Trintellix is a prescription medication used to treat major depressive disorder (MDD), a common mental health condition characterized by persistent feelings of sadness, hopelessness, and a lack of interest or pleasure in daily activities. Formerly known as Brintellix, it was approved by the U.S. Food and Drug Administration (FDA) in 2013 and is manufactured by Takeda Pharmaceuticals.

Trintellix works by targeting multiple brain receptors involved in regulating mood and emotions. Unlike traditional antidepressants, which mainly focus on serotonin reuptake inhibition, Trintellix is a multimodal agent. It acts as a serotonin transporter (SERT) inhibitor, but it also modulates several serotonin receptors (5-HT1A, 5-HT1B, 5-HT3, and 5-HT7) and the serotonin transporter (SERT).

Trintellix is indicated for the treatment of major depressive disorder in adults. It is not approved for use in children and adolescents. Physicians may prescribe Trintellix to patients who have not responded adequately to other antidepressant treatments or who have experienced intolerable side effects from other medications.

Trintellix offers several advantages over traditional antidepressants. Its multimodal action and unique mechanism make it a viable option for individuals who have not responded well to other treatments. Additionally, Trintellix’s side effect profile is generally favorable compared to some older antidepressants.

Warnings and Precautions

Trintellix is a widely prescribed antidepressant medication known for its effectiveness in treating major depressive disorder. However, like all medications, Trintellix comes with its own set of warnings and precautions that users must be aware of to ensure safe and successful treatment.

  • Consult Your Healthcare Provider: If you’re considering starting Trintellix, it’s essential to consult your healthcare provider first. Your doctor will assess your medical history, current medications, and overall health to determine if Trintellix is the right choice for you. Never start or stop any medication without professional medical advice.
  • Allergic Reactions: If you have a history of allergic reactions to vortioxetine or any of the inactive ingredients in Trintellix, it’s crucial to inform your healthcare provider before starting the medication. Allergic reactions can be severe and may include symptoms such as rash, itching, swelling, severe dizziness, and difficulty breathing.
  • Risk of Suicidal Thoughts: Like many antidepressants, Trintellix may increase the risk of suicidal thoughts, especially in young adults and teenagers. It’s essential to closely monitor anyone starting Trintellix, particularly during the initial weeks of treatment. If you or someone you know experiences unusual changes in mood, behavior, or worsening depression, seek immediate medical attention.
  • Serotonin Syndrome: Serotonin syndrome is a potentially life-threatening condition that can occur when taking medications that increase serotonin levels. Symptoms include agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, and loss of coordination. Avoid taking other drugs that increase serotonin while on Trintellix unless directed by your healthcare provider.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Trintellix with your doctor. The effects of Trintellix on unborn babies or infants through breast milk are not entirely understood, so caution is necessary.
  • Liver and Kidney Function: Individuals with impaired liver or kidney function may require dosage adjustments or special monitoring while taking Trintellix. Inform your doctor about any pre-existing liver or kidney conditions to ensure safe usage.
  • Elderly Individuals: Elderly individuals may be more susceptible to the side effects of Trintellix, such as bleeding problems, hyponatremia (low sodium levels), and falls. Extra caution and monitoring are necessary for this age group.
  • Bipolar Disorder: Trintellix is not approved for the treatment of bipolar disorder. If you have a history of bipolar disorder or mania, taking Trintellix may trigger a manic episode. Discuss your medical history thoroughly with your doctor.
  • Alcohol and Trintellix: Combining alcohol with Trintellix can exacerbate side effects and increase the risk of dizziness and drowsiness. Avoid consuming alcohol while on Trintellix.
  • Bleeding Risks: Trintellix may increase the risk of bleeding, particularly if you are taking blood thinners or nonsteroidal anti-inflammatory drugs (NSAIDs). Inform your doctor if you have a history of bleeding disorders or are on any medications that may affect blood clotting.
  • Changes in Sexual Function: Some individuals may experience changes in sexual function while taking Trintellix. If you notice any such changes, discuss them with your healthcare provider for appropriate management.
  • Discontinuation Syndrome: Abruptly stopping Trintellix can lead to discontinuation syndrome, characterized by flu-like symptoms, dizziness, and mood changes. It’s essential to follow your doctor’s guidance when discontinuing the medication.
  • Driving and Operating Machinery: Trintellix may cause dizziness and drowsiness, which can impair your ability to drive or operate machinery. Be cautious until you know how Trintellix affects you.
  • Hyponatremia (Low Sodium Levels): Trintellix may cause low sodium levels in some individuals. Watch for signs of hyponatremia, such as headache, weakness, confusion, and seizures. Report any such symptoms to your doctor immediately.
  • Worsening of Glaucoma: Trintellix may worsen glaucoma, an eye condition characterized by increased pressure within the eye. Inform your eye specialist if you have glaucoma before starting Trintellix.
  • Weight Changes: Some individuals may experience weight changes while taking Trintellix. If you notice significant weight gain or loss, consult your healthcare provider.
  • Bone Fracture Risk: Trintellix may increase the risk of bone fractures, especially in older adults. Take necessary precautions to prevent falls and fractures.
  • Seizures: In rare cases, Trintellix may trigger seizures. If you have a history of seizures or epilepsy, discuss the risks with your doctor.
  • Surgery Precautions: Inform your healthcare provider that you are taking Trintellix before undergoing any surgical procedures, as the medication may interact with anesthesia and other drugs used during surgery.
  • Cessation of Trintellix: If you and your healthcare provider decide to stop Trintellix, it’s essential to follow a gradual tapering schedule to minimize withdrawal symptoms.

Side Effects

Trintellix is an effective medication for managing major depressive disorder, but it’s crucial to be aware of its potential side effects.

Common Side Effects of Trintellix

  1. Nausea and Vomiting: One of the most frequently reported side effects of Trintellix is mild to moderate nausea, which may subside over time.
  2. Headache: Some individuals may experience headaches as their body adjusts to the medication.
  3. Diarrhea or Constipation: Trintellix can cause gastrointestinal disturbances, leading to either diarrhea or constipation in some patients.
  4. Dizziness: Feeling lightheaded or dizzy is another common side effect, especially during the initial days of treatment.
  5. Sleep Disturbances: Trintellix might cause sleep-related issues, such as insomnia or excessive drowsiness.
  6. Dry Mouth: Some patients may experience dryness in the mouth, which can be managed with increased fluid intake.
  7. Changes in Sexual Desire: Trintellix could potentially affect libido or sexual performance in some individuals.

Rare Side Effects of Trintellix

  1. Allergic Reactions: While rare, some people may develop allergic reactions to Trintellix. If you experience rash, itching, swelling, or severe dizziness, seek immediate medical attention.
  2. Hyponatremia: In rare cases, Trintellix may cause low sodium levels in the blood, leading to symptoms like confusion, weakness, or seizures.
  3. Manic Episodes: Trintellix has been associated with the development of manic or hypomanic episodes in individuals with a history of bipolar disorder.
  4. Serotonin Syndrome: Although uncommon, combining Trintellix with other serotonergic drugs may lead to serotonin syndrome, a potentially life-threatening condition.
  5. Abnormal Bleeding: Some individuals may experience increased bleeding, especially if they are also taking blood thinners.
  6. Vision Changes: Rarely, Trintellix may cause visual disturbances or changes in vision.

Severe Side Effects of Trintellix

  1. Suicidal Thoughts: Like many antidepressants, Trintellix carries a warning about an increased risk of suicidal thoughts, especially in young adults.
  2. Severe Allergic Reactions: In extremely rare cases, Trintellix may trigger severe allergic reactions, including anaphylaxis.
  3. Withdrawal Symptoms: Abruptly stopping Trintellix may lead to withdrawal symptoms, such as irritability, mood swings, and flu-like symptoms.
  4. Serotonin Syndrome: While rare, this condition can be life-threatening and requires immediate medical attention.
  5. Liver Problems: Trintellix may rarely cause liver abnormalities, which could be detected through blood tests.
  6. Low Blood Sodium: Severe hyponatremia may occur in some individuals, leading to seizures or coma.


While it offers significant benefits for those dealing with depression, it’s crucial to be aware of its interactions with other drugs, herbs, and food.

Drug Interactions with Trintellix

  1. SSRIs and SNRIs: Taking Trintellix with other selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) can increase the risk of serotonin syndrome, a potentially life-threatening condition characterized by agitation, rapid heartbeat, and high body temperature.
  2. MAOIs: Combining Trintellix with monoamine oxidase inhibitors (MAOIs) can lead to a dangerous condition known as serotonin syndrome. Therefore, there should be a sufficient washout period between discontinuing MAOIs and starting Trintellix.
  3. Anticoagulants: Trintellix may interact with anticoagulant medications, like warfarin, affecting blood clotting and potentially leading to bleeding complications.
  4. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Taking NSAIDs with Trintellix may increase the risk of bleeding and bruising.
  5. Cytochrome P450 (CYP) Substrates: Trintellix is primarily metabolized by CYP2D6 and CYP3A4 enzymes. Co-administration with drugs that inhibit or induce these enzymes can alter Trintellix’s concentration in the body.
  6. Anticonvulsants: Some anticonvulsant medications may interact with Trintellix, affecting the effectiveness of either drug.

Herbal Interactions with Trintellix

  1. St. John’s Wort: St. John’s Wort is a popular herbal supplement used for depression. However, taking it with Trintellix can lead to serotonin syndrome or reduce the effectiveness of Trintellix.
  2. Valerian Root: Valerian root, often used for anxiety and sleep disorders, may interact with Trintellix, causing excessive drowsiness or dizziness.
  3. Kava: Kava is known for its calming effects, but it may enhance the sedative effects of Trintellix, leading to increased drowsiness.
  4. Ginkgo Biloba: Ginkgo Biloba, used for memory enhancement, may increase the risk of bleeding when taken with Trintellix.

Food Interactions with Trintellix

  1. Grapefruit and Grapefruit Juice: Grapefruit and grapefruit juice can inhibit the enzymes responsible for metabolizing Trintellix, leading to increased drug levels in the body and potential side effects.
  2. Alcohol: Alcohol consumption can worsen the side effects of Trintellix, such as dizziness, drowsiness, and impaired judgment.


Proper dosing of Trintellix is crucial for its effectiveness and safety.

Initial Dose

The usual starting dose of Trintellix is 10 milligrams (mg) taken orally once daily. Your doctor may prescribe a lower initial dose, such as 5 mg, for certain individuals who are more sensitive to medications or have specific medical conditions. The starting dose is typically increased after a week to reach the maintenance dose.

The doctor will consider various factors to determine the appropriate initial dose of Trintellix for each patient. Factors include the individual’s medical history, age, other medications being taken, and the severity of the depression. The goal is to start with the lowest effective dose while closely monitoring the patient’s response to treatment.

Maintenance Dose

The maintenance dose of Trintellix usually ranges from 10 mg to 20 mg once daily. The doctor will adjust the dose based on the patient’s response to treatment and any side effects experienced. It may take several weeks for the full therapeutic effects of Trintellix to become evident.

Several factors can influence the determination of the maintenance dose. These include the patient’s body weight, individual metabolism, coexisting medical conditions, and the presence of drug-drug interactions. Close communication with the doctor is vital to ensure the appropriate dose is prescribed.

Missed Dose

If you forget to take your scheduled dose of Trintellix, take it as soon as you remember, unless it is close to the time for the next dose. In that case, skip the missed dose and resume the regular dosing schedule. Never take a double dose to make up for the missed one, as it may increase the risk of side effects.


Overdosing on Trintellix can be dangerous and requires immediate medical attention. Symptoms of an overdose may include nausea, vomiting, dizziness, rapid heartbeat, confusion, and even fainting. If you suspect an overdose, contact emergency services or go to the nearest hospital immediately.

An overdose on Trintellix can cause a range of symptoms, which may vary from person to person. Some common signs include extreme drowsiness, agitation, changes in blood pressure, hallucinations, and seizures. Prompt medical intervention is essential to prevent serious complications.


Proper storage not only maintains the drug’s potency but also ensures your safety and well-being.

  • Read the Medication Guide and Label: Before storing Trintellix, carefully read the medication guide provided by your pharmacist or healthcare professional. Pay close attention to the storage instructions mentioned on the label. Following the manufacturer’s recommendations is the first step toward proper storage.
  • Store at Room Temperature: Trintellix should be stored at room temperature, ideally between 68°F to 77°F (20°C to 25°C). Avoid exposing the medication to extreme temperatures, such as direct sunlight, heat, or freezing conditions. Bathroom cabinets are generally not suitable for storage due to temperature and humidity fluctuations.
  • Keep Away from Moisture: Moisture can degrade Trintellix and reduce its effectiveness. Always store the medication in a tightly closed container away from areas with high humidity, such as bathrooms and kitchens.
  • Protect from Light: Light exposure can also impact the stability of Trintellix. Keep the medication in its original packaging or a dark-colored container that shields it from light.
  • Avoid Storage in the Fridge: Trintellix should not be stored in the refrigerator. Extreme cold temperatures can cause the medication to lose its potency. Stick to room temperature storage as recommended.
  • Keep Out of Reach of Children and Pets: Ensure that Trintellix is stored in a secure location, out of reach of children and pets. Accidental ingestion can lead to severe consequences.
  • Use Pill Organizers with Caution: While pill organizers can be convenient, they may not be suitable for storing Trintellix. The medication’s exposure to air and light inside the organizer could compromise its stability.
  • Check Expiration Date: Regularly check the expiration date of Trintellix and dispose of any expired medication properly. Expired drugs may not be as effective and could potentially be harmful.
  • Don’t Transfer to Another Container: Avoid transferring Trintellix to a different container, especially if it’s not the original one provided by the pharmacy. The original packaging is designed to protect the medication optimally.
  • Keep Track of Storage Conditions: Maintain a record of the storage conditions of Trintellix. This can help you ensure that the medication is being stored correctly, especially if you have multiple prescriptions or medications.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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