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Zyprexa (Olanzapine)
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Zyprexa (olanzapine) is a prescription medicine that treats certain mental health conditions such as schizophrenia and bipolar disorder. The medication is categorized into a group of drugs named atypical antipsychotics.
The active substance targets Dopamine Receptors (D1, D2, D3, D4), to reduce hallucinations and delusions and works as an Serotonin receptor (5HT2A) antagonist to alleviate a lack of motivation and emotional flatness. The substance balances neurotransmission, which is important for emotional stability and behavior while minimizing side effects typically associated with older antipsychotics.
Zyprexa treats mental health ailments by modulating the activity of neurotransmitters in the brain, particularly dopamine and serotonin. The composition of the medicine is as follows.
| Forms | Active Substance | Quantity/Strengths | Inactive Substances |
| Oral | Olanzapine | 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg | Lactose, Crospovidone, Microcrystalline cellulose, Hydroxypropyl cellulose, Carnauba wax, Hypromellose, Magnesium stearate, Titanium dioxide (color coating), FD&C Blue No. 2 Aluminum Lake (in 15 mg only), Synthetic Red Iron Oxide for color (in 20 mg only) |
| Orally Disintegrating Tablets | Olanzapine | 5 mg, 10 mg, 15 mg, 20 mg | Sodium propylparaben, Mannitol, Gelatin, Sodium methyl paraben, Aspartame |
| Intravenous Solution | Olanzapine | 10 mg | Lactose monohydrate, Tartaric Acid |
Labelled Warning for Zyprexa
The medicine is not recommended for pregnant and breastfeeding women. Patients who are pregnant, planning a pregnancy, or breastfeeding should discuss the potential risks of Zyprexa with their doctor.
Zyprexa comes with labeled warnings that underscore that patients are at high risk of the following life-threatening conditions when using it.
- Sedation and Impaired Coordination
- Metabolic Changes
- Blood Disorders
- Neuroleptic Malignant Syndrome (NMS)
- Increased Mortality in Elderly Patients with Dementia-related psychosis
Benefits of Zyprexa
Zyprexa comes with significant benefits for patients diagnosed with certain mental health conditions like schizophrenia and bipolar disorder. The advantages are well-documented in clinical studies and are supported by its prescribing information.
The medicine is indicated for treating schizophrenia effectively with short-term studies demonstrating the medicine to control hallucinations and delusions. Patients using Zyprexa experienced improvement in their overall clinical state, as measured by the Positive and Negative Syndrome Scale (PANSS) and the Brief Psychiatric Rating Scale (BPRS).
Zyprexa assists in maintaining treatment response in patients who have been stable on the medication for approximately eight weeks, reducing the risk of relapse compared to placebo over extended periods. This long-term efficacy reinforces its role as a critical component in the management of schizophrenia.
Apart from treating schizophrenia, Zyprexa helps patients with bipolar disorder, especially during manic episodes. It is reported to be more effective than a placebo in alleviating agitation associated with manic episodes by providing rapid symptom relief within hours of administration.
The alleviation of the symptoms improves cognitive function which gives you a fresh perspective on life.
Precautions of Zyprexa
Your healthcare provider will monitor your weight, blood sugar, and cholesterol levels by performing tests before prescribing Zyprexa.
You should suggest certain lifestyle changes such as cutting down on your alcohol intake to avoid side effects (increased drowsiness, dizziness, and impaired judgment) that affects a patient’s ability to perform tasks that require mental alertness.
You need to proceed with caution when treating mental health conditions like bipolar disorder with Zyprexa. Your healthcare provider may not recommend this medicine if you have a history of the following conditions:
- Allergic reactions to olanzapine or any ingredients in the medicine
- Cardiovascular problems
- High blood sugar levels or diabetes
- High triglyceride or cholesterol levels
- Liver problems
- Inconsistent blood pressure
- Transient ischemic attacks (TIAs)
- Narrow-angle glaucoma
- Enlarged prostate in men
- Bowel obstruction
- Phenylketonuria
- Breast cancer
- Alzheimer’s disease
- Seizures or epilepsy
- Suicidal thoughts or hurting yourself
Side Effects of Zyprexa
Zyprexa is an effective medicine in treating certain mental health issues. However, patients may experience certain side effects, which are categorized as common and serious.
Common Side Effects
Common side effects are mild in nature and wean off on their own during the course of your treatment with Zyprexa. In case of serious side effects, discontinue the medicines and get yourself checked at a nearby hospital.
- Fatigue
- Dizziness
- Weight Gain
- Headache
- Sedation or drowsiness
- Constipation
- Dry Mouth
Serious Side Effects
You should discuss the risks associated with side effects of the medicine with your healthcare provider. If you want to manage your overall health successfully, then always bring any adverse reactions that you may experience to your doctor’s attention.
- Severe allergic reactions
- Trouble breathing
- Hives
- Rashes
- Severe skin irritation
- Swelling on the throat and face
- Neuroleptic Malignant Syndrome (NMS)
- Tardive Dyskinesia
- Seizures
- Metabolic Changes
- Blood Disorders
How to Use Zyprexa
It is important that Zyprexa users follow the dosing guidelines to achieve the best results with the medicine.
Zyprexa tablets should be stored at room temperature, away from moisture and heat whereas the injectable form should also be stored in a secure location until needed.
Zyprexa tablets are usually taken once daily with or without food. It is recommended that you take it at the same time each day as consistency maintains stable levels of the medication in the body, improving its efficacy.
Instructions for Zyprexa Injection
- Reconstitute the powder in the vial with 2.1 mL of sterile Water for injection to create a 5 mg/mL of olanzapine solution.
- Select the appropriate injection site (it’s usually administered to gluteal muscle or deltoid muscle).
- Clean the injection site with an alcohol swab and allow it to dry.
- The needle should be inserted at a 90-degree angle into the muscle.
- Inject the medication at a steady pace into the muscle mass.
Drug Interactions of Zyprexa
You may be at risk of serious side effects if you combine Zyprexa with certain medications. It is important for you to inform their healthcare provider about all medications to ensure safety.
The products that may interact with this medicine are:
- Losec (omeprazole)
- Melatonin
- Zoloft (sertraline)
- Cymbalta (duloxetine)
- Lithium
- BuSpar (buspirone)
- Klonopin (clonazepam)
- Lorazepam
- Synthroid (levothyroxine)
- Propranolol
- Lisinopril
- Tramadol
- Lexapro (escitalopram)
- Metformin
- Xanax (alprazolam)
- Lamictal (lamotrigine)
- Hydroxyzine
- Remeron (mirtazapine)
- Trazodone
- Gabapentin
- Prozac (fluoxetine)
- Topamax (topiramate)
- Adderall (amphetamine / dextroamphetamine)
- Depakote (divalproex sodium)
- Ativan (lorazepam)
- Celexa (citalopram)
- Clonazepam
- Vitamin D3 (cholecalciferol)
Zyprexa Alternatives
This is not the complete list of alternatives. You are advised to consult with a healthcare provider in this regard.
It is important that you discuss these alternatives and any other potential options with your doctor. Each medication has its unique benefits, side effects, and interactions which should be taken into consideration in the context of the individual’s overall health and treatment goals.
Your healthcare provider can help tailor a treatment plan that best addresses your specific condition while minimizing risks.
Here are a few examples of alternative medications:
- Olanzapine
- Risperidone
- Latuda
- Lamictal (lamotrigine)
- Abilify (aripiprazole)
- Clozapine
- Vraylar (cariprazine)
- Lybalvi (olanzapine/samidorphan)
- Seroquel (quetiapine)
FAQ for Zyprexa
What forms does Zyprexa come in?
Zyprexa (olanzapine) is currently available in oral tablets and intravenous forms
What are the strengths and dosages of Zyprexa?
The typical dosages for Schizophrenia patients are prescribed between 5 to 10 mg once daily the typical dose for patients with bipolar disorder is between 10 and 15 mg once daily. The dosage quantity and frequency varies depending on individual needs or treatment.
Does Zyprexa cause weight gain?
Yes, weight gain is listed as a potential side effect of Zyprexa. Patients may experience significant increases in weight when using the medicine.
How long does Zyprexa stay in your system?
Zyprexa ingredients can remain in the body for several days after the last dose due to its long half-life. It may typically take about one week for the drug to be eliminated from the system completely.
How long does it take for Zyprexa to work?
Patients can notice improvements within a few days, but it can take several weeks to achieve the full therapeutic effect.
How do you taper off Zyprexa?
Healthcare providers may recommend gradual dose reductions to minimize withdrawal symptoms and prevent relapse of the underlying condition.
What is the half-life of Zyprexa?
Zyprexa has an estimated half-life of around 21 to 54 hours, which means it can take several days for the drug to be fully cleared from the body.
What is the difference between Zyprexa and Zyprexa Zydis?
Zyprexa is a standard oral tablet formulation, while Zyprexa Zydis is an orally disintegrating tablet that dissolves on the tongue without water
What are the withdrawal symptoms for Zyprexa?
The withdrawal symptoms of Zyprexa are insomnia, nausea, vomiting, sweating, and anxiety after stopping the medicines. These symptoms can vary in intensity and duration depending on individual factors and dosage.
What should I do if I miss a dose of Zyprexa?
If the prescribed dose gets missed, it is taken immediately when you remember. The skipped dose should not be taken unless it’s almost time for your next dose. In that case, the missed dose should be skipped and you should continue with your regular schedule. Don’t take more than the prescribed amounts of pills to make up for the missed ones.
Can I consume alcohol while on Zyprexa treatment?
You should avoid taking alcohol when using Zyprexa due to potential interactions that can increase side effects such as drowsiness and dizziness.
How much does Zyprexa cost in the USA without insurance?
The 30-tablet supply of Zyprexa may set you back between $431.23 and $ $1,508.76 without insurance in the United States. The price varies depending on the medicine’s strength and forms along with pharmacy and location from where it is being purchased.
Why is Zyprexa so expensive?
Zyprexa’s high cost is attributed to its patent protection during its initial release along with ongoing research and development costs. Its classification as a brand-name medication also contributes to high prices.
Can I get Zyprexa at a discounted price through MyRx Outlet?
Yes, MyRx Outlet offers discounted prices for branded medications like Zyprexa.
Our Guarantee For Buying Zyprexa From A Canadian Pharmacy Partner
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Zyprexa at a discounted rate, call 1-888-551-2467.
IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.
