Medicine is typically prescribed for rosacea, acne, and other skin conditions. It can help decrease redness, swelling, irritation, and pimples caused by these issues. MetroGel also treats bacterial vaginosis and other female reproductive infections.

Metronidazole is an antibiotic that fights certain bacteria and parasite species. MetroGel is a topical gel meant to be applied to the skin, but metronidazole is also available in oral forms for other purposes.

As the name implies, MetroGel has a smooth, gel-like consistency.  Topical metronidazole is also available under other brand names, including MetroCream, Nuvessa, Noritate, Metro I.V., MetroLotion, and Flagyl. Some acne treatments combine metronidazole with different active ingredients.

How Does MetroGel Work?

DNA contains instructions to make proteins, which cells use to perform many different tasks. Bacterial cells must make proteins to make energy molecules, reproduce, remove waste products, and protect themselves. The MetroGel prevents bacterial cells from making proteins, so they can’t do cellular work. The bacteria also can’t repair their cell walls, making them vulnerable to damage. The infections should subside as MetroGel damages and eventually kills the bacteria.

MetroGel is typically prescribed for skin conditions like acne and rosacea. It’s also used as a topical treatment for bacteria vaginosis. Doctors use oral metronidazole to treat a broader range of concerns, including gastrointestinal infections. It also works as an anti-parasitic, so it’s prescribed for infections like trichomoniasis, giardiasis, and amebiasis.

MetroGel Precautions and Warnings

MetroGel isn’t suitable for patients allergic to metronidazole or other nitroimidazole antibiotics. Let your doctor know if you’re allergic to metronidazole or any other antibiotic so you can explore different treatment options. MetroGel and other forms of topical metronidazole include inactive ingredients that can also cause allergies. Don’t take this medication if you’re allergic to its ingredients.

Since MetroGel is a topical medicine that you only apply to your skin, it can be safely combined with many oral medications. Please be careful about using other topical products simultaneously, such as MetroGel. Different forms of acne medication work by causing minor skin irritation to increase cellular turnover. These medicines are available over-the-counter as well as by prescription. MetroGel may irritate your skin if you combine it with other topical medications. Ask your doctor or dermatologist what other skincare products you can use while taking MetroGel.

MetroGel and other antibiotics for acne and rosacea work by targeting the bacteria that cause breakouts. Ideally, this prevents new breakouts from forming. MetroGel may also reduce the severity of active acne or rosacea. However, not all patients experience this result. Your doctor may prescribe a separate medicine to address pre-existing blemishes.

Side Effects of MetroGel

Most MetroGel side effects are caused by irritation at the application site. Your skin may need time to adapt to a new medication. Many patients adjust to MetroGel within the first weeks of their prescription. Let your doctor know if your side effects continue after that.

It’s possible to have an allergic reaction to MetroGel, especially in patients who are allergic to metronidazole or antibiotics in the same family. Swelling, severe burning sensations, hives, and difficulty breathing are all signs of an allergic reaction. Allergies can also cause reactions in parts of the body where you didn’t apply MetroGel. Stop using MetroGel and get medical attention if you notice these symptoms.

Ask your doctor about lotions and moisturizers that can help with skin irritation while you get used to MetroGel. Skincare labeled gentle, sensitive, or non-comedogenic may help you soothe irritated or healing skin.

MetroGel side effects include:

  • Stinging
  • Dryness
  • Redness
  • Burning
  • Other skin irritation
  • Eye irritation or pink eye

Drug Interactions With MetroGel

Oral metronidazole interferes with other medicines, but topical MetroGel has few interactions. Since MetroGel is applied directly to the skin, it isn’t metabolized through the digestive system like oral medications are. This separate application means that MetroGel rarely causes negative interactions with other substances.

However, some interactions are still possible. Blood thinners and anticoagulants like warfarin or coumadin sometimes interfere with MetroGel.

MetroGel can irritate when combined with other topical acne or rosacea medicines, including over-the-counter skincare products. Tell your doctor about all the medicines you take and the skincare products you use.

Strengths and Dosages of MetroGel

MetroGel and other topical medicines containing metronidazole have several different strengths. The most muscular strength, highest dosage, or concentrated version isn’t always the best choice. Your doctor generally will prescribe the lowest dose that should deliver results. This strategy helps reduce irritation and other side effects while still offering relief.

Medication NameStrengthTypical Usage
MetroGel1% metronidazoleRosacea
MetroGel 750.75% metronidazoleRosocea and acne
MetroGel Vaginal0.75% metronidazoleBacterial vaginosis
Vandazole0.75% metronidazoleBacterial vaginosis
Nuvessa1.3% metronidazoleBacterial vaginosis

Alternatives to MetroGel

MetroGel is the only topical antibiotic that can be used for acne and rosacea. Oral antibiotics and retinoids are other common skin treatments. You can ask your doctor about these options if you want other medications besides MetroGel. Other options include:

  • Likmez
  • Noritate
  • Pretomanid
  • Rosadan
  • Solosec
  • Tindamax
  • Vandazole

MetroGel FAQs

Why did my doctor prescribe MetroGel?

MetroGel is a topical antibiotic for treating acne, rosacea, and other skin conditions. It can also be used topically to treat bacteria vaginosis and other female reproductive infections. Your doctor prescribed MetroGel to manage one of these infections.

Can I take MetroGel with other medicine?

MetroGel doesn’t cause negative interactions with most other medicines because it’s applied to the skin instead of taken orally. It’s more likely to interact with other topical medications, especially those for acne or rosacea. Other interactions are rare but still possible. Ask your doctor if your other medicines can continue while using MetroGel.

Can I use MetroGel with my regular skincare routine?

MetroGel can irritate your skin when combined with other skincare ingredients. Active ingredients like acids and retinoids are already irritating because they encourage skin healing and renewal. MetroGel may cause more irritation if you combine it with these ingredients. Your dermatologist or doctor should be able to tell you what products are safe to use with MetroGel.

Will MetroGel clear up my skin?

Conditions like acne and rosacea are complicated. Many different factors can contribute to these issues. Some patients achieve clear skin by using MetroGel. Others use MetroGel alongside other medications. Some people show partial improvement while still having some symptoms. Talk to your doctor if you don’t see the results you want from MetroGel.

What is the Cost of MetroGel in America?

A 45 g tube of MetroGel retails for around $200 in America. This is the price before any discounts or coupons. If your insurance covers MetroGel, you may pay a lower price. Pharmacy and manufacturer coupons can also decrease costs to around $40. Depending on your insurance plan, using a coupon may cost less than using your insurance.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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