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Onexton (Clindamycin, Benzoyl Peroxide) gel is an antibiotic topical medicine that treats a certain type of acne.
The medicine combines the power of the two substances to treat Acne Vulgaris, a certain type of acne. Clindamycin stops the growth of acne-causing bacteria whereas Benzoyl peroxide stops the growth of bacteria as well as reduces oil production in the skin that results in your pores staying open.
It is a combination product that contains two active ingredients:
- Clindamycin
- Benzoyl Peroxide

Precautions and Warnings with Onexton
The studies regarding the medicine’s effect on pregnant or breastfeeding women have been inconclusive. Therefore, they should inform their doctors before using this medication.
It is recommended that you seek your healthcare provider’s approval just to be on the safe side.
The medicine may also cause a severe intestinal condition due to bacteria called C. difficile after entering the bloodstream. It causes intense diarrhea that doesn’t stop along with abdominal or stomach pain/cramping blood/mucus in your stool after the patient is taken off antibiotics.
You should inform your healthcare provider immediately, as it could be a life-threatening condition.
Onexton may cause serious allergic reactions or severe skin irritation. Your doctor may not prescribe you the antibiotic if you have a history of the following conditions:
- Swelling
- Lightheadedness
- Respiratory issues
- Itching
- Hives
- Allergy to Clindamycin and Benzoyl Peroxide
- Inflamed intestine
- Abdominal issues associated with antibiotic use
- Ulcerative colitis

Onexton Side Effects
Onexton may cause side effects in some individuals which are different from person to person. They may be mild to more severe.
Benzyl peroxide may cause a rare but serious allergic reaction right after it has been applied. It could happen within a day or longer.
You need to know the side effects of the medicine and discuss your concerns about them with your healthcare provider before starting your treatment plan with Onexton.
Your healthcare provider will monitor your condition for any adverse changes, as it is important for safe and effective treatment.
Common Side Effects
- Skin problems (red or irritated)
- Dry or peeling on treated skin
- Itchy and tingling sensation
- Mild burning or stinging sensation
Serious Side Effects
- Watery or bloody diarrhea
- Peeling of treated skin
- Swelling on the face, throat, tongue, or lips
- Lightheadedness
- Respiratory problems
- Itching
- Hives
- Skin allergies

Drug Interactions with Onexton
It’s important to consider potential drug interactions with other medications when using Oxenton, as the substances in it can interact with others, which affects its effectiveness or leads to unexpected side effects.
Your healthcare provider will assess the patient’s medical history and condition before preparing a safe treatment plan. This makes emerging issues related to treatment are addressed.
You should inform your healthcare provider about the medications (prescription, over-the-counter, herbal, or hormonal) to minimize the risk of interactions. These medicines are known to interact with Oxenton:
- Atracurium
- Cisatracurium
- Rapacuronium
- Doxacurium
- Rocuronium
- Succinylcholine
- Pancuronium
- Isotretinoin
- Vecuronium
- Mivacurium
- Metocurine
- Tubocurarine
- Pipecuronium
- Adapalene
- Tazarotene
- Dapsone
- Tretinoin
- Clascoterone
- Trifarotene
- Alitretinoin
- Bexarotene

Strengths and Dosages of Onexton
Onexton gel comes in two strengths:
- 2%
- 75%
| Strengths | Active Ingredients | Quantity | Inactive Ingredients |
| 1.2% | Clindamycin and Benzoyl Peroxide
| 12 mg per gram | Potassium hydroxide, propylene glycol, carbomer 980, and purified water |
| 3.75% | Clindamycin and Benzoyl Peroxide
| 37.5 mg per gram | Potassium hydroxide, propylene glycol, carbomer 980, and purified water |
The medicine should not be applied in larger or smaller amounts or for longer than prescribed by the doctor or the quantity on the packaging. Applying more medicine than prescribed won’t increase the efficacy and increase the risk of side effects.
You can apply a “test dose” to see if you have a reaction by applying a small amount of the medicine to affected areas every day for three days in a row. You can use the full amount on the fourth day if there is no reaction.
You should avoid getting the medicine in your eyes, mouth, or nose and you should wash these areas, wash with water if it has. The medication should not be applied on broken, irritated, dry, windburned, or sunburnt skin.
It could take weeks before your symptoms improve. You should keep using the medicine as directed and tell your doctor if your condition does not improve.
You should follow the directions for use on your prescription label. Here’s how Onexton can be applied:
- Wash your hands before applying this medicine
- Wash your face with a mild cleanser (not soap)
- Pat the skin dry with a clean towel.
- Apply a small amount of the medicine once or twice (morning or evening daily on small acne areas every day for three days in a row.

Cost of Onexton in America
A 50-gram tube of Oxenton can cost you between $712.90 and $990.91 without insurance. The price may vary depending on
- The pharmacy from where the medicine was purchased
- Treatment plan
- Insurance coverage
Why is Onexton so expensive?
Onexton is a branded medicine without a generic counterpart. The lack of generic alternatives and the limited number of medicines prescribed for acne can make it difficult for dermatologists to find affordable options for their patients.
The medicines have two active ingredients (Clindamycin and Benzoyl Peroxide) and its unique formula is also a factor in its price increases.

Onexton Alternatives
You should consult with a dermatologist before switching to an alternative. Don’t self-medicate without your healthcare provider’s approval, as it may worsen your condition.
There are a variety of alternatives available in the market with the same treatment mechanism as Onexton. Your doctor can prescribe the following alternative options owing to your conditions as they have the same function.
- Spironolactone
- Isotretinoin
- Doxycycline
- Aldactone
- Minocycline
- Accutane
- Clindamycin topical
- Tretinoin topical (such as Retin-A or Stieva-A)

FAQs of Onexton
What is Onexton?
Onexton is a prescription medication that treats acne by combining two active ingredients: clindamycin phosphate (an antibiotic) and benzoyl peroxide.
What is Onexton used for?
Onexton treats acne vulgaris, which causes blackheads, pimples, and whiteheads.
How to use Onexton?
Onexton is applied to the affected skin once or daily. You should wash your face with a gentle cleanser and pat it dry. Take a thin layer of the medicine while avoiding the eyes, lips, and mucous membranes.
What does Onexton do for acne?
Onexton kills acne-causing bacteria and reduces inflammation. It unclogs pores and reduces the formation of acne lesions.
What happens if you use an expired Onexton?
An expired Onexton may be ineffective in treating acne as the ingredients could have degraded. You should check the expiration date before use and discard the expired medication.
How long does Onexton take to work?
Onexton may show its effect after a few weeks since the treatment plan starts. You should use it consistently as directed by your healthcare provider.
What should you avoid while taking Onexton?
It’s recommended to avoid excessive exposure to sunlight or artificial UV rays when using Onexton.
Can I use other skin treatments while taking Onexton?
Patients on Onexton are generally advised not to use skincare products while using Onexton unless directed by your healthcare provider as using excessive acne treatment products can increase the risk of skin irritation.
Our Guarantee For Buying Onexton From A Canadian Pharmacy Partner
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Onexton at a discounted rate, call 1-888-551-2467.
IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.