescribed dosages are meticulously calculated to achieve the desired therapeutic effect without jeopardizing patient safety.


Ensuring the efficacy of this medication requires vigilant attention to storage guidelines.

  • Temperature Control: Store Akynzeo at room temperature, ideally between 68°F and 77°F (20°C and 25°C). Avoid exposure to excessive heat or cold, as temperature fluctuations can compromise the medication’s composition.
  • Protection from Light: Keep the medication away from direct sunlight and artificial light sources. Store it in its original packaging, which is designed to shield the contents from light exposure.
  • Humidity Considerations: Maintain a relatively low humidity environment where Akynzeo is stored. High humidity levels can lead to moisture absorption, potentially altering the medication’s chemical structure.
  • Original Packaging: Always store Akynzeo in its original packaging. The packaging is designed to provide an additional layer of protection against external factors that could compromise the medication’s effectiveness.
  • Avoiding Containers with Moisture: Avoid transferring Akynzeo to containers that are not airtight or moisture-resistant. Moisture infiltration can lead to degradation of the medication.
  • Keep Away from Children and Pets: Store Akynzeo in a secure location, out of reach of children and pets. This prevents accidental consumption and ensures the medication’s availability when needed.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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