Tygacil is a broad-spectrum antibiotic used to treat various bacterial infections. It belongs to the glycylcycline class of antibiotics and is particularly effective against multidrug-resistant bacteria. It is usually prescribed for complicated skin infections, abdominal infections from surgical procedures, complicated UTIs (urinary tract infections), pneumonia treatments where alternative medicines have not been suitable, or other complex infections that occur in hospitalized patients. It is only administered in a clinical environment.

Tygacil stops bacteria from making proteins by attaching to a part called the 30S ribosomal subunit. This prevents the bacteria from adding building blocks called amino acids to their growing protein chain. This unique mechanism makes Tygacil effective against a wide range of bacteria. It’s a strong antibiotic option used in clinical environments often when there are other health complications.

Tygacil Precautions and Warnings

Please inform your healthcare provider about any allergies or previous adverse reactions to antibiotics (E.g., Amoxil). You should also avoid taking Tygacil if you’re pregnant or breastfeeding unless your doctor says otherwise. If your symptoms start to improve while taking your antibiotics, it’s essential to still complete the entire course of treatment, as with all antibiotics.

Tygacil may increase your risk of severe intestinal conditions like C. difficile-associated diarrhea. Patients with a history of liver problems should be monitored closely during Tygacil treatment.

Tygacil Side Effects

Like any medication, Tygacil can cause side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary. Most side effects are mild, and the more severe are rare but still important to note.

Common Side Effects

  • Nausea and Vomiting: Gastrointestinal symptoms such as nausea and vomiting are relatively common.
  • Diarrhea: Some individuals may experience diarrhea while taking Tygacil. Staying hydrated can help.
  • Headache: Headaches are reported as a common side effect, which could also be increased if you’re dehydrated or not well rested.
  • Injection Site Reactions: Pain, redness, or swelling at the injection site may occur. Please avoid scratching or rubbing it to avoid worsening the pain or leading to infection.
  • Increased Liver Enzymes: In some individuals, Tygacil may lead to elevated liver enzyme levels. This does not affect its own but could potentially indicate liver inflammation or damage, so it is recommended that you discuss it with your Doctor.
  • Skin Rashes: Skin reactions, such as rashes or itching, may occur. You may seek relief from topical remedies such as hydrocortisone over-the-counter or other anti-itch creams.
  • Fungal Infections: Use of broad-spectrum antibiotics like Tygacil can sometimes lead to overgrowth of fungi, causing conditions like oral or vaginal yeast infections.

Severe Side Effects

If you experience any severe side effects or have a mild side effect that is unusual for you, please call your doctor immediately. Below is a list of possible severe side effects of Tygacil.

  • Severe Allergic Reactions: Some people may experience severe allergic reactions, including difficulty breathing, swelling of the face or throat, and hives. Seek emergency medical attention immediately if this happens.
  • Liver Problems: Tygacil can occasionally lead to liver problems, resulting in symptoms such as yellowing of the skin or eyes (jaundice), dark urine, or persistent abdominal pain.
  • Pancreatitis: In rare cases, Tygacil has been associated with pancreatitis, characterized by severe abdominal pain.
  • Photosensitivity: Increased sensitivity to sunlight, leading to severe sunburn, may occur. It’s advisable to avoid prolonged sun exposure and always use sun protection.
  • Clostridioides difficile Infection (CDI): Tygacil, like many antibiotics, can increase the risk of Clostridioides difficile infection, which may cause severe diarrhea for weeks and months.
  • Increased Intracranial Pressure: In some instances, Tygacil has been associated with increased intracranial pressure, leading to severe headaches, blurred vision, and nausea.

Drug Interactions With Tygacil

Everyday drug interactions with Tygacil include:

Warfarin Tygacil may enhance the anticoagulant effect of warfarin, increasing your risk of bleeding. Close monitoring of clotting times is essential when these drugs are used together.
Digoxin Tygacil may increase digoxin concentrations, potentially leading to digoxin toxicity. Regularly monitoring digoxin levels is advisable when co-administered for anyone with irregular heartbeats or heart conditions.
Oral Contraceptives (such as Seasonique) Tygacil may reduce how well hormonal contraceptives may work. Additional or alternative contraceptive methods may be needed during Tygacil treatment.
Rifampin Rifampin (Rifadin) may reduce Tygacil concentrations, potentially compromising its effectiveness. The combination should be avoided, or the patient should be closely monitored for therapeutic response.

Strengths & Dosages of Tygacil

Tygacil is only available as an IV, administered in a doctor’s office or hospital under the supervision of a qualified medical expert. It is not sold over the counter, nor is it an at-home

remedy. The standard strength is 50 milligrams and is generally infused into the body over 30-60 minutes to ensure proper absorption and minimize the risk of negative reactions.  Typically, this dosage would be done over a schedule of every 12 hours throughout anywhere from 5 to 14 days. You should never self-administer Tygacil as it is a drug reserved for clinical settings only.

Frequently Asked Questions About Tygacil

Can Tygacil be taken with food?

Tygacil is usually administered intravenously (via an IV) and is not affected by food intake.

How long does it take for Tygacil to show improvement?

Improvement can vary based on the type and severity of the infection, but positive effects are typically observed within the first few days of treatment.

Are there any age restrictions for Tygacil use?

Tygacil is generally safe for adults, but its safety and efficacy in pediatric populations need to be better established.

Can Tygacil be used for viral infections?

No, Tygacil is an antibiotic and is only effective against bacterial infections. It does not treat viral infections.

What should I do if I miss a dose?

Contact your doctor immediately for guidance if you miss a dose of Tygacil. Remember to call your doctor for personalized advice and information regarding Tygacil. This product page is a general guide and not a substitute for professional medical advice.

How much does Tygacil cost in the USA?

A 50 mg vial of Tygacil in the United States typically ranges from $150 to $300. Still, the actual cost can vary based on location, specific dosage prescribed, and individual insurance plans and pharmacies.

Is there a generic for Tygacil?

There is no generic version of Tygacil on the market today. Still, suppose you are looking for a cost-effective alternative. In that case, you may discuss with your doctor to explore other antibiotics within the same therapeutic class or category available in generic form.

IMPORTANT NOTE: The information provided here is for educational purposes only and is not intended to serve as medical advice, diagnosis, or treatment recommendations. It should not be taken as an endorsement of any specific medication or treatment. Individual health conditions and responses to treatment can vary greatly; therefore, this information should not be seen as a guarantee of safety, suitability, or effectiveness for any particular individual. Always consult with a healthcare professional for personalized medical advice and before making any decisions regarding your health or treatment plans.

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