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Cresemba (isavuconazole) is an antifungal medication used to treat serious fungal infections, including invasive aspergillosis and invasive mucormycosis. These infections can be extremely dangerous, especially for those particularly dangerous for individuals with compromised immune systems, such as those undergoing chemotherapy or organ transplants.
Invasive aspergillosis is an infection caused by the Aspergillus mold, while invasive mucormycosis is caused by molds from the Mucormycetes group. Both are severe infections that require prompt medical treatment, typically occurring in individuals with compromised immune systems, such as those undergoing chemotherapy or organ transplants.
Cresemba works through a complex process that inhibits a key enzyme fungal cells need to maintain their cell membrane. In other words, Cresemba breaks down the integrity of the fungal cells’s protective outer membrane ultimately leading to the death of the cell.
Labeled Warnings of Cresemba
Cresemba comes with a black box warning from the FDA, displayed prominently on the drug’s prescribing information, surrounded by a black border, hence the name “black box.”
When a drug is given a black box warning, it means that it has been shown to cause severe adverse reactions, which could lead to hospitalization, permanent damage, or even death. The warning also indicates that these reactions could be more severe in specific groups, such as pregnant women, children, and the elderly. In these populations, extra caution is necessary, and the drug should only be used when absolutely essential.
Cresemba Precautions
Patients taking Cresemba should have their liver function closely monitored, as the medication can put a strain on the liver, leading to potential liver damage. Liver tests are recommended at the start of treatment and periodically throughout the therapy. If severe liver injury is detected, such as jaundice or significantly elevated liver enzymes, Cresemba should be stopped immediately.
Side Effects of Cresemba
Cresemba has a range of potential side effects, varying from mild to severe.
Common Side Effects
Some of the most commonly reported side effects include:
- Nausea
- Vomiting
- Diarrhea
- Low potassium levels
- Abdominal pain
- Headache
- Elevated liver values
- Trouble breathing
- Swelling of the limbs
- Constipation
- Fatigue
- Insomnia
- Back pain
- Kidney failure
Children Common Side Effects
Children may have a different set of common side effects. Here are the symptoms to watch for in a child who is taking Cresemba:
- Diarrhea
- Abdominal pain
- Vomiting
- Elevated liver values
- Rash
- Nausea
- Headaches
Serious Side Effects
Though less common, Cresemba can lead to serious health risks. These side effects can be life-threatening if left untreated. If you notice any of these symptoms in either yourself or your child, stop taking Cresemba immediately and contact and call your, or your child’s healthcare provider, or go to the nearest hospital emergency room right away.
Here are some of the more serious concerns to be watchful for:
Liver Problems
Liver problems can occur when taking Cresemba. Liver function should be monitored carefully while taking Cresemba. A healthcare professional should order blood tests to establish your baseline, or starting lover values before starting Cresemba. Your values can then be checked again as needed and compared t o the starting point to assess the strain on your liver. Call your or your child’s healthcare provider right away if you or your child notice any of the following serious symptoms of an unhealthy liver.
- Itchy skin
- Nausea or vomiting
- Yellowing of your eyes
- Fatigue
- Flu-like symptoms
Severe Allergic Reaction
Severe allergic reactions are possible with Cresemba, as with any medication. Be watchful for signs of a severe allergic reaction which may include:
- Swelling of the face, lips, mouth, or tongue
- Wheezing
- Skin rash or skin hives
- Tachycardia
- Trouble breathing
- Severe itching
- Dizziness
- Sweating
Cresemba Drug Interactions
Patients should inform their healthcare provider of all medications, supplements, and herbal products they are using before starting Cresemba.
Cresemba can interact with various other medications, potentially altering its effectiveness or producing unexpected, and unwanted symptoms.
- Atorvastatin
- Barbiturates
- Bupropion
- Carbamazepine
- Digoxin
- Ketoconazole
- Lopinavir
- Midazolam
- Ritonavir
- Sirolimus
- John’s wort
- Tacrolimus
Cresemba Forms, Strengths & Dosages
Cresemba is available in oral capsules and a powder form that must be reconstituted to form a liquid injectable.
| Strength | Form | Quantity |
| 372 mg | Cresemba powder for injection | (10) packets of powder (372 mg each) |
| 186 mg | Cresemba capsules | Each box contains (14) 186 mg oral capsules |
| 74.5 mg | Cresemba capsules | Each box contains (35) 74.5 mg oral capsules |
Cresemba Dosage for Children & Adults
| Age (years) | Weight (kg) | Loading Dose (Day 1 and Day 2) | Maintenance Dose* (Day 3 and on) |
| 6 – 18 | 16 kg – < 18 kg | Take (2) 74.5 mg oral capsules at the same time, every 8 hours for the first 48 hours | Take (2) 74.5 mg oral capsules at the same time, once daily |
| 6 – 18 | 18 kg – < 25 kg | Take (3) 74.5 mg oral capsules at the same time, every 8 hours for the first 48 hours | Take (3) 74.5 mg oral capsules at the same time, once daily |
| 6 – 18 | 25 kg – < 32 kg | Take (4) 74.5 mg oral capsules at the same time, every 8 hours for the first 48 hours | Take (4) 74.5 mg oral capsules at the same time, once daily |
| 6 – 18 | 32 kg + | Take (5) 74.5 mg oral capsules at the same time, every 8 hours for the first 48 hours | Take (5) 74.5 mg at the same time, once daily |
| 18 + | 32 kg + | Take (5) 74.5 mg oral capsules at the same time, every 8 hours for the first 48 hours | Take (5) 74.5 mg oral capsules at the same time, once daily |
| Take (2) 186 mg oral capsules at the same time, every 8 hours for the first 48 hours | Take (2) 186 mg oral capsules at the same time, once a day |
Cost of Cresemba in America
Cresemba is pricier than its closest alternative treatment, Voriconazole, however, it has also been shown to be more effective against a wider range of fungal agents and produces fewer side effects than its alternatives. The exact cost to purchase Cresemba will vary depending on the formulation and the location it is purchased from.
At the time of this writing, Cresemba powder for reconstituting is available for $3,847.97 for 10 packs. When reconstituted, each pack will produce one 372 ml dose, making the price for Cresemba solution $384.94 per dose
Cresemba 186 mg capsules are currently priced at $1,497.96 for a box of 14 capsules, or $107 per capsule. The 74.5 mg strength is available in a box of 35 capsules for $1669.64, or $47.70 per capsule.
Cresemba Alternatives
Alternatives to Cresemba include other antifungal drugs like voriconazole, posaconazole, and amphotericin B. These alternatives might be considered depending on the specific fungal infection, patient tolerance, and individual cost factors
FAQs About Cresemba
What is Cresemba used for?
Cresemba treats serious invasive fungal infections, such as invasive aspergillosis and invasive mucormycosis.
What is an invasive fungal infection?
While molds and fungus are naturally occurring in the general environment, Invasive fungal infections occur when molds or fungi enter the body, causing serious, sometimes life-threatening conditions. These are particularly dangerous for individuals with compromised immune systems, such as those with cancer, organ transplants, diabetes, HIV, or severe burn injuries.
How long does Cresemba take to work?
The time it takes for Cresemba to work can vary depending on the severity of the infection and the patient’s overall health. Some improvements may be noticeable within a few days, but it may take several weeks for symptoms to fully resolve.
What is the difference between Cresemba and Voriconazole?
Both Cresemba and voriconazole are azole antifungal medications. While voriconazole has long been a standard treatment for invasive aspergillosis, Cresemba is a newer option that has been shown to offer benefits in terms of fewer side effects and a broader spectrum of coverage. However, because it is still relatively new, there is no approved generic version of Cresemba. This means that for the immediate future, Cresemba will be more expensive than its closest competitors.
Why is Cresemba so expensive?
The US and UK public health authorities have performed cost-analysis studies on Cresemba and deemed the drug to be a cost-effective treatment. It is pricier than its closest competitor because it is still in the early stages of release. There is not yet an approved generic version of the drug to offer a more affordable option.
How is Cresemba administered?
Cresemba can be taken orally in capsule form or administered via intravenous injection by a healthcare professional in a hospital setting. Cresemba solution is distributed in powder form and must be reconstituted properly to create an injectable solution. The injectable form must be administered through an intravenous filter infusion set.
Is Cresemba safe for children?
Cresemba solution can be used to treat invasive aspergillosis and invasive mucormycosis in children. Cresemba oral capsules are safe for children who are 6 years old or older. This makes Cresemba the only antifungal agent of its kind that is approved for treating invasive fungal infections in children.
Can you take Cresemba while pregnant?
Cresemba may cause fetal harm when administered during pregnancy. It should only be used if the potential benefits justify the potential risks to the fetus.
Who should not take Cresemba?
Cresemba should not be used by those with a history of allergic reactions to antifungals, or other medications. Additionally, those with a history of heart disease or liver problems should not take Cresemba unless these risks have been thoroughly discussed with a physician.
Can you drink alcohol while taking Cresemba?
Alcohol should be avoided while taking Cresemba. There is a small risk of liver damage associated with the use of Cresemba. Alcohol consumption increases this risk as well as the risk of developing gastrointestinal upset. Additionally, weakens the immune system making it more difficult for Cresemba to resolve the infection.
Our Guarantee For Buying Cresemba From A Canadian Pharmacy Partner
At MyRx Outlet, we are committed to delivering safe, high-quality medications that you can trust. We adhere to strict regulations in every country we operate in, ensuring that your order is handled by a licensed Canadian pharmacy or a trusted partner overseas. Each medication has been legally approved by Health Canada or other respected authorities. To purchase Cresemba at a discounted rate, call 1-888-551-2467.
IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.
