Skyrizi (risankizumab) is a prescription medicine that treats inflammation caused by autoimmune disorders such as plaque psoriasis, psoriatic arthritis, ulcerative colitis, or Crohn’s disease among adults who are potential subjects for therapy or phototherapy.

Skyrizi may be self-administered or used under the supervision of a healthcare provider.

The medicine targets a protein called interleukin-23 in the immune system that causes inflammation and improves the symptoms.

The medicine is administered as follows:

  • Intravenous infusion (psoriatic arthritis and plaque psoriasis)
  • Subcutaneous injection (ulcerative colitis and Crohn’s disease)

Precautions and Warnings with Skyrizi

Skyrizi may not be used if you have recently traveled, received a vaccine, or are scheduled for a booster dose.

The effects of the medicine on pregnant or breastfeeding women are unknown. You should inform your doctor or healthcare provider if you are expecting or breastfeeding before taking the medicine.

The medicine should be kept out of children’s and pets’ reach.

Your healthcare provider may not prescribe Skyrizi if you are allergic to risankizumab-rzaa (active ingredient), along with sodium succinate, polysorbate 20, sorbitol, and succinic acid (inactive ingredients).

You should inform your doctor if you have the following conditions:

Skyrizi Side Effects

This is not the complete list of side effects associated with Skyrizi. They vary on a patient-to-patient basis and may not be experienced by everyone.

The common side effects go away on their own as the body adjusts to the medicine, but serious side effects need immediate medical attention. You should address your concerns about the potential side effects with your healthcare provider before starting the treatment with the medication.

Your healthcare provider will do blood tests before diagnosing liver problems. They may stop administering Skyrizi if you develop them.

Skyrizi is documented to cause certain side effects, such as liver problems, especially among adults diagnosed with Crohn’s disease and ulcerative colitis.

The side effects of Skryizi are:

Common Side Effects

  • Stomach pain
  • Headache
  • Fatigue
  • Pain, redness, or irritation at the injection site
  • Joint pain
  • Back pain

Serious Side Effects

  • Skin infection at the injection site
  • Warmth, pain, swelling, pain or redness
  • Low red blood cell count
  • Lightheaded
  • Falls
  • Trouble breathing
  • Liver problems (dark yellow or brown urine, yellowing of the eyes or skin, jaundice, loss of appetite)
  • Pain or trouble during urination
  • Poor healing and discomfort

Drug Interactions with Skyrizi

Skyrizi may interact with certain medications that you might be taking while treating the symptoms. The drug-to-drug interaction may reduce the efficacy of the medicine and put you at risk of side effects.

You should share the list of products (prescription, over-the-counter, supplements, hormonal productions) that are taken along with alcohol, nicotine, and street drug intake before starting treatment with your healthcare provider for safe and effective treatment.

Your doctor may switch you from Skyrizi or change the dosage if the interaction worsens your condition.

Skyrizi can interact with these medicines:

Strengths and Dosages with Skyrizi

The medicine is available in the following forms:

  • Vial
  • Pen
  • Prefilled Syringe
  • Prefilled Cartridge
FormsActive IngredientQuantityInactive Ingredient
Vialrisankizumab(600 mg/10 mL)Purified water, succinic acid, polysorbate 20, sorbitol, and sodium succinate
Penrisankizumab(150 mg/mL)Purified water, succinic acid, polysorbate 20, sorbitol, and sodium succinate
Syringerisankizumab(75 mg/0.83 mL ; 150 mg/mL)Purified water, succinic acid, polysorbate 20, sorbitol, and sodium succinate
Cartridgerisankizumab(180 mg/1.2 mL ; 360 mg/2.4 mL)Purified water, succinic acid, polysorbate 20, sorbitol, and sodium succinate

It’s recommended to inject the medicine on a different site to reduce the chances of soreness. The medicine should not be administered on tender, bruised, red, or hard areas or those affected by psoriasis, scars, or stretch marks.

The medicine should be in yellow color. It should not be used.  It should not be used if it has changed colors, contains particles, or is dropped or damaged.

The medicine should not be used if frozen.

The syringe or injection pen should be disposed of after one use, even if there is still medicine left inside.

Skyrizi should be used exactly as per the instructions of your healthcare provider or on the product description.

How To Inject Skyrizi

  • Remove your dose from the fridge
  • Let it come to room temperature for 15 to 30 minutes
  • Select the area of injection (front of your thighs, the lower part of the abdomen (at least two inches away from your belly button), or the outer area of the upper arm).
  • Clean the targeted area with an alcohol wipe and let it dry
  • Pinch the skin and insert the needle at a 45-degree angle using a quick, short movement.
  • Slowly push the plunger until liquid is injected, and pull the needle out
  • Dispose of the syringe into
  • Apply a band-aid to stop bleeding

Cost of Skyrizi In America

Skyrizi may cost you back between $11,381.65 and $ 21,017.36 without insurance. The medicine may be available at discount prices offered by certain pharmacies.

The price of the medicine varies depending on:

  • The pharmacy from where it was purchased
  • Insurance coverage
  • Treatment plan

Why is Skyrizi so Expensive?

Skyrizi is expensive because of the high costs associated with extensive research and clinical trials for its production. There are limited alternatives to the medicine, which leaves no option for patients but to pay high prices for treatment.

Skyrizi Alternatives

Your healthcare provider may switch you from Skyrizi to alternative versions of the medicine if the interaction or side effects worsen your conditions.

Your healthcare provider will prescribe Skyrizi after judging that the benefits of the medicine are higher than the risk of interactions and side effects.

The above-mentioned alternatives have their pros and cons, and you should not switch to different versions of the medicine without your doctor’s approval.

The alternatives of Skyrizi are:

Skyrizi FAQs

What is Skyrizi?

Skyrizi (risankizumab) is a prescription medicine that treats a variety of conditions, including plaque psoriasis, psoriatic arthritis, ulcerative colitis, and Crohn’s disease in adults who are undergoing systemic therapy or phototherapy.

What is Skyrizi used for?

Skyrizi primarily treats plaque psoriasis, a chronic autoimmune condition that causes red and scaly patches on the skin.

How long do Skyrizi side effects last?

The side effects of Skyrizi vary in duration and intensity. Common side effects may go away on their own within a few days to weeks after administration, but it is important to discuss any concerns with your healthcare provider.

Who makes Skyrizi?

The global biopharmaceutical company AbbVie Inc. manufactures Skyrizi.

How long does Skyrizi take to work?

Skyrizi may start working within a few weeks to months after starting treatment. The exact time frame of efficacy may vary between individuals.

How often do you take Skyrizi?

Skyrizi is usually administered as an injection under the skin once every 12 weeks (every three months) after an initial loading dose.

How long can Skyrizi stay out of the fridge?

Skyrizi should be refrigerated at two °C to 8°C (36°F to 46°F). It can be kept at room temperature (up to 25°C or 77°F) for up to 30 days before use.

How long does Skyrizi stay in your system?

Skyrizi may stay in your system for approximately 28 days.

How do you inject Skyrizi?

Skyrizi is injected under the skin (subcutaneously). The medicine may be self-administered or given by a healthcare provider after proper training.

What should you avoid while taking Skyrizi?

Your healthcare provider may ask you to avoid medicines and certain vaccines while taking Skyrizi. You can also consult with the provider about any specific warnings and precautions based on your conditions and medicines that you are taking.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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