Intuniv is a brand name for guanfacine. It is an alpha-2 adrenergic agonist and is a part of the centrally acting antiadrenergic agents drug class. It is used to help manage attention deficit hyperactivity disorder (ADHD) in children 6 years old and older.

Intuniv reduces nerve impulses in the heart and blood vessels. It does this by inhibiting the stimulation of the central nervous system’s alpha-adrenergic receptors and decreasing sympathetic stimulation of the blood vessels and the heart. Additionally, it stops the release of catecholamines, which are usually released as a stress response. Intuniv is used to slow the heart rate and relax the blood vessels.

Intuniv Precautions and Warnings

Intuniv may cause serious health issues, and the risks may be higher for certain groups. Intuniv may cause low blood pressure or heart rate, extreme sleepiness, rebound high blood pressure, and heart problems. This medication can lower the patient’s blood pressure, causing them to feel dizzy. This is more likely to occur when the dose is raised, or the medication is just being started.

Feelings of extreme sleepiness or a lowered ability to focus, think, or react may occur during the first few days of starting Intuniv. During this time, activities that require alertness should be avoided. Intuniv may also cause high blood pressure. This is often a rebound effect after the drug has been taken for a long time and suddenly stopped. Symptoms include headache, faster heart rate, nausea, tight chest, and feelings of nervousness or anxiousness.

Those with a history of heart problems should not take Intinuv, as it may raise the risk of irregular rhythm. Intuniv should also not be taken if the patient has an allergy to the medication or any of its ingredients. Extra caution should also be used when taking Intuniv if the patient has a history of kidney problems, fainting, or stroke.

Animal studies indicate a potential risk of harm to the fetus while taking Intuniv. Patients should discuss with their doctor ahead of time if they are pregnant, plan to become pregnant, or are breastfeeding before taking Intruniv.

Intuniv Side Effects

A range of serious and more common side effects may be experienced while taking Intuniv.

Common Side Effects

Common side effects of Intuniv include:

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Constipation
  • Fatigue
  • Nausea
  • Headache
  • Stomach pain
  • Weight gain
  • Irritability

Severe Side Effects

More severe side effects of Intruniv that require immediate medical attention include:

  • Anxiety
  • Nervousness
  • Hallucinations
  • Severe drowsiness
  • Slow heartbeats
  • Lightheadedness
  • Headaches
  • Confusion
  • Rapid heartbeats
  • Tremors
  • Increased blood pressure
  • Vision problems
  • Seizures
  • Severe dizziness
  • Slow heartbeat
  • Fainting
  • Mental/mood changes
  • Slurred speech
  • Weakness in the arms or legs
  • High fever
  • Muscle stiffness
  • Profuse sweating
  • Unsteadiness or loss of coordination
  • Confusion
  • Fluttering in the chest

Drug Interactions with Intuniv

There are many drug interactions associated with Intuniv. Some drugs known to create severe interactions with Intuniv include:

  • Aprepitant
  • Berotralstat
  • Conivaptan
  • Mifepristone
  • Tizanidine
  • Voxelotor
  • Fluconazole
  • Xanax
  • Valium
  • Benadryl
  • Ketoconazole
  • Antiviral medications
  • Anticancer agents
  • Certain antibiotics
  • Antifungal medications
  • Anticonvulsant medications
  • Psychiatric Medications
  • Cardiovascular Medications

Strengths and Dosages of Intuniv

Strengths and doses for Intuniv may vary based on weight.

WeightTypical Dose
25-33.9 kg (55.1 – 74.8 lbs)2-3 mg/day
34-41.4 kg (75.0 – 91.3 lbs)2-4 mg/day
41.5-49.4 kg (91.5 – 108.9 lbs)3-5 mg/day
49.5-58.4 kg (109.1 – 128.8 lbs)3-6 mg/day
58.5-91 kg (129.0 – 200.6 lbs)4-7 mg/day
>91 kg (>200.6 lbs)5-7 mg/day

Cost of Intuniv in America?

The cost of Intuniv is around $1,032 for a supply of 100 tablets without insurance for any other coupons. The generic version of guanfacine may be available at a cheaper rate.

Why is Intuniv So Expensive?

Intinuiv is a name-brand drug and has an extended-release formulation. Both of these factors make the drug more expensive. Intuniv is also one of the few non-stimulant ADHD medications available, creating a higher demand with less competition. This also can raise the cost.

Intuniv Alternatives

Certain blood-pressure medications and antidepressants may also be sometimes used instead of Intuniv to treat ADHD.

Other non-stimulant ADHD medication alternatives include:

  • Atomoxetine (Strattera)
  • Viloxazine (Qelbree)
  • Clonidine ER (Kapvay)
  • Clonidine (Catapres)
  • Guanfacine (Tenex)

Intuniv FAQs

What is Intuniv used for?

Intuniv is a non-stimulant medication that is used to help manage attention deficit hyperactivity disorder (ADHD).

How long does it take for Intuniv to work?

The main effects of Intuniv are often felt within 1 to 2 hours of taking the medication. However, it may take closer to 4 to 8 weeks to feel its full benefits.

How long do withdrawal systems last with Intuniv?

Guanfacine withdrawal symptoms may begin to appear within 24 hours of discontinuation and can persist for a duration of up to 2 weeks before subsiding. Patients should gradually taper off of the medication if they decide to stop taking it to avoid severe complications such as seizures.

What drug class does Intuniv belong to?

Intuniv is an alpha-2 adrenergic agonist drug used to lower the heart rate and relax the blood vessels.

When is the best time to take Intuniv?

Intuniv may be taken in the morning or the evening as long as it is at the same time each day. However, it should not be taken with a high-fat meal, as this may increase the drug’s absorption and side effects.

What happens if you miss a dose of Intuniv?

If the patient forgets to take a dose of Intuniv, they should take the dose as soon as they remember unless it is within 12 hours of their next scheduled dose. If the next scheduled dose is to be taken soon, skip the missed dose and continue following the regular dosing schedule. schedule as normal. If more than one dose is missed consecutively, a doctor should be contacted as they may need to make adjustments to the strengths of the following doses. Missing doses may worsen the condition or cause unwanted side effects due to withdrawals, such as anxiety, depression, irritability, insomnia, headaches, nausea, and more.

What happens if you take too much Intuniv?

Taking too much Intuniv may lead to an overdose. Signs of an Intuniv overdose include on may cause drowsiness, dizziness, low blood pressure, and slow heart rate. Since Intuniv is an extended-release medication, symptoms of overdose may also be prolonged or delayed. If the patient takes too much Intuniv, they should seek immediate medical attention.

Does Intuniv cause weight gain?

Yes, weight gain may occur as a result of taking Intuniv. Higher doses and strengths of the medication increase the likelihood of weight gain.

Who makes Intuniv?

Shire LLC holds the registered trademark for Intuniv. The medication is manufactured by Takeda Pharmaceuticals America, Inc.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

Product was successfully added to your cart!