Invokamet is a medication prescribed to adults with type 2 diabetes. It combines two active drugs—canagliflozin and metformin—that help to manage blood glucose levels. This dual treatment method removes sugar from the kidneys while curbing sugar production in the liver. By taking Invokamet, patients may not only experience healthier sugar levels but may also benefit from weight loss or maintenance—a significant advantage for those managing type 2 diabetes.

Invokamet: Precautions and Warnings 

Patients must consult with a healthcare professional before starting Invokamet, as outcomes and effects differ by condition and existing treatment plans. Patients with kidney or liver issues, a history of heart disease, or who are pregnant or breastfeeding should proceed with caution and speak to a doctor about these conditions before taking Invokamet. Additionally, while taking Invokamet, patients should watch for signs of adverse reactions and contact a medical professional if concerning or life-threatening symptoms arise.

  • Patients who have been diagnosed with severe renal impairment and patients with known allergies to the drugs canagliflozin or metformin should not take Invokamet or its extended-release counterpart, Invokament XR.
  • While all patients should be screened for metabolic acidosis, including diabetic ketoacidosis, regardless of initial blood glucose results, those at risk of diabetic complications must monitor their ketone levels closely. Patients should stop taking Invokamet immediately if signs of ketoacidosis arise.
  • Initial ketoacidosis symptoms may include dire thirst, the frequent need to urinate, abdominal pain, or vomiting. More severe symptoms can be rapid or deep breathing, skin and mouth dryness, a reddened face, breath that has a fruity odor, headaches, muscle stiffness, fatigue, and nausea and vomiting. Additional symptoms include blurred vision, diarrhea, confusion, lightheadedness, or foul, ketone, or acetone-smelling breath.
  • Make sure to tell your doctor if you are pregnant before taking Invokamet, as this medication may pose risks to unborn fetuses. Women who are breastfeeding should not take Invokamet.
  • Premenopausal women should be aware that taking Invokamet can lead to unintended pregnancy or lead anovulatory female patients to ovulate.

Invokamet Side Effects

Commonly reported side effects include yeast and urinary tract infections, along with alterations in urination patterns. Individuals might also suffer from gastrointestinal upset or dehydration. Exceptionally, severe health problems like lactic acidosis or ketoacidosis may emerge. Should you observe any symptoms that persist or deteriorate, it’s crucial to contact your medical professional.

Common Side Effects

  • Diarrhea, bloating, and gas
  • Abdominal pain
  • Headache
  • Loss of appetite
  • Skin rashes or swelling of the throat, lips, and face
  • Difficulty breathing or wheeziness
  • Yeast infections
  • Dehydration
  • An increase in urination
  • Vitamin B deficiencies
  • The buildup of lactic acid, or lactic acidosis
  • Unexplained bruising or bleeding

Severe Side Effects

  • An increased likelihood of toe, foot, and leg amputations among patients treated with canagliflozin, one of the components of Invokamet.
  • Hypotension, or low blood pressure, can be brought on by various factors, including volume depletion, which is a significant side effect of medications like Invokamet. Monitoring blood pressure levels is critical for patients taking Invokamet, especially if they experience symptoms that could indicate low blood pressure, like heart palpitations, dizziness, confusion, nausea, fatigue, and muscle pain.
  • Hypovolemia, or the loss of blood volume or bodily fluids, has occurred in patients taking Invokamet. Canagliflozin, a core element of the drug Invokamet, directs the kidneys to eliminate glucose from the body through urination. This process can cause excessive dehydration, leading to the loss of bodily fluids essential to maintain adequate blood volume.
  • Acute kidney injury: According to the FDA, patients taking diabetes medications, including Invokamet, are at higher risk of acute kidney injury related to volume depletion. Increased risk is most closely found in patients suffering from impaired renal function, volume depletion, or who are taking loop diuretics for hypertension, cirrhosis, nephrotic syndrome, or heart failure.
  • Bone fractures were observed in type 2 diabetes patients using canagliflozin with an elevated risk of cardiovascular disease during two clinical drug trials.
  • While rare, Fournier’s gangrene, a life-threatening bacterial infection of the perineum, or area between the anus and the genitals, has been linked to patients taking Invokamet. Fournier’s gangrene requires immediate attention and requires surgery to remove dead tissue. Symptoms to watch out for include a fever accompanied by redness, tenderness, or swelling in the genital area.

Drug Interactions With Invokamet

Certain medications can interact with Invokamet, altering its effectiveness or increasing the risk of harmful effects. To avoid unintended interactions, it’s essential to inform your healthcare provider of all drugs you’re taking, including over-the-counter medicines, supplements, and herbal products.

  • Carbonic anhydrase inhibitors used to treat glaucoma can have adverse effects when taken with Invokamet. Examples of these medications include Topiramate, Methazolamide, Acetazolamide, Dorzolamide, and Brinzolamide.
  • Drugs that lower the body’s ability to get rid of metformin can adversely interact with Invokamet. These medications include Glucophage, Ranolazine, Vandetanib, and Cimetidine, but they should not be taken with Invokamet due to their ability to increase the amount of metformin in the bloodstream.
  • Diuretics or blood pressure medications can also interact with Invokamet, causing dehydration or negatively influencing the drug’s effect on blood glucose levels.

Strengths and Dosages With Invokamet

Invokamet is available in various strengths and dosages to accommodate individual treatment needs. Since Invokamet is one pill made up of two drugs, Invokama ( or canagliflozin) and metformin, the dosages outlined below break down the composition of the two ingredients found in the one tablet.

To determine the appropriate dose, your doctor will assess your overall medical condition and how this is likely to impact your response to treatment.

Patient is not currently being treated with either canagliflozin or metformin HCl.1 50 mg tablet (100 mg of canagliflozin and 1,000 mg of metformin HCl).Twice a day, taken orally with meals
Patient is currently taking Metformin HCl*1 50 mg tablet (100 mg of canagliflozin and the nearest appropriate daily dose of metformin HCl).Twice a day, taken orally with meals
Patient is currently taking Canagliflozin (Invokana)Patient continues the same daily dose of canagliflozin and adds on a total daily dose of 1,000 mg metformin HCI.Twice a day, taken orally with meals
Patient is currently taking Canagliflozin (Invokana) and metformin HCIPatient continues the same daily dose of canagliflozin and metformin HCI, taking up to 1,000 mg twice daily.Twice a day, taken orally with meals

For patients who can tolerate 50 mg twice daily without issue, the dosage of canagliflozin may be adjusted up to the highest suggested amount of 150 mg twice daily. Similarly, the amount of metformin a patient takes can be increased to 1,000 mg twice daily. Your doctor will make gradual dosage increases to minimize gastrointestinal side effects associated with metformin.

FAQs About Invokamet 

What is Invokamet used for?

Invokamet is a prescription drug used to manage blood sugar levels in adults with type 2 diabetes. It combines canagliflozin and metformin, which work together to control blood sugar.

Can I take Invokamet if I have type 1 diabetes?

Invokamet is specifically designed for adults with type 2 diabetes and should not be used by those with type 1 diabetes.

What is the difference between Invokamet and Invokana?

Both Invokamet and Invokana are medications used to manage type 2 diabetes. While both drugs contain canagliflozin (sold under the brand name Invokana), Invokament differs from Invokana as it contains canagliflozin and another diabetes medication, metformin, to lower blood sugar.

What is the difference between Invokamet and Invokamet XR?

While both Invokamet and Invokamet XR are used to manage blood sugar levels in people with type 2 diabetes, their formulas differ regarding the frequency at which they must be taken. Invokamet is typically taken twice daily with meals, while Invokamet XR is an extended-release pill taken once a day. The XR version is designed as a slow-release option for patients who benefit from the gradual release of the medication over the course of the day.

Should I monitor my blood sugar levels while on Invokamet?

Yes, it is essential to regularly monitor your blood sugar levels when taking any diabetes medication, including Invokamet.

How fast does Invokamet work?

The amount of time it takes to feel the effects of Invokamet varies by patient. Still, individuals taking the medication may typically notice improvements in their blood sugar levels within one week. Depending on the patient’s baseline blood sugar levels and overall condition, it may take longer to feel the drug’s full effects.

Can Invokamet be used in combination with other diabetes medications?

Yes, Invokamet can be combined with other diabetes medications, including insulin, when additional blood sugar control is needed. However, combining medications should be done under the guidance of a healthcare provider to ensure consistent blood sugar levels.

How long does Invokamet stay in your system?

Invokamet combines two medications, canagliflozin, and metformin, each of which has a specific elimination time. The half-life of canagliflozin is roughly 10.6 to 13.1 hours, meaning it takes approximately this amount of time for canagliflozin in the bloodstream to decrease by half. For metformin, the half-life is roughly 17.6 hours. However, removing Invokamet from the system can take four to five days, depending on kidney function and overall health. Who makes Invokamet?

What company makes Invokamet?

Janssen Pharmaceuticals, a subsidiary of Johnson & Johnson, is the manufacturer of  Invokamet. Janssen is a leading pharmaceutical company that develops and markets a wide range of healthcare products, including medications for treating diabetes.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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