Domperidone
Domperidone is a prescription dopamine-2 receptor antagonist used in several countries for certain gastrointestinal motility and nausea/vomiting indications. In the United States, domperidone is not FDA-approved for any human use and access is limited to specific regulatory pathways
We only dispense medications with a valid prescription from a licensed prescriber.
All prescriptions are reviewed and verified before dispensing. Orders may be delayed or declined if prescription details are missing, do not match the patient information on file, appear altered, or are expired. We may also refuse service if we believe an order is intended for resale or redistribution.
What You Receive
- Domperidone in sealed manufacturer packaging
- Personalized prescription instructions based on your prescriber’s directions
- Medication information leaflet provided by the manufacturer
- Itemized invoice detailing your order
- Rx Required
Shipping & Delivery
- Shipped from licensed pharmacy partners
- Tracking information is provided once your order ships
Delivery times may vary based on location and prescription verification.
This page is for general information only and is not medical advice. For medical questions, please speak with your prescriber. See Sources & Methodology for how this information is reviewed and referenced.
Domperidone Key Facts
What Domperidone is
A prescription medicine that blocks dopamine-2 receptors, primarily outside the brain.
What it’s used for
Common approved uses outside the U.S. include:
Nausea and vomiting (restricted use in parts of Europe/UK)
Certain upper gastrointestinal motility disorders such as diabetic gastroparesis (examples in Canadian product monographs)
How it works
It increases upper GI motility and can reduce nausea/vomiting by blocking dopamine receptors involved in gut movement and emetic signaling.
Domperidone Safety Overview
Domperidone can affect cardiac electrical activity and has been associated with QT prolongation and serious ventricular arrhythmias in higher-risk patients. Use the lowest effective dose for the shortest duration and avoid use in patients with significant cardiac risk factors.
Domperidone Warnings & Precautions
Seek urgent care for fainting, severe palpitations, or sudden dizziness.
Do not use Domperidone if:
- Known QT prolongation or significant cardiac conduction risk
- Concomitant use of QT-prolonging medicines or potent CYP3A4 inhibitors
- Severe hepatic impairment
Common high-risk situations to avoid or review carefully with a prescriber
- Existing QT prolongation or conditions where cardiac conduction may be impaired
- Significant underlying heart disease
- Moderate to severe hepatic impairment
- Doses above the recommended maximum in local labeling (cardiac risk increases with higher daily dose)
Side Effects and When to Get Help
The main safety concern is heart rhythm risk in susceptible patients or when combined with interacting medicines. Stop and seek urgent medical care for fainting, new rapid heartbeat, severe palpitations, or unexplained dizziness. Contact your prescriber if side effects are persistent or worsening.
Potential side effects may include
- Dry mouth
- Headache
- Abdominal cramping or diarrhea
- Breast-related effects such as galactorrhea or menstrual changes (from prolactin effects)
Get urgent help right away for
- Fainting or near-fainting
- Severe palpitations or rapid/irregular heartbeat
- Sudden severe dizziness
Interactions
Domperidone interaction risk is largely driven by QT prolongation and medicines that raise domperidone blood levels. Avoid combining domperidone with QT-prolonging drugs or potent CYP3A4 inhibitors unless a prescriber determines it is appropriate. Always provide a complete medication list before starting.
Interactions to review with your prescriber may include:
- QT-prolonging medicines (additive arrhythmia risk)
- Potent CYP3A4 inhibitors (can increase domperidone exposure and cardiac risk)
- Other medicines that increase arrhythmia risk in susceptible patients (clinical review required)
Domperidone Drug Facts
| Category | Details |
|---|---|
| Brand Name | Varies by country (examples include Motilium in some markets) |
| Drug Class | Dopamine-2 receptor antagonist, prokinetic/antiemetic |
| Indication | Depends on local approval; commonly nausea/vomiting and select GI motility disorders in certain countries |
| Dosage Forms | Tablets and other forms vary by market (Canadian monographs include tablets) |
| Strengths | Commonly 10 mg tablets in many markets |
| Dosing Limits | In European/UK safety restrictions, oral dosing is limited to 10 mg up to three times daily with short duration for nausea/vomiting |
| Key Safety Alert | QT prolongation and serious ventricular arrhythmia risk in higher-risk patients and with interacting drugs |
| Who should not use it | Patients with cardiac conduction risk/QT prolongation, severe hepatic impairment, or taking QT-prolonging drugs or potent CYP3A4 inhibitors |
| U.S. Regulatory Status | Not FDA-approved for any human indication; access is limited to specific regulatory pathways |
| Alternatives | Metoclopramide, ondansetron (Zofran), prochlorperazine, promethazine (Phenergan) |
Helpful Information
How To Buy Domperidone Online
1
Select Your Prescribed Domperidone Dosage & Strength
Choose the strength and quantity that matches your prescription, then add it to your cart. Orders are limited to a 90-day supply per fill.
2
Complete Checkout
Ensure your shipping and contact information is correct so your order can be processed without delays.
3
Submit Your Domperidone Prescription
Upload your prescription at checkout. If you need a transfer, provide your prescriber or current pharmacy details and we will request it on your behalf.
Prescription & Dispensing Standards
- Prescription required for all orders and reviewed for pharmacy and regulatory compliance
- Dispensed by licensed pharmacy partners
- Orders are held if information is missing, unclear, or does not match.
- No substitutions without prescriber approval, and no controlled substances.
Our Guarantee
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Domperidone at a discounted rate, call 1-888-551-2467.
FAQs
What is domperidone used for?
Uses depend on the country. Many regions restrict use primarily to nausea and vomiting, while some product monographs include certain GI motility disorders.
Why is domperidone considered higher-risk?
Safety reviews link domperidone to QT prolongation and serious ventricular arrhythmias in higher-risk patients, especially with interacting medicines.
Who should avoid domperidone?
People with QT prolongation or significant heart disease, severe hepatic impairment, or those taking QT-prolonging medicines or potent CYP3A4 inhibitors should avoid it unless a prescriber determines otherwise.
What symptoms mean I should seek urgent care?
Fainting, severe palpitations, rapid or irregular heartbeat, or sudden severe dizziness require urgent medical assessment.
Is domperidone FDA-approved in the United States?
No. The FDA states domperidone is not approved for any indication or use in humans in the U.S.
Ordering & Prescription FAQs
Do I need a prescription?
Yes. Domperidone is prescription-only where authorized.
How do I submit my prescription?
You can upload it through our Upload Prescription page, email it to info@myrxoutlet.com, or fax it to 1-888-230-1245. If you need a prescription transfer, just let us know at checkout and include your pharmacy or prescriber contact details.
When is my payment processed?
Your payment is processed only after your prescription and order have been reviewed and approved by our licensed pharmacy team. Once everything is confirmed, we’ll process payment and prepare your order for shipping.
What happens if my prescription can’t be verified?
Your order may be placed on hold or declined if prescription details are missing, don’t match, are expired, or can’t be confirmed.
Sources
FDA Information about Domperidone
FDA How to Request Domperidone for Expanded Access Use
Health Canada Product Monograph, Domperidone Maleate Tablets (example Canadian monograph, PDF)
https://pdf.hres.ca/dpd_pm/00077626.PDF
UK MHRA Drug Safety Update, domperidone contraindications and cardiac risk
https://www.gov.uk/drug-safety-update/domperidone-for-nausea-and-vomiting-lack-of-efficacy-in-children-reminder-of-contraindications-in-adults-and-adolescents