Janumet is a prescription medication used to treat type 2 diabetes. It combines two active ingredients: sitagliptin and metformin. Sitagliptin belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors, while metformin is a biguanide. Together, the two ingredients work to control blood sugar levels in patients with type 2 diabetes by targeting different mechanisms in the body.

How Does Janumet Work?

Sitagliptin works by increasing the levels of incretin hormones in the body, which stimulate the release of insulin and inhibit the release of glucagon. Metformin works by decreasing the amount of sugar produced by the liver and improving the body’s response to insulin. By combining these two medications, Janumet provides a dual mechanism of action to effectively manage blood sugar levels in patients with type 2 diabetes.

Precautions and Warnings With Janumet

  • Hypoglycemia: Janumet can sometimes cause low blood sugar levels (hypoglycemia), especially when used in combination with other diabetes medications or insulin.
  • Kidney Function: Janumet should be used with caution in patients with impaired kidney function, as it may increase the risk of a rare but severe side effect called lactic acidosis.
  • Pancreatitis: Pancreatitis (inflammation of the pancreas) is a severe possible side effect for patients taking Janumet. As such, patients should be monitored for signs and symptoms of pancreatitis, such as severe abdominal pain, and Janumet should be discontinued if pancreatitis is suspected.
  • Heart Failure: Janumet should not be used in patients with severe heart failure.
  • Allergic Reactions: Some patients may experience allergic reactions to Janumet, including rash, itching, or swelling of the face, lips, or tongue.
  • Hypersensitivity: Janumet should be used with caution in patients with a history of hypersensitivity reactions to either sitagliptin or metformin.

Janumet Side Effects

While Janumet is generally well-tolerated, like any medication, it may cause side effects in some individuals. Side effects associated with Janumet may include:

Common Side Effects

  • Low blood sugar (if you also use insulin or another oral diabetes medication)
  • Upset stomach, indigestion, gas, diarrhea, nausea, vomiting
  • Headache, weakness
  • Cold symptoms such as runny or stuffy nose, sneezing, sore throat

Serious Side Effects

  • Unusual muscle pain
  • Feeling cold
  • Trouble breathing
  • Feeling dizzy, light-headed, tired, or very weak
  • Stomach pain, nausea with vomiting
  • Slow or irregular heartbeat
  • Itching, blisters, breakdown of the outer layer of skin
  • Severe or ongoing pain in your joints
  • Little or no urinating
  • Shortness of breath (even while lying down)
  • Swelling in your legs or feet
  • Rapid weight gain
  • Signs of low blood sugar
    • Headache
    • Sleepiness
    • Dizziness
    • Sweating
    • Feeling jittery
    • Hunger
    • Fast heartbeat

Drug Interactions With Janumet

Janumet may interact with other medications, supplements, or substances, potentially affecting its effectiveness or increasing the risk of adverse effects. Some notable drug interactions with Janumet include:

  • Acetazolamide
  • Alcohol
  • Angiotensin Converting Enzyme Inhibitors (ACEIs): Captopril, Enalapril, Ramipril
  • Antipsychotics: Clozapine, Haloperidol, Olanzapine, Seroquel, Risperidone
  • β2-Agonists: Salbutamol, Formoterol
  • Basiliximab
  • Birth Control Pills (Yaz and Seasonique)
  • Brinzolamide
  • Buserelin
  • Calcium Channel Blockers: Amlodipine, Diltiazem, Nifedipine, Verapamil
  • Cephalexin (Keflex)
  • Chloroquine
  • Cimetidine
  • Inhaled Corticosteroids: Budesonide (Entocort), Ciclesonide (Alvesco), Fluticasone (Flovent Diskus)
  • Oral Corticosteroids: Dexamethasone, Hydrocortisone, Prednisone
  • Cyproterone
  • Danazol
  • Other Diabetes Medications: Acarbose, Canagliflozin, Glyburide, Insulin, Metformin, Rosiglitazone
  • Digoxin
  • Disopyramide
  • Diuretics (Water Pills): Hydrochlorothiazide, Furosemide
  • Dorzolamide
  • Epinephrine
  • Estrogens: Conjugated Estrogen, Estradiol (Vivelle), Ethinyl Estradiol
  • Everolimus
  • Goserelin
  • Glucagon
  • Glycopyrrolate
  • Hepatitis C Antivirals: Elbasvir, Glecaprevir
  • HIV Integrase Inhibitors: Bictegravir, Dolutegravir (Tivicay)
  • HIV Protease Inhibitors: Atazanavir, Indinavir
  • Hydroxychloroquine (Plaquenil)
  • Iodinated Contrast Material
  • Isoniazid
  • Lamotrigine (Lamictal)
  • Lanreotide
  • Leuprolide
  • Mifepristone
  • Monoamine Oxidase Inhibitors (MAOIs): Moclobemide, Phenelzine
  • Nicotinic Acid
  • Nilotinib
  • Non-Steroidal Anti-Inflammatory Medications (NSAIDs): Diclofenac (Voltaren), Ibuprofen
  • Octreotide
  • Ondansetron (Zofran)
  • Pasireotide
  • Pegvisomant
  • Progestins: Dienogest (Visanne), Levonorgestrel
  • Quinine
  • Quinolone Antibiotics: Ciprofloxacin, Levofloxacin (Levaquin)
  • Ranolazine
  • John’s Wort
  • Salicylates (ASA)
  • Selective Serotonin Reuptake Inhibitors (SSRIs): Citalopram, Fluoxetine (Prozac)
  • Sirolimus
  • Somatropin
  • Statin Anticholesterol Medications: Atorvastatin, Lovastatin
  • Sulfonamides: Sulfamethoxazole
  • Sunitinib
  • Tacrolimus
  • Testosterone
  • Thyroid Replacements: Desiccated Thyroid, Levothyroxine (Synthroid)
  • Topiramate
  • Tramadol
  • Trimethoprim
  • Trospium
  • Warfarin
  • Vandetanib
  • Vorinostat

Strengths and Dosages of Janumet

Available Strengths

  • Janumet is available in tablet form for oral administration.
  • The available strengths of Janumet include:
    • Janumet 50 mg/500 mg (sitagliptin/metformin)
    • Janumet 50 mg/850 mg (sitagliptin/metformin)
    • Janumet 50 mg/1000 mg (sitagliptin/metformin)

Recommended Dosages

  • The dosage of Janumet is often individualized based on factors such as the patient’s current blood sugar levels, kidney function, and response to treatment.
  • The usual starting dose of Janumet is one tablet taken twice daily with meals.
  • The maximum recommended dose of Janumet is 100 mg of sitagliptin and 2000 mg of metformin per day.

Cost of Janumet in America

At this time of writing, the cost for Janumet oral tablet (1000 mg-50 mg) to be approximately $613 for a supply of 60 tablets.

Patients are encouraged to check with their local pharmacies, insurance providers, or explore patient assistance programs to determine the most cost-effective option for obtaining Janumet.

 Why is Janumet so Expensive?

  • Research and Development Costs: The development of pharmaceuticals like Janumet involves extensive research and development (R&D) efforts, which can span over many years and involve significant financial investment. These R&D expenses are often factored into the pricing of Janumet to recoup the investment made by the pharmaceutical company.
  • Patent Protection: Pharmaceutical companies typically hold patents on their medications, including Janumet, which grant them exclusive rights to produce and sell the drug for a certain period. During this time, known as the patent exclusivity period, generic versions of the medication cannot enter the market, allowing the manufacturer to set higher prices without competition.
  • Complex Manufacturing Processes: Janumet is a combination medication that contains two active ingredients, sitagliptin and metformin, in specific formulations. Manufacturing such complex formulations involves intricate processes and quality control measures to ensure consistency and efficacy. These manufacturing complexities can drive up production costs, which may be reflected in the pricing of Janumet.
  • Regulatory Compliance: Pharmaceutical companies are required to adhere to strict regulatory standards set by government agencies such as the Food and Drug Administration (FDA) in the US. The costs associated with regulatory compliance, including fees for drug approvals and ongoing monitoring, often contribute to the overall expenses of bringing Janumet to market and influence its pricing.
  • Marketing and Distribution: Pharmaceutical companies invest significant resources in marketing and distribution efforts to promote their medications and make them available to healthcare providers and patients. While these activities are essential for raising awareness and ensuring widespread availability of Janumet, they also add to the overall cost of the medication, which may be passed on to consumers.

Janumet Alternatives

  • Metformin (Glucophage): Metformin is a first-line medication for the treatment of type 2 diabetes. It works by reducing the amount of sugar produced by the liver and improving the body’s response to insulin.
  • Sitagliptin (Januvia): Sitagliptin is another medication used to treat type 2 diabetes. It belongs to the same class of drugs as sitagliptin in Janumet, known as dipeptidyl peptidase-4 (DPP-4) inhibitors. Sitagliptin works by increasing the levels of incretin hormones in the body, which stimulate the release of insulin and inhibit the release of glucagon.
  • SGLT2 Inhibitors (e.g., Invokana, Jardiance): Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a class of medications that work by blocking the reabsorption of glucose by the kidneys, leading to increased glucose excretion in the urine.
  • Sulfonylureas (e.g., Glimepiride, Glipizide): Sulfonylureas are a class of medications that stimulate the pancreas to release more insulin, helping to lower blood sugar levels in patients with type 2 diabetes.
  • Thiazolidinediones (e.g., Pioglitazone, Rosiglitazone): Thiazolidinediones are medications that improve insulin sensitivity in the body and decrease insulin resistance.
  • GLP-1 Receptor Agonists (e.g., Liraglutide, Dulaglutide): Glucagon-like peptide-1 (GLP-1) receptor agonists are injectable medications that stimulate insulin secretion, inhibit glucagon secretion, and slow gastric emptying, leading to improved blood sugar control in patients with type 2 diabetes.
  • DPP-4 Inhibitors (e.g., Sitagliptin, Saxagliptin): Dipeptidyl peptidase-4 (DPP-4) inhibitors, similar to sitagliptin in Janumet, work by increasing the levels of incretin hormones in the body, which stimulate insulin secretion and inhibit glucagon secretion.
  • Insulin Therapy: Insulin therapy is often necessary for patients with type 2 diabetes who have failed to achieve adequate glycemic control with oral medications alone.

FAQs of Janument

What is Janumet?

Janumet is a medication used to treat type 2 diabetes. It is a combination of two drugs, sitagliptin and metformin, which work together to help control blood sugar levels.

When will generic Janumet be available?

Generic versions of Janumet may become available after the expiration of patent protection. The availability of generic Janumet will depend on various factors, including patent expiration dates and regulatory approvals.

How long does Janumet stay in your system?

The duration of Janumet’s presence in the body can vary depending on factors such as metabolism and kidney function. Generally, Janumet has a half-life of approximately 12 hours, meaning it may take several days for the medication to be completely eliminated from the body.

How does Janumet work?

Janumet works by increasing the levels of incretin hormones in the body, which stimulate the release of insulin and inhibit the release of glucagon. This helps to lower blood sugar levels in patients with type 2 diabetes.

How long does it take for Janumet to work?

Janumet begins to work immediately after ingestion, with peak effects typically occurring within 2 to 3 hours after administration. However, it may take several weeks to months to see the full benefits of Janumet in terms of lowering blood sugar levels.

Who makes Janumet?

Janumet is manufactured by Merck & Co., Inc., a global pharmaceutical company headquartered in the United States.

How long do Janumet side effects last?

The duration of Janumet side effects can vary depending on the individual and the specific side effect experienced. Some side effects may resolve on their own after a few days or weeks, while others may persist for a longer duration.

How to take Janumet?

Janumet is typically taken orally, with or without food, as directed by your healthcare provider.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

Product was successfully added to your cart!