Domperidone is a medication classified as a dopamine antagonist, primarily used as an antiemetic (anti-sickness) and prokinetic drug. It belongs to a group of medications known as dopamine antagonists and serves multiple purposes in the management of gastrointestinal issues, nausea, and vomiting.

The primary action of Domperidone involves regulating the movement and contractions of the stomach and bowel. By blocking dopamine receptors in the gut, it enhances the muscle contractions in the stomach and upper gastrointestinal tract, aiding in the efficient movement of food through the digestive system. Additionally, Domperidone acts on the chemoreceptor trigger zone outside the blood-brain barrier, effectively alleviating symptoms of nausea and vomiting.

This medication has proven effective in treating various gastrointestinal conditions, including nausea, vomiting, and stomach pain associated with decreased stomach and upper gastrointestinal movement. It is also utilized to manage stomach-related discomfort caused by certain medications used to treat Parkinson’s disease.

It is important to note that Domperidone may be available under different brand names and in various forms, depending on the region and specific condition being treated. Your doctor may prescribe Domperidone for conditions other than those mentioned here, as its applications can extend beyond the listed uses.

It is crucial to follow your doctor’s instructions and not discontinue the medication without consulting them. Domperidone should not be shared with others, as it can be harmful if taken without proper medical guidance.

If you have any questions or concerns about Domperidone, its uses, or its potential side effects, speak with your healthcare provider. They can provide the necessary information and guidance to ensure the safe and effective use of this medication.

Warnings & Precautions

Before taking domperidone, it is crucial to be aware of certain warnings and precautions to ensure its safe and effective use. Please consult your healthcare professional for personalized advice, and do not disregard their instructions.

Avoid Domperidone if you:

  • Have a known allergy to domperidone or any of its ingredients.
  • Take medications belonging to the same drug families as ketoconazole, erythromycin, ritonavir, or nefazodone.
  • Consume medications known to cause QT prolongation, a specific type of irregular heartbeat.
  • Experience bleeding in the stomach or intestines.
  • Have a blockage in the stomach or intestines.
  • Suffer from breaks in the lining of the stomach or intestines.
  • Have a prolactinoma, a tumor affecting the pituitary gland.
  • Present uncorrected levels of potassium, magnesium, or calcium in the blood.
  • Have cardiac disease, such as heart failure.
  • Exhibit QT prolongation, a specific type of irregular heartbeat.
  • Experience moderate or severe liver impairment.

Individuals who may not be suitable for taking domperidone:

  • Those who have a history of allergic reactions to domperidone or any other medication.
  • Individuals weighing less than 35kg.
  • People with conditions that can cause bowel blockage, such as Crohn’s disease or diverticulitis.
  • Those who have recently undergone abdominal surgery, including hernia operation or caesarean section.
  • Individuals with a history of bleeding from the stomach or gut.
  • People with tumors affecting the pituitary gland.
  • Individuals with liver, kidney, or heart problems, or an irregular heartbeat (arrhythmia).

Side Effects

Domperidone, like any medication, has the potential to cause certain side effects. It’s important to be aware of these effects and seek medical attention if necessary.

Serious Side Effects

Stop taking domperidone and consult your doctor or visit a hospital immediately if you experience any of the following:

Allergic Reactions

If you notice swelling of the hands, feet, ankles, face, lips, or throat, which may result in difficulty swallowing or breathing, along with an itchy, lumpy rash (hives) or nettle rash (urticaria), you may be experiencing an allergic reaction to the medication.

Uncontrolled Movements

Irregular eye movements, unusual movements of the tongue, and abnormal postures like a twisted neck, trembling, and muscle stiffness may occur. These symptoms are more likely to occur in children and should cease upon discontinuing the medication.

Rapid or Unusual Heartbeat

If you experience a very fast or irregular heartbeat, it could be a sign of a potentially life-threatening heart problem and requires immediate medical attention.

Seizures

If you have a fit or seizure while taking domperidone, seek medical assistance promptly.

Common Side Effects

Side effects that tend to be common in domperidone include:

  • Dry mouth
  • Lowered sexual drive (libido) in men
  • Feeling anxious
  • Drowsiness
  • Headaches
  • Diarrhea
  • Itchy skin with the possibility of a rash
  • Unusual production of breast milk in both men and women
  • Painful or tender breasts
  • General feeling of weakness

Rare Side Effects

In very rare occasions, side effects of domperidone may include:

  • Cardiovascular disorders: Reports of heart rhythm disorders (rapid or irregular heartbeat) have been noted. If this occurs, discontinue the treatment immediately. Domperidone may carry an increased risk of heart rhythm disorders and cardiac arrest, particularly in individuals over 60 years old or those taking doses higher than 30 mg per day.
  • Feeling agitated or irritable
  • Heightened nervousness
  • Abnormal eye movements
  • Inability to urinate
  • Breast enlargement in men
  • Irregular or absent menstrual periods in women
  • Altered liver function as indicated by a blood test
  • Patients using domperidone for longer-term medical supervision may experience restlessness, swollen or enlarged breasts, unusual discharge from breasts, irregular menstrual periods in women, difficulty breastfeeding, depression, and hypersensitivity.

 

Side effects such as drowsiness, nervousness, agitation, or irritability are more commonly observed in children.

Please consult your doctor for medical advice regarding side effects. You can also report any side effects to the FDA at 1-800-FDA-1088. Remember, this list may not encompass all possible side effects of domperidone, and individual experiences may vary.

Drug Interactions

Please inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements.

Avoid taking domperidone if you are using medications to treat the following conditions:

  1. Fungal Infections: Specifically, azole antifungals like oral ketoconazole, fluconazole, or voriconazole.
  2. Bacterial Infections: Including erythromycin, Biaxin, telithromycin, moxifloxacin, or pentamidine (these are antibiotics).
  3. Heart Problems or High Blood Pressure: Such as amiodarone, dronedarone, quinidine, disopyramide, dofetilide, sotalol, diltiazem, or verapamil.
  4. Psychoses: Including haloperidol, pimozide, or sertindole.
  5. Depression: Such as Celexa or Cipralex.
  6. Gastrointestinal Disorders: Including cisapride, dolasetron, or prucalopride.
  7. Allergy: Such as mequitazine or mizolastine.
  8. Malaria: Particularly halofantrine.
  9. AIDS/HIV: Specifically protease inhibitors.
  10. Cancer: Including toremifene, vandetanib, or vincamine.

 

Inform your doctor or pharmacist if you are taking medications to treat infections, heart problems, or AIDS/HIV.

Consult your doctor if you require both domperidone and apomorphine. Your doctor will assess your ability to tolerate both medications when used together. Seek advice from your doctor or specialist.

It is crucial to consult your doctor or pharmacist to determine the safety of using domperidone when taking other medications, including those obtained without a prescription.

Considerations

When deciding to use this medication, you and your doctor must carefully evaluate the risks versus the potential benefits. It’s essential to disclose any allergies you may have, including reactions to medications, foods, dyes, preservatives, or animals. If using non-prescription products, carefully review the label or package ingredients.

Pediatric Use

Studies on domperidone have been conducted primarily in adult patients, and specific information comparing its use in children with other age groups is limited. Therefore, its safety and effectiveness in pediatric patients are not yet established.

Geriatric Use

The use of domperidone in older adults has not been extensively studied. Differences in response and potential side effects between older and younger adults may exist. Consult your doctor to determine the appropriateness of domperidone for your age group.

Remember, the information provided here is not exhaustive. Always consult your healthcare provider for personalized advice and guidance before using domperidone or any other medication.

Usage

Follow these guidelines for taking domperidone to ensure its proper use. It’s important to note that individual dosing instructions may vary, so always consult your doctor or pharmacist for personalized advice.

Tablets

  • Swallow the tablet whole with a drink of water. Do not crush or chew it.
  • Take domperidone up to three times a day, but only when necessary.
  • Leave at least 8 hours between each dose.
  • Ideally, take domperidone 15 to 30 minutes before a meal or snack.
  • If you have difficulty swallowing tablets, consult your healthcare professional for alternative dosage forms.

Duration of Use

  • Typically, domperidone is used for a maximum of one week to minimize the risk of irregular heartbeat (arrhythmia) associated with prolonged or high-dose use.
  • Your doctor will determine the duration of treatment and recommend the lowest effective dose for your condition.

General Instructions

  • Always take domperidone exactly as prescribed by your doctor or pharmacist. If you have any uncertainties, consult them for clarification.
  • For gastric symptoms, such as nausea or vomiting, most individuals experience relief within 3-4 days of using domperidone. Do not exceed 7 days of continuous use without consulting your doctor.
  • For oral forms (tablets, suspension, drops, orally disintegrating tablets), swallow the tablets whole with water. Do not crush or chew them unless advised otherwise.
  • Orally disintegrating tablets dissolve in the mouth and do not require water.
  • If using the oral suspension, use the plastic measuring cup provided to ensure accurate dosing.
  • For suppositories containing domperidone:
    • Wash your hands before handling the suppository.
    • Moisturize the suppository before insertion.
    • Insert it into the rectum as deeply as possible.
    • Contract your muscles to prevent the suppository from being expelled.
    • Food and drink do not affect the absorption of domperidone suppositories.

Pregnancy

Please inform your doctor if you are currently pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed.

The use of domperidone is generally not recommended during pregnancy. Limited information is available regarding the use of this medication in pregnant individuals. Domperidone should only be used during pregnancy if the potential therapeutic benefits outweigh the potential risks. It is important to consult your doctor for advice before taking this medication if you are pregnant.

When it comes to breastfeeding, domperidone is generally not recommended. Small amounts of the medication have been found in breast milk and may lead to unwanted side effects related to the baby’s heart. Domperidone should only be used during breastfeeding if your doctor determines that it is clearly necessary. Prior to taking this medication, seek advice from your doctor regarding its use while breastfeeding.

Storage

Store the medication at room temperature, maintaining a range between 68-77°F (20-25°C), or as directed by your healthcare provider. Avoid exposure to extreme temperatures.

Protect the medication from light by keeping it in a closed container. This helps maintain the stability and effectiveness of the medication.

Refrain from refrigerating or freezing domperidone suppositories. They should be stored at temperatures not exceeding 77°F (25°C).

Always keep the medicine out of sight and reach of children. Store it in a secure location to prevent accidental ingestion or misuse.

Do not keep outdated medicine or medication that is no longer needed. Properly dispose of any unused or expired medication according to the recommended guidelines provided by your local waste disposal authority.

By following these storage instructions, you can help maintain the quality and safety of your domperidone medication.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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