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Tresiba (Insulin Degludec)
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Tresiba is a prescription medication used in adults and children aged 1 year and older to treat type 1 and type 2 diabetes.
This medication contains the active substance insulin degludec, a long-acting insulin that effectively controls blood sugar in people with diabetes. However, you need to note that Tresiba does not treat diabetic ketoacidosis.
Tresiba Medication Table
| Usage | Long-acting insulin for type 1 and type 2 diabetes. Provides steady blood sugar control for up to 42 hours. |
| Mechanism of Action | Mimics natural insulin. Forms multi-hexamers under the skin for slow, steady insulin release. |
| Administration Method | Subcutaneous injection using FlexTouch pen or vial. Taken once daily, same time each day. |
| Precautions & Warnings | Risk of hypoglycemia and heart failure. Use with caution in liver/kidney issues. Avoid alcohol. May cause dizziness—don’t drive or use machinery until you know how it affects you. |
| Side Effects |
Common: Diarrhea, headache, cold symptoms, low blood sugar, injection site irritation. Serious: Seizures, chest tightness, vision problems, irregular heartbeat, anxiety. |
| Drug Interactions | Hydrochlorothiazide, tricyclic antidepressants, NSAIDs, metoprolol, olanzapine, simvastatin. |
| Strengths & Dosages |
FlexTouch Pens: - U-100: 100 units/mL, 3 mL per pen, max 80 units per injection, 1-unit increments. - U-200: 200 units/mL, 3 mL per pen, max 160 units per injection, 2-unit increments. Vials: - U-100: 100 units/mL, 10 mL per vial, allows dosing in half-unit increments. |
| Missed Dose | Inject as soon as remembered. If close to next dose, skip missed dose. Do not double dose. |
| Overdose | May cause severe hypoglycemia. Seek immediate medical attention. |
How Does Tresiba Work?
Tresiba works by mimicking the action of naturally produced insulin by the body. Once injected, Tresiba forms multi-hexamers under the skin hence allowing slow and consistent release of the medication into the blood.
This steady release enables the medication to remain effective in the body for a long time and offers stable and continuous blood sugar glucose control for a period that lasts up to 42 hours.
Tresiba Precautions and Warnings
Hypokalemia: The medication has the potential to cause hypokalemia. Patients with pre-existing hypokalemia may experience worsening of their condition. You should monitor your potassium levels often when under medication.
Allergic Conditions: If you experience any allergic condition when using Tresiba or any of its components, stop using the medication and inform your doctor immediately.
Taking Alcohol: Do not consume alcohol when taking Tresiba, because alcohol may increase the risk of hypoglycemia.
Driving or Operating Heavy Machinery: Tresiba has a side effect of dizziness, therefore, avoid driving or operating heavy machinery when taking the medication.
Heart Failure: If you are suffering from heart failure your condition may worsen with Tresiba use. In case you experience signs and symptoms of heart failure discontinue the medication immediately.
Kidney and Liver Condition: Individuals with liver or kidney problems may face an increased risk of hypoglycemia while taking Tresiba. Before being given Tresiba inform your doctor about your history of liver and kidney problems.
Side Effects of Tresiba
Tresiba may cause side effects which can range from mild to severe, and impact various organ systems like the gastrointestinal tract. Being aware of the effects helps manage diabetes and ensures patient safety.
Common Side Effects
- Diarrhea
- Headache
- Common cold
- Low blood sugar
- Swelling or redness at the site of injection
- Dizziness
- Slurred speech
- Increased or decreased appetite
Severe Side Effects
- Anxiety
- Blurred vision
- Seizures
- Irregular or fast heartbeat
- Unusual weight gain or loss
- Difficulty swallowing
- Pale, cool skin
- Chest tightness
Drug Interactions With Tresiba
Understanding the potential interaction of Tresiba and other medications is important for its safety and effectiveness in managing diabetes mellitus. It also helps to minimize the risks of hypoglycemia or adverse effects on your body.
| Drug | Interaction |
| Hydrochlorothiazide | Using hydrochlorothiazide with Tresiba concurrently can lead to hypoglycemia. Patients may experience symptoms such as confusion, dizziness, and sweating because of having low blood sugar levels. |
| Tricyclic antidepressant | Combining these two medications may intensify symptoms such as palpitations, weakness, and sweating due to hypoglycemia. |
| Nonsteroidal anti-inflammatory drugs | When Nonsteroidal anti-inflammatory drugs are used directly with Tresiba, they can impair kidney function which may affect insulin clearance from the body. |
| Metoprolol | The interaction between metoprolol and Tresiba can lead to difficulties in recognizing and treating hypoglycemic episodes which may result in severe hypoglycemia. |
| Olanzapine | Taking Tresiba while using olanzapine medication causes insulin resistance leading to hyperglycemia. You may develop symptoms like fatigue, increased thirst, and frequent urination. |
| Simvastatin | Concurrent use of Tresiba and simvastatin can worsen glycemic control in patients having diabetes. You may experience elevated blood sugar levels and an increased risk of developing diabetes complications. |
Strengths and Dosages of Tresiba
Prescription Tresiba is available in concentrations of 100 units/mL (vial and FlexTouch pen) and 200 units/mL (FlexTouch pen).
Your doctor will initiate treatment with the recommended lower dosage for your condition and adjust the dosage gradually to find the optimal amount based on your blood sugar level. There is no maximum recommended dose for Tresiba.
Before using Tresiba, monitor your blood sugar frequently, especially before, after, and during bedtime. This approach reduces the risk of experiencing dangerously low blood sugar levels.
Tresiba dosage is determined by your doctor after considering several factors such as:
- Age
- Prior insulin medication
- Existing health conditions
- Weight
- Type of diabetes
- The severity of the condition
- Other diabetes management medication
- Fluctuations in blood sugar.
Cost of Tresiba in America
The cost of a 10-millilitre supply of Tresiba subcutaneous solution (100ml/units) is approximately $366. This price is for individuals paying with cash and can vary depending on the pharmacy you choose to purchase the medication.
Patients who achieve the desired results may end up paying less for the medication. You may also opt for the generic version of Tresiba referred to as degludec which is available at a cheaper price.
Why is Tresiba So Expensive?
Tresiba is a long-acting formulation known for its stability and extended duration of action. This adds to its production costs compared to other insulin formulations. Patients looking to cut costs and purchase this medication cheaply can opt for health insurance that covers Tresiba, coupons, savings cards, and patient assistance programs.
Alternatively, patients can purchase Tresiba from services like MyRx Outlet which charges way less than standard US pharmacies.
Tresiba Alternatives
Tresiba is effective for many patients but some may seek alternative medication for various reasons, including cost, side effects, or preference. Understanding the range of alternatives available patients and healthcare providers can make informed choices for suitable treatment options in managing diabetes.
- Basaglar: It works by providing a steady release of insulin over 24 hours. This helps in the regulation of blood sugar levels during the day and night.
- Novolog: This medication is a rapid-acting insulin that works by rapidly lowering blood sugar levels after taking a meal. Novolog is designed to match the body’s natural insulin response to food intake.
- Levemir: Levemir works by providing a slow and steady release of insulin over an extended period. It helps in the regulation of blood sugar levels by replacing basal insulin needed by the body.
Tresiba FAQs
What is Tresiba?
Tresiba is a medication that is a long-acting insulin analog used in the management of blood sugar levels in patients with type 1 and type 2 diabetes mellitus.
Who makes Tresiba?
Tresiba is made by Novo Nordisk, a company that specializes in diabetes care and other chronic diseases.
How does Tresiba work?
The medication mimics the action of naturally produced insulin in the body, providing a steady level of insulin that controls blood glucose day and night.
How long does Tresiba last?
Tresiba is a long-acting insulin medication that provides a glucose-lowering effect that will last for at least 42 hours.
How to use Tresiba flextouch?
To use Tresiba flextouch prepare the injection site by cleaning it with an alcohol swab. Check the insulin to ensure it is clear and colorless. Select the dose and inject the insulin then remove the needle. Always rotate the injection site to prevent skin irritation.
How many Tresiba pens in a box?
Tresiba pens can be either 5 or 3 available in a box, depending on the packaging or the prescribing healthcare profession.
How long does Tresiba take to work?
The medication takes effect immediately one hour after the injection, and its glucose-lowering effects last throughout the day.
Where to inject Tresiba?
You can inject Tresiba in either your upper arm, thigh, or abdomen to allow effective absorption of the medicine in your bloodstream.
When does Tresiba peak?
The medication starts working within 60 minutes of administration and reaches its peak activity approximately 12 hours after injection.
How often do you take Tresiba?
Adult diabetics should take Tresiba once daily, at the same time of the day, choosing their ideal time.
How fast does Tresiba work?
Tresiba starts working one hour after injection. It provides glucose-lowering effects throughout the entire day.
IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.
