Synjardy is a prescription medication that combines two active ingredients: empagliflozin and metformin. Empagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor, and metformin is a biguanide antidiabetic agent. Together, they form a potent combination that aids in managing blood sugar levels in patients with type 2 diabetes.

It is primarily prescribed for individuals diagnosed with type 2 diabetes. This chronic condition affects the body’s ability to regulate blood sugar levels, leading to insulin resistance and improper glucose utilization. By combining empagliflozin and metformin, Synjardy helps improve insulin sensitivity and reduces glucose absorption in the kidneys, leading to better glycemic control.

Empagliflozin, as an SGLT2 inhibitor, works by blocking the reabsorption of glucose in the kidneys. This action leads to increased glucose excretion through urine, reducing blood sugar levels. Metformin, on the other hand, primarily targets the liver, suppressing glucose production and promoting insulin sensitivity in peripheral tissues.

The combined action of both ingredients in Synjardy results in a multifaceted approach to managing type 2 diabetes. By reducing glucose production in the liver, increasing glucose excretion, and improving insulin sensitivity, Synjardy helps maintain stable blood sugar levels.

The effectiveness of Synjardy in managing type 2 diabetes has been well-documented through clinical trials and real-world use. Studies have shown that patients taking Synjardy experience significant improvements in glycemic control compared to those on individual monotherapies.

Moreover, Synjardy has been associated with additional benefits, such as weight loss and blood pressure reduction. These effects can be particularly advantageous for patients with type 2 diabetes, as they often struggle with weight management and are at higher risk for cardiovascular complications.

Type 2 Diabetes

Type 2 diabetes is a chronic metabolic disorder that affects the way your body processes glucose, leading to high blood sugar levels. It is the most common form of diabetes, accounting for around 90% of all diabetes cases. Unlike Type 1 diabetes, where the body doesn’t produce insulin at all, Type 2 diabetes occurs when the body becomes resistant to insulin’s effects, or it doesn’t produce enough insulin to maintain normal blood sugar levels.

The exact cause of Type 2 diabetes is not fully understood, but several factors contribute to its development. These may include:

  1. Insulin Resistance: The body’s cells become less responsive to insulin, impairing glucose uptake.
  2. Genetic Predisposition: Family history of diabetes can increase the risk of Type 2 diabetes.
  3. Obesity: Excess body weight, especially around the abdomen, is a significant risk factor.
  4. Sedentary Lifestyle: Lack of physical activity can increase the likelihood of developing Type 2 diabetes.
  5. Poor Diet: A diet high in processed foods, sugar, and unhealthy fats can contribute to the condition.

Warnings and Precautions

Like any prescription drug, it comes with its own set of warnings and precautions.

  1. Consult Your Healthcare Provider: Before starting Synjardy, consult your healthcare provider, as they will determine if this medication is suitable for your specific medical condition.
  2. Allergies and Sensitivities: Inform your doctor about any known allergies or sensitivities to active ingredients in Synjardy to avoid adverse reactions.
  3. Kidney Function: Assess your kidney function before beginning the medication, as Synjardy may not be recommended for individuals with certain kidney conditions.
  4. Liver Function: Regularly monitor liver function while using Synjardy, as it may affect liver enzymes.
  5. Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to conceive, or breastfeeding, as the safety of Synjardy during these periods requires evaluation.
  6. Hypoglycemia: Be cautious of the risk of hypoglycemia (low blood sugar) while using Synjardy, especially if you are taking other medications that may lower blood sugar levels.
  7. Hyperglycemia: Monitor your blood sugar levels regularly to prevent hyperglycemia (high blood sugar) while using Synjardy.
  8. Lactic Acidosis: Understand the symptoms of lactic acidosis, a rare but serious side effect of Synjardy, and seek immediate medical attention if you experience any.
  9. Dehydration: Stay adequately hydrated while using Synjardy, as dehydration can increase the risk of kidney-related issues.
  10. Surgery and Medical Procedures: Inform healthcare professionals about your Synjardy usage before any surgery or medical procedure, as temporary discontinuation may be necessary.
  11. Alcohol Interaction: Limit alcohol consumption while taking Synjardy, as it may interact and exacerbate certain side effects.
  12. Drug Interactions: Inform your doctor about all medications, supplements, or herbal products you are taking to avoid potential drug interactions with Synjardy.
  13. Hemodialysis: If you are on hemodialysis, your doctor will adjust the dosing schedule of Synjardy to suit your condition.
  14. Hypotension: Be cautious of the risk of hypotension (low blood pressure) while using Synjardy, especially if you have a history of blood pressure issues.
  15. Vision Changes: If you experience any vision changes while using Synjardy, consult your doctor immediately.
  16. Infections: Synjardy may increase the risk of urinary tract infections, so promptly report any symptoms to your doctor.
  17. Peripheral Edema: Inform your healthcare provider if you notice swelling in your extremities while on Synjardy.
  18. Bone Fracture: Long-term use of Synjardy may increase the risk of bone fractures, so exercise caution and discuss any concerns with your doctor.
  19. Heart Failure: If you have a history of heart failure, monitor your condition closely while using Synjardy.
  20. Pancreatitis: In rare cases, Synjardy may lead to pancreatitis. Watch for symptoms such as severe abdominal pain and seek medical attention immediately if experienced.
  21. Driving and Machinery: Be aware of potential dizziness or drowsiness while on Synjardy and avoid activities that require full attention, such as driving or operating heavy machinery.
  22. Elderly Patients: Elderly individuals may be more susceptible to certain side effects of Synjardy, so special care and monitoring are required.
  23. Storage: Store Synjardy in a cool, dry place, away from direct sunlight and out of reach of children and pets.
  24. Disposal: Properly dispose of unused or expired medication following local guidelines and regulations.
  25. Follow Doctor’s Instructions: Adhere to your doctor’s instructions regarding dosage, timing, and usage of Synjardy to ensure its effectiveness and safety.

Side Effects

Common Side Effects

  • Frequent Urination and Increased Thirst: Some users may experience an increased need to urinate and feel thirsty more often than usual. This occurs due to the medication’s mechanism of action in promoting glucose excretion through the urine.
  • Genital Yeast Infections: In certain cases, individuals may develop yeast infections in the genital area. This is more commonly observed in females.
  • Nausea and Stomach Discomfort: Users may experience mild stomach discomfort and nausea, particularly during the initial stages of treatment.
  • Headaches: Occasional headaches have been reported by some individuals as their bodies adjust to the medication.
  • Weight Loss: As a positive side effect for some, Synjardy may lead to gradual weight loss.

Rare Side Effects

  • Lactic Acidosis: This is a severe condition where there is a buildup of lactic acid in the bloodstream. It requires immediate medical attention.
  • Hypotension (Low Blood Pressure): In isolated cases, Synjardy may cause a drop in blood pressure, leading to dizziness or fainting.
  • Allergic Reactions: Rarely, individuals may develop allergic reactions characterized by itching, hives, swelling, and difficulty breathing. Seek medical help immediately if this occurs.
  • Dehydration: Some users may experience dehydration due to increased urination. Staying well-hydrated is crucial while on this medication.
  • Changes in Urination Patterns: In a few instances, users may notice changes in urine color or frequency, which may indicate kidney-related issues.

Severe Side Effects

  • Ketoacidosis: This is a serious complication where the body produces high levels of ketones, potentially leading to a life-threatening condition.
  • Severe Hypoglycemia: In rare cases, Synjardy may cause very low blood sugar levels, leading to confusion, dizziness, and even loss of consciousness.
  • Pancreatitis: A severe inflammation of the pancreas that requires immediate medical attention.
  • Acute Kidney Injury: This is a serious condition that affects kidney function and may occur in some individuals taking Synjardy.
  • Bone Fractures: Some studies have suggested an increased risk of bone fractures in individuals using empagliflozin, one of the components of Synjardy.


While it can be a beneficial medication for diabetes management, it’s essential to understand potential interactions with other drugs, herbs, and foods to ensure safe and effective treatment.

Drug Interactions

  1. Anti-hypertensive Medications: Combining Synjardy with other blood pressure-lowering medications may lead to additive effects, causing an excessive drop in blood pressure. Regular monitoring is necessary to avoid complications.
  2. Diuretics (Water Pills): Diuretics can increase the risk of dehydration when taken with Synjardy, as both medications can promote water loss. Proper hydration is essential to prevent potential kidney issues.
  3. SGLT-2 Inhibitors: Since empagliflozin, one of the components in Synjardy, is an SGLT-2 inhibitor, combining it with other drugs from the same class may increase the risk of ketoacidosis, a serious condition that can lead to coma or death.
  4. NSAIDs (Non-Steroidal Anti-Inflammatory Drugs): NSAIDs can reduce the effectiveness of diuretics, potentially counteracting the blood sugar-lowering effects of Synjardy.
  5. Beta-Blockers: Beta-blockers mask the symptoms of low blood sugar (hypoglycemia), making it challenging to identify and treat this condition promptly.
  6. Corticosteroids: Corticosteroids can elevate blood sugar levels, which may interfere with the effectiveness of Synjardy in controlling diabetes.

Herbal Interactions

  1. Ginseng: Ginseng may lower blood sugar levels, which can enhance the effects of Synjardy, leading to hypoglycemia. Regular blood sugar monitoring is crucial when combining these two.
  2. Garlic: Garlic supplements may also lower blood sugar, potentially increasing the risk of hypoglycemia when taken alongside Synjardy.
  3. Aloe Vera: Aloe vera supplements can interact with diabetes medications and may lead to fluctuations in blood sugar levels.
  4. Cinnamon: Cinnamon may enhance insulin sensitivity, which could potentially interact with metformin in Synjardy.
  5. Fenugreek: Fenugreek may also lower blood sugar levels, which can be risky when combined with Synjardy.
  6. St. John’s Wort: St. John’s Wort can reduce the effectiveness of Synjardy, leading to poorly controlled diabetes.

Food Interactions

  1. Grapefruit: Grapefruit and its juice can inhibit an enzyme responsible for metabolizing certain medications, including empagliflozin in Synjardy, leading to increased drug levels and potential side effects.
  2. Alcohol: Drinking alcohol while taking Synjardy can increase the risk of lactic acidosis, a rare but serious condition.
  3. High-Fat Meals: High-fat meals can delay the absorption of metformin in Synjardy, potentially reducing its effectiveness in controlling blood sugar.
  4. Caffeine: Caffeine can affect blood sugar levels, so it’s essential to monitor its consumption while on Synjardy.
  5. Sugary Foods: Consuming excessive sugary foods may counteract the blood sugar-lowering effects of Synjardy.


Synjardy comes in different strengths, each tailored to the specific needs of individual patients. The strengths are denoted by the milligram dosage of empagliflozin followed by the milligram dosage of metformin. The available strengths are as follows:


This strength of Synjardy contains 5 milligrams of empagliflozin and 500 milligrams of metformin. It is often prescribed as an initial dose for patients who are new to diabetes medication.


In this combination, Synjardy contains 5 milligrams of empagliflozin and 850 milligrams of metformin. It is typically prescribed when a patient requires a higher dosage of metformin for better glycemic control.


This strength consists of 5 milligrams of empagliflozin and 1000 milligrams of metformin. It is commonly used when a patient needs a higher dose of both medications to manage their diabetes effectively.


The 12.5 milligrams of empagliflozin combined with 500 milligrams of metformin is a variation designed to meet specific patient requirements.


This combination contains 12.5 milligrams of empagliflozin and 850 milligrams of metformin. It is used in cases where higher metformin doses are necessary, but the patient may require a lower dose of empagliflozin.


For patients needing both higher doses of empagliflozin and metformin, the 12.5 milligrams of empagliflozin combined with 1000 milligrams of metformin can be prescribed.


Understanding the dosing guidelines for Synjardy is crucial for its safe and effective use in managing type 2 diabetes.

Initial Dosing

When starting Synjardy, it is essential to follow the initial dosing guidelines provided by your healthcare professional. The recommended starting dose may vary based on your current diabetes medications, overall health, and kidney function. Generally, the initial dose involves taking one tablet of Synjardy once daily with meals.

Maintenance Dosing

After the initial dosing period, your healthcare provider may adjust the maintenance dose based on your blood sugar levels and how well your body responds to the medication. The typical maintenance dose of Synjardy involves taking one tablet twice daily, once in the morning and once in the evening, with meals.

Missed Dose

If you accidentally miss a dose of Synjardy, it is crucial to take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. In such cases, skip the missed dose and continue with your regular dosing schedule. Never take two doses at the same time to make up for the missed one.


An overdose of Synjardy can be dangerous and may lead to severe hypoglycemia (low blood sugar) or lactic acidosis (a buildup of lactic acid in the blood). If you suspect an overdose or experience symptoms such as extreme weakness, dizziness, confusion, rapid breathing, or fainting, seek immediate medical attention.


If you or your loved ones are taking Synjardy, it’s essential to understand how to store the medication properly to maintain its effectiveness and potency.

  1. Store in a Cool, Dry Place: Keep Synjardy in its original packaging and store it in a cool, dry place away from direct sunlight, heat, or moisture.
  2. Temperature Range: Ensure the storage temperature is between 68°F to 77°F (20°C to 25°C). Avoid extreme temperatures, as they can compromise the medication’s quality.
  3. Keep Away from Children and Pets: Store Synjardy in a location inaccessible to children and pets. Consider using childproof containers for added safety.
  4. Avoid Bathroom Storage: Refrain from keeping the medication in the bathroom or any other area with high humidity. Humidity can lead to degradation of the drug.
  5. Do Not Freeze: Avoid freezing Synjardy, as freezing temperatures can cause irreversible damage to the medication.
  6. Protect from Light: Protect the medication from exposure to direct light. Keep it in its original amber-colored container to shield it from light exposure.
  7. Reseal the Container Properly: After each use, make sure to reseal the container tightly. This step helps prevent air and moisture from entering, which can accelerate deterioration.
  8. Use the Original Container: Always keep Synjardy in its original container, with the label and instructions intact. Do not transfer it to other containers, as this may lead to confusion and misuse.
  9. Check Expiry Date: Regularly check the expiry date of your Synjardy medication. Dispose of any expired or unused medication following proper guidelines.
  10. Avoid Extreme Humidity: High humidity can affect the stability of the medication. Store it in a dry environment to prevent moisture-related damage.
  11. Store Away from Heat Sources: Keep Synjardy away from heat sources like stoves, radiators, or heating vents, as exposure to heat can alter its composition.
  12. Do Not Store in the Car: Avoid leaving Synjardy in the car, especially during hot or cold weather, as car temperatures can fluctuate drastically.
  13. Traveling with Synjardy: If you need to travel with Synjardy, ensure it is stored in a cool, insulated bag and protected from extreme temperatures.
  14. Keep Medications Separate: Store Synjardy away from other medications, vitamins, or supplements. Mixing drugs may lead to cross-contamination or reduced potency.
  15. Store Away from Moisture-Absorbing Packets: While many medications come with moisture-absorbing packets, Synjardy does not require them. Keep the medication away from these packets to prevent moisture buildup.
  16. Organize Medications by Date: If you have multiple prescriptions, arrange them by the expiration date. This practice ensures you use older medications first and minimizes wastage.
  17. Keep Record of Storage Conditions: Maintain a record of the storage conditions, including temperature and humidity levels, to ensure compliance with ideal storing guidelines.
  18. Dispose of Damaged Packaging: If the original packaging is damaged, replace it or transfer the medication to a new, appropriate container with a childproof cap.
  19. Consult Pharmacist for Doubts: If you have any doubts about storing Synjardy, don’t hesitate to consult your pharmacist for guidance.
  20. Follow Storage Instructions from the Manufacturer: Adhere to the storage instructions provided by the manufacturer on the medication’s packaging or leaflet.
  21. Keep Medication Dry: Ensure that the medication does not come into direct contact with water or any liquids, as it may lead to degradation.
  22. Keep Away from Electric Appliances: Avoid storing Synjardy near electric appliances that generate heat, such as ovens or space heaters.
  23. Don’t Split Tablets in Advance: Only split Synjardy tablets at the time of consumption, if necessary. Pre-splitting can lead to exposure and degradation.
  24. Maintain Consistent Temperature: Try to maintain a consistent room temperature where you store the medication to prevent temperature fluctuations.
  25. Secure Medication During Earthquakes: If you live in an earthquake-prone area, secure the medication in a safe and stable location to avoid spillage or damage.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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