Entuzity is a biosynthetic human insulin containing high concentrations of insulin per mL. It is used to control glucose concentration in people suffering from diabetes and who need at least 200 UI per day.

People suffering from Type 1 and 2 diabetes need insulin to control their blood sugar. While some diabetics may require a few units of insulin, others need a lot of insulin to effectively control blood sugar and live healthily.

Some patients may even require as much as 200 units of insulin to control blood sugar appropriately. For these patients, doctors may recommend medications that have higher concentrations of insulin such as Entuzity

How Does Entuzity Work?

Entuzity mimics human insulin in controlling blood sugar levels by increasing the amount of sugar that is stored in body tissues like the liver and muscles.

By increasing the sugar stored in tissues, Entuzity helps to significantly decrease the concentration of sugar in the blood in people suffering from Type 1 and 2 diabetes who need at least 200 UI per day.

This medication can function as meal-time insulin (fast-acting), starting to work in 30 to 60 minutes, as well as basal insulin (long-acting), working for up to 8 hours.

Precautions and Warnings of Entuzity

When used as directed, Entuzity, a pharmaceutical medicine intended to treat particular medical disorders, offers patients several advantages. To guarantee maximum safety and efficacy, it is crucial to understand and abide by the warnings and precautions related to its use.

  • Liver Conditions: If you are suffering from liver disease, inform your doctor before the administration of Entuzity. Since the liver is the primary site where insulin clearance occurs, liver conditions may affect the amount of insulin in your body.
  • Driving and Operating Heavy Machinery: Avoid driving cars or operating heavy machinery while taking the medication. Entuzity can change blood sugar levels which will affect your mental and physical abilities making it unsafe to drive or operate machines.
  • Hypoglycemia: Taking an overdose of the medication, skipping meals, or exercising more than usual while taking the medication can cause hypoglycemia. Inform your doctor if you experience any symptoms of hypoglycemia such as profuse sweating and shakiness.
  • Low Potassium levels: Entuzity may lower potassium levels in your bloodstream. Therefore, tell your doctor if you experience symptoms of reduced potassium levels such as vomiting, tiredness, and numbness.
  • Kidney Functions: Kidneys play a role in the clearance of insulin in the body hence affecting insulin plasma levels. Your doctor will have to monitor you if you have kidney diseases and adjust dosage as required.
  • Allergic Reactions: In case you have any allergic conditions or are allergic to the medication ensure you inform your healthcare provider before using the medication to avoid any adverse side effects.

Entuzity Side Effects

Entuzity may present several side effects when using it, although not every patient will experience these side effects. The unwanted side effects can either be mild and easy to manage or severe and require medical attention.

Common Side Effects

  • Profuse sweating
  • Hunger
  • Headaches
  • Swelling of your ankles or feet
  • Abdominal pain
  • Drowsiness
  • Loss or increase of appetite
  • Nausea

Severe Side Effects

  • Dehydration
  • Allergic reactions
  • Weight gain or loss
  • Fast heartbeat
  • Low blood sugar
  • Blurred vision

Drug Interactions With Entuzity

Entuzity may interact with many medications affecting its efficacy or posing a risk of having low or high blood sugar. The interactions necessitate close monitoring by healthcare providers to adjust insulin doses accordingly and prevent adverse side effects. This ensures safe and effective management of diabetes and concurrent conditions.

Drug Interaction
SulfonylureasUsing sulfonylureas medication while using Entuzity may increase the risk of having low blood sugar levels.
Thiazolidinediones (TZDs)The concurrent use of thiazolidinediones (such as Avandamet) and Entuzity can heighten the risk of fluid retention and heart failure.
Thyroid hormone medicationsThyroid hormone medications may interact with Enzuity and affect glucose metabolism. Your doctor may have to alter the medication dosages.
Beta-BlockersThe interaction of Entuzity with beta-blocker medication may mask symptoms of hypoglycemia such as tremors, and cause weight gain.
Glucagon-like peptide-1 (GLP-1)Combining Entuzity with Glucagon-like peptide-1 (such as Ozempic or Mounjaro) may enhance adverse side effects such as hypoglycemia.
CorticosteroidsThe use of corticosteroids and Entuzity concurrently can antagonize the glucose-lowering effects of Entuzity, leading to high blood sugar.

Strengths and Dosages of Entuzity

Entuzity is available as a clear and colorless aqueous solution containing 500 units of insulin per mL. The medication comes in a 3 mL KwikPen, a prefilled pen containing 1500 units of insulin.

The pen is injected subcutaneously, depending on your insulin requirements. Your doctor should be able to determine the appropriate insulin dosage.

Method of AdministrationDosage/Form
Subcutaneous Injection3 mL KwikPen (Prefilled pen containing 1500 UI)

Entuzity Alternatives

Entuzity has several alternative medications which can be used in the treatment of diabetes. The medications provide insulin to replace the insulin produced by the pancreas in patients with insulin-resistant diabetes. They include:

  • Insulin Glulisine: Insulin glulisine (such as Apidra) helps regulate the blood sugar level by replacing the insulin normally secreted by the pancreas in response to meals.
  • Insulin Determiner: It works by binding to albumin in the bloodstream, hence prolonging its duration of action compared to regular human insulin.
  • Insulin Glargine: Insulin glargine (such as Lantus and Basaglar) mimics the basal insulin secretion of the pancreas. This helps in providing a steady level of insulin throughout the day. It regulates the blood sugar level over an extended period, lasting about 24 hours after injection.
  • Other Medication: Other alternative medications of Enzuzity include insulin aspart (Fiasp), insulin lispro (Humalog), and insulin degludec (Tresiba).

FAQs of Entuzity

What does Entuzity treat?

Entuzity is a medication used in treating insulin-resistant patients with diabetes who require high-dose insulin.

How does Entuzity work?

The medication works by regulating blood sugar levels and managing diabetes in patients who have developed insulin resistance or require high doses of insulin for effective glycemic control.

What are the side effects of Entuzity?

The side effects of Entuzity include hunger, low blood sugar, blurred vision, dizziness, difficulty speaking, dehydration, profuse sweating, and allergic reactions.

What is the difference between Entuzity and other types of insulin?

Entuzity has a relatively higher concentration of insulin (500 ml) than that of regular insulin (100 ml).

How do I use Entuzity?

The medication comes in a prefilled pen that’s injected subcutaneously as directed by your doctor.

Who should use Entuzity?

The medication is prescribed to adults and children with diabetes who require more than 200 ml units of insulin per day.

What happens if I stop taking the medication?

Stopping Entuzity abruptly without consulting your doctor may be dangerous and lead to serious health complications such as high blood pressure leading to symptoms such as increased thirst, frequent urination, fatigue, and blurry vision.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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